Claims for Patent: 9,388,161

Summary for Patent: 9,388,161

Title:	Tetrahydroquinoline compositions as BET bromodomain inhibitors
Abstract:	The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: ##STR00001## wherein W, X, Y, Z, R.sup.1, R.sup.2, R.sup.5, and R.sup.8 are as described herein.
Inventor(s):	Bair; Kenneth W. (Wellesley, MA), Herbertz; Torsten (Stow, MA), Kauffman; Goss S. (Ledyard, CT), Kayser-Bricker; Katherine J. (Branford, CT), Luke; George P. (Clinton, CT), Martin; Matthew W. (Arlington, MA), Millan; David S. (Watertown, MA), Schiller; Shawn E. R. (Haverhill, MA), Talbot; Adam C. (Guilford, CT)
Assignee:	Forma Therapeutics, Inc. (Watertown, MA)
Application Number:	14/546,775
Patent Claims:	1. A compound of Formula I: ##STR00645## or a pharmaceutically acceptable salt, enantiomer, hydrate, solvate, isomer, or tautomer thereof, wherein: W is O, S, C(O), or CHR.sup.3; X is N or CR.sup.4; Y is N or CR.sup.6; Z is N or CR.sup.7; R.sup.1 is C.sub.1-C.sub.6 alkyl, or C.sub.1-C.sub.6 haloalkyl; R.sup.2 is hydrogen or NR.sup.aR.sup.b; R.sup.3 is hydrogen, halogen, hydroxyl, C.sub.1-C.sub.6 alkyl, or C.sub.1-C.sub.6 haloalkyl; R.sup.4 is hydrogen, --(CH.sub.2).sub.nR.sup.d, --O(CH.sub.2).sub.nR.sup.d, --N(CH.sub.2)R.sup.d, --O(CH.sub.2)C(O)R.sup.d, or --O(CH.sub.2).sub.nS(O).sub.2R.sup.d; R.sup.5 is halogen, cyano, C.sub.1-C.sub.6 alkyl, C.sub.2-C.sub.6 alkenyl, C.sub.2-C.sub.6 alkynyl, C.sub.1-C.sub.6 haloalkyl, C.sub.3-C.sub.8 cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, --(C.sub.1-C.sub.6)-alkylene-aryl, --(C.sub.1-C.sub.6)-alkylene-heteroaryl, --(C.sub.1-C.sub.6)-alkylene-heterocycloalkyl, --(CR.sup.aR.sup.b).sub.nOR.sup.c, --(CR.sup.aR.sup.b).sub.nR.sup.c, --O(CR.sup.aR.sup.b).sub.nNR.sup.aR.sup.b, --NR.sup.aR.sup.b, --NR.sup.aC(O)R.sup.b, --NR.sup.aS(O).sub.2R.sup.b, or R.sup.c, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, and heteroaryl are optionally substituted with one or more substituents independently selected from R.sup.a, R.sup.b, and R.sup.c; R.sup.6 is hydrogen, halogen, cyano, C.sub.1-C.sub.6 alkyl, C.sub.2-C.sub.6 alkenyl, C.sub.2-C.sub.6 alkynyl, C.sub.1-C.sub.6 haloalkyl, C.sub.3-C.sub.8 cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, --(C.sub.1-C.sub.6)-alkylene-aryl, --(C.sub.1-C.sub.6)-alkylene-heteroaryl, --(C.sub.1-C.sub.6)-alkylene-heterocycloalkyl, --(CR.sup.aR.sup.b).sub.nOR.sup.c, --(CR.sup.aR.sup.b).sub.nR.sup.c, --O(CR.sup.aR.sup.b).sub.nNR.sup.aR.sup.b, --NR.sup.aR.sup.b, --NR.sup.aC(O)R.sup.b, --NR.sup.aS(O).sub.2R.sup.b, or R.sup.c, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, and heteroaryl are optionally substituted with one or more substituents independently selected from R.sup.a, R.sup.b, and R.sup.c; R.sup.7 is hydrogen or halogen; R.sup.8 is R.sup.a, --OR, --NR.sup.a, or heterocycloalkyl; R.sup.a and R.sup.b are each independently hydrogen, halogen, C.sub.1-C.sub.6 alkyl, cycloalkyl, or heterocycloalkyl, wherein C.sub.1-C.sub.6 alkyl, cycloalkyl, or heterocycloalkyl is optionally substituted with one or more R.sup.e; R.sup.c is --NH.sub.2, OH, --NH(C.sub.1-C.sub.6 alkyl), --O(CH.sub.2).sub.nNR.sup.aR.sup.b, --NH(C.sub.1-C.sub.6 alkoxy), --(CH.sub.2).sub.nR, --(CH.sub.2).sub.nOR.sup.a, --C(O)R.sup.a, --C(O)OR.sup.a, --C(O)NR.sup.aR.sup.b, --(CH.sub.2).sub.nS(O).sub.2CH.sub.3, --S(O).sub.2R.sup.a, --S(O).sub.2NR.sup.aR.sup.b, --NR.sup.a--S(O).sub.2R.sup.b, --NHC(O)R.sup.a, C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, C.sub.1-C.sub.6 alkoxy, C.sub.2-C.sub.6 alkenyl, C.sub.2-C.sub.6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, halo, cyano, or oxo, wherein C.sub.1-C.sub.6 alkyl, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, C.sub.1-C.sub.6 alkoxy, C.sub.2-C.sub.6 alkenyl, C.sub.2-C.sub.6 alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl are optionally susbtitued with one or more R.sup.e; or two adjacent R.sup.c can combine with the carbons to which they are attached to form a carbocycle or heterocycle; R.sup.d is hydrogen, NH(C.sub.1-C.sub.6 alkyl), N(C.sub.1-C.sub.6 alkyl).sub.2, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, C.sub.1-C.sub.6 alkoxy, C.sub.2-C.sub.6 alkenyl, C.sub.2-C.sub.6 alkynyl, C.sub.1-C.sub.6 alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein said alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more substituents independently selected from R.sup.a, R.sup.b, and R.sup.c; R.sup.e is hydrogen, halogen, OH, C.sub.1-C.sub.6 alkyl, cycloalkyl, heterocycloalkyl, oxo, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, C.sub.1-C.sub.6 alkoxy, or S(O).sub.2(C.sub.1-C.sub.6 alkyl); and n is 0, 1, or 2. 2. The compound of claim 1, wherein X is CR.sup.4 and Y and Z are CH. 3. The compound of claim 2, wherein W is CHR.sup.3. 4. The compound of claim 1, having the Formula II ##STR00646## or a pharmaceutically acceptable salt, enantiomer, hydrate, solvate, isomer, or tautomer thereof, wherein: W is O, C(O), or CHR.sup.3; Ar is aryl or heteroaryl; R.sup.2 is hydrogen or NR.sup.aR.sup.b; R.sup.3 is hydrogen, hydroxy, or halo; R.sup.4 hydrogen, --O(CH.sub.2).sub.nR.sup.d, --O(CH.sub.2).sub.nC(O)R.sup.d, or --O(CH.sub.2).sub.nS(O).sub.2R.sup.d; R.sup.7 is hydrogen or halo; R.sup.8 is R.sup.a, --OR.sup.a, or heterocycloalkyl; R.sup.a and R.sup.b are independently hydrogen, C.sub.1-C.sub.6 alkyl, heterocycloalkyl, or cycloalkyl; R.sup.c is R.sup.a, --(CH.sub.2).sub.nOR.sup.a, --C(O)R.sup.a, --C(O)OR.sup.a, --C(O)NR.sup.aR.sup.b--S(O).sub.2R.sup.a, halo, or oxo; and n is 0, 1, or 2. 5. The compound of claim 4, wherein W is CHR.sup.3. 6. The compound of claim 4, wherein Ar is pyrazole or phenyl. 