Claims for Patent: 9,422,281

Summary for Patent: 9,422,281

Title:	Benzopiperazine compositions as BET bromodomain inhibitors
Abstract:	The present invention relates to inhibitors of bromo and extra terminal (BET) br`omodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): ##STR00001## wherein X, Y, Z, R.sub.1, R.sub.2, R.sub.4 and R.sub.7 are defined herein.
Inventor(s):	Bair; Kenneth W. (Wellesley, MA), Herbertz; Torsten (Stow, MA), Kauffman; Goss S. (Ledyard, CT), Kayser-Bricker; Katherine J. (Branford, CT), Luke; George P. (Clinton, CT), Martin; Matthew W. (Arlington, MA), Millan; David S. (Watertown, MA), Schiller; Shawn E. R. (Haverhill, MA), Talbot; Adam C. (Giulford, CT), Tebbe; Mark J. (Arlington, MA)
Assignee:	Forma Therapeutics, Inc. (Watertown, MA)
Application Number:	14/546,896
Patent Claims:	1. A compound of Formula (I) ##STR01421## or a pharmaceutically acceptable salt, enantiomer hydrate, solvate, isomer, or tautomer thereof, wherein: X is selected from N or CR.sub.3; Y is selected from N or CR.sub.5; Z is selected from N or CR.sub.6; R.sub.1 is C.sub.1-C.sub.6 alkyl, or C.sub.1-C.sub.6 haloalkyl; R.sub.2 is --C(O)(CR.sup.kR.sup.l).sub.nO(CR.sup.kR.sup.l).sub.mR.sup.d, --C(O)(CR.sup.kR.sup.l).sub.nR.sup.e, --S(O).sub.2(CR.sup.kR.sup.l).sub.nR.sup.f, --(CR.sup.kR.sup.l).sub.nR.sup.g, --C(O)(CR.sup.kR.sup.l).sub.nNR.sup.aR.sup.g or --C(O)(CR.sup.kR.sup.l).sub.nS(CR.sup.kR.sup.l).sub.mR.sup.f; R.sub.3 and R.sub.6 are independently selected from hydrogen or halogen; R.sub.4 is C.sub.2-C.sub.6 alkyl, F, Cl, I, C.sub.3-C.sub.6 cycloalkyl, C.sub.6-C.sub.10 aryl, heterocycloalkyl, heteroaryl, --NR.sup.aR.sup.b, --C(O)R.sup.h, --OR.sup.h, C.sub.1-C.sub.6 haloalkyl, C.sub.2-C.sub.6 alkenyl, C.sub.2-C.sub.6 alkynyl, --C.sub.1-C.sub.4 alkyl(aryl), --C.sub.1-C.sub.4 alkyl(heteroaryl), or --C.sub.1-C.sub.4 alkyl(heterocycloalkyl), wherein the cycloalkyl, aryl, heterocycloalkyl, heteroaryl, and alkyl are optionally substituted with one or more R.sub.10; R.sub.5 is hydrogen, halogen, C.sub.1-C.sub.6 alkyl, nitro, --NH.sub.2, C.sub.1-C.sub.6 alkylamino, C.sub.1-C.sub.6 dialkylamino, C.sub.1-C.sub.6 aminoalkyl, C.sub.1-C.sub.6 aminoalkoxy, CN, C.sub.1-C.sub.6 alkoxy, --C(O)NR.sup.aR.sup.b, --NR.sup.aS(O).sub.2R.sup.b, --NR.sup.aC(O)R.sup.b, --NR.sup.aC(O)OR.sup.b, --NR.sup.aC(O)NR.sup.bR.sup.c, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, --S(O).sub.2NR.sup.aR.sup.b, or --S(O).sub.2R.sup.a; R.sub.7 is --C(O)R.sub.8, --C(O)OR.sub.8, --C(O)NR.sub.8R.sub.9, or --S(O).sub.2R.sub.8; R.sub.8 and R.sub.9 are independently hydrogen, --(CR.sup.kR.sup.l).sub.mOR.sup.a, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 haloalkyl, C.sub.3-C.sub.6 cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; each R.sub.10 is independently at each occurrence selected from the group consisting of C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 hydroxyalkyl, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, --OR.sup.i, --NR.sup.aR.sup.i, CN, oxo, --(CR.sup.kR.sup.l).sub.nS(O).sub.2R.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aS(O).sub.2R.sup.i, --(CR.sup.kR.sup.l).sub.nS(O).sub.2NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aR.sup.iS(O).sub.2NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nC(O)OR.sup.a, --(CR.sup.kR.sup.l).sub.nC(O)R.sup.i, --(CR.sup.kR.sup.l).sub.nC(O)NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nR.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aC(O)NR.sup.b, --(CR.sup.kR.sup.l).sub.nNR.sup.aC(O)OR.sup.b, and oxo, wherein each alkyl is substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form an aryl ring optionally substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form a heteroaryl ring optionally substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form a heterocycloalkyl ring optionally substituted with one or more R.sub.11; each R.sub.11 is independently at each occurrence selected from halogen, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, hydroxy, CN, C.sub.1-C.sub.6 hydroxyalkyl, --(CR.sup.kR.sup.l).sub.mNH.sub.2, C.sub.1-C.sub.6 alkylamino, C.sub.1-C.sub.6 dialkylamino, --C(O)NR.sup.aR.sup.b, --C(O)OR.sup.a, --C(O)R.sup.a, --S(O).sub.2R.sup.a, --C(O)H, --NR.sup.aC(O)OR.sup.a, --NR.sup.aC(O)C.sub.1-C.sub.6 alkyl, or oxo; or two R.sub.11 together can form a heterocycloalkyl ring; R.sup.a, R.sup.b, and R.sup.c are each independently at each occurrence hydrogen, C.sub.1-C.sub.6 alkyl, --C.sub.1-C.sub.4 alkyl(aryl), or aryl, wherein the alkyl and aryl are optionally substituted with one or more R.sub.10; R.sup.d is C.sub.1-C.sub.6 alkyl, C.sub.2-C.sub.6 alkenyl, C.sub.2-C.sub.6 alkynyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, CN, --C(O)C.sub.1-C.sub.6 alkyl, C.sub.3-C.sub.7 cycloalkyl, aryl, heteroaryl, or heterocycloalkyl, wherein cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sub.12; R.sup.e is hydrogen, C.sub.1-C.sub.6 alkyl, C.sub.2-C.sub.6 alkenyl, C.sub.2-C.sub.6 alkynyl, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, C.sub.1-C.sub.6 alkoxy, CN, C.sub.3-C.sub.7 cycloalkyl, aryl, heteroaryl, or heterocycloalkyl, wherein cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sub.12; R.sup.f is C.sub.3-C.sub.7 cycloalkyl, aryl, heteroaryl, or heterocycloalkyl, wherein cycloalkyl, aryl, heteroaryl and heterocycloalkyl are optionally substituted with one or more R.sub.12; R.sup.g is C.sub.1-C.sub.6 alkyl, C.sub.3-C.sub.7 cycloalkyl, --C.sub.1-C.sub.4 alkyl(C.sub.3-C.sub.7 cycloalkyl), aryl, --C.sub.1-C.sub.4 alkyl(aryl), heteroaryl, --C.sub.1-C.sub.4alkyl(heteroaryl), heterocycloalkyl or --C.sub.1-C.sub.4 alkyl(heterocycloalkyl), wherein cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sub.12; R.sup.h is C.sub.3-C.sub.7 cycloalkyl, aryl, heteroaryl, or heterocycloalkyl, wherein cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sub.10; R.sup.i is hydrogen, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 hydroxyalkyl, C.sub.1-C.sub.6 haloalkyl, --(CH.sub.2).sub.qN(H)C.sub.1-C.sub.6 alkyl, --(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, --(CR.sup.kR.sup.l).sub.mC.sub.3-C.sub.7 cycloalkyl, --(CR.sup.kR.sup.l).sub.maryl, --(CR.sup.kR.sup.l).sub.mheteroaryl, or --(CR.sup.kR.sup.l).sub.mheterocycloalkyl, wherein alkyl, cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sup.11; each R.sub.12 is independently at each occurrence selected from C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, hydroxy, NO.sub.2, --NH.sub.2, CH.sub.2NH.sub.2, --(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, C.sub.1-C.sub.6 alkylamino, C.sub.1-C.sub.6 dialkylamino, --O(CH.sub.2).sub.qN(H)C.sub.1-C.sub.6 alkyl, --O(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, aryl, heteroaryl, --NH-heteroaryl, --O-aryl, --S(O).sub.p--C.sub.1-C.sub.6 alkyl, --S(O).sub.p--N(H)C.sub.1-C.sub.6 alkyl, --S(O).sub.p--N(C.sub.1-C.sub.6 alkyl).sub.2, --C(O)C.sub.1-C.sub.6 alkyl, --C(O)OC.sub.1-C.sub.6 alkyl, --NHC(O)(C.sub.1-C.sub.6 alkyl), or oxo, wherein aryl and heteroaryl are optionally substituted with one or more substituents selected from C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, hydroxy, NO.sub.2, --NH.sub.2, C.sub.1-C.sub.6 alkylamino, or C.sub.1-C.sub.6 dialkylamino; or two R.sub.12 together with the carbon to which they are attached can form a 4- to 6 membered heterospirocycle; or two R.sub.12 together when on adjacent carbons form a C.sub.4-C.sub.6 cycloalkyl optionally substituted with one or more R.sub.13; or two R.sub.12 together when on adjacent carbons form an aryl optionally substituted with one or more R.sub.13; or two R.sub.12 together when on adjacent carbons form a heteroaryl optionally substituted with one or more R.sub.13; or two R.sub.12 together when on adjacent carbons form a heterocycloalkyl optionally substituted with one or more R.sub.13; or R.sub.12 with the carbon to which it is attached and the adjacent carbon form a C.sub.3 cycloalkyl optionally substituted with one or more R.sub.13; each R.sub.13 is independently at each occurrence selected from C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, hydroxy, NO.sub.2, --NH.sub.2, CH.sub.2NH.sub.2, --(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, C.sub.1-C.sub.6 alkylamino, C.sub.1-C.sub.6 dialkylamino, --O(CH.sub.2).sub.qN(H)C.sub.1-C.sub.6 alkyl, --O(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, aryl, heteroaryl, --NH-heteroaryl, --O-aryl, --S(O).sub.p--C.sub.1-C.sub.6 alkyl, --S(O).sub.p--N(H)C.sub.1-C.sub.6 alkyl, --S(O).sub.p--N(C.sub.1-C.sub.6 alkyl).sub.2, --C(O)C.sub.1-C.sub.6 alkyl, --NHC(O)(C.sub.1-C.sub.6 alkyl), or oxo, wherein aryl and heteroaryl are optionally substituted with one or more substituents selected from the group consisting of C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, hydroxy, NO.sub.2, --NH.sub.2, C.sub.1-C.sub.6 alkylamino, and C.sub.1-C.sub.6 dialkylamino; R.sup.k and R.sup.l are each independently at each occurrence selected from H, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, or halogen; each m, n, and p is independently at each occurrence 0, 1, or 2; and each q is independently at each occurrence 1, 2, 3 or 4; provided that when m is 0, R.sup.d is not C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkoxy, or CN. 2. The compound of claim 1, wherein R.sub.3 and R.sub.6 are independently selected from hydrogen or F. 3. The compound of claim 1, wherein X and Z are independently selected from N or CH. 4. The compound of claim 1, wherein Y is N or CR.sub.5 and R.sub.5 is hydrogen, halogen, nitro, --NH.sub.2, CN, C.sub.1-C.sub.3 alkoxy, --C(O)NR.sup.aR.sup.b, --NR.sup.aS(O).sub.2R.sup.b, --NR.sup.aC(O)R.sup.b, --NR.sup.aC(O)OR.sup.b, or --NR.sup.aC(O)NR.sup.bR.sup.c. 5. The compound of claim 1, wherein R.sub.4 is hydrogen, C.sub.3-C.sub.6 cycloalkyl, C.sub.6-C.sub.10 aryl, heterocycloalkyl, heteroaryl, --NR.sup.aR.sup.b, --C(O)R.sup.h, --OR.sup.h, wherein the cycloalkyl, aryl, heterocycloalkyl, heteroaryl, and alkyl are optionally substituted with one or more R.sub.10. 6. The compound of claim 1, wherein R.sub.1 is methyl. 7. The compound of claim 1, wherein R.sub.4 is selected from the group consisting of: ##STR01422## ##STR01423## 8. The compound of claim 1, wherein R.sub.4 is phenyl, pyridine, pyridazine, pyrimidine or pyrazole. 9. The compound of claim 1, wherein R.sub.7 is --C(O)R.sub.8, --C(O)OR.sub.8, or --C(O)NR.sub.8R.sub.9. 10. The compound of claim 1, wherein R.sub.8 is --CH.sub.3, or -cyclopropyl. 11. The compound of claim 1, wherein R.sub.2 is --C(O)(CH.sub.2).sub.nO(CH.sub.2).sub.mR.sup.d, --C(O)(CH.sub.2).sub.nR.sup.e, --S(O).sub.2(CH.sub.2).sub.nR.sup.f, --(CH.sub.2).sub.nR.sup.g, --C(O)(CH.sub.2).sub.nNR.sup.aR.sup.g. 12. The compound of claim 1, wherein R.sub.2 is --C(O)O(CH.sub.2).sub.mR.sup.d or --C(O)(CH.sub.2).sub.nR.sup.e. 13. The compound of claim 1, wherein, R.sup.d and R.sup.e are independently cyclopropyl, cyclobutyl, iso-propyl, or methyl. 14. The compound of claim 1, wherein X is CH, Y is CH, and Z is CH. 15. The compound of claim 1, wherein X is CH, Y is CH, Z is CH, and R.sub.1 is methyl. 16. The compound of claim 1, wherein X is CH, Y is CH, Z is CH, R.sub.1 is methyl and R.sub.2 is --C(O)O(CH.sub.2).sub.mR.sup.d or --C(O)(CH.sub.2).sub.nR.sup.e. 17. The compound of claim 1, wherein X is CH, Y is CH, Z is CH, R.sub.1 is methyl, R.sub.2 is --C(O)O(CH.sub.2).sub.mR.sup.d or --C(O)(CH.sub.2).sub.nR.sup.e, and R.sub.4 is phenyl, pyridine, pyridazine, pyrimidine, or pyrazole. 18. The compound of claim 1, having Formula (II): ##STR01424## or a pharmaceutically acceptable salt, enantiomer hydrate, solvate, isomer, or tautomer thereof, wherein: Ar is C.sub.6-C.sub.10 aryl or heteroaryl; R.sub.2 is --C(O)(CR.sup.kR.sup.l).sub.nO(CR.sup.kR.sup.l).sub.mR.sup.d, --C(O)(CR.sup.kR.sup.l).sub.nR.sup.e, --S(O).sub.2(CR.sup.kR.sup.l).sub.nR.sup.f, --(CR.sup.kR.sup.l).sub.nR.sup.g, --C(O)(CR.sup.kR.sup.l).sub.nNR.sup.aR.sup.g or --C(O)(CR.sup.kR.sup.l).sub.nS(CR.sup.kR.sup.l).sub.mR.sup.f; R.sub.8 is --(CR.sup.kR.sup.l).sub.mOR.sup.a, C.sub.1-C.sub.6 alkyl, or C.sub.3-C.sub.6 cycloalkyl; each R.sub.10 is independently at each occurrence selected from the group consisting of C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 hydroxyalkyl, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, --OR.sup.i, --NR.sup.aR.sup.i, CN, oxo, --(CR.sup.kR.sup.l).sub.nS(O).sub.2R.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aS(O).sub.2R.sup.i, --(CR.sup.kR.sup.l).sub.nS(O).sub.2NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aR.sup.iS(O).sub.2NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nC(O)OR.sup.a, --(CR.sup.kR.sup.l).sub.nC(O)R.sup.i, --(CR.sup.kR.sup.l).sub.nC(O)NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nR.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aC(O)NR.sup.b, and --(CR.sup.kR.sup.l).sub.nNR.sup.aC(O)OR.sup.b, wherein each alkyl is substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form an aryl ring optionally substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form a heteroaryl ring optionally substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form a heterocycloalkyl ring optionally substituted with one or more R.sub.11; each R.sub.11 is independently at each occurrence selected from halogen, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, hydroxy, CN, C.sub.1-C.sub.6 hydroxyalkyl, --(CR.sup.kR.sup.l).sub.mNH.sub.2, C.sub.1-C.sub.6 alkylamino, C.sub.1-C.sub.6 dialkylamino, --C(O)NR.sup.aR.sup.b, --C(O)OR.sup.a, --C(O)R.sup.a, --S(O).sub.2R.sup.a, --C(O)H, --NR.sup.aC(O)OR.sup.a, --NR.sup.aC(O)C.sub.1-C.sub.6 alkyl, or oxo; or two R.sub.11 together can form a heterocycloalkyl ring; R.sup.a and R.sup.b are each independently at each occurrence hydrogen, C.sub.1-C.sub.6 alkyl, --C.sub.1-C.sub.4alkyl(aryl), or aryl, wherein the alkyl and aryl are optionally substituted with one or more R.sub.10; R.sup.d is C.sub.1-C.sub.6 alkyl, C.sub.2-C.sub.6 alkenyl, C.sub.2-C.sub.6 alkynyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, CN, --C(O)C.sub.1-C.sub.6 alkyl, C.sub.3-C.sub.7 cycloalkyl, aryl, heteroaryl, or heterocycloalkyl, wherein cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sub.12; R.sup.e is hydrogen, C.sub.1-C.sub.6 alkyl, C.sub.2-C.sub.6 alkenyl, C.sub.2-C.sub.6 alkynyl, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, C.sub.1-C.sub.6 alkoxy, CN, C.sub.3-C.sub.7 cycloalkyl, aryl, heteroaryl, or heterocycloalkyl, wherein cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sub.12; R.sup.f is C.sub.3-C.sub.7 cycloalkyl, aryl, heteroaryl, or heterocycloalkyl, wherein cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sub.12; R.sup.g is C.sub.1-C.sub.6 alkyl, C.sub.3-C.sub.7 cycloalkyl, --C.sub.1-C.sub.4alkyl(C.sub.3-C.sub.7 cycloalkyl), aryl, --C.sub.1-C.sub.4alkyl(aryl), heteroaryl, --C.sub.1-C.sub.4alkyl(heteroaryl), heterocycloalkyl or --C.sub.1-C.sub.4 alkyl(heterocycloalkyl), wherein cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sub.12; R.sup.i is hydrogen, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 hydroxyalkyl, C.sub.1-C.sub.6 haloalkyl, --(CH.sub.2).sub.qN(H)C.sub.1-C.sub.6 alkyl, --(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, --(CR.sup.kR.sup.l).sub.mC.sub.3-C.sub.7 cycloalkyl, --(CR.sup.kR.sup.l).sub.maryl, --(CR.sup.kR.sup.l).sub.mheteroaryl, or --(CR.sup.kR.sup.l).sub.mheterocycloalkyl, wherein alkyl, cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sup.11; each R.sub.12 is independently at each occurrence selected from C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, hydroxy, NO.sub.2, --NH.sub.2, CH.sub.2NH.sub.2, --(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, C.sub.1-C.sub.6 alkylamino, C.sub.1-C.sub.6 dialkylamino, --O(CH.sub.2).sub.qN(H)C.sub.1-C.sub.6 alkyl, --O(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, aryl, heteroaryl, --NH-heteroaryl, --O-aryl, --S(O).sub.p--C.sub.1-C.sub.6 alkyl, --S(O).sub.p--N(H)C.sub.1-C.sub.6 alkyl, --S(O).sub.p--N(C.sub.1-C.sub.6 alkyl).sub.2, --C(O)C.sub.1-C.sub.6 alkyl, --C(O)OC.sub.1-C.sub.6 alkyl, --NHC(O)(C.sub.1-C.sub.6 alkyl), or oxo, wherein aryl and heteroaryl are optionally substituted with one or more substituents selected from C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, hydroxy, NO.sub.2, --NH.sub.2, C.sub.1-C.sub.6 alkylamino, or C.sub.1-C.sub.6 dialkylamino; or two R.sub.12 together with the carbon to which they are attached can form a 4- to 6 membered heterospirocycle; or two R.sub.12 together when on adjacent carbons form a C.sub.4-C.sub.6 cycloalkyl optionally substituted with one or more R.sub.13; or two R.sub.12 together when on adjacent carbons form an aryl optionally substituted with one or more R.sub.13; or two R.sub.12 together when on adjacent carbons form a heteroaryl optionally substituted with one or more R.sub.13; or two R.sub.12 together when on adjacent carbons form a heterocycloalkyl optionally substituted with one or more R.sub.13; or R.sub.12 with the carbon to which it is attached and the adjacent carbon form a C.sub.3 cycloalkyl optionally substituted with one or more R.sub.13; each R.sub.13 is independently at each occurrence selected from C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, hydroxy, NO.sub.2, --NH.sub.2, CH.sub.2NH.sub.2, --(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, C.sub.1-C.sub.6 alkylamino, C.sub.1-C.sub.6 dialkylamino, --O(CH.sub.2).sub.qN(H)C.sub.1-C.sub.6 alkyl, --O(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, aryl, heteroaryl, --NH-heteroaryl, --O-aryl, --S(O).sub.p--C.sub.1-C.sub.6 alkyl, --S(O).sub.p--N(H)C.sub.1-C.sub.6 alkyl, S(O).sub.p--N(C.sub.1-C.sub.6 alkyl).sub.2, --C(O)C.sub.1-C.sub.6 alkyl, --NHC(O)(C.sub.1-C.sub.6 alkyl), or oxo, wherein aryl and heteroaryl are optionally substituted with one or more substituents selected from the group consisting of C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, hydroxy, NO.sub.2, --NH.sub.2, C.sub.1-C.sub.6 alkylamino, and C.sub.1-C.sub.6 dialkylamino; R.sup.k and R.sup.l are each independently at each occurrence selected from H, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, or halogen; each m, n, and p is independently at each occurrence 0, 1, or 2; each q is independently at each occurrence 1, 2, 3 or 4; and s is 1, 2, 3, 4, or 5; provided that when m is 0, R.sup.d is not C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkoxy, or CN. 19. The compound of claim 1, having Formula (III) ##STR01425## or a pharmaceutically acceptable salt, enantiomer hydrate, solvate, isomer, or tautomer thereof, wherein: Ar is C.sub.6-C.sub.10 aryl or heteroaryl; each R.sub.10 is independently at each occurrence selected from the group consisting of C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 hydroxyalkyl, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, --OR.sup.i, --NR.sup.aR.sup.i, CN, oxo, --(CR.sup.kR.sup.l).sub.nS(O).sub.2R.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aS(O).sub.2R.sup.i, --(CR.sup.kR.sup.l).sub.nS(O).sub.2NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aR.sup.iS(O).sub.2NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nC(O)OR.sup.a, --(CR.sup.kR.sup.l).sub.nC(O)R.sup.i, --(CR.sup.kR.sup.l).sub.nC(O)NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nR.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aC(O)NR.sup.b, and --(CR.sup.kR.sup.l).sub.nNR.sup.aC(O)OR.sup.b, wherein each alkyl is substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form an aryl ring optionally substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons a heteroaryl ring optionally substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form a heterocycloalkyl ring optionally substituted with one or more R.sub.11; each R.sub.11 is independently at each occurrence selected from halogen, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, hydroxy, CN, C.sub.1-C.sub.6 hydroxyalkyl, --(CR.sup.kR.sup.l).sub.mNH.sub.2, C.sub.1-C.sub.6 alkylamino, C.sub.1-C.sub.6 dialkylamino, --C(O)NR.sup.aR.sup.b, --C(O)OR.sup.a, --C(O)R.sup.a, --S(O).sub.2R.sup.a, --C(O)H, --NR.sup.aC(O)OR.sup.a, --NR.sup.aC(O)C.sub.1-C.sub.6 alkyl, or oxo; or two R.sub.11 together can form a heterocycloalkyl ring; R.sup.a and R.sup.b are each independently at each occurrence hydrogen, C.sub.1-C.sub.6 alkyl, --C.sub.1-C.sub.4alkyl(aryl), or aryl, wherein the alkyl and aryl are optionally substituted with one or more R.sub.10; R.sup.i is hydrogen, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 hydroxyalkyl, C.sub.1-C.sub.6 haloalkyl, --(CH.sub.2)--N(H)C.sub.1-C.sub.6 alkyl, --(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, --(CR.sup.kR.sup.l).sub.mC.sub.3-C.sub.7 cycloalkyl, --(CR.sup.kR.sup.l).sub.maryl, --(CR.sup.kR.sup.l).sub.mheteroaryl, or --(CR.sup.kR.sup.l).sub.mheterocycloalkyl, wherein alkyl, cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sup.11; R.sup.k and R.sup.l are each independently at each occurrence selected from H, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, or halogen; each m and n is independently at each occurrence 0, 1, or 2; each q is independently at each occurrence 1, 2, 3 or 4; and s is 1, 2, 3, 4, or 5. 20. The compound of claim 1, having Formula (IV) ##STR01426## or a pharmaceutically acceptable salt, enantiomer hydrate, solvate, isomer, or tautomer thereof, wherein: Ar is C.sub.6-C.sub.10 aryl or heteroaryl; each R.sub.10 is independently at each occurrence selected from the group consisting of C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 hydroxyalkyl, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, --OR.sup.i, --NR.sup.aR.sup.i, CN, oxo, --(CR.sup.kR.sup.l).sub.nS(O).sub.2R.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aS(O).sub.2R.sup.i, --(CR.sup.kR.sup.l).sub.nS(O).sub.2NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aR.sup.iS(O).sub.2NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nC(O)OR.sup.a, --(CR.sup.kR.sup.l).sub.nC(O)R.sup.i, --(CR.sup.kR.sup.l).sub.nC(O)NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nR.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aC(O)NR.sup.b, and --(CR.sup.kR.sup.l).sub.nNR.sup.aC(O)OR.sup.b, wherein each alkyl is substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form an aryl ring optionally substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form a heteroaryl ring optionally substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form a heterocycloalkyl ring optionally substituted with one or more R.sub.11; each R.sub.11 is independently at each occurrence selected from halogen, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, hydroxy, CN, C.sub.1-C.sub.6 hydroxyalkyl, --(CR.sup.kR.sup.l).sub.mNH.sub.2, C.sub.1-C.sub.6 alkylamino, C.sub.1-C.sub.6 dialkylamino, --C(O)NR.sup.aR.sup.b, --C(O)OR.sup.a, --C(O)R.sup.a, --S(O).sub.2R.sup.a, --C(O)H, --NR.sup.aC(O)OR.sup.a, --NR.sup.aC(O)C.sub.1-C.sub.6 alkyl, or oxo; or two R.sub.11 together can form a heterocycloalkyl ring; R.sup.a and R.sup.b are each independently at each occurrence hydrogen, C.sub.1-C.sub.6 alkyl, --C.sub.1-C.sub.4 alkyl(aryl), or aryl, wherein the alkyl and aryl are optionally substituted with one to three R.sub.10; R.sup.i is hydrogen, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 hydroxyalkyl, C.sub.1-C.sub.6 haloalkyl, --(CH.sub.2).sub.qN(H)C.sub.1-C.sub.6 alkyl, --(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, --(CR.sup.kR.sup.l).sub.mC.sub.3-C.sub.7 cycloalkyl, --(CR.sup.kR.sup.l).sub.maryl, --(CR.sup.kR.sup.l).sub.mheteroaryl, or --(CR.sup.kR.sup.l).sub.mheterocycloalkyl, wherein alkyl, cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sup.11; R.sup.k and R.sup.l are each independently at each occurrence selected from H, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, or halogen; each m and n is independently at each occurrence 0, 1, or 2; each q is independently at each occurrence 1, 2, 3 or 4; and s is 1, 2, 3, 4, or 5. 21. The compound of claim 1, having Formula (V): ##STR01427## or a pharmaceutically acceptable salt, enantiomer hydrate, solvate, isomer, or tautomer thereof, wherein: Ar is C.sub.6-C.sub.10 aryl or heteroaryl; each R.sub.10 is independently at each occurrence selected from the group consisting of C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 hydroxyalkyl, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, --OR.sup.i, --NR.sup.aR.sup.i, CN, oxo, --(CR.sup.kR.sup.l).sub.nS(O).sub.2R.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aS(O).sub.2R.sup.i, --(CR.sup.kR.sup.l).sub.nS(O).sub.2NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aR.sup.iS(O).sub.2NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nC(O)OR.sup.a, --(CR.sup.kR.sup.l).sub.nC(O)R.sup.i, --(CR.sup.kR.sup.l).sub.nC(O)NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nR.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aC(O)NR.sup.b, and --(CR.sup.kR.sup.l).sub.nNR.sup.aC(O)OR.sup.b, wherein each alkyl is substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form an aryl ring optionally substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form a heteroaryl ring optionally substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form a heterocycloalkyl ring optionally substituted with one or more R.sub.11; each R.sub.11 is independently at each occurrence selected from halogen, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, hydroxy, CN, C.sub.1-C.sub.6 hydroxyalkyl, --(CR.sup.kR.sup.l).sub.mNH.sub.2, C.sub.1-C.sub.6 alkylamino, C.sub.1-C.sub.6 dialkylamino, --C(O)NR.sup.aR.sup.b, --C(O)OR.sup.a, --C(O)R.sup.a, --S(O).sub.2R.sup.a, --C(O)H, --NR.sup.aC(O)OR.sup.a, --NR.sup.aC(O)C.sub.1-C.sub.6 alkyl, or oxo; or two R.sub.11 together can form a heterocycloalkyl ring; R.sup.a and R.sup.b are each independently at each occurrence hydrogen, C.sub.1-C.sub.6 alkyl, --C.sub.1-C.sub.4 alkyl(aryl), or aryl, wherein the alkyl and aryl are optionally substituted with one or more R.sub.10; R.sup.d is C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 haloalkyl, C.sub.3-C.sub.7 cycloalkyl, aryl, heteroaryl, or heterocycloalkyl, wherein cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sub.12; R.sup.i is hydrogen, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 hydroxyalkyl, C.sub.1-C.sub.6 haloalkyl, --(CH.sub.2).sub.qN(H)C.sub.1-C.sub.6 alkyl, --(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, --(CR.sup.kR.sup.l).sub.mC.sub.3-C.sub.7 cycloalkyl, --(CR.sup.kR.sup.l).sub.maryl, --(CR.sup.kR.sup.l).sub.mheteroaryl, or --(CR.sup.kR.sup.l).sub.mheterocycloalkyl, wherein alkyl, cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sup.11; each R.sub.12 is independently at each occurrence selected from C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, hydroxy, NO.sub.2, --NH.sub.2, CH.sub.2NH.sub.2, --(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, C.sub.1-C.sub.6 alkylamino, C.sub.1-C.sub.6 dialkylamino, --O(CH.sub.2).sub.qN(H)C.sub.1-C.sub.6 alkyl, --O(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, aryl, heteroaryl, --NH-heteroaryl, --O-aryl, --S(O).sub.p--C.sub.1-C.sub.6 alkyl, --S(O).sub.p--N(H)C.sub.1-C.sub.6 alkyl, --S(O).sub.p--N(C.sub.1-C.sub.6 alkyl).sub.2, --C(O)C.sub.1-C.sub.6 alkyl, --C(O)0C.sub.1-C.sub.6 alkyl, --NHC(O)(C.sub.1-C.sub.6 alkyl), or oxo, wherein aryl and heteroaryl are optionally substituted with one or more substituents selected from C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, hydroxy, NO.sub.2, --NH.sub.2, C.sub.1-C.sub.6 alkylamino, or C.sub.1-C.sub.6 dialkylamino; or two R.sub.12 together with the carbon to which they are attached may form a 4- to 6 membered heterospirocycle; or two R.sub.12 together when on adjacent carbons form a C.sub.4-C.sub.6 cycloalkyl optionally substituted with one or more R.sub.13; or two R.sub.12 together when on adjacent carbons form an aryl optionally substituted with one or more R.sub.13; or two R.sub.12 together when on adjacent carbons form a heteroaryl optionally substituted with one or more R.sub.13; or two R.sub.12 together when on adjacent carbons form a heterocycloalkyl optionally substituted with one or more R.sub.13; or R.sub.12 with the carbon to which it is attached and the adjacent carbon form a C.sub.3 cycloalkyl optionally substituted with one or more R.sub.13; each R.sub.13 is independently at each occurrence selected from C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, hydroxy, NO.sub.2, --NH.sub.2, CH.sub.2NH.sub.2, --(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, C.sub.1-C.sub.6 alkylamino, C.sub.1-C.sub.6 dialkylamino, --O(CH.sub.2).sub.qN(H)C.sub.1-C.sub.6 alkyl, --O(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, aryl, heteroaryl, --NH-heteroaryl, --O-aryl, --S(O).sub.p--C.sub.1-C.sub.6 alkyl, --S(O).sub.p--N(H)C.sub.1-C.sub.6 alkyl, --S(O).sub.p--N(C.sub.1-C.sub.6 alkyl).sub.2, --C(O)C.sub.1-C.sub.6 alkyl, --NHC(O)(C.sub.1-C.sub.6 alkyl), or oxo, wherein aryl and heteroaryl are optionally substituted with one or more substituents selected from the group consisting of C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, hydroxy, NO.sub.2, --NH.sub.2, C.sub.1-C.sub.6 alkylamino, and C.sub.1-C.sub.6 dialkylamino; R.sup.k and R.sup.l are each independently at each occurrence selected from H, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, or halogen; each m, n, and p is independently at each occurrence 0, 1, or 2; each q is independently at each occurrence 1, 2, 3 or 4; and s is 1, 2, 3, 4, or 5; provided that when m is 0, R.sup.d is not C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkoxy, or CN. 22. The compound of claim 1, having Formula (VI): ##STR01428## or a pharmaceutically acceptable salt, enantiomer hydrate, solvate, isomer, or tautomer thereof, wherein: R.sub.10 is independently selected from the group consisting of C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 hydroxyalkyl, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, CN, oxo, --(CR.sup.kR.sup.l).sub.nS(O).sub.2R.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aS(O).sub.2R.sup.i, --(CR.sup.kR.sup.l).sub.nS(O).sub.2NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aR.sup.iS(O).sub.2NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nC(O)OR.sup.a, --(CR.sup.kR.sup.l).sub.nC(O)R.sup.i, --(CR.sup.kR.sup.l).sub.nC(O)NR.sup.aR.sup.i, --(CR.sup.kR.sup.l).sub.nR.sup.i, --(CR.sup.kR.sup.l).sub.nNR.sup.aC(O)NR.sup.b, and --(CR.sup.kR.sup.l).sub.nNR.sup.aC(O)OR.sup.b, wherein each alkyl is substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form an aryl ring optionally substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form a heteroaryl ring optionally substituted with one or more R.sub.11; or two R.sub.10 together when on adjacent carbons form a heterocycloalkyl ring optionally substituted with one or more R.sub.11; each R.sub.11 is independently at each occurrence selected from halogen, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, hydroxy, CN, C.sub.1-C.sub.6 hydroxyalkyl, --(CR.sup.kR.sup.l).sub.mNH.sub.2, C.sub.1-C.sub.6 alkylamino, C.sub.1-C.sub.6 dialkylamino, --C(O)NR.sup.aR.sup.b, --C(O)OR.sup.a, --C(O)R.sup.a, --S(O).sub.2R.sup.a, --C(O)H, --NR.sup.aC(O)OR.sup.a, --NR.sup.aC(O)C.sub.1-C.sub.6 alkyl, or oxo; or two R.sub.11 together can form a heterocycloalkyl ring; R.sup.a and R.sup.b are each independently hydrogen, C.sub.1-C.sub.6 alkyl, --C.sub.1-C.sub.4 alkyl(aryl), or aryl, wherein the alkyl and aryl are optionally substituted with one or more R.sub.10; R.sup.d is C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 haloalkyl, C.sub.3-C.sub.7 cycloalkyl, aryl, heteroaryl, or heterocycloalkyl, wherein cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sub.12; R.sup.i is hydrogen, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 hydroxyalkyl, C.sub.1-C.sub.6 haloalkyl, --(CH.sub.2).sub.qN(H)C.sub.1-C.sub.6 alkyl, --(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, --(CR.sup.kR.sup.l).sub.mC.sub.3-C.sub.7 cycloalkyl, --(CR.sup.kR.sup.l).sub.maryl, --(CR.sup.kR.sup.l).sub.mheteroaryl, or --(CR.sup.kR.sup.l).sub.mheterocycloalkyl, wherein alkyl, cycloalkyl, aryl, heteroaryl, and heterocycloalkyl are optionally substituted with one or more R.sup.11; each R.sub.12 is independently at each occurrence selected from C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, hydroxy, NO.sub.2, --NH.sub.2, CH.sub.2NH.sub.2, --(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, C.sub.1-C.sub.6 alkylamino, C.sub.1-C.sub.6 dialkylamino, --O(CH.sub.2).sub.qN(H)C.sub.1-C.sub.6 alkyl, --O(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, aryl, heteroaryl, --NH-heteroaryl, --O-aryl, --S(O).sub.p--C.sub.1-C.sub.6 alkyl, --S(O).sub.p--N(H)C.sub.1-C.sub.6 alkyl, --S(O).sub.p--N(C.sub.1-C.sub.6 alkyl).sub.2, --C(O)C.sub.1-C.sub.6 alkyl, --C(O)OC.sub.1-C.sub.6 alkyl, --NHC(O)(C.sub.1-C.sub.6 alkyl), or oxo, wherein aryl and heteroaryl are optionally substituted with one or more substituents selected from C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, hydroxy, NO.sub.2, --NH.sub.2, C.sub.1-C.sub.6 alkylamino, or C.sub.1-C.sub.6 dialkylamino; or two R.sub.12 together with the carbon to which they are attached may form a 4- to 6 membered heterospirocycle; or two R.sub.12 together when on adjacent carbons form a C.sub.4-C.sub.6 cycloalkyl optionally substituted with one or more R.sub.13; or two R.sub.12 together when on adjacent carbons form an aryl optionally substituted with one or more R.sub.13; or two R.sub.12 together when on adjacent carbons form a heteroaryl optionally substituted with one or more R.sub.13; or two R.sub.12 together when on adjacent carbons form a heterocycloalkyl optionally substituted with one or more R.sub.13; or R.sub.12 with the carbon to which it is attached and the adjacent carbon form a C.sub.3 cycloalkyl optionally substituted with one or more R.sub.13; each R.sub.13 is independently at each occurrence selected from C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, hydroxy, NO.sub.2, --NH.sub.2, CH.sub.2NH.sub.2, --(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, C.sub.1-C.sub.6 alkylamino, C.sub.1-C.sub.6 dialkylamino, --O(CH.sub.2).sub.qN(H)C.sub.1-C.sub.6 alkyl, --O(CH.sub.2).sub.qN(C.sub.1-C.sub.6 alkyl).sub.2, aryl, heteroaryl, --NH-heteroaryl, --O-aryl, --S(O).sub.p--C.sub.1-C.sub.6 alkyl, --S(O).sub.p--N(H)C.sub.1-C.sub.6 alkyl, --S(O).sub.p--N(C.sub.1-C.sub.6 alkyl).sub.2, --C(O)C.sub.1-C.sub.6 alkyl, --NHC(O)(C.sub.1-C.sub.6 alkyl), or oxo, wherein aryl and heteroaryl are optionally substituted with one or more substituents selected from consisting of C.sub.1-C.sub.6 alkyl, halogen, CN, C.sub.1-C.sub.6 alkoxy, hydroxy, NO.sub.2, --NH.sub.2, C.sub.1-C.sub.6 alkylamino, and C.sub.1-C.sub.6 dialkylamino; R.sup.k and R.sup.l are each independently at each occurrence selected from H, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkyl, or halogen; each m, n, and p is independently at each occurrence 0, 1, or 2; and each q is independently at each occurrence 1, 2, 3 or 4; provided that when m is 0, R.sup.d is not C.sub.1-C.sub.6 alkoxy, C.sub.1-C.sub.6 haloalkoxy, or CN. 23. A compound selected from the group consisting of: 3,3-difluorocyclobutyl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thietan-3-yl)-1H-pyrazol-4-y- l]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 4,4-difluorocyclohexyl (3S)-4-acetyl-3-methyl-7-[1-(oxan-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-methoxyphenyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 3,3-difluorocyclobutyl (3S)-4-acetyl-3-methyl-7-[1-(oxan-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 3,3-difluorocyclobutyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(oxetan-3-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-2-methyl-6-[1-(oxetan-3-yl)-1H-pyrazol-4-yl- ]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; propan-2-yl (3S)-4-acetyl-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1H-pyrazol-4-yl)-1,2,3,4-tetrahy- droquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1H-pyrazol-3-yl)-1,2,3,4-tetrahy- droquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(2-methyl-1,3-thiazol-5-yl)-1,2,3- ,4-tetrahydroquinoxalin-1-yl]ethan-1-one; phenyl (3S)-4-acetyl-3-methyl-7-(1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoxaline-- 1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; 1-[(2S)-4-(furan-2-carbonyl)-6-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-2-met- hyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-3-methyl-7-(1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoxaline-- 1-carboxylate; cyclopentyl (3S)-4-acetyl-3-methyl-7-(1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoxaline-- 1-carboxylate; ethyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; cyclopentyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1-cyclobutyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahydr- oquinoxaline-1-carboxylate; cyclopentyl (3S)-4-acetyl-7-(1-cyclobutyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahydr- oquinoxaline-1-carboxylate; 3,3-difluorocyclobutyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 3,3-difluorocyclobutyl (3S)-4-acetyl-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; 3,3-difluorocyclobutyl (3S)-4-acetyl-7-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-3-methyl-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; 3,3-difluorocyclobutyl (3S)-4-acetyl-7-[4-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)phenyl]-3- -methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 3,3-difluorocyclobutyl (3S)-4-acetyl-7-(4-methanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxaline-1-carboxylate; 4,4-difluorocyclohexyl (3S)-4-acetyl-7-(4-methanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxaline-1-carboxylate; 4,4-difluorocyclohexyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 4,4-difluorocyclohexyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 4,4-difluorocyclohexyl (3S)-4-acetyl-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; 4,4-difluorocyclohexyl (3S)-4-acetyl-7-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-3-methyl-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; 4,4-difluorocyclohexyl (3S)-4-acetyl-7-[4-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)phenyl]-3- -methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thietan-3-yl)-1H-pyrazol-4-y- l]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-3-methyl-7-[1-(oxan-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; cyclobutyl (3S)-4-acetyl-3-methyl-7-[1-(oxan-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 4-cyclopentyl 1-methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoxa- line-1,4-dicarboxylate; cyclopentyl (3S)-4-cyclopropanecarbonyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; methyl (2S)-4-cyclopropanecarbonyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoxa- line-1,4-dicarboxylate; 1-[(2S)-4-(1,3-benzoxazol-2-yl)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methy- l-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-(pyrimidin-2-yl)-1,2,3,4-t- etrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(1,3-benzoxazol-2-yl)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,- 3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-(pyridin-2-yl)-1,2,3,4-tet- rahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-(quinazolin-2-yl)-1,2,3,4-- tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-(4-phenylpyrimidin-2-yl)-1- ,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-(5-phenylpyrimidin-2-yl)-1- ,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-4-(quinazolin-2-yl)-1,- 2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-4-(1-methyl-1H-indazol- -3-yl)-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(1-methyl-1H-indazol-3-yl)-6-[1-(oxetan-3-yl)-1H-pyraz- ol-4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-4-(6-fluoro-1-methyl-1H-indazol- -3-yl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-4-(5-fluoro-1-methyl-1H-indazol- -3-yl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(1,3-benzoxazol-2-yl)-6-[1-(1,3-benzoxazol-2-yl)-1H-pyrazol-4-y- l]-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(3S)-1-(furan-2-carbonyl)-7-(4-methanesulfonylphenyl)-3-methyl-1H,2H,3- H,4H-pyrido[3,4-b]pyrazin-4-yl]ethan-1-one; propan-2-yl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1H,2H,3H,4H-pyrido[3,4- -b]pyrazine-1-carboxylate; oxetan-3-yl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; cyclobutylmethyl (3S)-4-acetyl-3- methyl-7-[1- (oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoxaline-1-carboxylat- e; (3-methyloxetan-3-yl)methyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 2,2-dichloroethyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; (3-ethyl oxetan-3-yl)methyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; oxetan-3-ylmethyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 3,3-difluorocyclobutyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; (3-fluorooxetan-3-yl)methyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 2-(oxetan-3-yl)ethyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-trahyd- roquinoxaline-1-carboxylate; 2,2-difluoropropyl (3S)-4-acetyl-3-methyl -7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoxaline-1-carb- oxylate; 3,3,3-trifluoropropyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 2-oxaspiro[3.3]heptan-6-yl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 2,2,2-trifluoroethyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 1,3-difluoropropan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; (2,2-dimethylcyclopropyl)methyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; bicyclo[3.1.0]hexan-3-yl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; (2,2-difluorocyclopropyl)methyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 1-methylcyclopropyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 2-fluoro-2-methylpropyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 3,3,3-trifluoropropyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2,2,2-trifluoroethyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 1,3-difluoropropan-2-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 3,3,3-trifluoropropyl (3S)-4-acetyl-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; 2,2,2-trifluoroethyl (3S)-4-acetyl-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; 1,3-difluoropropan-2-yl (3S)-4-acetyl-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; 2,2-difluoroethyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 4-fluorophenyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 4-methoxyphenyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; phenyl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; pyridin-3-yl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; pyridin-4-yl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; pyridin-2-yl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; (2S)-4-(1,3-benzoxazol-2-yl)-1-cyclopropanecarbonyl-6-(1-cyclopropyl-1H-p- yrazol-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoxaline; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-4-(1H-indazol-3-yl)-2-methyl-1,- 2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(1H-indazol-3-yl)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4-- tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(1,2-benzoxazol-3-yl)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methy- l-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; (2S)-4-(furan-2-carbonyl)-1-methanesulfonyl-6-(4-methanesulfonylphenyl)-2- -methyl-1,2,3,4-tetrahydroquinoxaline; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-phenoxy-1H,2H,3H,4H-pyrido[2,3-- b]pyrazin-1-yl]ethan-1-one; cyclobutyl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thietan-3-yl)-1H-pyrazol-4-y- l]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; phenyl (3S)-4-acetyl-3-methyl-7-[4-(piperazine-1-carbonyl)phenyl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-(pyrrolidine-1-carbonyl)-1- ,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(pyrroli dine-1-carbonyl)-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carbaldehyde; (2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4-te- trahydroquinoxaline-1-carb al dehyde; 1-[(2S)-6-(4-methanesulfonylphenyl)-2,4-dimethyl-1,2,3,4-tetrahydroquinox- alin-1-yl]ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoxalin-1-yl]-3-methylbutan-1-one; 1-[(3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoxalin-1-yl]-2,2-difluoroethan-1-one; 1-[(3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoxalin-1-yl]-2-cyclopropylethan-1-one; 