7. The compound of claim 1, having the Formula III ##STR00647## or a pharmaceutically acceptable salt, enantiomer, hydrate, solvate, isomer, or tautomer thereof, wherein: Ar is pyrazolyl or phenyl; R.sup.4 is hydrogen, --O(CH.sub.2).sub.nR.sup.d, --O(CH.sub.2).sub.nC(O)R.sup.d, or --O(CH.sub.2).sub.nS(O).sub.2R.sup.d; R.sup.8 is methyl, methoxy, or cyclopropyl; R.sup.a and R.sup.b are independently hydrogen or C.sub.1-C.sub.6 alkyl; R.sup.c is --(CH.sub.2).sub.nR.sup.a, --(CH.sub.2).sub.nOR.sup.a, --C(O)R.sup.a, --C(O)OR.sup.a, --C(O)NR.sup.aR.sup.b, --(CH.sub.2).sub.nS(O).sub.2CH.sub.3, --S(O).sub.2R.sup.a, --S(O).sub.2NR.sup.aR.sup.b, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, cycloalkyl, heterocycloalkyl, halo, cyano, or oxo; R.sup.d is hydrogen, NH(C.sub.1-C.sub.6 alkyl), N(C.sub.1-C.sub.6 alkyl).sub.2, C.sub.1-C.sub.6 alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein said alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more substituents independently selected from R.sup.a, R.sup.b, and R.sup.c; and n is 0, 1, or 2. 8. The compound of claim 7, wherein Ar is pyrazole and R.sup.c is cycloalkyl or heterocycloalkyl. 9. The compound of claim 8, wherein R.sup.c is cyclopropyl. 10. The compound of claim 7, wherein Ar is phenyl, R.sup.c is --(CH.sub.2).sub.nS(O).sub.2CH.sub.3. 11. The compound of claim 1, having the Formula IV ##STR00648## or a pharmaceutically acceptable salt, enantiomer, hydrate, solvate, isomer, or tautomer thereof, wherein: R.sup.4 is --O(CH.sub.2).sub.nR.sup.d, --O(CH.sub.2).sub.nC(O)R.sub.d, or --O(CH.sub.2).sub.nS(O).sub.2R.sup.d; R.sup.8 is alkyl, cycloalkyl, O-alkyl, or O-cycloalkyl R.sup.a and R.sup.b are independently hydrogen or C.sub.1-C.sub.6 alkyl; R.sup.c is --(CH.sub.2).sub.nR.sup.a, --(CH.sub.2).sub.nOR.sup.a, --C(O)R.sup.a, --C(O)OR.sup.a, --C(O)NR.sup.aR.sup.b--S(O).sub.2R.sup.a, --S(O).sub.2NR.sup.aR.sup.b, C.sub.1-C.sub.6 haloalkyl, C.sub.1-C.sub.6 haloalkoxy, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, halo, cyano, or oxo; R.sup.d is hydrogen, NH(C.sub.1-C.sub.6 alkyl), N(C.sub.1-C.sub.6 alkyl).sub.2, C.sub.1-C.sub.6 alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein said alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are optionally substituted with one or more substituents independently selected from R.sup.a, R.sup.b, and R.sup.c; and n is 0, 1, or 2. 12. The compound of claim 11, wherein R.sup.c is cycloalkyl, or heterocycloalkyl. 13. The compound of claim 12, wherein R.sup.4 is --O(CH.sub.2).sub.nR.sup.d. 14. The compound of claim 13, wherein R.sup.d is aryl, heteroaryl, or cycloalkyl. 15. The compound of claim 1 selected from the group consisting of: methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-{[3-(hydroxymethyl)oxetan-3-yl]m- ethoxy}-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-fluorophenoxy)-2-methyl-6-(1-{octahydrocyclopenta[c]pyrrol-5-yl- }-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(3,3-difluorocyclobutoxy)-2-meth- yl-1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-(1H-1,2,3-triazol-4-yl)-- 1,2,3,4-tetrahydroquinoline; methyl (2S)-5-(azetidin-3-ylmethoxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-- 1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(3-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-- 1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(2,2,2-trifluoroetho- xy)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-5-(3-chlorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-- 1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(2,2-difluoroethoxy)-2-methyl- -1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(4-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(2,2-difluoropropoxy)-2-methy- l-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(4-chlorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-[(1,3-difluoropropan-2-yl)oxy- ]-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(3,4-difluorophenoxy)-2-meth- yl-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(3-hydroxy-2,2-dimethylpropox- y)-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-2-methyl-5-phenoxy-1,2,3,4-tet- rahydroquinoline-1-carboxylate; 2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}-2-methylpropanamide; (2S)-1-cyclopropanecarbonyl-5-(2-methoxyphenoxy)-2-methyl-6-[1-(piperidin- -4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(3,3,3-trifluoroprop- oxy)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; (2S)-1-cyclopropanecarbonyl-5-(3-methoxyphenoxy)-2-methyl-6-[1-(piperidin- -4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; 1-(2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-t- etrahydroquinolin-5-yl]oxy}ethyl)pyrrolidin-2-one; (2S)-1-cyclopropanecarbonyl-5-(4-methoxyphenoxy)-2-methyl-6-[1-(piperidin- -4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; 2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}-1-(morpholin-4-yl)ethan-1-one; methyl (2S)-5-(2-methoxyphenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]- -1,2,3,4-tetrahydroquinoline-1-carboxylate; 2-(2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-t- etrahydroquinolin-5-yl]oxy}ethyl)-1.lamda..sup.6,2-thiazolidine-1,1-dione; methyl (2S)-5-(3-methoxyphenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazo- l-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; {[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetrah- ydroquinolin-5-yl]oxy}methanesulfonamide; methyl (2S)-5-(4-methoxyphenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]- -1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}-N,N-dimethylmethanesulfonamide; methyl (2S)-2-methyl-5-phenoxy-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-te- trahydroquinoline-1-carboxylate; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[2-(oxetan-3-yl)etho- xy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-5-phenoxy-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4- -tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-[(2,2-difluorocyclopropyl)met- hoxy]-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 3-{[(2S)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol- -4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oxy}benzonitrile; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-{[3-(hydroxymethyl)oxetan-3-y- l]methoxy}-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-(pyridin-2-ylox- y)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-[(3-fluorooxetan-3-yl)methoxy- ]-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(3-methoxyphenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-- yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(3,3-difluorocyclobutoxy)-2-m- ethyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(azetidin-3-ylmethoxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-meth- yl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-(1-methyl-1H-1,2,3-t- riazol-4-yl)-1,2,3,4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-(1H-pyrazol-4-yl)-1,- 2,3,4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-(1-methyl-1H-pyrazol- -4-yl)-1,2,3,4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-(1H-pyrazol-5-yl)-1,- 2,3,4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-(1-methyl-1H-imidazo- l-4-yl)-1,2,3,4-tetrahydroquinoline; methyl (2S)-5-({1-[(tert-butoxy)carbonyl]azetidin-3-yl}oxy)-6-(1-cyclopropyl-1H-- pyrazol-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(azetidin-3-yloxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,- 3,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-5-(azetidin-3-yloxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1- ,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-5-cyclobutoxy-6-[1-(1,1-dioxo-1.lamda..sup.6-thietan-3-yl)-1H-pyrazo- l-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-[1-(1,1-dioxo-1.lamda..sup.6-thian-3-yl)-1H-pyrazol-- 4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; (2R)-2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4- -tetrahydroquinolin-5-yl]oxy}-2-fluoroacetamide; (2S)-2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4- -tetrahydroquinolin-5-yl]oxy}-2-fluoroacetamide; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-[(3-fluorooxetan-3-yl)methoxy]-2- -methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; 2-{([(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tet- rahydroquinolin-5-yl]oxy}-2,2-difluoroacetamide; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(2-fluoro-2-methylpropoxy)-2-- methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-5-cyclobutoxy-2-methyl-6-[1-(oxan-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoline-1-carboxylate; 1-[(2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-propoxy-1,2,3,4- -tetrahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4- -tetrahydroquinolin-5-yl]oxy}-N,N-dimethylacetamide; methyl (2S)-5-[(dimethylcarbamoyl)methoxy]-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl- ]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; 2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}-N-ethylacetamide; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(2-fluoroethoxy)-2-methyl-1,2- ,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}-N-cyclopropyl-N-methylacetamide; 2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}-1-(azetidin-1-yl)ethan-1-one; 2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}-1-(piperidin-1-yl)ethan-1-one; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(2,2,2-trifluoroethoxy)- -1,2,3,4-tetrahydroquino line-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(2,2-difluoroethoxy)-2-methyl-1,- 2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(2-fluoroethoxy)-2-methyl-1,2,3,- 4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(2,2-difluoropropoxy)-2-methyl-1- ,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(3,3,3-trifluoropropoxy- )-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(carbamoyldifluoromethoxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-met- hyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-[(1,3-difluoropropan-2-yl)oxy]-2- -methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(2-fluoro-2-methylpropoxy)-2-met- hyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(3-hydroxy-2,2-dimethylpropoxy)-- 2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(1-carbamoyl-1-methylethoxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-m- ethyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(R)-carbamoyl(fluoro)methoxy]-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2- -methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(S)-carbamoyl(fluoro)methoxy]-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2- -methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-[(ethylcarbamoyl)methoxy]-2-meth- yl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-{[cyclopropyl(methyl)carbamoyl]methoxy}-6-(1-cyclopropyl-1H-pyrazo- l-4-yl)-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[2-(azetidin-1-yl)-2-oxoethoxy]-6-(1-cyclopropyl-1H-pyrazol-4-yl)-- 2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[2-oxo-2-(piperidin-1-y- l)ethoxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[2-(2-oxopyrrolidin-1-y- l)ethoxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[2-(morpholin-4-yl)-2-o- xoethoxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-[2-(1,1-dioxo-1.lamda..sup.6,2-t- hiazolidin-2-yl)ethoxy]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate- ; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(sulfamoylmetho- xy)-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-[(dimethylsulfamoyl)methoxy]-2-m- ethyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[2-(oxetan-3-yl)ethoxy]- -1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-[(2,2-difluorocyclopropyl)methox- y]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(quinazolin-2-yloxy)- -1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(1,3-benzoxazol-2-yloxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-me- thyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(1,3-benzoxazol-2-yloxy)-2-methyl-6-[1-(oxetan-3-yl)-1H-pyrazol- -4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-(pyrimidin-2-yl- oxy)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}pyridine-3-carboxamide; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-1H-pyrazolo[3,4-d]py- rimidin-6-yloxy)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(1,3-thiazol-2-yloxy- )-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}pyridine-3-carbonitrile; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-{[4-(trifluoromethyl- )pyrimidin-2-yl]oxy}-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-{[3-(trifluoromethyl- )pyridin-2-yl]oxy}-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-[(3-chloropyridin-2-yl)oxy]-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2- -methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(pyrazin-2-yloxy)-1,- 