1-[(3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoxalin-1-yl]-3,3,3-trifluoropropan-1-one; 1-[(3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoxalin-1-yl]-2-methylpropan-1-one; 1-[(2S)-2-methyl-4-(oxane-4-carbonyl)-6-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoxalin-1-yl]-2-cyclopentylethan-1-one; 1-[(2S)-4-[(1 S)-2,2-dichlorocyclopropanecarbonyl]-2-methyl-6-[1-(oxetan-3-yl)-1H-pyraz- ol-4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-[(1R)-2,2-dichlorocyclopropanecarbonyl]-2-methyl-6-[1-(oxetan-3- -yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(1-methylcyclopropanecarbonyl)-6-[1-(oxetan-3-yl)-1H-p- yrazol-4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoxalin-1-yl]-2-chloro-2-methylpropan-1-one; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(pyrazin-2-ylmethyl)-1H-pyrazol-4-yl]-1,2,3,4- -tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(pyridin-4-ylmethyl)-1H-pyrazol-4-yl]-1,2,3,4- -tetrahydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(pyridin-4-ylmethyl)-1H-pyra- zol-4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(pyridin-3-ylmethyl)-1H-pyrazol-4-yl]-1,2,3,4- -tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(pyridin-2-ylmethyl)-1H-pyrazol-4-yl]-1,2,3,4- -tetrahydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(pyridin-2-ylmethyl)-1H-pyra- zol-4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(pyridin-3-ylmethyl)-1H-pyra- zol-4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(pyrazin-2-ylmethyl)-1H-pyra- zol-4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-{1-[(3-methyloxetan-3-yl)methyl- ]-1H-pyrazol-4-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 2-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl}-1-(morpholin-4-yl)ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(pyrimidin-2-ylmethyl)-1H-py- razol-4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-6-[1-(1H-imidazol-4-ylmethyl)-1H-pyrazol-4- -yl]-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(pyrimidin-5-ylmethyl)-1H-py- razol-4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; propan-2-yl (3S)-4-acetyl-7-{1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl}-3-methyl-1,2- ,3,4-tetrahydroquinoxaline-1-carboxylate; 2-{4-[(2S)-1-acetyl-2-methyl-4-[(propan-2-yloxy)carbonyl]-1,2,3,4-tetrahy- droquinoxalin-6-yl]-1H-pyrazol-1-yl}acetic acid; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(1,2-oxazol-5-ylmethyl)-1H-pyrazol-4-yl]-1,2,- 3,4-tetrahydroquinoxaline-1-carboxylate; 2-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl}-N-methylacetamide; propan-2-yl (3S)-4-acetyl-7-{1-[(3-fluorooxetan-3-yl)methyl]-1H-pyrazol-4-yl}-3-methy- l-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-{1-[(methylcarbamoyl)methyl]-1H-pyrazol-4-yl}-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-- tetrahydroquinoxaline-1-carboxylate; 3-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl}propanoic acid; propan-2-yl (3S)-4-acetyl-7-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tr- ahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(1-carbamoyl-1-methylethyl)-1H-pyrazol-4-yl]-3-methyl-- 1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-{1-[2-(1H-1,2,4-triazol-1-yl)ethyl]-1H-pyrazol-4- -yl}-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(2-fluoro-2-methylpropyl)-1H-pyrazol-4-yl]-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-{1-[(3-methyl-1,2-oxazol-5-yl)methyl]-1H-pyrazol- -4-yl}-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(3,3,3-trifluoropropyl)-1H-pyrazol-4-yl]-1,2,- 3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(1,3-thiazol-5-ylmethyl)-1H-pyrazol-4-yl]-1,2- ,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-6-[1-(2-fluoro-2-methylpropyl)-1H-pyrazol-- 4-yl]-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-6-{1-[2-(dimethylamino)ethyl]-1H-pyrazol-4- -yl}-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-{1-[(4-methyl-1,2,5-oxadiazol-3- -yl)methyl]-1H-pyrazol-4-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one- ; 1-[(2S)-4-cyclopropanecarbonyl-6-{1-[(2,2-difluorocyclopropyl)methyl]-1H- -pyrazol-4-yl}-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-{1-[(3-methyl-1,2-oxazol-5-yl)m- ethyl]-1H-pyrazol-4-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(3,3,3-trifluoropropyl)-1H-p- yrazol-4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-{1-[2-(morpholin-4-yl)ethyl]-1H- -pyrazol-4-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 4,4-difluorocyclohexyl (3S)-4-acetyl-7-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; 4,4-difluorocyclohexyl (3S)-4-acetyl-3-methyl-7-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; cyclobutyl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thian-4-yl)-1H-pyrazol-4-yl]- -3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thian-4-yl)-1H-pyrazol-4-yl]- -3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thian-4-yl)-1H-pyrazol-4-yl]- -3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 4-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl}-1.lamda..sup.6-thiane-1,1-dione; cyclobutyl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thian-3-yl)-1H-pyrazol-4-yl]- -3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-{1-[(2S)-2-methylazetidin-3-yl]-1H-pyrazol-4-yl}- -1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-{1-[(2S)-2-methylazetidin-3-yl]- -1H-pyrazol-4-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; oxan-4-yl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thian-3-yl)-1H-pyrazol-4-yl]- -3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 3,3-difluorocyclobutyl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thian-3-yl)-1H-pyrazol-4-yl]- -3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-3-methyl-7-[1-(2-oxopiperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,- 4-tetrahydroquinoxaline-1-carboxylate; 3,3-difluorocyclobutyl (3S)-4-acetyl-3-methyl-7-[1-(2-oxopiperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,- 4-tetrahydroquinoxaline-1-carboxylate; 4,4-difluorocyclohexyl (3S)-4-acetyl-3-methyl-7-[1-(2-oxopiperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,- 4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(2-oxopiperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,- 4-tetrahydroquinoxaline-1-carboxylate; 4-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl }piperidin-2-one; 3,3-difluorocyclobutyl (3S)-4-acetyl-3-methyl-7-{1-[(2S)-2-methylazetidin-3-yl]-1H-pyrazol-4-yl}- -1,2,3,4-tetrahydroquinoxaline-1-carboxylate; cyclopropylmethyl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thian-4-yl)-1H-pyrazol-4-yl]- -3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; cyclobutyl (3S)-4-acetyl-3-methyl-7-{1-[(2R)-2-methyl azetidin-3-yl]-1H-pyrazol-4-yl}-1,2,3,4-tetrahydroquinoxaline-1-carboxyla- te; cyclopropylmethyl (3S)-4-acetyl-7-{1-[(3R)-1,1-dioxo-1.lamda..sup.6-thian-3-yl]-1H-pyrazol-- 4-yl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; cyclopropylmethyl (3S)-4-acetyl-7-{1-[(3S)-1,1-dioxo-1.lamda..sup.6-thian-3-yl]-1H-pyrazol-- 4-yl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; cyclobutyl (3S)-4-acetyl-7-{1-[(3R)-1,1-dioxo-1.lamda..sup.6-thian-3-yl]-1H-pyrazol-- 4-yl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; cyclobutyl (3S)-4-acetyl-7-{1-[(3S)-1,1-dioxo-1.lamda..sup.6-thian-3-yl]-1H-pyrazol-- 4-yl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; cyclobutyl (3S)-4-acetyl-3-methyl-7-[1-(2-oxopiperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,- 4-tetrahydroquinoxaline-1-carboxylate; cyclobutyl (3S)-4-acetyl-3-methyl-7-{1-[(4R)-2-oxopiperidin-4-yl]-1H-pyrazol-4-yl}-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; cyclobutyl (3S)-4-acetyl-3-methyl-7-{1-[(4 S)-2-oxopiperidin-4-yl]-1H-pyrazo1-4-yl}-1,2,3,4-tetrahydroquinoxaline-1-- carboxylate; cyclobutyl (3S)-4-acetyl-3-methyl-7-{1-[(2S)-2-methylazetidin-3-yl]-1H-pyrazol-4-yl}- -1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-4-(7-fluoro-1-methyl-1H-indazol- -3-yl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(7-fluoro-1-methyl-1H-indazol-3-yl)-6-[1-(2-hydroxyethyl)-1H-py- razol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(1-methyl-1 H-indazol-3-yl)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydro- quinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-{1-methyl-1H-pyrazolo[3,4-c]pyridin-3-yl }-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoxalin-1-y- l]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-4-(4-fluoro-1-methyl-1H-indazol- -3-yl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-4-{1-methyl-1H-pyrazol- o[3,4-b]pyridin-3-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-4-{1-methyl-1H-pyrazol- o[3,4-c]pyridin-3-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-4-{1-methyl-1H-pyrazol- o[4,3-c]pyridin-3-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-4-{1-methyl-1H-pyrazol- o[4,3-b]pyridin-3-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(6-fluoro-1-methyl-1H-indazol-3-yl)-6-[1-(2-hydroxyethyl)-1H-py- razol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(5-fluoro-1-methyl-1H-indazol-3-yl)-6-[1-(2-hydroxyethyl)-1H-py- razol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(4-fluoro-1-methyl-1H-indazol-3-yl)-6-[1-(2-hydroxyethyl)-1H-py- razol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-(1H-pyrazol-4-yl)-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-(1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoxaline-- 1-carboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-(1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoxaline-1,4-dicar- boxylate; phenyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; ethyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 2-chlorophenyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 4-chlorophenyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 2-methoxyphenyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 4-nitrophenyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 4-(methoxycarbonyl)phenyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; benzyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; butyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 4-methylphenyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 4-methoxyphenyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 4-fluorophenyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; methyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; cyclopentyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 3-(trifluoromethyl)phenyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; naphthalen-2-yl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; prop-2-yn-1-yl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 1-[(3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxalin-1-yl]ethan-1-one; 1-[(3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxalin-1-yl]-2-methylpropan-1-one; 1-[(3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxalin-1-yl]-2,2-dimethylpropan-1-one; 1-[(2S)-4-cyclopentanecarbonyl-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3- ,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxalin-1-yl]-2-cyclopentylethan-1-one; 3-[(3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxalin-1-yl]-3-oxopropanenitrile; (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-N,N,3-trimethyl-1,2,3,4-tetrahy- droquinoxaline-1-carboxamide; 2-methoxyethyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 2-methylpropyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; naphthal en-1-yl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; propyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-N, 3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxami de; propan-2-yl (2S)-1-acetyl-6-(4-methanesulfonylphenyl)-2-methyl-1H,2H,3H,4H-pyrido[2,3- -b]pyrazine-4-carboxylate; propan-2-yl (2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1H,2H,3H,4H-pyri- do[2,3-b]pyrazine-4-carboxylate; phenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-chlorophenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-methoxyphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 3-(trifluoromethyl)phenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 4-chlorophenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 4-fluorophenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 4-(methoxycarbonyl)phenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 4-methoxyphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 4-methylphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; naphthal en-1-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 4-fluoro-3-methylphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N-cyclopropylbenzene-1-sulfonamide; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-propyl-1H-pyrazol-4-yl)-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(1, 5-dimethyl-1H-pyrazol-4-yl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahy- droquinoxalin-1-yl]ethan-1-one; 1-[(3S)-1-(furan-2-carbonyl)-7-(4-methanesulfonylphenyl)-3-methyl-1H,2H,3- H,4H-pyrido[2,3-b]pyrazin-4-yl]ethan-1-one; 4-[(3S)-4-acetyl-1-(furan-2-carbonyl)-3-methyl-1H,2H,3H,4H-pyrido[2,3-b]p- yrazin-7-yl]-N,N-dimethylbenzamide; 1-[(3S)-1-(furan-2-carbonyl)-3-methyl-7-(1-propyl-1H-pyrazol-4-yl)-1H,2H,- 3H,4H-pyrido[2,3-b]pyrazin-4-yl]ethan-1-one; 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N-(propan-2-yl)benzene-1-sulfonamide; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[4-(morpholine-4-sulfonyl)phenyl]- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-{4-[2-(dimethylamino)ethoxy]phenyl}-4-(furan-2-carbonyl)-2-meth- yl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N,N-dimethylbenzene-1-sulfonamide; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-{4-[(4-methylpiperazin-1-yl)sulfo- nyl]phenyl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; N-{4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}methanesulfonamide; {4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxa- lin-6-yl]phenyl}urea; 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]benzene-1-sulfonamide; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[4-(pyrrolidine-1-carbonyl)phenyl- ]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[4-(morpholine-4-carbonyl)phenyl]- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-{4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}-3,3-dimethylurea; N-{4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}morpholine-4-carboxamide; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[4-(pyrroli dine-1-sulfonyl)phenyl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; N-{4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}cyclopropanesulfonamide; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[4-(propane-2-sulfonyl)phenyl]-1,- 2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-[4-(azeti dine-1-sulfonyl)phenyl]-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroq- uinoxalin-1-yl]ethan-1-one; 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N-(2-hydroxyethyl)benzamide; 1-[(2S)-6-[4-(cyclopropanesulfonyl)phenyl]-4-(furan-2-carbonyl)-2-methyl-- 1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N-cyclopropylbenzamide; S-{4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}-2-hydroxyethane-1-sulfonamido; propan-2-yl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 1-[(2S)-6-(6-aminopyridin-3-yl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tet- rahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(2-aminopyrimi din-5-yl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl- ]ethan-1-one; propan-2-yl (3R)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[4-(pyrrolidin-1-yl)phenyl]-1,2,3- ,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-(1-methane sulfonyl-2,3-dihydro-1H-indol-5-yl)-2-methyl-1,2,3,4-tetrahydroquinoxalin- -1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-methyl-1H,2H,3- H,4H-pyrido[2,3-b]pyrazin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-6-(4-methanesulfonylphenyl)-2-methyl-1H,2H- ,3H,4H-pyrido[2,3-b]pyrazin-1-yl]ethan-1-one; 1-[(2S)-6-cyclopropyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroqui- noxalin-1-yl]ethan-1-one; propan-2-yl (3S)-4-acetyl-7-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-3-methyl-1,2- ,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(carbamoylmethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{1-[(dimethylcarbamoyl)methyl]-1H-pyrazol-4-yl}-3-methyl-- 1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-{1-[2-(morpholin-4-yl)ethyl]-1H-pyrazol-4-yl}-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(oxan-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-- tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl- ]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-7-[1-(carbamoylmethyl)-1H-pyrazol-4-yl]-4-cyclopropanecarbonyl-3-met- hyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-{1-[(dimethylcarbamoyl)methyl]-1H-pyrazol-4- -yl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-{1-[2-(morpholin-4-yl)ethyl]-1H-py- razol-4-yl}-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-[1-(oxan-4-yl)-1H-pyrazol-4-yl]-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-3-meth- yl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-3-meth- yl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-3-m- ethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-- 1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-[1-(2-methanesulfonyl ethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoxaline-1,4-dicarb- oxylate; 1-methyl 4-propan-2-yl (2S)-6-[1-(carbamoylmethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroq- uinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-{1-[(dimethylcarbamoyl)methyl]-1H-pyrazol-4-yl}-2-methyl-1,2,3,4-t- etrahydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-{1-[2-(morpholin-4-yl)ethyl]-1H-pyrazol-4-yl}-1,2,3,4-tet- rahydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-[1-(oxan-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoxa- line-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroqu- inoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroqu- inoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydr- oquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquino- xaline-1,4-dicarboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-3-methyl-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-- yl]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-te- trahydroquinoxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-acetyl-7-(1-tert-butyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahydr- oquinoxaline-1-carboxylate; propan-2-yl (3S)-7-(1-tert-butyl-1H-pyrazol-4-yl)-4-cyclopropanecarbonyl-3-methyl-1,2- ,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-(1-tert-butyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoxal- ine-1,4-dicarboxylate; propan-2-yl (3S)-4-acetyl-7-(3,5-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahydr- oquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-(1-phenyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroqui- noxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[3-(trifluoromethyl)-1H-pyrazol-4-yl]-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-(3-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroqui- noxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahydr- oquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1, 5-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carb- oxylate; 2-{4-[(2S)-1-cyclopropanecarbonyl-2-methyl-4-[(propan-2-yloxy)car- bonyl]-1,2,3,4-tetrahydroquinoxalin-6-yl]-1H-pyrazol-1-yl}acetic acid; 2-{4-[(2S)-1-(methoxycarbonyl)-2-methyl-4-[(propan-2-yloxy)carbonyl]-1,2,- 3,4-tetrahydroquinoxalin-6-yl]-1H-pyrazol-1-yl}acetic acid; 1-[(2S)-4-cyclopropanecarbonyl-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-m- ethyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol- -4-yl]-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-{4-cyclopropanecarbonyl-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-- 2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl}ethan-1-one; propan-2-yl (3S)-4-acetyl-7-(4-methanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(N-methylmethane sulfonamido)phenyl]-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1-methanesulfonyl-2,3-dihydro-1H-indol-5-yl)-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; N-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]phenyl}methanesulfonamide; N-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]phenyl}-N-methylmethanesulfonamide; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroqu- inoxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-7-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-4-cyclopropanecarbonyl-3-methy- l-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroqui- noxaline-1,4-dicarboxylate; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-- 4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-4-cyclopropanecarbonyl-2-me- thyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 2,2,2-trifluoro-1-[(2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-- 2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 4-[(2S)-4-(furan-2-carbonyl)-2-methyl-1-(trifluoroacetyl)-1,2,3,4-tetrahy- droquinoxalin-6-yl]-N,N-dimethylbenzamide; 2,2,2-trifluoro-1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-propyl-1H-pyra- zol-4-yl)-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; (2S)-1-cyclopropanecarbonyl-4-(furan-2-carbonyl)-6-(4-methanesulfonylphen- yl)-2-methyl-1,2,3,4-tetrahydroquinoxaline; 1-[(2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4- -tetrahydroquinoxalin-1-yl]propan-1-one; methyl (2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; 1-[(2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4- -tetrahydroquinoxalin-1-yl]-2-hydroxyethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4- -tetrahydroquinoxalin-1-yl]-2-methoxyethan-1-one; (2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-N,N,2-trimethyl-1,2- ,3,4-tetrahydroquinoxaline-1-carboxamide; 1-[(2S)-4-(furan-2-carbonyl)-6-(4-methane sulfonylphenyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-methylpropa- n-1-one; ethyl (2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; propan-2-yl (2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; (2S)-1-cyclopentanecarbonyl-4-(furan-2-carbonyl)-6-(4-methanesulfonylphen- yl)-2-methyl-1,2,3,4-tetrahydroquinoxaline; (2S)-1-cyclobutanecarbonyl-4-(furan-2-carbonyl)-6-(4-methanesulfonylpheny- l)-2-methyl-1,2,3,4-tetrahydroquinoxaline; (2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-methyl-1-(1,2-oxa- zole-5-carbonyl)-1,2,3,4-tetrahydroquinoxaline; (2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-methyl-1-(pyrroli- dine-1-carbonyl)-1,2,3,4-tetrahydroquinoxaline; (2S)-1,4-dicyclopropanecarbonyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methy- l-1,2,3,4-tetrahydroquinoxaline; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; ethyl (3S)-4-cyclopropanecarbonyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; 4-ethyl 1-methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoxa- line-1,4-dicarboxylate; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(pyridin-2-yl)-1,2,3,4-tetrahydro- quinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-{imidazo[1,2-a]pyridin-6-yl}-2-methyl-1,2,- 3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(pyrimidin-2-yl)-1,2,3,4-tetrahyd- roquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(pyrazin-2-yl)-1,2,3,4-tetrahydro- quinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-(1H-indol-5-yl)-2-methyl-1,2,3,4-tetrahydr- oquinoxalin-1-yl]ethan-1-one 1-[(2S)-6-(2,3-dihydro-1-benzofuran-7-yl)-4-(furan-2-carbonyl)-2-methyl-1- ,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 5-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]pyrazine-2-carbonitrile; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-methyl-1H-imidazol-2-yl)-1,2,3- ,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-methyl-1H-imidazol-5-yl)-1,2,3- ,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1,2-oxazol-4-yl)-1,2,3,4-tetrahy- droquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-{imidazo[1,2-a]pyridin-3-yl}-2-methyl-1,2,- 3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 6-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]pyridine-3-carbonitrile; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-{3-methyl-[1,2,4]triazolo[4,3-a]p- yridin-6-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 5-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-2,3-dihydro-1H-1,3-benzodiazol-2-one; 5-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-1,3-dimethyl-2,3-dihydro-1H-1,3-benzodiazol-2-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-{[1,2,4]triazolo[4,3-b]pyridazin-- 6-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-{1H-pyrrolo[3,2-b]pyridin-5-yl}-1- ,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-{imidazo[1,2-b]pyridazin-6-yl}-2-methyl-1,- 2,3,4-trahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-methyl-1H-1,3-benzodiazol-6-yl- )-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-methyl-1H-1,3-benzodiazol-5-yl- )-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-methyl-1H-imidazol-4-yl)-1,2,3- ,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[3-(5-methyl-1,2,4-oxadiazol-3-yl- )phenyl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(5-methyl-1,3,4-thi adi azol-2-yl)-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(2-methyl-2H-indazol-5-yl)-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[3-(pyrimi din-2-yl)phenyl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-{imidazo[1,2-a]pyrimidin-7-yl}-2-methyl-1,- 2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-(5-methanesulfonylpyridin-2-yl)-2-methyl-1- ,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-benzoyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxa- lin-1-yl]ethan-1-one; 1-[(2S)-6-(1-benzyl-1H-pyrazol-4-yl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N,N-dimethyl-1H-imidazole-1-sulfonamide; 5-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-1-methyl-1,2-dihydropyridin-2-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[4-(1,3-oxazol-2-yl)phenyl]-1,2,3- ,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(5-aminopyrazin-2-yl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tet- rahydroquinoxalin-1-yl]ethan-1-one; methyl N-{4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}carbamate; 1-[(2S)-4-(furan-2-carbonyl)-6-[4-(3-hydroxyoxetan-3-yl)phenyl]-2-methyl-- 1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[4-(1,3,4-oxadiazol-2-yl)phenyl]-- 1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 4-{4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}-1.lamda..sup.6-thiomorpholine-1,1-dione; {4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxa- lin-6-yl]phenyl}methanesulfonamide; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(2-methyl-2H-1,2,3-triazol-4-yl)-- 1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-methyl-1H-1,2,3-triazol-4-yl)-- 1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 3-{4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}-1H-pyrazole-5-carboxylic acid; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[4-(piperazine-1-carbonyl)phenyl]- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-[4-(2-hydroxyethanesulfonyl)phenyl]-2-meth- yl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 2-{4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}-1.lamda..sup.6,2-thiazolidine-1,1-dione; 1-[(2S)-6-[4-(2-aminoethanesulfonyl)phenyl]-4-(furan-2-carbonyl)-2-methyl- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N-(2-aminoethyl)benzamide; 2-({4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquin- oxalin-6-yl]phenyl}methyl)-1.lamda..sup.6,2-thiazolidine-1,1-dione; 3-{4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenoxy }propanenitrile; 1-[(2S)-4-(furan-2-carbonyl)-6-[4-(1H-imidazol-2-yl)phenyl]-2-methyl-1,2,- 3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(5-amino-1,3,4-thi adi azol-2-yl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin- -1-yl]ethan-1-one; 1-[(2S)-6-(5-amino-1,3-thiazol-2-yl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1,2-thiazol-4-yl)-1,2,3,4-tetrah- ydroquinoxalin-1-yl]ethan-1-one; 2-{4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]benzenesulfonyl}-N,N-dimethylacetamide; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1,2-thiazol-5-yl)-1,2,3,4-tetrah- ydroquinoxalin-1-yl]ethan-1-one; 4-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]phenyl}-1.lamda..sup.6-thiomorpholine-1,1-dione; 4-{4-[(2S)-1,4-dicyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]phenyl}-1.lamda..sup.6-thiomorpholine-1,1-dione; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[4-(piperazine-1-carbonyl)pheny- l]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; (2S)-1,4-dicyclopropanecarbonyl-2-methyl-6-[4-(piperazine-1-carbonyl)phen- yl]-1,2,3,4-tetrahydroquinoxaline; 2-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]phenyl}-1.lamda..sup.6,2-thiazolidine-1,1-dione; 2-{4-[(2S)-1,4-dicyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]phenyl}-1.lamda..sup.6,2-thiazolidine-1,1-dione; 1-[(2S)-6-(5-aminopyrazin-2-yl)-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-t- etrahydroquinoxalin-1-yl]ethan-1-one; 5-[(2S)-1,4-dicyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxalin-- 6-yl]pyrazin-2-amine; 1-[(2S)-4-cyclopropanecarbonyl-6-[4-(3-hydroxyoxetan-3-yl)phenyl]-2-methy- l-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 3-{4-[(2S)-1,4-dicyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]phenyl}oxetan-3-ol; {4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}methanesulfonamide; {4-[(2S)-1,4-dicyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxalin- -6-yl]phenyl}methanesulfonamide; 1-[(2S)-6-[4-(2-aminoethanesulfonyl)phenyl]-4-cyclopropanecarbonyl-2-meth- yl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 2-{4-[(2S)-1,4-dicyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]benzenesulfonyl}ethan-1-amine; 1-[(2S)-4-cyclopropanecarbonyl-6-[4-(2-hydroxyethanesulfonyl)phenyl]-2-me- thyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 2-{4-[(2S)-1,4-dicyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]benzenesulfonyl}ethan-1-ol ; 4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinox- alin-6-yl]-N-(2-aminoethyl)benzamide; N-(2-aminoethyl)-4-[(2S)-1,4-dicyclopropanecarbonyl-2-methyl-1,2,3,4-tetr- ahydroquinoxalin-6-yl]benzamide; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-(1-methyl-1H-1,2,3-triazol-4-yl- )-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; (2S)-1,4-dicyclopropanecarbonyl-2-methyl-6-(1-methyl-1H-1,2,3-triazol-4-y- l)-1,2,3,4-tetrahydroquinoxaline; methyl (2S)-4-cyclopropanecarbonyl-6-[4-(1,1-dioxo-1.lamda..sup.6-thiomorpholin-- 4-yl)phenyl]-2-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; methyl (2S)-4-cyclopropanecarbonyl-2-methyl-6-[4-(piperazine-1-carbonyl)phenyl]-- 1,2,3,4-tetrahydroquinoxaline-1-carboxylate; methyl (2S)-4-cyclopropanecarbonyl-6-[4-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-- 2-yl)phenyl]-2-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; methyl (2S)-6-(5-aminopyrazin-2-yl)-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; methyl (2S)-4-cyclopropanecarbonyl-6-[4-(3-hydroxyoxetan-3-yl)phenyl]-2-methyl-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; methyl (2S)-4-cyclopropanecarbonyl-2-methyl-6-[4-(sulfamoylmethyl)phenyl]-1,2,3,- 4-tetrahydroquinoxaline-1-carboxylate; methyl (2S)-6-[4-(2-aminoethanesulfonyl)phenyl]-4-cyclopropanecarbonyl-2-methyl-- 1,2,3,4-tetrahydroquinoxaline-1-carboxylate; methyl (2S)-4-cyclopropanecarbonyl-6-[4-(2-hydroxyethanesulfonyl)phenyl]-2-methy- l-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; methyl (2S)-6-{4-[(2-aminoethyl)carbamoyl]phenyl}-4-cyclopropanecarbonyl-2-methy- l-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; methyl (2S)-4-cyclopropanecarbonyl-2-methyl-6-(1-methyl-1H-1,2,3-triazol-4-yl)-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-(1-methyl-1H-1,2,3-triazol-4-yl)-1,2,3,4-tetrahy- droquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-[4-(2-hydroxyethanesulfonyl)phenyl]-2-methyl-1,2,3,4-tetrahydroqui- noxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(1,1-dioxo-1.lamda..sup.6-thiomorpholin-4-yl)phenyl]-3- -methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-[4-(1,1-dioxo-1.lamda..sup.6-thiomorpholin-- 4-yl)phenyl]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxyl ate; propan-2-yl (3S)-4-acetyl-7-[4-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)phenyl]-3- -methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-[4-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-- 2-yl)phenyl]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate propan-2-yl (3S)-4-acetyl-7-(5-aminopyrazin-2-yl)-3-methyl-1,2,3,4-tetrahydroquinoxal- ine-1-carboxylate; propan-2-yl (3S)-7-(5-aminopyrazin-2-yl)-4-cyclopropanecarbonyl-3-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(3-hydroxyoxetan-3-yl)phenyl]-3-methyl-1,2,3,4-tetrahy- droquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-[4-(3-hydroxyoxetan-3-yl)phenyl]-3-methyl-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(sulfamoylmethyl)phenyl]-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-[4-(sulfamoylmethyl)phenyl]-1,2,3,- 4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(2-aminoethanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(2-hydroxyethanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-[4-(2-hydroxyethane sulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(2-aminoethyl)carbamoyl]phenyl}-3-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-7-{4-[(2-aminoethyl)carbamoyl]phenyl}-4-cyclopropanecarbonyl-3-methy- l-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-(1-methyl-1H-1,2,3-triazol-4-yl)-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-[4-(1,1-dioxo-1.lamda..sup.6-thiomorpholin-4-yl)phenyl]-2-methyl-1- ,2,3,4-tetrahydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-[4-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)phenyl]-2-methyl-1- ,2,3,4-tetrahydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-(5-aminopyrazin-2-yl)-2-methyl-1,2,3,4-tetrahydroquinoxaline-1,4-d- icarboxylate; 1-methyl 4-propan-2-yl (2S)-6-[4-(3-hydroxyoxetan-3-yl)phenyl]-2-methyl-1,2,3,4-tetrahydroquinox- aline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-[4-(sulfamoylmethyl)phenyl]-1,2,3,4-tetrahydroquinoxaline- -1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-[4-(2-aminoethane sulfonyl)phenyl]-2-methyl-1,2,3,4-tetrahydroquinoxaline-1,4-dicarboxylate- ; 1-methyl 4-propan-2-yl (2S)-6-{4-[(2-aminoethyl)carbamoyl]phenyl}-2-methyl-1,2,3,4-tetrahydroqui- noxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-(1-methyl-1H-1,2,3-triazol-4-yl)-1,2,3,4-tetrahydroquinox- aline-1,4-dicarboxylate; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1,3-oxazol-2-yl)-1,2,3,4-tetrahy- droquinoxalin-1-yl]ethan-1-one; N-{4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}-N-methylmethanesulfonamide; cyclobutyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; butan-2-yl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; cyclopropylmethyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; oxetan-3-yl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-3-methyl-7-[4-(piperazine-1-carbonyl)phenyl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; 2,4-difluorophenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 3-methoxyphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 3-cyanophenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 3-fluorophenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2,5-difluorophenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-chloro-4-methylphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-chloro-4-methoxyphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-methoxy-4-methylphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 4-cyano-2-methoxyphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-methoxy-5-methylphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-methylphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; pyridin-3-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 6-methylpyridin-3-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; quinolin-6-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-methylquinolin-6-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-methylpyridin-3-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-methylquinolin-8-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2,4-dimethylphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 3-methylphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 3-chlorophenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-fluorophenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-trahydro- quinoxaline-1-carboxylate; 5-methylpyridin-3-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-methoxypyridin-3-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 3-methoxy-2-methylpyridin-4-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-fluoro-4-methoxyphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-fluoro-5-methoxyphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; isoquinolin-4-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 5-cyano-2-methoxyphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 1,3-benzothiazol-6-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-chloro-4-cyanophenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 4-chloro-2-methoxyphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 5-chloro-2-methoxyphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-chloro-5-methoxyphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(3R)-3-aminopyrrolidine-1-carbonyl]phenyl}-3-methyl-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(4-{[2-(dimethylamino)ethyl]carbamoyl}phenyl)-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(carbamoylmethyl)carbamoyl]phenyl}-3-methyl-1,2,3,4-t- etrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(phenylcarbamoyl)phenyl]-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(diethylcarbamoyl)phenyl]-3-methyl-1,2,3,4-tetrahydroq- uinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(piperidine-1-carbonyl)phenyl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(thiomorpholine-4-carbonyl)phenyl]-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(4-{[2-(dimethylamino)ethyl](methyl)carbamoyl}phenyl)-3-m- ethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(3R)-3-acetamidopyrrolidine-1-carbonyl]phenyl}-3-meth- yl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(3S)-3-acetamidopyrrolidine-1-carbonyl]phenyl}-3-meth- yl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(3R)-3-(dimethylamino)pyrrolidine-1-carbonyl]phenyl}-- 3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(3S)-3-(dimethylamino)pyrrolidine-1-carbonyl]phenyl}-- 3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(4-methylpiperazine-1-carbonyl)phenyl]-1,2,3,- 4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(4-formylpiperazine-1-carbonyl)phenyl]-3-methyl-1,2,3,- 4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[4-(methoxycarbonyl)piperazine-1-carbonyl]phenyl}-3-me- thyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(3-oxopiperazine-1-carbonyl)phenyl]-1,2,3,4-t- etrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(4-acetylpiperazine-1-carbonyl)phenyl]-3-methyl-1,2,3,- 4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(4-methanesulfonylpiperazine-1-carbonyl)phenyl]-3-meth- yl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(4-{[(dimethylcarbamoyl)methyl](methyl)carbamoyl}phenyl)-- 3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-(4-{methyl[2-(pyrrolidin-1-yl)ethyl]carbamoyl}ph- enyl)-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-{4-[methyl(pyridin-2-yl)carbamoyl]phenyl}-1,2,3,- 4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(4-methyl-1,4-diazepane-1-carbonyl)phenyl]-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-(4-{methyl [(methylcarbamoyl)methyl]carbamoyl }phenyl)-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-7-{4-[(3 aR,6aR)-1-methyl-octahydropyrrol o [3,4-b]pyrrole-5-carbonyl]phenyl}-4-acetyl-3-methyl-1,2,3,4-tetrahydroqui- noxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(1R,5 S)-3-{[(tert-butoxy)carbonyl]amino}-8-azabicyclo[3.2.1]octane-8-carbonyl]- phenyl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(piperazine-1-carbonyl)phenyl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-[4-(piperazine-1-carbonyl)phenyl]-- 1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-[4-(piperazine- -carbonyl)phenyl]-1,2,3,4-tetrahydroquinoxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-(4-{[(dimethylcarbamoyl)methyl](methyl)carb- amoyl}phenyl)-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-(4-{[(dimethylcarbamoyl)methyl](methyl)carbamoyl}phenyl)-2-methyl-- 1,2,3,4-tetrahydroquinoxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-(4-{methyl[(methylcarbamoyl)methyl- ]carbamoyl}phenyl)-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-(4-{methyl[(methylcarbamoyl)methyl]carbamoyl}phenyl)-1,2,- 3,4-tetrahydroquinoxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-{4-[(3R)-3-(dimethylamino)pyrrolidine-1-car- bonyl]phenyl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-{4-[(3R)-3-(dimethylamino)pyrrolidine-1-carbonyl]phenyl}-2-methyl-- 1,2,3,4-tetrahydroquinoxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-{4-[(3S)-3-(dimethylamino)pyrrolidine-1-car- bonyl]phenyl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-{4-[(3S)-3-(dimethylamino)pyrrolidine-1-carbonyl]phenyl}-2-methyl-- 1,2,3,4-tetrahydroquinoxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-{4-[(3R)-3-acetamidopyrrolidine-1-carbonyl]- phenyl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-{4-[(3R)-3-acetamidopyrrolidine-1-carbonyl]phenyl}-2-methyl-1,2,3,- 4-tetrahydroquinoxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-{4-[(3S)-3-acetamidopyrrolidine-1-carbonyl]- phenyl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-{4-[(3S)-3-acetamidopyrrolidine-1-carbonyl]phenyl}-2-methyl-1,2,3,- 4-tetrahydroquinoxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-[4-(4-methanesulfonylpiperazine-1-carbonyl)- phenyl]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-[4-(4-methanesulfonylpiperazine-1-carbonyl)phenyl]-2-methyl-1,2,3,- 4-tetrahydroquinoxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-{4-[(3S)-3-hydroxypyrrolidine-1-carbonyl]ph- enyl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-{4-[(3S)-3-hydroxypyrrolidine-1-carbonyl]phenyl}-2-methyl-1,2,3,4-- tetrahydroquinoxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-{4-[(3R)-3-hydroxypyrrolidine-1-carbonyl]ph- enyl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-{4-[(3R)-3-hydroxypyrrolidine-1-carbonyl]phenyl}-2-methyl-1,2,3,4-- tetrahydroquinoxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-[4-(3-hydroxyazetidine-1-carbonyl)phenyl]-3- -methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-[4-(3-hydroxyazetidine-1-carbonyl)phenyl]-2-methyl-1,2,3,4-tetrahy- droquinoxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(3S)-3-hydroxypyrrolidine-1-carbonyl]phenyl}-3-methyl- -1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(3R)-3-hydroxypyrrolidine-1-carbonyl]phenyl}-3-methyl- -1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(3-hydroxyazeti dine-1-carbonyl)phenyl]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxyl- ate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-{4-[(1,3-oxazol-2-ylmethyl)carbamoyl]phenyl}-1,2,3,4-tetr- ahydroquinoxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-{4-[(1,3-oxazol-2-ylmethyl)carbamoyl]phenyl}-1,2- ,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-{4-[(1,3-oxazol-2-ylmethyl)carbamo- yl]phenyl}-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(3-aminopyrrolidine-1-carbonyl)phenyl]-3-methyl-1,2,3,- 4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(3R)-3-aminopyrrolidine-1-carbonyl]phenyl}-3-methyl-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(3S)-3-aminopyrrolidine-1-carbonyl]phenyl}-3-methyl-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(3R)-3-aminopiperidine-1-carbonyl]phenyl}-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(4-aminopiperidine-1-carbonyl)phenyl]-3-methyl-1,2,3,4- -tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[2-(aminomethyl)piperidine-1-carbonyl]phenyl}-3-methyl- -1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(2R)-2-(aminomethyl)pyrrolidine-1-carbonyl]phenyl}-3-- methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(1 