2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(pyridin-2-yloxy)-1,- 2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-[(4,6-dimethylpyrimidin-2-yl)- oxy]-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 6-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}pyridazine-3-carbonitrile; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[(5-methylpyrimidin-- 2-yl)oxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-{[2-(trifluoromethyl- )pyrimidin-4-yl]oxy}-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-- 1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-5-propoxy-1,2,3,4-tetrahydroquinoline; (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-cyclobutoxy-1-cyclopropaneca- rbonyl-2-methyl-1,2,3,4-tetrahydroquinoline; (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-cyclopropanecarbonyl-2-methy- l-5-propoxy-1,2,3,4-tetrahydroquinoline; 1-[(2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-propoxy-1,2,3,4- -tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-propoxy-1,2,3,4-te- trahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-2-methyl-6-[1-(pyrrolidin-3-yl)-1H-pyrazol-4-yl]-1,2,3- ,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-2-methyl-6-(1-{octahydrocyclopenta[c]pyrrol-5-yl}-1H-p- yrazol-4-yl)-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-[6-(4-methanesulfonylphenyl)-2-methyl-5-phenoxy-1,2,3,4-tetrahydroquino- lin-1-yl]ethan-1-one; 1-(2-methyl-5-phenoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one; 1-[(2S)-5-cyclopropoxy-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4- -tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(5-methanesulfonylpyridin-2-yl)-2-methyl-5-propoxy-1,2,3,4-tetr- ahydroquinolin-1-yl]ethan-1-one; N-{6-[(2S)-1-acetyl-2-methyl-5-propoxy-1,2,3,4-tetrahydroquinolin-6-yl]py- ridin-3-yl}methanesulfonamide; 2-{[(2S)-1-acetyl-6-(5-methanesulfonylpyridin-2-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}-N,N-dimethylacetamide; 1-[(2S)-6-(1,3-benzoxazol-2-yl)-2-methyl-5-propoxy-1,2,3,4-tetrahydroquin- olin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-5-propoxy-6-(pyrazolo[1,5-a]pyridin-2-yl)-1,2,3,4-tetrah- ydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-{imidazo[1,2-a]pyridin-2-yl}-2-methyl-5-propoxy-1,2,3,4-tetrahy- droquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1,3-benzothiazol-2-yl)-2-methyl-5-propoxy-1,2,3,4-tetrahydroqu- inolin-1-yl]ethan-1-one; 1-[(2S)-6-(1H-1,3-benzodiazol-2-yl)-2-methyl-5-propoxy-1,2,3,4-tetrahydro- quinolin-1-yl]ethan-1-one; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-(5-methyl-1,3,4-thia- diazol-2-yl)-1,2,3,4-tetrahydroquinoline; 5-[(2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahydroq- uinolin-6-yl]-1,3,4-thiadiazol-2-amine; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-(1H-1,2,3-triazol-4-- yl)-1,2,3,4-tetrahydroquinoline; methyl (2S)-5-(4-chloro-2-cyanophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazo- l-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(2-cyano-4-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazo- l-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(2-chloro-4-cyanophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazo- l-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-cyano-2-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazo- l-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate 2-{[(2S)-1-acetyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4- -tetrahydroquinolin-5-yl]oxy}benzonitrile; methyl (2S)-5-(2-cyanophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1- ,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(2-cyanophenoxy)-2-methyl-1,- 2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(2-cyano-3-fluorophenoxy)-2-- methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; 4-{[(2S)-1-acetyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4- -tetrahydroquinolin-5-yl]oxy}benzonitrile; 1-[(2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[3-(trifluorom- ethyl)pyridin-2-yl]oxy}-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-[(3-chloropyridin-2-yl)oxy]-2-methyl-6-[1-(piperidin-4-yl)-1H-p- yrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4- -tetrahydroquinolin-5-yl]oxy}pyridine-3-carbonitrile; 1-[(2S)-2-methyl-5-[(5-methylpyrimidin-2-yl)oxy]-6-[1-(piperidin-4-yl)-1H- -pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-(pyrazin-2-ylox- y)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-5-(4-cyanophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1- ,2,3,4-tetrahydroquino line-1-carboxylate; methyl (2S)-5-[(3-cyanopyridin-2-yl)oxy]-2-methyl-6-[1-(piperidin-4-yl)-1H-pyraz- ol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(2-cyano-3-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazo- l-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(3-chloro-2-cyanophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pryazo- l-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; 2-{[(2S)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol- -4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oxy}benzonitrile; 2-{[(2S)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol- -4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oxy}-6-fluorobenzonitrile; 4-{[(2S)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol- -4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oxy)}-3-fluorobenzonitrile; 2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}benzonitrile; methyl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(3-chloro-4-fluorophenoxy)-2- -methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; 4-{[(2S)-1-acetyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4- -tetrahydroquinolin-5-yl]oxy}benzamide; 1-[(2S)-5-(2-chlorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-5-(4-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-- 1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-chlorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-- 1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(2-chlorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-- 1,2,3,4-tetrahydroquino line-1-carboxylate; methyl (2S)-5-(4-carbamoylphenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(3-cyano-4-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazo- l-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(3-chloro-4-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyraz- ol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-1-cyclopropanecarbonyl-5-(4-fluorophenoxy)-2-methyl-6-[1-(piperidin-- 4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-5-(2-chlorophenoxy)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-- 4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-5-(4-chlorophenoxy)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-- 4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; 4-{[(2S)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol- -4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oxy}benzonitrile; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-[1-(piperidin-4-yl)-1H-p- yrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-5-(3-chloro-4-fluorophenoxy)-1-cyclopropanecarbonyl-2-methyl-6-[1-(p- iperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-cyclopropanecarbonyl-5-(4-fl- uorophenoxy)-2-methyl-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-(3-fluorophenoxy)-2-methyl-6-[1-(piperidin-- 4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-(3,4-di fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-te- trahydroquinoline; (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-cyclopropanecarbonyl-5-(3-fl- uorophenoxy)-2-methyl-1,2,3,4-tetrahydroquinoline; (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-cyclopropanecarbonyl-5-(3,4-- di fluorophenoxy)-2-methyl-1,2,3,4-tetrahydroquinoline; (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-cyclopropanecarbonyl-2-methy- l-5-phenoxy-1,2,3,4-tetrahydroquinoline; methyl (2S)-5-(3,4-difluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-- yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(3-chlorophenoxy)-2-methyl-1- ,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(3-chlorophenoxy)-1-cyclopro- panecarbonyl-2-methyl-1,2,3,4-tetrahydroquinoline; (2S)-5-(3-chlorophenoxy)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-- 4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; methyl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(3,5-difluorophenoxy)-2-meth- yl-1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-cyclopropanecarbonyl-5-(3,5-- di fluorophenoxy)-2-methyl-1,2,3,4-tetrahydroquinoline; methyl (2S)-5-(3,5-difluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-- yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-1-cyclopropanecarbonyl-5-(3,5-difluorophenoxy)-2-methyl-6-[1-(piperi- din-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; 5-[(2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-1,2,3,4-tetrahydroquino- lin-6-yl]-1,3,4-thiadiazol-2-amine; methyl (2S)-5-(4-fluorophenoxy)-2-methyl-6-[1-(pyrrolidin-3-yl)-1H-pyrazol-4-yl]- -1,2,3,4-tetrahydroquinoline-1-carboxylate; 4-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}benzamide; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-(1H-pyrazol-5-yl)-1,2,3,- 4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-6-(1-methyl-1H-1,2,3-triazol-4-yl)-5- -phenoxy-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-6-(5-methyl-1,3,4-thiadiazol-2-yl)-5- -phenoxy-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-6-(1-methyl-1H-imidazol-4-yl)-5-phen- oxy-1,2,3,4-tetrahydroquinoline; methyl (2S)-6-[1-(1,1-dioxo-1.lamda..sup.6-thian-3-yl)-1H-pyrazol-4-yl]-5-(4-flu- orophenoxy)-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(1,1-dioxo-1.lamda..sup.6-thietan-3-yl)-1H-pyrazol-4-yl]-5-(4-f- luorophenoxy)-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-1-cyclopropanecarbonyl-2-methyl-6-(1-methyl-1H-pyrazol-4-yl)-5-pheno- xy-1,2,3,4-tetrahydroquinoline; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(4-fluorophenoxy)-2-methyl-1,- 2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(4-chlorophenoxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,- 2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(2-fluorophenoxy)-2-methyl-1,2,3- ,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(2-fluorophenoxy)-2-methyl-1,- 2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-(I H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoline; 3-{4-[(2S)-1-cyclopropanecarbonyl-5-(4-fluorophenoxy)-2-methyl-1,2,3,4-te- trahydroquinolin-6-yl]-1H-pyrazol-1-yl}-1.lamda..sup.6-thietane-1,1-dione; 3-{4-[(2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-1,2,3,4-tetrahydroqu- inolin-6-yl]-1H-pyrazol-1-yl}-1.lamda..sup.6-thietane-1,1-dione; 1-[(2S)-5-(2-chlorophenoxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,- 2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(4-fluorophenoxy)-2-methyl-1,2,3- ,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-cyanophenoxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,- 4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-chlorophenoxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3- ,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(2-chlorophenoxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3- ,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-carbamoylphenoxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,- 2,3,4-tetrahydroquinoline-1-carboxylate; 4-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}benzonitrile; methyl (2S)-5-(4-chloro-2-cyanophenoxy)-2-methyl-6-[1-(1-methylpiperidin-4-yl)-1- H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-{[1-(propan-2-yl)aze- tidin-3-yl]oxy}-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-2-methyl-6-[1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl]- -1,2,3,4-tetrahydroquinolin-5-yl]oxy}benzonitrile; methyl (2S)-5-cyclobutoxy-2-methyl-6-[1-(1-methylpyrrolidin-3-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-2-methyl-6-(1-{2-methyl-octahydrocyclopenta[c]pyrrol-5- -yl}-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-fluorophenoxy)-2-methyl-6-[1-(1-methylpyrrolidin-3-yl)-1H-pyraz- ol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-fluorophenoxy)-2-methyl-6-(1-{2-methyl-octahydrocyclopenta[c]py- rrol-5-yl}-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-[(1-ethylazetidin-3-yl)ox- y]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-{[1-(propan-2-yl)azetid- in-3-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-[(1-ethylazetidin-3-yl)oxy]-2- -methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[(4-methylpyridin-2-- yl)oxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[(6-methylpyridin-2-- yl)oxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(isoquinolin-1-yloxy)-2-methy- l-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(2-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-5-(2-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-- 1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-1-cyclopropanecarbonyl-5-(2-fluorophenoxy)-2-methyl-6-[1-(piperidin-- 4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-cyclopropanecarbonyl-5-(2-fl- uorophenoxy)-2-methyl-1,2,3,4-tetrahydroquinoline; methyl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(2-fluorophenoxy)-2-methyl-1- ,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(2,4-difluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-- yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-1-cyclopropanecarbonyl-5-(2,4-difluorophenoxy)-2-methyl-6-[1-(piperi- din-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-cyclopropanecarbonyl-5-(2,4-- difluorophenoxy)-2-methyl-1,2,3,4-tetrahydroquinoline; methyl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(2,4-difluorophenoxy)-2-meth- yl-1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-1-cyclopropanecarbonyl-5-(2,3-difluorophenoxy)-2-methyl-6-[1-(piperi- din-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-cyclopropanecarbonyl-5-(2,3-- difluorophenoxy)-2-methyl-1,2,3,4-tetrahydroquinoline; methyl (2S)-5-(2,3-difluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-- yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(2,3-difluorophenoxy)-2-meth- yl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(2,5-difluorophenoxy)-2-meth- yl-1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-cyclopropanecarbonyl-5-(2,5-- difluorophenoxy)-2-methyl-1,2,3,4-tetrahydroquinoline; methyl (2S)-5-(2,5-difluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-- yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-1-cyclopropanecarbonyl-5-(2,5-di fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-te- trahydroquinoline; 1-[(2S)-5-(3,4-difluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol- -4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(2,5-difluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol- -4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one 1-[(2S)-5-{[(E)-2-chloroethenyl]oxy}-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-- methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-{1H,2H,3H-pyrazolo[1- ,5-a]imidazol-7-yl}-1,2,3,4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-6-{1-methanesulfonyl-1H,2H,3H-p- yrazolo[1,5-a]imidazol-7-yl}-2-methyl-1,2,3,4-tetrahydroquinoline; methyl (2S)-5-cyclobutoxy-6-[2-(4-hydroxypiperidin-4-yl)-1,3-thiazol-4-yl]-2-met- hyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-[2-(4-fluoropiperidin-4-yl)-1,3-thiazol-4-yl]-2-meth- yl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-fluorophenoxy)-2-methyl-6-[1-(1-methylazetidin-3-yl)-1H-pyrazol- -4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-fluorophenoxy)-2-methyl-6-[1-(1-methylpiperidin-4-yl)-1H-pyrazo- l-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-2-methyl-6-[1-(1-methylazetidin-3-yl)-1H-pyrazol-4-yl]- -1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-2-methyl-6-[1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl- ]-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[(3-methylpyridin-2-- yl)oxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[(5-methylpyridin-2-- yl)oxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-[(5-chloropyridin-2-yl)oxy]-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2- -methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(7H-purin-2-yloxy)-1- ,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-5-cyclobutoxy-6-[1-(3-methoxypiperidin-4-yl)-1H-pyrazol-4-yl]-2-meth- yl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-fluorophenoxy)-6-[1-(3-methoxypiperidin-4-yl)-1H-pyrazol-4-yl]-- 2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-[1-(3-methoxy-1-methylpiperidin-4-yl)-1H-pyrazol-4-y- l]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-fluorophenoxy)-6-[1-(3-methoxy-1-methylpiperidin-4-yl)-1H-pyraz- ol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; 3-{4-[(2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-1,2,3,4-tetrahydroqu- inolin-6-yl]-1H-pyrazol-1-yl}-1.lamda..sup.6-thiane-1,1-dione; 3-{4-[(2S)-1-cyclopropanecarbonyl-5-(4-fluorophenoxy)-2-methyl-1,2,3,4-te- trahydroquinolin-6-yl]-1H-pyrazol-1-yl}-1.lamda..sup.6-thiane-1,1-dione; methyl (2S)-5-cyclobutoxy-2-methyl-6-[1-(2-oxopiperidin-4-yl)-1H-pyrazol-- 4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-fluorophenoxy)-2-methyl-6-[1-(2-oxopiperidin-4-yl)-1H-pyrazol-4- -yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-fluorophenoxy)-2-methyl-6-{1-[(2S)-2-methylazetidin-3-yl]-1H-py- razol-4-yl}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-2-methyl-6-{1-[(2S)-2-methylazetidin-3-yl]-1H-pyrazol-- 