S,4 S)-2,5-diazabicyclo[2.2.1]heptane-2-carbonyl]phenyl}-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(4-{[(1R,3 S,5S)-8-azabicyclo[3.2.1]octan-3-yl]carbamoyl}phenyl)-3-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{1-[(1,1-dioxo-1.lamda..sup.6-thian-4-yl)methyl]-1H-pyraz- ol-4-yl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1-{[cyclopropyl(methyl)carbamoyl]methyl}-1H-pyrazol-4-yl- )-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{1-[2-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)ethyl]- -1H-pyrazol-4-yl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{1-[2-(1H-imidazol-1-yl)ethyl]-1H-pyrazol-4-yl}-3-methyl-- 1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-{1-[2-oxo-2-(piperidin-1-yl)ethyl]-1H-pyrazol-4-- yl}-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1-{[3-(hydroxymethyl)oxetan-3-yl]methyl}-1H-pyrazol-4-yl- )-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(1H-imidazol-4-ylmethyl)-1H-pyrazol-4-yl]-3-methyl-1,2- ,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{1-[(dimethyl-1,2-oxazol-4-yl)methyl]-1H-pyrazol-4-yl}-3-- methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-t- etrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]-1,2,3- ,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-{1-[(3-methyloxetan-3-yl)methyl]-1H-pyrazol-4-yl- }-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(2-carbamoylethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-t- etrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(cyanomethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(oxan-4-ylmethyl)-1H-pyrazol-4-yl]-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; propan -2-yl (3S)-4-cyclopropanecarbonyl-7-{1-[(1,1-dioxo-1.lamda..sup.6-thian-4-yl)me- thyl]-1H-pyrazol-4-yl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylat- e; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-(1-{[cyclopropyl(methyl)carbamoyl]methyl}-1- H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-{1-[2-(1,1-dioxo-1.lamda..sup.6,2-thiazolid- in-2-yl)ethyl]-1H-pyrazol-4-yl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-c- arboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-{1-[2-(1H-imidazol-1-yl)ethyl]-1H-pyrazol-4- -yl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-[1-(2-methanesulfonamidoethyl)-1H-pyrazol-4- -yl]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-{1-[2-oxo-2-(piperidin-1-yl)ethyl]- -1H-pyrazol-4-yl}-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-(1-{[3-(hydroxymethyl)oxetan-3-yl]methyl}-1- H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-[1-(1H-imidazol-4-ylmethyl)-1H-pyrazol-4-yl- ]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-{1-[(dimethyl-1,2-oxazol-4-yl)methyl]-1H-py- razol-4-yl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-7-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-4-cyclopropanecarbonyl-3-me- thyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-[1-(2,2,2-trifluoroethyl)-1H-pyraz- ol-4-yl]-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-{1-[(3-methyloxetan-3-yl)methyl]-1- H-pyrazol-4-yl}-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-7-[1-(2-carbamoylethyl)-1H-pyrazol-4-yl]-4-cyclopropanecarbonyl-3-me- thyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-7-[1-(cyanomethyl)-1H-pyrazol-4-yl]-4-cyclopropanecarbonyl-3-methyl-- 1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-[1-(oxan-4-ylmethyl)-1H-pyrazol-4-- yl]-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-6-{1-[(1,1-dioxo-1.lamda..sup.6-thian-4-yl)methyl]-1H-pyrazol-4-yl}-- 2-methyl-1,2,3,4-tetrahydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-(1-{[cyclopropyl(methyl)carbamoyl]methyl}-1H-pyrazol-4-yl)-2-methy- l-1,2,3,4-tetrahydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-{1-[2-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)ethyl]-1H-pyraz- ol-4-yl}-2-methyl-1,2,3,4-tetrahydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-{1-[2-(1H-imidazol-1-yl)ethyl]-1H-pyrazol-4-yl}-2-methyl-1,2,3,4-t- etrahydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-{1-[2-(2-oxopyrrolidin-1-yl)ethyl]-1H-pyrazol-4-yl}-1,2,3- ,4-tetrahydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-{1-[2-oxo-2-(piperidin-1-yl)ethyl]-1H-pyrazol-4-yl}-1,2,3- ,4-tetrahydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-(1-{[3-(hydroxymethyl)oxetan-3-yl]methyl}-1H-pyrazol-4-yl)-2-methy- l-1,2,3,4-tetrahydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-[1-(1H-imidazol-4-ylmethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetr- ahydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-[1-(pyrimidin-5-ylmethyl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-[1-(pyrazin-2-ylmethyl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahyd- roquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-{1-[(dimethyl-1,2-oxazol-4-yl)methyl]-1H-pyrazol-4-yl}-2-methyl-1,- 2,3,4-tetrahydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydro- quinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-[1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-{1-[(3-methyloxetan-3-yl)methyl]-1H-pyrazol-4-yl}-1,2,3,4- -tetrahydroquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-[1-(2- carbamoylethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoxaline-1- ,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-[1-(cyanomethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquino- xaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-[1-(pyridin-4-ylmethyl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahyd- roquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-[1-(oxan-4-ylmethyl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroq- uinoxaline-1,4-dicarboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(oxetan-3-ylmethyl)-1H-pyrazol-4-yl]-1,2,3,4-- tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-[1-(oxetan-3-ylmethyl)-1H-pyrazol-- 4-yl]-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-[1-(oxetan-3-ylmethyl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydr- oquinoxaline-1,4-dicarboxylate; 1-methyl 4-propan-2-yl (2S)-6-{1-[2-(dimethyl amino)ethyl]-1H-pyrazol-4-yl}-2-methyl-1,2,3,4-tetrahydroquinoxaline-1,4-- dicarboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-7-{1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl- }-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(propan-2-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 2-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl}-2-methylpropanamide; 1-[(2S)-4-cyclopropanecarbonyl-6-{1-[(3-fluorooxetan-3-yl)methyl]-1H-pyra- zol-4-yl}-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 3-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl }propanenitrile; 1-[(2S)-4-cyclopropanecarbonyl-6-[1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]-- 2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-{1-[(1-methyl-1H-pyrazol-5-yl)m- ethyl]-1H-pyrazol-4-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(propan-2-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-{1-[2-(morpholin-4-yl)-2-oxoethyl]-1H-pyrazol-4-- yl}-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 2-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl }acetamide; 1-[(2S)-6-[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-4-cyclopropanecarbonyl-2- -methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(oxan-4-ylmethyl)-1H-pyrazol- -4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 2-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl}-N-cyclopropyl-N-methylacetamide; 2-(2-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydro- quinoxalin-6-yl]-1H-pyrazol-1-yl }ethyl)-1.lamda..sup.6,2-thiazolidine-1,1-dione; 1-(2-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydro- quinoxalin-6-yl]-1H-pyrazol-1-yl }ethyl)pyrrolidin-2-one; 2-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl}-1-(piperidin-1-yl)ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-6-(1-{[3-(hydroxymethyl)oxetan-3-yl]methyl- }-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(1,2-oxazol-5-ylmethyl)-1H-p- yrazol-4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; propan-2-yl (3S)-4-acetyl-7-{1-[(ethylcarbamoyl)methyl]-1H-pyrazol-4-yl}-3-methyl-1,2- ,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-{1-[(5-methyl-1,2-oxazol-3-yl)methyl]-1H-pyrazol- -4-yl}-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(2-fluoroethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{1-[2-(azetidin-1-yl)-2-oxoethyl]-1H-pyrazol-4-yl}-3-meth- yl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-{1-[(5-methyl-1,2,4-oxadiazol-3- -yl)methyl]-1H-pyrazol-4-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one- ; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-{1-[(5-methyl-1,2-oxazol-3-yl)- methyl]-1H-pyrazol-4-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(2-methylpropyl)-1H-pyrazol-- 4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-6-[1-(2-fluoroethyl)-1H-pyrazol-4-yl]-2-me- thyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 2-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl}-1-(azetidin-1-yl)ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-6-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-- methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 3-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl }propanamide; 2-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl }acetonitrile; 2-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl }acetic acid; propan-2-yl (3S)-4-acetyl-3-methyl-7-{1-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-1H-py- razol-4-yl}-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{1-[(2,2-difluorocyclopropyl)methyl]-1H-pyrazol-4-yl}-3-m- ethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(2-cyanoethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-{1-[(1-methyl-1H-pyrazol-5-yl)methyl]-1H-pyrazol- -4-yl}-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 2-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl}-N-ethylacetamide; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-{1-[(1-methyl-1H-pyrazol-3-yl)m- ethyl]-1H-pyrazol-4-yl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 2-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl}-N,N-dimethylacetamide; 4-({4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqu- inoxalin-6-yl]-1H-pyrazol-1-yl }methyl)-1.lamda..sup.6-thiane-1,1-dione; propan-2-yl (3S)-4-acetyl-3-methyl-7-{1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]-1H-py- razol-4-yl}-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(1,3-thiazol-5-ylmethyl)-1H-- pyrazol-4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; propan-2-yl (3S)-4-acetyl-3-methyl-7-{1-[(3R)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}- -1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-{1-[(3S)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}- -1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-{1-[(3R)-pyrrolidin-3-ylmethyl]-1H- -pyrazol-4-yl}-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-{1-[(3S)-pyrrolidin-3-ylmethyl]-1H- -pyrazol-4-yl}-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-{1-[(3R)-pyrroli din-3-ylmethyl]-1H-pyrazol-4-yl}-1,2,3,4-tetrahydroquinoxaline-1,4-dicarb- oxylate; 1-methyl 4-propan-2-yl (2S)-2-methyl-6-{1-[(3S)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1,2,3,4-- tetrahydroquinoxaline-1,4-dicarboxylate; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-3-(dimethyla- mino)propan-1-one; 1-[(2S)-4-benzoyl-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-phenyletha- n-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-3-ph- enylpropan-1-one; 1-[(2S)-4-cyclohexanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]- ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(4-methoxy- phenyl)ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(3-methoxy- phenyl)ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-3-methoxypro- pan-1-one; 1-[(2S)-4-(2H-1,3-benzodioxole-5-carbonyl)-2-methyl-1,2,3,4-tet- rahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(2-methoxybenzoyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]e- than-1-one; 1-[(2S)-2-methyl-4-(4-phenylbenzoyl)-1,2,3,4-tetrahydroquinoxalin-1-yl]et- han-1-one; 1-[(2S)-2-methyl-4-(pyridine-4-carbonyl)-1,2,3,4-tetrahydroquin- oxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(2-methyl-1,3-thiazole-4-carbonyl)-1,2,3,4-tetrahydroq- uinoxalin-1-yl]ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(oxan-4-yl- )ethan-1-one 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(4-phenylp- henyl)ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-3-methylbuta- n-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(2- H-1,3-benzodioxol-5-yl)ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-[3-(triflu- oromethyl)phenyl]ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(2-methoxy- phenyl)ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-phenoxyeth- an-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-c- yclopentyl ethan-1-one; 1-[(2S)-4-cyclopentanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl- ]ethan-1-one; (2R)-1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-pheny- lpropan-1-one; 1-[(2S)-2-methyl-4-(naphthal ene-2-carbonyl)-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(2,3-dihydro-1-benzofuran-5-carbonyl)-2-methyl-1,2,3,4-tetrahyd- roquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(3-chlorobenzoyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]et- han-1-one; 1-[(2S)-2-methyl-4-(naphthal ene-1-carbonyl)-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]e- than-1-one; 1-[(2S)-2-methyl-4-(5-methylpyrazine-2-carbonyl)-1,2,3,4-tetrahydroquinox- alin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(5-methyl-1,2-oxazole-3-carbonyl)-1,2,3,4-tetrahydroqu- inoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-[4-(1H-pyrazol-1-yl)benzoyl]-1,2,3,4-tetrahydroquinoxa- lin-1-yl]ethan-1-one; 1-[(2S)-4-(1,3-benzothiazole-6-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-{2-[(pyridin-3-yl)amino]-1,3-thiazole-4-carbonyl}-1,2,- 3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-[2-(pyridin-3-yl)-1,3-thiazole-5-carbonyl]-1,2,3,4-tet- rahydroquinoxalin-1-yl]ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(phenylsul- fanyl)ethan-1-one; 1-[(2S)-2-methyl-4-[5-(propan-2-yl)pyridine-2-carbonyl]-1,2,3,4-tetrahydr- oquinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-[6-(propan-2-yl)pyridine-3-carbonyl]-1,2,3,4-tetrahydr- oquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(1H-indole-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-- yl]ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(thiophen-- 2-yl)ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(4-chlorop- henoxy)ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(4-methoxy- phenoxy)ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(naphthale- n-2-yloxy)ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(4-fluorop- henoxy)ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(naphthale- n-1-yloxy)ethan-1-one; 1-[(2S)-4-(2,3-dihydro-1,4-benzodioxine-2-carbonyl)-2-methyl-1,2,3,4-tetr- ahydroquinoxalin-1-yl]ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-methoxyeth- an-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(- 5-chloro-1-benzothiophen-3-yl)ethan-1-one; (2R)-1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-metho- xy-2-phenylethan-1-one; (2S)-1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-metho- xy-2-phenylethan-1-one; 1-[(2S)-2-methyl-4-(4-phenoxybenzoyl)-1,2,3,4-tetrahydroquinoxalin-1-yl]e- than-1-one; 1-[(2S)-4-(4-chlorobenzoyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]et- han-1-one; 1-[(2S)-2-methyl-4-(2-phenoxybenzoyl)-1,2,3,4-tetrahydroquinoxa- lin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinoxalin-1-- yl]ethan-1-one; 1-[(2S)-4-(1-benzothiophene-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinox- alin-1-yl]ethan-1-one; 1-[(2S)-4-(4-methoxythiophene-3-carbonyl)-2-methyl-1,2,3,4-tetrahydroquin- oxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(1-methyl-1H-indole-2-carbonyl)-1,2,3,4-tetrahydroquin- oxalin-1-yl]ethan-1-one; 1-[(2S)-4-(2,5-dimethylfuran-3-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-1-yl]ethan-1-one; 1-[(2S)-4-(4,5-dimethylfuran-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-1-yl]ethan-1-one; 1-[(2S)-4-(1-benzofuran-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin- -1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(quinoline-3-carbonyl)-1,2,3,4-tetrahydroquinoxalin-1-- yl]ethan-1-one; 1-[(2S)-4-(4-methoxyquinoline-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquin- oxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(quinoline-4-carbonyl)-1,2,3,4-tetrahydroquinoxalin-1-- yl]ethan-1-one; 1-[(2S)-4-(1,5-dimethyl-1H-pyrazole-3-carbonyl)-2-methyl-1,2,3,4-tetrahyd- roquinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-[1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carbonyl]-- 1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(4-methyl-1,2,3-thiadiazole-5-carbonyl)-1,2,3,4-tetrah- ydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(2-methoxypyridine-3-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-1-yl]ethan-1-one; 1-[(2S)-4-(5-chloro-1-benzofuran-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroq- uinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(1H-indole-6-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-- yl]ethan-1-one; 1-[(2S)-2-methyl-4-[2-(trifluoromethyl)-1,3-thiazole-4-carbonyl]-1,2,3,4-- tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(1-methane- sulfonylpiperidin-4-yl)ethan-1-one; 1-[(2S)-4-(5-fluoropyridine-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinox- alin-1-yl]ethan-1-one; 1-1-{2-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-oxoet- hyl}azepan-2-one; 1-1-{3-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-3-oxopr- opyl}azepan-2-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(1H-1,3-be- nzodiazol-1-yl)ethan-1-one; 4-{2-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-oxoethy- l}-1.lamda..sup.6-thiomorpholine-1,1-dione; 1-[(2S)-4-(dimethyl-1,2-oxazole-4-carbonyl)-2-methyl-1,2,3,4-tetrahydroqu- inoxalin-1-yl]ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(5-methyl-- 2-phenyl-1,3-oxazol-4-yl)ethan-1-one; 1-[(2S)-4-(1H-indole-4-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-- yl]ethan-1-one; 1-[(2S)-2-methyl-4-{pyrazolo[1,5-a]pyridine-2-carbonyl}-1,2,3,4-tetrahydr- oquinoxalin-1-yl]ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]-2-(2-methylp- ropoxy)ethan-1-one; 1-[(2S)-2-methyl-4-{5H,6H,7H-pyrazolo[3,2-b][1,3]oxazine-3-carbonyl}-1,2,- 3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-{4H,5H,6H-pyrrolo[1,2-b]pyrazole-2-carbonyl}-1,2,3,4-t- etrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-{thieno[2,3-c]pyridine-2-carbonyl}-1,2,3,4-tetrahydroq- uinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-{imidazo[1,2-a]pyridine-6-carbonyl}-2-methyl-1,2,3,4-tetrahydro- quinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-{furo[2,3-c]pyridine-2-carbonyl}-2-methyl-1,2,3,4-tetrahydroqui- noxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-{1H-pyrrolo[3,2-c]pyridine- -2-carbonyl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-{imidazo[1,2-a]pyrazine-2-carbonyl}-6-(4-methanesulfonylphenyl)- -2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-[4-(trifluoromethyl)benzoy- l]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3- ,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-(pyridine-2-carbonyl)-1,2,- 3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-(1,2,3-thiadiazole-4-carbo- nyl)-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-(1-methyl-1H-imidazole-2-c- arbonyl)-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(5-chloro-1H-indole-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-m- ethyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(5-hydroxy-1H-indole-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-- methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(6-chloro-1H-indole-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-m- ethyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-[5-(trifluoromethoxy)-1H-i- ndole-2-carbonyl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-{1H-pyrrolo[2,3-b]pyridine- -2-carbonyl}-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-(3-phenyl-1-benzofuran-2-c- arbonyl)-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-7-(quinolin-6-yl)-1,2,3,4-tetrahydroquinoxalin-- 1-yl]-2-phenoxyethan-1-one; 1-[(3S)-4-acetyl-3-methyl-7-(3-phenylphenyl)-1,2,3,4-tetrahydroquinoxalin- -1-yl]-2-phenoxyethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(3-phenylphenyl)-1,2,3,4-tetrahyd- roquinoxalin-1-yl]ethan-1-one; 1-[(3S)-4-acetyl-7-(2-fluorophenyl)-3-methyl-1,2,3,4-tetrahydroquinoxalin- -1-yl]-2-phenoxyethan-1-one; 1-[(2S)-6-(2-fluorophenyl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahyd- roquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-methyl-1H-indol-5-yl)-1,2,3,4-- tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(3S)-4-acetyl-3-methyl-7-(4-phenylphenyl)-1,2,3,4-tetrahydroquinoxalin- -1-yl]-2-phenoxyethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(4-phenylphenyl)-1,2,3,4-tetrahyd- roquinoxalin-1-yl]ethan-1-one; 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]benzoic acid; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[6-(morpholin-4-yl)pyridin-3-yl]-- 1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 3-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N-methylbenzamide; 3-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N-cyclopropylbenzamide; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[4-(1H-pyrazol-1-yl)phenyl]-1,2,3- ,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-phenyl-1,2,3,4-tetrahydroquinoxal- in-1-yl]ethan-1-one; 1-[(2S)-6-(4-chlorophenyl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahyd- roquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(2H-1,3-benzodioxol-5-yl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4- -tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-(4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahy- droquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[4-(trifluoromethoxy)phenyl]-1,2,- 