4-yl}-1,2,3,4-tetrahydroquinoline-1-carboxylate; N-{4-[(2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahyd- roquinolin-6-yl]-1-cyclopropyl-1H-pyrazol-5-yl}methanesulfonamide; N-{4-[(2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahyd- roquinolin-6-yl]-1-cyclopropyl-1H-pyrazol-5-yl}acetamide; methyl (2S)-5-cyclobutoxy-6-[1-(3-hydroxycyclobutyl)-1H-pyrazol-4-yl]-2-methyl-1- ,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-2-methyl-6-[2-(piperidin-4-yl)-1H-imidazol-4-yl]-1,2,3- ,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-2-methyl-6-[1-methyl-2-(piperidin-4-yl)-1H-imidazol-4-- yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; 2-{[(2S)-1-acetyl-2-methyl-6-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4-te- trahydroquinolin-5-yl]oxy}-N-methylacetamide; 1-[(2S)-2-methyl-5-(1,2-oxazol-5-ylmethoxy)-6-[1-(oxetan-3-yl)-1H-pyrazol- -4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; N-(2-{[(2S)-1-acetyl-2-methyl-6-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-1,2,3,4- -tetrahydroquinolin-5-yl]oxy}ethyl)methanesulfonamide; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(1,2-oxazol-5-ylmeth- oxy)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; N-(2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-t- etrahydroquinolin-5-yl]oxy}ethyl)methanesulfonamide; 2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}-N-methylacetamide; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(oxetan-3-yloxy)-1,2- ,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(cyclopentylmethoxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl- -1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-[2-(dimethylamino)ethoxy]-2-m- ethyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-propoxy-1,2,3,4-tetr- ahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(propan-2-yloxy)-1,2- ,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-cyclobutoxy-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-- tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(cyclopropylmethoxy)-2-methyl- -1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 2-{([(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tet- rahydroquinolin-5-yl]oxy}acetamide; 1-[(2S)-5-(cyclobutylmethoxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-- 1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(benzyloxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-- tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(2-methylpropoxy)-1,- 2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[(3-methyloxetan-3-y- l)methoxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(cyclopentyloxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2- ,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}acetonitrile; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(2-methoxyethoxy)-2-methyl-1,- 2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(pyridin-3-ylmethoxy- )-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(oxan-4-ylmethoxy)-1- ,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}-N,N-dimethylacetamide; 1-[(2S)-5-(cyclohexylmethoxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-- 1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(pyridin-2-ylmethoxy- )-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-methoxy-2-methyl-1,2,3,4-tetr- ahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[(1-methyl-1H-pyrazo- l-3-yl)methoxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(1,3-thiazol-5-ylmet- hoxy)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-5-propoxy- -1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-propo- xy-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-cyclobutoxy-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-me- thyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-cyclobutoxy-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-- methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-cyclobutoxy-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-1,2- ,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-cyclobutoxy-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2- ,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-5-(oxan-4- -ylmethoxy)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-(oxan- -4-ylmethoxy)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-(oxan-4-ylmetho- xy)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-5-(oxan-4-ylmethoxy)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-- yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl- -1,2,3,4-tetrahydroquinolin-5-yl]oxy}-N,N-dimethylacetamide; 2-{[(2S)-1-acetyl-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-meth- yl-1,2,3,4-tetrahydroquinolin-5-yl]oxy}-N,N-dimethylacetamide; 2-{[(2S)-1-acetyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4- -tetrahydroquinolin-5-yl]oxy}-N,N-dimethylacetamide; 1-[(2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-5-(2-meth- ylpropoxy)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-(2-me- thylpropoxy)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-(2-methylpropox- y)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-5-(2-methylpropoxy)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(cyclopentylmethoxy)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4- -yl]-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(cyclopentylmethoxy)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol- -4-yl]-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(cyclopentylmethoxy)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-m- ethyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(cyclopentylmethoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-- 4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl- -1,2,3,4-tetrahydroquinolin-5-yl]oxy}-1-(pyrrolidin-1-yl)ethan-1-one; 2-{[(2S)-1-acetyl-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-meth- yl-1,2,3,4-tetrahydroquinolin-5-yl]oxy}-1-(pyrrolidin-1-yl)ethan-1-one; 