3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N,N-dimethylbenzamide; 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]benzamide; 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]benzonitrile; 3-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]benzonitrile; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(4-phenoxyphenyl)-1,2,3,4-tetrahy- droquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-[3-fluoro-4-(1H-pyrazol-1-yl)phenyl]-4-(furan-2-carbonyl)-2-met- hyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[4-(trifluoromethyl)phenyl]-1,2,3- ,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(dimethyl-1,2-oxazol-4-yl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4- -tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-fluorophenyl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahyd- roquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(pyridin-3-yl)-1,2,3,4-tetrahydro- quinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(pyridin-4-yl)-1,2,3,4-tetrahydro- quinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(pyrimidin-5-yl)-1,2,3,4-tetrahyd- roquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-methyl-1H-pyrazol-4-yl)-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(quinolin-3-yl)-1,2,3,4-tetrahydr- oquinoxalin-1-yl]ethan-1-one; 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N-methylbenzamide; 1-[(2S)-6-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-(furan-2-carbonyl)-2-methy- l-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-fluoro-2-methoxyphenyl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; N-{2-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}methanesulfonamide; 1-[(2S)-6-(4-fluoro-3-methoxyphenyl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; 5-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-2-fluoro-N-(propan-2-yl)benzamide; 1-[(2S)-6-(5-fluoropyridin-3-yl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-te- trahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-[2-(dimethylamino)pyrimidin-5-yl]-4-(furan-2-carbonyl)-2-methyl- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(5-chloropyridin-3-yl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-te- trahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-(6-methoxypyridin-3-yl)-2-methyl-1,2,3,4-t- etrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-(2-methoxypyrimidin-5-yl)-2-methyl-1,2,3,4- -tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-(5-methoxypyridin-3-yl)-2-methyl-1,2,3,4-t- etrahydroquinoxalin-1-yl]ethan-1-one; 5-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N-methylpyridine-2-carboxamide; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[6-(trifluoromethyl)pyridin-3-yl]- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[3-(morpholine-4-carbonyl)phenyl]- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-methyl-1H-indol-2-yl)-1,2,3,4-- tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(2-methyl-2H-indazol-6-yl)-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; 3-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]benzene-1-sulfonamide; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-methyl-1H-indazol-7-yl)-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-methyl-1H-indazol-6-yl)-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; N-{3-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}methanesulfonamide; 3-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N,N-dimethylbenzene-1-sulfonamide; 1-[(2S)-4-(furan-2-carbonyl)-6-(1H-indol-4-yl)-2-methyl-1,2,3,4-tetrahydr- oquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-(3-methanesulfonylphenyl)-2-methyl-1,2,3,4- -tetrahydroquinoxalin-1-yl]ethan-1-one; 3-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N,N-dimethylbenzamide; 1-[(2S)-6-(2H-1,3-benzodioxo1-4-yl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4- -tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[4-(morpholin-4-yl)phenyl]-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[1-methyl-3-(trifluoromethyl)-1H-- pyrazol-5-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-methyl-1H-indazol-5-yl)-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[3-(1H-pyrazol-1-yl)phenyl]-1,2,3- ,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[3-(5-methyl-1,3,4-oxadiazol-2-yl- )phenyl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-[3-(furan-2-yl)phenyl]-2-methyl-1,2,3,4-te- trahydroquinoxalin-1-yl]ethan-1-one; 3-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]benzamide; 1-[(2S)-6-[3-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl]-4-(furan-2-carbonyl)-2- -methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-methyl-1H-indazol-4-yl)-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; N-{3-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}-4-methylbenzene-1-sulfonamide; N-{4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}-4-methylbenzene-1-sulfonamide; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[2-(trifluoromethyl)pyridin-4-yl]- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[2-(morpholin-4-yl)pyridin-4-yl]-- 1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-(2-methoxypyridin-4-yl)-2-methyl-1,2,3,4-t- etrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-(isoquinolin-6-yl)-2-methyl-1,2,3,4-tetrah- ydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(1,3-benzothiazol-5-yl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-t- etrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(4-trifluoromethanesulfonylphenyl- )-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[3-(piperidin-1-yl)phenyl]-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; 3-[1-acetyl-4-(furan-2-carbonyl)-1,2,3,4-tetrahydroquinoxalin-6-yl]-N-met- hylbenzamide; 1-[(2S)-6-(3, 5-difluorophenyl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxa- lin-1-yl]ethan-1-one; 1-[(2S)-6-[3-(dimethylamino)phenyl]-4-(furan-2-carbonyl)-2-methyl-1,2,3,4- -tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-[4-(dimethylamino)phenyl]-4-(furan-2-carbonyl)-2-methyl-1,2,3,4- -tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(5-methylthi ophen-2-yl)-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(1-benzothiophen-7-yl)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-te- trahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[4-(4-methylpiperazin-1-yl)phenyl- ]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N-methylbenzene-1-sulfonamide; N-{3-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-6-yl]phenyl}ethane-1-sulfonamide; 1-[(2S)-6-(4-methanesulfonylphenyl)-4-(4-methoxybenzoyl)-2-methyl-1,2,3,4- -tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(4-fluorobenzoyl)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4-- tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-[4-(trifluoromethoxy)benzo- yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-[5-(3,5-dichlorophenoxy)furan-2-carbonyl]-6-(4-methanesulfonylp- henyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-(1-methyl-1H-imidazole-4-c- arbonyl)-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-4-(5-methoxy-1H-indole-2-carbonyl)-2-- methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-4-(4-methoxy-1H-indole-2-carbonyl)-2-- methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-(5-methyl-1,3-oxazole-4-ca- rbonyl)-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-(2-phenyl-1,3-thiazole-4-c- arbonyl)-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-(5-phenylfuran-2-carbonyl)- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-[5-(trifluoromethyl)furan-- 2-carbonyl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(5-methanesulfonylfuran-2-carbonyl)-6-(4-methanesulfonylphenyl)- -2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; N-{3-[(3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carbonyl]phenyl}acetamide; 1-[(2S)-4-[5-(aminomethyl)furan-2-carbonyl]-6-(4-methanesulfonylphenyl)-2- -methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-{[4-(dimethylamino)phenyl]methyl}-2-methyl-1,2,3,4-tetrahydroqu- inoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-{[4-(propan-2-yl)phenyl]methyl}-1,2,3,4-tetrahydroquin- oxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-[(3-methylphenyl)methyl]-1,2,3,4-tetrahydroquinoxalin-- 1-yl]ethan-1-one; 1-[(2S)-4-[(2,4-dichlorophenyl)methyl]-2-methyl-1,2,3,4-tetrahydroquinoxa- lin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-[(4-methylphenyl)methyl]-1,2,3,4-tetrahydroquinoxalin-- 1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-[(2-methylphenyl)methyl]-1,2,3,4-tetrahydroquinoxalin-- 1-yl]ethan-1-one; 1-[(2S)-4-[(2,4-difluorophenyl)methyl]-2-methyl-1,2,3,4-tetrahydroquinoxa- lin-1-yl]ethan-1-one; 1-[(2S)-4-[(4-chloro-3-fluorophenyl)methyl]-2-methyl-1,2,3,4-tetrahydroqu- inoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-{[3-(trifluoromethyl)phenyl]methyl}-1,2,3,4-tetrahydro- quinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-methyl-1,2,3,4-tetra- hydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-[(4-ethylphenyl)methyl]-2-methyl-1,2,3,4-tetrahydroquinoxalin-1- -yl]ethan-1-one; 1-[(2S)-4-[(3,5-dimethoxyphenyl)methyl]-2-methyl-1,2,3,4-tetrahydroquinox- alin-1-yl]ethan-1-one; 1-[(2S)-4-[(2,5-dimethylphenyl)methyl]-2-methyl-1,2,3,4-tetrahydroquinoxa- lin-1-yl]ethan-1-one; 1-[(2S)-4-[(4-hydroxy-3-methylphenyl)methyl]-2-methyl-1,2,3,4-tetrahydroq- uinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-[(1,3-dimethyl-1H-pyrazol-5-yl)methyl]-2-methyl-1,2,3,4-tetrahy- droquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-({2-[2-(dimethylamino)ethoxy]phenyl}methyl)-2-methyl-1,2,3,4-te- trahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-({4-[2-(dimethylamino)ethoxy]phenyl}methyl)-2-methyl-1,2,3,4-te- trahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-({3-[2-(dimethylamino)ethoxy]phenyl}methyl)-2-methyl-1,2,3,4-te- trahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-benzyl-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(cyclohexylmethyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]e- than-1-one; 1-[(2S)-2-methyl-4-{[6-(trifluoromethyl)pyridin-3-yl]methyl}-1,2,3,4-tetr- ahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(pyridin-4-ylmethyl)-1,2,3,4-tetrahydroquinoxalin-1-yl- ]ethan-1-one; 1-[(2S)-2-methyl-4-(pyridin-2-ylmethyl)-1,2,3,4-tetrahydroquinoxalin-1-yl- ]ethan-1-one; 1-[(2S)-4-[(5-methoxypyridin-3-yl)methyl]-2-methyl-1,2,3,4-tetrahydroquin- oxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(1,3-thiazol-2-ylmethyl)-1,2,3,4-tetrahydroquinoxalin-- 1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-[(4-phenylphenyl)methyl]-1,2,3,4-tetrahydroquinoxalin-- 1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-{[4-(propan-2-yloxy)phenyl]methyl}-1,2,3,4-tetrahydroq- uinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-[(3-phenoxyphenyl)methyl]-1,2,3,4-tetrahydroquinoxalin- -1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-[(4-phenoxyphenyl)methyl]-1,2,3,4-tetrahydroquinoxalin- -1-yl]ethan-1-one; 1-[(2S)-4-(2H-1,3-benzodioxol-5-ylmethyl)-2-methyl-1,2,3,4-tetrahydroquin- oxalin-1-yl]ethan-1-one; 1-[(2S)-4-(2H-1,3-benzodioxol-4-ylmethyl)-2-methyl-1,2,3,4-tetrahydroquin- oxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-{[6-(morpholin-4-yl)pyridin-3-yl]methyl}-1,2,3,4-tetra- hydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-[(4-hydroxyphenyl)methyl]-2-methyl-1,2,3,4-tetrahydroquinoxalin- -1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(pyridin-3-ylmethyl)-1,2,3,4-tetrahydroquinoxalin-1-yl- ]ethan-1-one; 1-[(2S)-2-methyl-4-(oxan-4-ylmethyl)-1,2,3,4-tetrahydroquinoxalin-1-yl]et- han-1-one; 1-[(2S)-2-methyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-- tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(2-methylpentyl)-1,2,3,4-tetrahydroquinoxalin-1-yl]eth- an-1-one; 1-[(2S)-4-[(1-acetylpiperidin-3-yl)methyl]-2-methyl-1,2,3,4-tetr- ahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-{[1-(propan-2-yl)piperidin-4-yl]methyl}-1,2,3,4-tetrah- ydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(2,5-dimethoxybenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-1-yl]ethan-1-one; 1-[(2S)-4-(2-fluorobenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin- -1-yl]ethan-1-one; 1-[(2S)-4-(benzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]et- han-1-one; 1-[(2S)-2-methyl-4-[(1-methyl-1H-pyrazol-3-yl)sulfonyl]-1,2,3,4- -tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(pyridine-3-sulfonyl)-1,2,3,4-tetrahydroquinoxalin-1-y- l]ethan-1-one; 1-[(2S)-4-(4-chlorobenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin- -1-yl]ethan-1-one; 1-[(2S)-4-(4-methoxybenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoxali- n-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-[4-(trifluoromethyl)benzenesulfonyl]-1,2,3,4-tetrahydr- oquinoxalin-1-yl]ethan-1-one; 4-{[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]sulfonyl}ben- zonitrile; 1-[(2S)-2-methyl-4-[4-(trifluoromethoxy)benzenesulfonyl]-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(4-methylbenzenesulfonyl)-1,2,3,4-tetrahydroquinoxalin- -1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(2-methylbenzenesulfonyl)-1,2,3,4-tetrahydroquinoxalin- -1-yl]ethan-1-one; 1-[(2S)-4-(2-chlorobenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin- -1-yl]ethan-1-one; 2-{[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]sulfonyl }benzonitrile; 3-{[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]sulfonyl}ben- zonitrile; 1-[(2S)-4-(3-methoxybenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydr- oquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(3-chlorobenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin- -1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-[3-(trifluoromethyl)benzenesulfonyl]-1,2,3,4-tetrahydr- oquinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-(3-methylbenzenesulfonyl)-1,2,3,4-tetrahydroquinoxalin- -1-yl]ethan-1-one; 1-[(2S)-4-(2,4-dimethylbenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinox- alin-1-yl]ethan-1-one; 1-[(2S)-4-(2,4-dimethoxybenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquino- xalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-{[6-(trifluoromethyl)pyridin-3-yl]sulfonyl}-1,2,3,4-te- trahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(cyclopropanesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-- yl]ethan-1-one; 1-[(2S)-4-[(2-chlorophenyl)methanesulfonyl]-2-methyl-1,2,3,4-tetrahydroqu- inoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-phenylmethanesulfonyl-1,2,3,4-tetrahydroquinoxalin-1-y- l]ethan-1-one; 1-[(2S)-4-[(3-chlorophenyl)methanesulfonyl]-2-methyl-1,2,3,4-tetrahydroqu- inoxalin-1-yl]ethan-1-one; 1-[(2S)-4-[(1,2-dimethyl-1H-imidazol-4-yl)sulfonyl]-2-methyl-1,2,3,4-tetr- ahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(4-acetylbenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin- -1-yl]ethan-1-one; 3-({[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]sulfonyl}me- thyl)benzonitrile; 1-[(2S)-4-(4-chloro-2-methoxybenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydro- quinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(4-methoxy-2-methylbenzenesulfonyl)-2-methyl-1,2,3,4-tetrahydro- quinoxalin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-4-[(1-methyl-1H-imidazol-4-yl)sulfonyl]-1,2,3,4-tetrahyd- roquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-[(4-chlorophenyl)methanesulfonyl]-2-methyl-1,2,3,4-tetrahydroqu- inoxalin-1-yl]ethan-1-one; 4-({[(3S)-4-acetyl-3-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]sulfonyl }methyl)benzonitrile; (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-N-phenyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxamide; (3S)-4-acetyl-N-ethyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrah- ydroquinoxaline-1-carboxamide; (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-N-(2-methylphenyl)-1,2- ,3,4-tetrahydroquinoxaline-1-carboxamide; (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-N-(3-methoxyphenyl)-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxamide; (3S)-4-acetyl-N-cyclopentyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-- tetrahydroquinoxaline-1-carboxamide; (3S)-4-acetyl-N-(3-chlorophenyl)-7-(4-methanesulfonylphenyl)-3-methyl-1,2- ,3,4-tetrahydroquinoxaline-1-carboxamide; (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-N-(2-methoxyphenyl)-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxamide; (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-N-(3-methylphenyl)-1,2- ,3,4-tetrahydroquinoxaline-1-carboxamide; (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-N-[(2-methoxyphenyl)methyl]-3-m- ethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamide; (3S)-4-acetyl-N-(2-chlorophenyl)-7-(4-methanesulfonylphenyl)-3-methyl-1,2- ,3,4-tetrahydroquinoxaline-1-carboxamide; (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-N-(4-methylphenyl)-1,2- ,3,4-tetrahydroquinoxaline-1-carboxamide; (3S)-4-acetyl-N-(4-chlorophenyl)-7-(4-methanesulfonylphenyl)-3-methyl-1,2- ,3,4-tetrahydroquinoxaline-1-carboxamide; (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-N-[(4-methylphenyl)met- hyl]-1,2,3,4-tetrahydroquinoxaline-1-carboxamide; (3S)-4-acetyl-N-[(2-chlorophenyl)methyl]-7-(4-methanesulfonylphenyl)-3-me- thyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamide; (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-N-(2-methylpropyl)-1,2- ,3,4-tetrahydroquinoxaline-1-carboxamide; (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-N-(thiophen-3-yl)-1,2,- 3,4-tetrahydroquinoxaline-1-carboxamide; (3S)-4-acetyl-N-(furan-2-ylmethyl)-7-(4-methanesulfonylphenyl)-3-methyl-1- ,2,3,4-tetrahydroquinoxaline-1-carboxamide; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-4-(5-methyl-1H-pyrazole-3-ca- rbonyl)-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(1H-imidazole-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-methyl-- 1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 5-[(3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxaline-1-carbonyl]-N,N-dimethylfuran-2-sulfonamide; 1-[(2S)-4-{5-[(dimethylamino)methyl]furan-2-carbonyl}-6-(4-methanesulfony- lphenyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(3-aminobenzoyl)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4-t- etrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(4-aminobenzoyl)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4-t- etrahydroquinoxalin-1-yl]ethan-1-one; (2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxamide; (2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-N,2-dimethyl-1,2,3,- 4-tetrahydroquinoxaline-1-carboxamide; 1-[(2S)-6-(benzylamino)-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroq- uinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-[benzyl(methyl)amino]-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tet- rahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(phenylamino)-1,2,3,4-tetrahydroq- uinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-[methyl(phenyl)amino]-1,2,3,4-tet- rahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(pyrrolidin-1-yl)-1,2,3,4-tetrahy- droquinoxalin-1-yl]ethan-1-one; cyclopropylmethyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; cyclopropylmethyl (3S)-4-cyclopropanecarbonyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; 4-cyclopropylmethyl 1-methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoxa- line-1,4-dicarboxylate; oxetan-3-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; oxetan-3-yl (3S)-4-cyclopropanecarbonyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-oxetan-3-yl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoxa- line-1,4-dicarboxylate; oxan-4-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-cyclopropanecarbonyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-oxan-4-yl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoxa- line-1,4-dicarboxylate; cyclobutyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; cyclobutyl (3S)-4-cyclopropanecarbonyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; 4-cyclobutyl 1-methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoxa- line-1,4-dicarboxylate; phenyl (3S)-4-acetyl-7-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-3-methyl-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; pyridin-3-yl (3S)-4-acetyl-7-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-3-methyl-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-[(2S)-2-ethyl-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-1,2,3,4-- tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[2-(fluoromethyl)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-1,2,- 3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-6-[4-(ethanesulfonyl)phenyl]-2-methyl-1,2,- 3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-6-[4-(ethanesulfonyl)phenyl]-2-methyl-1,2,3- ,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-7-[4-(ethanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahydroqui- noxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(ethanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahydroqui- noxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-6-[4-(cyclopropanesulfonyl)phenyl]-2-methy- l-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-6-[4-(cyclopropanesulfonyl)phenyl]-2-methyl- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-7-[4-(cyclopropanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahy- droquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(cyclopropanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahy- droquinoxaline-1-carboxylate; S-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]phenyl}-2-hydroxyethane-1-sulfonamido; S-{4-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquin- oxalin-6-yl]phenyl}-2-hydroxyethane-1-sulfonamido; ethyl (3S)-4-acetyl-7-{4-[(2-hydroxyethyl)sulfamoyl]phenyl}-3-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{4-[(2-hydroxyethyl)sulfamoyl]phenyl}-3-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; 3-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinox- alin-6-yl]benzene-1-sulfonamide; 3-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxa- lin-6-yl]benzene-1-sulfonamide; ethyl (3S)-4-acetyl-3-methyl-7-(3-sulfamoylphenyl)-1,2,3,4-tetrahydroquinoxalin- e-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-(3-sulfamoylphenyl)-1,2,3,4-tetrahydroquinoxalin- e-1-carboxylate; N-{3-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]phenyl}methanesulfonamide; N-{3-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquin- oxalin-6-yl]phenyl}methanesulfonamide; ethyl (3S)-4-acetyl-7-(3-methanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxaline-1-carboxylate; 3-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinox- alin-6-yl]-N,N-dimethylbenzene-1-sulfonamide; 3-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxa- lin-6-yl]-N,N-dimethylbenzene-1-sulfonamide; ethyl (3S)-4-acetyl-7-[3-(dimethylsulfamoyl)phenyl]-3-methyl-1,2,3,4-tetrahydro- quinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[3-(dimethylsulfamoyl)phenyl]-3-methyl-1,2,3,4-tetrahydro- quinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-6-(3-methanesulfonylphenyl)-2-methyl-1,2,3- ,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-6-(3-methanesulfonylphenyl)-2-methyl-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-7-(3-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(3-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; N-{3-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]phenyl}ethane-1-sulfonamide; N-{3-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquin- oxalin-6-yl]phenyl}ethane-1-sulfonamide; ethyl (3S)-4-acetyl-7-(3-ethanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(3-ethanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[4-(morpholin-4-yl)phenyl]-1,2,- 3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-2-methyl-6-[4-(morpholin-4-yl)phenyl]-1,2,3- ,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-3-methyl-7-[4-(morpholin-4-yl)phenyl]-1,2,3,4-tetrahydroqui- noxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(morpholin-4-yl)phenyl]-1,2,3,4-tetrahydroqui- noxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[4-(propane-2-sulfonyl)phenyl]-- 1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-2-methyl-6-[4-(propane-2-sulfonyl)phenyl]-1- ,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-3-methyl-7-[4-(propane-2-sulfonyl)phenyl]-1,2,3,4-tetrahydr- oquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(propane-2-sulfonyl)phenyl]-1,2,3,4-tetrahydr- oquinoxaline-1-carboxylate; 4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinox- alin-6-yl]benzene-1-sulfonamide; 4-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxa- lin-6-yl]benzene-1-sulfonamide; ethyl (3S)-4-acetyl-3-methyl-7-(4-sulfamoylphenyl)-1,2,3,4-tetrahydroquinoxalin- e-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-(4-sulfamoylphenyl)-1,2,3,4-tetrahydroquinoxalin- e-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[4-(propane-1-sulfonyl)phenyl]-- 1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-2-methyl-6-[4-(propane-1-sulfonyl)phenyl]-1- ,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-3-methyl-7-[4-(propane-1-sulfonyl)phenyl]-1,2,3,4-tetrahydr- oquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(propane-1-sulfonyl)phenyl]-1,2,3,4-tetrahydr- oquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-6-(4-cyclopropylmethanesulfonylphenyl)-2-m- ethyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-6-(4-cyclopropylmethanesulfonylphenyl)-2-me- thyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-7-(4-cyclopropylmethanesulfonylphenyl)-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(4-cyclopropylmethanesulfonylphenyl)-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[4-(2-methylpropanesulfonyl)phe- nyl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-2-methyl-6-[4-(2-methylpropanesulfonyl)phen- yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-3-methyl-7-[4-(2-methylpropanesulfonyl)phenyl]-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(2-methylpropanesulfonyl)phenyl]-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-6-(3-fluoro-4-methanesulfonylphenyl)-2-met- hyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-6-(3-fluoro-4-methanesulfonylphenyl)-2-meth- yl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-7-(3-fluoro-4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(3-fluoro-4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-6-[3-(cyclopropanesulfonyl)phenyl]-2-methy- l-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-6-[3-(cyclopropanesulfonyl)phenyl]-2-methyl- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-7-[3-(cyclopropanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahy- droquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[3-(cyclopropanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahy- droquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-6-[3-(ethanesulfonyl)phenyl]-2-methyl-1,2,- 3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-6-[3-(ethanesulfonyl)phenyl]-2-methyl-1,2,3- ,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-7-[3-(ethanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahydroqui- noxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[3-(ethanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahydroqui- noxaline-1-carboxylate; 1-[(2S)-6-(3-chloro-5-methanesulfonylphenyl)-4-cyclopropanecarbonyl-2-met- hyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-6-(3-chloro-5-methanesulfonylphenyl)-4-cyclobutanecarbonyl-2-meth- yl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-7-(3-chloro-5-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(3-chloro-5-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-6-(4-fluoro-3-methanesulfonylphenyl)-2-met- hyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-6-(4-fluoro-3-methanesulfonylphenyl)-2-meth- yl-1,2,3,4-trahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-7-(4-fluoro-3-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(4-fluoro-3-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; ethyl (3S)-4-acetyl-7-[4-(2-methanesulfonylethoxy)phenyl]-3-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(2-methanesulfonylethoxy)phenyl]-3-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; 3-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinox- alin-6-yl]-N-methylbenzene-1-sulfonamide; 3-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxa- lin-6-yl]-N-methylbenzene-1-sulfonamide; ethyl (3S)-4-acetyl-3-methyl-7-[3-(methylsulfamoyl)phenyl]-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[3-(methylsulfamoyl)phenyl]-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; S-{3-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]phenyl}-2-hydroxyethane-1-sulfonamido; S-{3-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquin- oxalin-6-yl]phenyl}-2-hydroxyethane-1-sulfonamido; ethyl (3S)-4-acetyl-7-{3-[(2-hydroxyethyl)sulfamoyl]phenyl}-3-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{3-[(2-hydroxyethyl)sulfamoyl]phenyl}-3-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; 5-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinox- alin-6-yl]-N,N-di ethyl-2-methoxybenzene-1-sulfonamide; 5-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxa- lin-6-yl]-N,N-di ethyl-2-methoxybenzene-1-sulfonamide; ethyl (3S)-4-acetyl-7-[3-(diethylsulfamoyl)-4-methoxyphenyl]-3-methyl-1,2,3,4-t- etrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[3-(diethylsulfamoyl)-4-methoxyphenyl]-3-methyl-1,2,3,4-t- etrahydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclobutanecarbonyl-2-methyl-6-[4-(1H-pyrazole-1-sulfonyl)pheny- l]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-3-methyl-7-[4-(1H-pyrazole-1-sulfonyl)phenyl]-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(1H-pyrazole-1-sulfonyl)phenyl]-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; 4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahy droquinoxalin-6-yl]-N-methylbenzene-1-sulfonamide; 4-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxa- lin-6-yl]-N-methylbenzene-1-sulfonamide; ethyl (3S)-4-acetyl-3-methyl-7-[4-(methylsulfamoyl)phenyl]-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(methylsulfamoyl)phenyl]-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; 4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinox- alin-6-yl]-N,N-dimethylbenzene-1-sulfonamide; 4-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxa- lin-6-yl]-N,N-dimethylbenzene-1-sulfonamide; ethyl (3S)-4-acetyl-7-[4-(dimethylsulfamoyl)phenyl]-3-methyl-1,2,3,4-tetrahydro- quinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(dimethylsulfamoyl)phenyl]-3-methyl-1,2,3,4-tetrahydro- quinoxaline-1-carboxylate; 4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinox- alin-6-yl]-N-tert-butylbenzene-1-sulfonamide; 4-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxa- lin-6-yl]-N-tert-butylbenzene-1-sulfonamide; ethyl (3S)-4-acetyl-7-[4-(tert-butylsulfamoyl)phenyl]-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(tert-butylsulfamoyl)phenyl]-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 1-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]phenyl}pyrrolidin-2-one; 1-{4-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquin- oxalin-6-yl]phenyl}pyrrolidin-2-one; ethyl (3S)-4-acetyl-3-methyl-7-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,2,3,4-tetrahy- droquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,2,3,4-tetrahy- droquinoxaline-1-carboxylate; N-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]phenyl}ethane-1-sulfonamide; N-{4-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquin- oxalin-6-yl]phenyl}ethane-1-sulfonamide; ethyl (3S)-4-acetyl-7-(4-ethanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(4-ethanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; N-{5-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-2-methoxyphenyl}methanesulfonamide; N-{5-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquin- oxalin-6-yl]-2-methoxyphenyl}methanesulfonamide; ethyl (3S)-4-acetyl-7-(3-methanesulfonamido-4-methoxyphenyl)-3-methyl-1,2,3,4-t- etrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(3-methanesulfonamido-4-methoxyphenyl)-3-methyl-1,2,3,4-t- etrahydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-6-{3-[(dimethylsulfamoyl)amino]phenyl}-2-m- ethyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-6-{3-[(dimethylsulfamoyl)amino]phenyl}-2-me- thyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-7-{3-[(dimethylsulfamoyl)amino]phenyl}-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-{3-[(dimethylsulfamoyl)amino]phenyl}-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; cyclopentyl (3S)-4-acetyl-3-methyl-7-[1-(oxan-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; cyclopentyl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thian-3-yl)-1H-pyrazol-4-yl]- -3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 2-{3-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]phenyl}-1.lamda..sup.6,2-thiazolidine-1,1-dione; propan-2-yl (3S)-4-acetyl-7-[3-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)phenyl]-3- -methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 2-{4-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquin- oxalin-6-yl]-2-fluorophenyl}-1.lamda..sup.6,2-thiazolidine-1,1-dione; ethyl (3S)-4-acetyl-7-[4-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)-3-- fluorophenyl]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)-3-fluoro- phenyl]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-6-(1-methanesulfonyl-1,2,3,4-tetrahydroqui- nolin-6-yl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclobutanecarbonyl-6-(1-methanesulfonyl-1,2,3,4-tetrahydroquin- olin-6-yl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; ethyl (3S)-4-acetyl-7-(1-methanesulfonyl-1,2,3,4-tetrahydroquinolin-6-yl)-3-met- hyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1-methanesulfonyl-1,2,3,4-tetrahydroquinolin-6-yl)-3-met- hyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 2-{3-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquin- oxalin-6-yl]phenyl}-1.lamda..sup.6,2-thiazolidine-1,1-dione; ethyl (3S)-4-acetyl-7-[3-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)phenyl]-3- -methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 2-{3-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-5-(trifluoromethyl)phenyl}-1.lamda..sup.6,2-thiazolidine-1,1- -dione; 2-{3-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahy- droquinoxalin-6-yl]-5-(trifluoromethyl)phenyl}-1.lamda..sup.6,2-thiazoli dine-1,1-di one; ethyl (3S)-4-acetyl-7-[3-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)-5-(trifl- uoromethyl)phenyl]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[3-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)-5-(trifl- uoromethyl)phenyl]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 2-{5-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-2-methoxyphenyl}-1.lamda..sup.6,2-thiazolidine-1,1-dione; 2-{5-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquin- oxalin-6-yl]-2-methoxyphenyl}-1.lamda..sup.6,2-thiazolidine-1,1-dione; ethyl (3S)-4-acetyl-7-[3-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)-4-- methoxyphenyl]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[3-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)-4-methox- yphenyl]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; N-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-2-methylphenyl}methanesulfonamide; N-{4-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquin- oxalin-6-yl]-2-methylphenyl}methanesulfonamide; ethyl (3S)-4-acetyl-7-(4-methanesulfonamido-3-methylphenyl)-3-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(4-methanesulfonamido-3-methylphenyl)-3-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; 6-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinox- alin-6-yl]-1-methyl-1,3-dihydro-2.lamda..sup.6,1,3-benzothiadiazole-2,2-di- one; 6-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1-methyl-1,3-dihydro-2.lamda..sup.6,1,3-benzothiadiazole-2,2- -dione; propan-2-yl (3S)-4-acetyl-3-methyl-7-(3-methyl-2,2-di oxo-1,3-dihydro-2.lamda..sup.6,1,3-benzothiadiazol-5-yl)-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 5-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinox- alin-6-yl]-1,3-dihydro-2k.sup.6,1-benzothiazole-2,2-dione; propan-2-yl (3S)-4-acetyl-7-(2,2-dioxo-1,3-dihydro-2.lamda..sup.6,1-benzothiazol-5-yl- )-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; N-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-2-fluorophenyl}methanesulfonamide; N-{4-[(2S)-1-acetyl-4-cyclobutanecarbonyl-2-methyl-1,2,3,4-tetrahydroquin- oxalin-6-yl]-2-fluorophenyl}methanesulfonamide; ethyl (3S)-4-acetyl-7-(3-fluoro-4-methanesulfonamidophenyl)-3-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(3-fluoro-4-methanesulfonamidophenyl)-3-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-6-(1-methanesulfonyl-1,2,3,4-tetrahydroqui- nolin-7-yl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; propan-2-yl (3S)-4-acetyl-7-(1-methanesulfonyl-1,2,3,4-tetrahydroquinolin-7-yl)-3-met- hyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 5-chloropyridin-3-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 3-(trifluoromethyl)pyridin-2-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 5-fluoropyridin-3-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2,6-dimethylpyridin-3-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; quinolin-5-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; isoquinolin-6-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 5-chloro-2-methoxypyridin-3-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 5-fluoro-2-methoxypyridin-3-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 5-chloro-2-methoxypyridin-4-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-methoxy-5-methylpyridin-3-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 4-fluoro-2-methoxyphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2,4-dichlorophenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 4-(1H-1,2,4-triazol-1-yl)phenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; quinolin-8-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 5-chloroquinolin-8-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 5,7-dichloroquinolin-8-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 2-fluoro-5-methylphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 6-methoxypyridin-3-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 5-fluoro-2-methylphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 5-fluoro-2-methoxyphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; quinolin-7-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; quinolin-3-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; quinoxalin-5-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 1-methyl-1H-1,3-benzodiazol-5-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; isoquinolin-7-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-[4-(ethanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahydroqui- noxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7[4-(ethanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-[4-(cyclopropanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahy- droquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-[4-(cyclopropanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahy- droquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-{4-[(2-hydroxyethyl)sulfamoyl]phenyl}-3-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-{4-[(2-hydroxyethyl)sulfamoyl]phenyl}-3-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-3-methyl-7-(3-sulfamoylphenyl)-1,2,3,4-tetrahydroquinoxalin- e-1-carboxylate; oxan-4-yl (3S)-4-acetyl-3-methyl-7-(3-sulfamoylphenyl)-1,2,3,4-tetrahydroquinoxalin- e-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-(3-methanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-(3-methanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-[3-(dimethylsulfamoyl)phenyl]-3-methyl-1,2,3,4-tetrahydro- quinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-[3-(dimethylsulfamoyl)phenyl]-3-methyl-1,2,3,4-tetrahydro- quinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-(3-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-(3-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-(3-ethanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-(3-ethanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-3-methyl-7-[4-(morpholin-4-yl)phenyl]-1,2,3,4-tetrahydroqui- noxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-3-methyl-7-[4-(morpholin-4-yl)phenyl]-1,2,3,4-tetrahydroqui- noxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-3-methyl-7-[4-(propane-2-sulfonyl)phenyl]-1,2,3,4-tetrahydr- oquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-3-methyl-7-[4-(propane-2-sulfonyl)phenyl]-1,2,3,4-tetrahydr- oquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-3-methyl-7-(4-sulfamoylphenyl)-1,2,3,4-tetrahydroquinoxalin- e-1-carboxylate; oxan-4-yl (3S)-4-acetyl-3-methyl-7-(4-sulfamoylphenyl)-1,2,3,4-tetrahydroquinoxalin- e-1-carboxylate; cyclohexyl (3S)-4-acetyl-3-methyl-7-[4-(propane-1-sulfonyl)phenyl]-1,2,3,4-tetrahydr- oquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-3-methyl-7-[4-(propane-1-sulfonyl)phenyl]-1,2,3,4-tetrahydr- oquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-(4-cyclopropylmethanesulfonylphenyl)-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-(4-cyclopropylmethanesulfonylphenyl)-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-3-methyl-7-[4-(2-methylpropanesulfonyl)phenyl]-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-3-methyl-7-[4-(2-methylpropanesulfonyl)phenyl]-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-(3-fluoro-4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-(3-fluoro-4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-[3-(cyclopropanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahy- droquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-[3-(cyclopropanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahy- droquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-[3-(ethanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahydroqui- noxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-[3-(ethanesulfonyl)phenyl]-3-methyl-1,2,3,4-tetrahydroqui- noxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-(3-chloro-5-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-(3-chloro-5-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-(4-fluoro-3-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-(4-fluoro-3-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-[4-(2-methanesulfonylethoxy)phenyl]-3-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-[4-(2-methanesulfonylethoxy)phenyl]-3-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-3-methyl-7-[3-(methylsulfamoyl)phenyl]-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-3-methyl-7-[3-(methylsulfamoyl)phenyl]-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-{3-[(2-hydroxyethyl)sulfamoyl]phenyl}-3-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-{3-[(2-hydroxyethyl)sulfamoyl]phenyl}-3-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-[3-(diethylsulfamoyl)-4-methoxyphenyl]-3-methyl-1,2,3,4-t- etrahydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-[3-(diethylsulfamoyl)-4-methoxyphenyl]-3-methyl-1,2,3,4-t- etrahydroquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-3-methyl-7-[4-(1H-pyrazole-1-sulfonyl)phenyl]-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-3-methyl-7-[4-(1H-pyrazole-1-sulfonyl)phenyl]-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-3-methyl-7-[4-(methylsulfamoyl)phenyl]-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-3-methyl-7-[4-(methylsulfamoyl)phenyl]-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-[4-(dimethylsulfamoyl)phenyl]-3-methyl-1,2,3,4-tetrahydro- quinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-[4-(dimethylsulfamoyl)phenyl]-3-methyl-1,2,3,4-tetrahydro- quinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-[4-(tert-butylsulfamoyl)phenyl]-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-[4-(tert-butylsulfamoyl)phenyl]-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-3-methyl-7-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,2,3,4-tetrahy- droquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-3-methyl-7-[4-(2-oxopyrrolidin-1-yl)phenyl]-1,2,3,4-tetrahy- droquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-(4-ethanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-(4-ethanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroqu- inoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-(3-methanesulfonamido-4-methoxyphenyl)-3-methyl-1,2,3,4-t- etrahydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-(3-methanesulfonamido-4-methoxyphenyl)-3-methyl-1,2,3,4-t- etrahydroquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-{3-[(dimethylsulfamoyl)amino]phenyl}-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; oxan-4-yl (3S)-4-acetyl-7-{3-[(dimethylsulfamoyl)amino]phenyl}-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(4-cyclopropanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; N-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]phenyl}cyclopropanesulfonamide; 1-[(2S)-4-cyclopropanecarbonyl-6-(1-methanesulfonyl-2,3-dihydro-1H-indol-- 5-yl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; propan-2-yl (3S)-4-acetyl-7-[1-(1-hydroxy-2-methylpropan-2-yl)-1H-pyrazol-4-yl]-3-met- hyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-3-yl (2S)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4-tetrahydroquinoxaline-1- ,4-dicarboxylate; pyridin-3-yl (3S)-4-acetyl-7-(4-methanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxaline-1-carboxylate; 1-methyl 4-pyridin-3-yl (2S)-6-(4-methanesulfonamidophenyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin- e-1,4-dicarboxylate; pyridin-3-yl (3S)-4-acetyl-7-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-3-methyl-1,2- ,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-3-yl (2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetr- ahydroquinoxaline-1,4-dicarboxylate; pyridin-3-yl (3S)-4-acetyl-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-3-yl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroqu- inoxaline-1,4-dicarboxylate; 1-methyl 4-pyridin-3-yl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoxa- line-1,4-dicarboxylate; pyridin-3-yl (3S)-4-acetyl-7-[1-(1-hydroxy-2-methylpropan-2-yl)-1H-pyrazol-4-yl]-3-met- hyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-3-yl (2S)-6-[1-(1-hydroxy-2-methylpropan-2-yl)-1H-pyrazol-4-yl]-2-methyl-1,2,3- ,4-tetrahydroquinoxaline-1,4-dicarboxylate; pyridin-3-yl (3S)-4-acetyl-7-[4-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)phenyl]-3- -methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-3-yl (2S)-6-[4-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)phenyl]-2-methyl-1- ,2,3,4-tetrahydroquinoxaline-1,4-dicarboxylate; pyridin-3-yl (3S)-4-acetyl-7-[1-(2-cyanoethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-3-yl (2S)-6-[1-(2-cyanoethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquin- oxaline-1,4-dicarboxylate; pyridin-3-yl (3S)-4-acetyl-7-(1-methanesulfonyl-2,3-dihydro-1H-indol-5-yl)-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-3-yl (2S)-6-(1-methanesulfonyl-2,3-dihydro-1H-indol-5-yl)-2-methyl-1,2,3,4-tet- rahydroquinoxaline-1,4-dicarboxylate; pyridin-3-yl (3S)-4-acetyl-3-methyl-7-[4-(N-methylmethanesulfonamido)phenyl]-1,2,3,4-t- etrahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-3-yl (2S)-2-methyl-6-[4-(N-methylmethanesulfonamido)phenyl]-1,2,3,4-tetrahydro- quinoxaline-1,4-dicarboxylate; pyridin-3-yl (3S)-4-acetyl-7-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-3-yl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroqui- noxaline-1,4-dicarboxylate; 1-methyl 4-pyridin-3-yl (2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroqu- inoxaline-1,4-dicarboxylate; 4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahy droquinoxalin-6-yl]-2-fluorobenzene-1-sulfonamide; propan-2-yl (3S)-4-acetyl-7-(3-fluoro-4-sulfamoylphenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(dimethylsulfamoyl)-3-methylphenyl]-3-methyl-1,2,3,4-t- etrahydroquinoxaline-1-carboxylate; 4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinox- alin-6-yl]-N,N,2-trimethylbenzene-1-sulfonamide; cyclohexyl (3S)-4-acetyl-3-methyl-7-[1-(oxan-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(oxan-4-yl)-1H-pyrazol-4-yl]- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; cyclohexyl (3S)-4-acetyl-3-methyl-7-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; 3-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl}-1.lamda..sup.6-thietane-1,1-dione; propan-2-yl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thietan-3-yl)-1H-pyrazol-4-y- l]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; cyclopentyl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thietan-3-yl)-1H-pyrazol-4-y- l]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thietan-3-yl)-1H-pyrazol-4-y- l]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1H,2H,3H,4H-pyri- do[2,3-b]pyrazine-1-carboxylate; 3-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl}-1.lamda..sup.6-thiane-1,1-dione; propan-2-yl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thian-3-yl)-1H-pyrazol-4-yl]- -3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; cyclohexyl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thian-3-yl)-1H-pyrazol-4-yl]- -3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-2-yl (2S)-6-[1-(1-hydroxy-2-methylpropan-2-yl)-1H-pyrazol-4-yl]-2-methyl-1,2,3- ,4-tetrahydroquinoxaline-1,4-dicarboxylate; pyridin-2-yl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 1-methyl 4-pyridin-2-yl (2S)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4-tetrahydroquinoxaline-1- ,4-dicarboxylate; pyridin-2-yl (3S)-4-acetyl-7-(4-methanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxaline-1-carboxylate; 1-methyl 4-pyridin-2-yl (2S)-6-(4-methanesulfonamidophenyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin- e-1,4-dicarboxylate; pyridin-2-yl (3S)-4-acetyl-7-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-3-methyl-1,2- ,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-2-yl (2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetr- ahydroquinoxaline-1,4-dicarboxylate; pyridin-2-yl (3S)-4-acetyl-7-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-3-methyl-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-2-yl (2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-te- trahydroquinoxaline-1,4-dicarboxylate; pyridin-2-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 1-methyl 4-pyridin-2-yl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoxa- line-1,4-dicarboxylate; pyridin-2-yl (3S)-4-acetyl-7-[4-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)phenyl]-3- -methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-2-yl (2S)-6-[4-(1,1-dioxo-1.sup.6,2-thiazolidin-2-yl)phenyl]-2-methyl-1,2,3,4-- tetrahydroquinoxaline-1,4-dicarboxylate; pyridin-2-yl (3S)-4-acetyl-7-[1-(2-cyanoethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-2-yl (2S)-6-[1-(2-cyanoethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquin- oxaline-1,4-dicarboxylate; pyridin-2-yl (3S)-4-acetyl-7-(1-methanesulfonyl-2,3-dihydro-1H-indol-5-yl)-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-2-yl (2S)-6-(1-methanesulfonyl-2,3-dihydro-1H-indol-5-yl)-2-methyl-1,2,3,4-tet- rahydroquinoxaline-1,4-dicarboxylate; pyridin-2-yl (3S)-4-acetyl-3-methyl-7-[4-(N-methylmethanesulfonamido)phenyl]-1,2,3,4-t- etrahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-2-yl (2S)-2-methyl-6-[4-(N-methylmethanesulfonamido)phenyl]-1,2,3,4-tetrahydro- quinoxaline-1,4-dicarboxylate; pyridin-2-yl (3S)-4-acetyl-3-methyl-7-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-2-yl (2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroqu- inoxaline-1,4-dicarboxylate; pyridin-2-yl (3S)-4-acetyl-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; 1-methyl 4-pyridin-2-yl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroqu- inoxaline-1,4-dicarboxylate; 2,4-difluorophenyl (3S)-4-acetyl-7-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-3-methyl-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; 4-chloro-2-methylphenyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 4-fluorophenyl (3S)-4-acetyl-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; 4-fluorophenyl (3S)-4-acetyl-7-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-3-methyl-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; 4-fluorophenyl (3S)-4-acetyl-7-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-3-methyl-1,2- ,3,4-tetrahydroquinoxaline-1-carboxylate; 4-fluorophenyl (3S)-4-acetyl-7-[1-(2-cyanoethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; 4-fluorophenyl (3S)-4-acetyl-7-(4-methanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxaline-1-carboxylate; 4-fluorophenyl (3S)-4-acetyl-3-methyl-7-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; 4-fluorophenyl (3S)-4-acetyl-7-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; 4-fluorophenyl (3S)-4-acetyl-7-[1-(1-hydroxy-2-methylpropan-2-yl)-1H-pyrazol-4-yl]-3-met- hyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 2,4-difluorophenyl (3S)-4-acetyl-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; 2,4-difluorophenyl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 2,4-difluorophenyl (3S)-4-acetyl-7-[4-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)phenyl]-3- -methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 2,4-difluorophenyl (3S)-4-acetyl-7-[1-(2-cyanoethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; 2,4-difluorophenyl (3S)-4-acetyl-7-(4-methanesulfonamidophenyl)-3-methyl-1,2,3,4-tetrahydroq- uinoxaline-1-carboxylate; 2,4-difluorophenyl (3S)-4-acetyl-7-[1-(1-hydroxy-2-methylpropan-2-yl)-1H-pyrazol-4-yl]-3-met- hyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 4-fluorophenyl (3S)-4-acetyl-7-[4-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)phenyl]-3- -methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 2,4-difluorophenyl (3S)-4-acetyl-3-methyl-7-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; 4-(4-fluorophenyl) 1-methyl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroqu- inoxaline-1,4-dicarboxylate; 4-(4-fluorophenyl) 1-methyl (2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-te- trahydroquinoxaline-1,4-dicarboxylate; 4-(4-fluorophenyl) 1-methyl (2S)-6-[1-(1-hydroxy-2-methylpropan-2-yl)-1H-pyrazol-4-yl]-2-methyl-1,2,3- ,4-tetrahydroquinoxaline-1,4-dicarboxylate; 4-(4-fluorophenyl) 1-methyl (2S)-6-[1-(2-cyanoethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquin- oxaline-1,4-dicarboxylate; 4-(4-fluorophenyl) 1-methyl (2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroqu- inoxaline-1,4-dicarboxylate; 2 S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-N-(4-fluorophenyl)-2-methyl- -1H,2H,3H,4H-pyrido[2,3-b]pyrazine-4-carboxamide; (2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-N-(propan-2-yl)-- 1H,2H,3H,4H-pyrido[2,3-b]pyrazine-4-carboxamide; 4-fluorophenyl (3S)-4-acetyl-7-(1-methanesulfonyl-2,3-dihydro-1H-indol-5-yl)-3-methyl-1,- 2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-6-nitro-1,2,3,4-- tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-6-amino-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-- tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-6-methanesulfonamido-3-me- thyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-6-acetamido-3-methyl-1,2,- 3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-6-[(methylcarbam- oyl)amino]-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; (3S)-4-acetyl-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-N,3-dimethyl-N-(prop- an-2-yl)-1,2,3,4-tetrahydroquinoxaline-1-carboxamide; (3S)-4-acetyl-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-N,3-dimethyl-N-pheny- l-1,2,3,4-tetrahydroquinoxaline-1-carboxamide; propan-2-yl (3S)-4-acetyl-6-bromo-7-(4-methanesulfonylphenyl)-3-methyl-1 ,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-6-chloro-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-6-cyano-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-6-fluoro-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-6-acetamido-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-te- trahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-6-[(methoxycarbonyl)amino]-3-me- thyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-6-amino-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrah- ydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-6-methoxy-3-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-6-acetamido-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carbox- ylate; propan-2-yl (3S)-4-acetyl-6-methanesulfonamido-3-methyl-1,2,3,4-tetrahydroquinoxaline- -1-carboxylate; propan-2-yl (3S)-4-acetyl-6-[(methoxycarbonyl)amino]-3-methyl-1,2,3,4-tetrahydroquino- xaline-1-carboxylate propan-2-yl (3S)-4-acetyl-7-bromo-6-acetamido-3-methyl-1,2,3,4-tetrahydroquinoxaline-- 1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-6-[(methoxycarbonyl)amino- ]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-6-acetamido-7-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl- ]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-6-fluoro-3-methyl-1,2,3,4- -tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-6-chloro-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4- -tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-6-bromo-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-- tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-6-methoxy-3-methyl-1,2,3,- 4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-6-cyano-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-- tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-6-carbamoyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,- 3,4-tetrahydroquinoxaline-1-carboxylate; and propan-2-yl (3S)-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-4-(methylcarbamoyl)-1H,2H- ,3H,4H-pyrido[2,3-b]pyrazine-1-carboxylate. 24. The compound of claim 23 selected from the group consisting of: cyclobutyl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thian-4-yl)-1H-pyrazol-4-yl]- -3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; cyclobutyl (3S)-4-acetyl-3-methyl-7-{1-[(4S)-2-oxopiperidin-4-yl]-1H-pyrazol-4-yl}-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; cyclobutyl (3S)-4-acetyl-3-methyl-7-{1-[(4R)-2-oxopiperidin-4-yl]-1H-pyrazol-4-yl}-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-{1-[(2S)-2-methylazetidin-3-yl]-1H-pyrazol-4-yl}- -1,2,3,4-tetrahydroquinoxaline-1-carboxylate; cyclobutyl (3S)-4-acetyl-7-[1-(1,1-dioxo-1.lamda..sup.6-thietan-3-yl)-1H-pyrazol-4-y- l]-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(oxan-4-yl)-1H-pyrazol-4-yl]- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; oxan-4-yl (3S)-4-acetyl-3-methyl-7-[1-(oxan-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; 1-[(2S)-2-methyl-4-(1-methyl-1H-indazol-3-yl)-6-[1-(piperidin-4-yl)-1H-py- razol-4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-cyclopropanecarbonyl-6-(1-methanesulfonyl-2,3-dihydro-1H-indol-- 5-yl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 4-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]phenyl}-1.lamda..sup.6-thiomorpholine-1,1-dione; cyclobutyl (3S)-4-acetyl-7-{1-[(3R)-1,1-dioxo-1.lamda..sup.6-thian-3-yl]-1H-pyrazol-- 4-yl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; cyclobutyl (3S)-4-acetyl-7-{1-[(3S)-1,1-dioxo-1.lamda..sup.6-thian-3-yl]-1H-pyrazol-- 4-yl}-3-methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 3-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinox- alin-6-yl]benzene-1-sulfonamide; 1,3-difluoropropan-2-yl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoxalin-6-yl]- phenyl}methanesulfonamide; 1-[(2S)-4-cyclopropanecarbonyl-6-{1-[(2,2-difluorocyclopropyl)methyl]-1H-- pyrazol-4-yl}-2-methyl-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; propan-2-yl (3S)-4-acetyl-7-[1-(2-cyanoethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tetra- hydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-2-methyl-6-[1-(oxan-4-ylmethyl)-1H-pyrazol- -4-yl]-1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; 3-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]-1H-pyrazol-1-yl}propanenitrile; propan-2-yl (3S)-4-cyclopropanecarbonyl-3-methyl-7-[1-(2,2,2-trifluoroethyl)-1H-pyraz- ol-4-yl]-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-3-methyl-1- ,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-3-methyl-7-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-3-methyl-1,2,3,4-tet- rahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-3-methyl-1,2- ,3,4-tetrahydroquinoxaline-1-carboxylate; 1-[(2S)-4-cyclopropanecarbonyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl- -1,2,3,4-tetrahydroquinoxalin-1-yl]ethan-1-one; propan-2-yl (3S)-4-acetyl-7-{4-[(2-aminoethyl)carbamoyl]phenyl}-3-methyl-1,2,3,4-tetr- ahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)phenyl]-3- -methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-[4-(1,1-dioxo-1.lamda..sup.6-thiomorpholin-4-yl)phenyl]-3- -methyl-1,2,3,4-tetrahydroquinoxaline-1-carboxylate; 2-{4-[(2S)-1-acetyl-4-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroqui- noxalin-6-yl]phenyl}-1.lamda..sup.6,2-thiazolidine-1,1-dione; ethyl (3S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-1,2,3,4-tetrahyd- roquinoxaline-1-carboxylate; propan-2-yl (3S)-4-acetyl-7-(4-methanesulfonylphenyl)-3-methyl-1,2,3,4-tetrahydroquin- oxaline-1-carboxylate; 1-[(2S)-4-(furan-2-carbonyl)-2-methyl-6-(1-methyl-1H-pyrazol-4-yl)-1,2,3,- 4-tetrahydroquinoxalin-1-yl]ethan-1-one; 1-[(2S)-4-(furan-2-carbonyl)-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4- -tetrahydroquinoxalin-1-yl]ethan-1-one; 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]benzamide; and 4-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxal- in-6-yl]-N,N-dimethylbenzamide. 25. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier. 26. A method of modulating one or more of BET-family bromodomains, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claim 1. 27. A method of inhibiting one or more of BET-family bromodomains, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claim 1. 28. A method of inhibiting one or more of BET-family bromodomains, comprising administering to a patient in need thereof a therapeutically effective amount of the pharmaceutical composition of claim 25. 29. A method of treating, a cancer in a patient associated with the inhibition of one or more of BET-family bromodomains, the method comprising administering a therapeutically effective amount of a compound of claim 1, wherein the cancer is selected from the group consisting of lung cancer, cervix cancer, colon cancer, breast cancer, stomach cancers, hematologic cancers, leukemia, lymphoma, multiple myeloma, midline carcinomas, mesenchymal tumors, hepatic tumors, renal tumors, and neurological tumors, melanoma, actinic keratosis, squamous cell carcinoma, and cutaneous T-cell lymphoma. 30. The pharmaceutical composition of claim 25, further comprising a therapeutically effective amount of one or more additional therapeutic agents. 31. The pharmaceutical composition of claim 30, wherein said one or more additional therapeutic agents are selected from the group consisting of cytotoxic agent, cisplatin, doxorubicin, etoposide, irinotecan, topotecan, paclitaxel, docetaxel, the epothilones, tamoxifen, 5-fluorouracil, methotrexate, temozolomide, cyclophosphamide, lonafarnib, tipifarnib, 4-[[-5-[[-4-(3-Chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl- ]methyl]benzonitrile monohydrochloride, (3R)-3-benzyl-1-(1H-imidazol-5-ylmethyl)-4-thiophen-2-ylsulfonyl-3,5-dihy- dro-2H-1,4-benzodiazepine-7-carbonitrile, gefitinib, erlotinib hydrochloride, cetuximab, imatinib, interferon alfa 2b, pegylated interferon alfa-2b, aromatase combinations, gemcitabine, uracil mustard, chlormethine, ifosfamide, melphalan, chlorambucil, pipobroman, triethylenemelamine, triethylenethiophosphoramine, busulfan, carmustine, lomustine, streptozocin, dacarbazine, floxuridine, cytarabine, 6-mercaptopurine, 6-thioguanine, fludarabine phosphate, leucovorin, oxaliplatin, pentostatine, vinblastine, vincristine, vindesine, bleomycin, dactinomycin, daunorubicin, epirubicin, idarubicin, plicamycin, deoxycoformycin, mitomycin-C, L-asparaginase, teniposide, 17.alpha.-ethinylestradiol, diethylstilbestrol, testosterone, prednisone, fluoxymesterone, dromostanolone propionate, testolactone, megestrol acetate, methylprednisolone, methyltestosterone, prednisolone, triamcinolone, chlorotrianisene, 17.alpha.-hydroxyprogesterone, aminoglutethimide, estramustine, medroxyprogesteroneacetate, leuprolide acetate, flutamide, toremifene, goserelin acetate, carboplatin, hydroxyurea, amsacrine, procarbazine, mitotane, mitoxantrone, levamisole, vinorelbine, anastrazole, letrazole, capecitabine, reloxafine, droloxafine, hexamethylmelamine, bevacizumab, trastuzumab, tositumomab, bortezomib, ibritumomab tiuxetan, arsenic trioxide, porfimer sodium, cetuximab, thiotepa, altretamine, melphalan, fulvestrant, exemestane, rituximab, alemtuzumab, dexamethasone, bicalutamide, megestrol, or valrubicin. 32. A method of treating an inflammatory disorder in a patient associated with the inhibition of one or more of BET-family bromodomains, the method comprising administering a therapeutically effective amount of a compound of claim 1, wherein the inflammatory disorder is a chronic autoimmune inflammatory condition or an acute inflammatory condition selected from the group consisting of systemic lupus erythematosus, rheumatoid arthritis, atherosclerosis, psoriasis, and alopecia. 33. The method of claim 32, wherein the inflammatory disorder is rheumatoid arthritis. 34. A method of treating leukaemia comprising administering to a patient in need thereof a therapeutically effective amount of the compound of claim 24. 35. A method of treating lymphoma comprising administering to a patient in need thereof a therapeutically effective amount of the compound of claim 24.

Details for Patent 9,422,281

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978		2033-11-18
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986		2033-11-18
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132			2033-11-18
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132			2033-11-18
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	11/26/1997		2033-11-18
Idec Pharmaceuticals Corp.	RITUXAN	rituximab	Injection	103737	02/19/2002		2033-11-18