2-{[(2S)-1-acetyl-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4- -tetrahydroquinolin-5-yl]oxy}-1-(pyrrolidin-1-yl)ethan-1-one; 2-{[(2S)-1-acetyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4- -tetrahydroquinolin-5-yl]oxy}-1-(pyrrolidin-1-yl)ethan-1-one; (5R)-5-(([(2S)-1-acetyl-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-- methyl-1,2,3,4-tetrahydroquinolin-5-yl]oxy methyl)pyrrolidin-2-one; (5R)-5-({[(2S)-1-acetyl-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-- 2-methyl-1,2,3,4-tetrahydroquinolin-5-yl]oxy}methyl)pyrrolidin-2-one; (5R)-5-({[(2S)-1-acetyl-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-1- ,2,3,4-tetrahydroquinolin-5-yl]oxy}methyl)pyrrolidin-2-one; (5R)-5-({[(2S)-1-acetyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1- ,2,3,4-tetrahydroquinolin-5-yl]oxy}methyl)pyrrolidin-2-one; N-(2-{[(2S)-1-acetyl-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-met- hyl-1,2,3,4-tetrahydroquinolin-5-yl]oxy}ethyl)-N-methylmethanesulfonamide; N-(2-{[(2S)-1-acetyl-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-m- ethyl-1,2,3,4-tetrahydroquinolin-5-yl]oxy}ethyl)-N-methylmethanesulfonamid- e; N-(2-{[(2S)-1-acetyl-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-1,- 2,3,4-tetrahydroquinolin-5-yl]oxy}ethyl)-N-methylmethanesulfonamide; N-(2-{[(2S)-1-acetyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,- 3,4-tetrahydroquinolin-5-yl]oxy}ethyl)-N-methylmethanesulfonamide; 1-[(2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-[(3S)-pyrrolidi- n-3-ylmethoxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-5-propoxy-1,- 2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-propoxy-- 1,2,3,4-tetrahydroquino line-1-carboxylate; methyl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-propoxy-1,2,3,4-te- trahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methy- l-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-met- hyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,- 4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,- 4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-5-(oxan-4-yl- methoxy)-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-(oxan-4-- ylmethoxy)-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-(oxan-4-ylmethoxy)- -1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-5-(oxan-4-ylmethoxy)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]- -1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(dimethylcarbamoyl)methoxy]-6-[1-(2-methanesulfonylethyl)-1H-pyra- zol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(dimethylcarbamoyl)methoxy]-6-[1-(2-hydroxy-2-methylpropyl)-1H-py- razol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(dimethylcarbamoyl)methoxy]-2-methyl-6-[1-(piperidin-4-yl)-1H-pyr- azol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-5-(2-methylp- ropoxy)-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-(2-methy- lpropoxy)-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-(2-methylpropoxy)-- 1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-5-(2-methylpropoxy)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-- 1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(cyclopentylmethoxy)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl- ]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(cyclopentylmethoxy)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-- yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(cyclopentylmethoxy)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-meth- yl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(cyclopentylmethoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-5-[2-oxo-2-(- pyrrolidin-1-yl)ethoxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-[2-oxo-2- -(pyrrolidin-1-yl)ethoxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-[2-oxo-2-(p- yrrolidin-1-yl)ethoxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-5-[2-oxo-2-(pyrrolidin-1-yl)ethoxy]-6-[1-(piperidin-4-yl)-1- H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-5-{[(2R)-5-o- xopyrrolidin-2-yl]methoxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-{- [(2R)-5-oxopyrrolidin-2-yl]methoxy}-1,2,3,4-tetrahydroquinoline-1-carboxyl- ate; methyl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-{[(2R)-5-oxopyrrol- idin-2-yl]methoxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-5-{[(2R)-5-oxopyrrolidin-2-yl]methoxy}-6-[1-(piperidin-4-yl- )-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-5-[2-(N-meth- ylmethanesulfonamido)ethoxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-[- 2-(N-methylmethanesulfonamido)ethoxy]-1,2,3,4-tetrahydroquinoline-1-carbox- ylate; methyl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-[2-(N-methylmethan- esulfonamido)ethoxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-5-[2-(N-methylmethanesulfonamido)ethoxy]-6-[1-(piperidin-4-- yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-5-[(3S)-pyrr- olidin-3-ylmethoxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-[(3S)-py- rrolidin-3-ylmethoxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-[(3S)-pyrrolidin-3- -ylmethoxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-[(3S)-pyrrolidin-3- -ylmethoxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[(5-methyl-1,3-oxazo- l-2-yl)methoxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(pyridin-4-ylmethoxy- )-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(1,3-benzoxazol-2-ylmethoxy)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-- 2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(4-methanesulfonylphenyl)-2-methyl-5-propoxy-1,2,3,4-tetrahydro- quinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-6-(4-methanesulfonylphenyl)-2-methyl-1,2,3,4-tetrahydro- quinolin-5-yl]oxy}-N,N-dimethylacetamide; 1-[(2S)-6-[4-(ethanesulfonyl)phenyl]-2-methyl-5-propoxy-1,2,3,4-tetrahydr- oquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-6-[4-(ethanesulfonyl)phenyl]-2-methyl-1,2,3,4-tetrahydr- oquinolin-5-yl]oxy}-N,N-dimethylacetamide; 1-[(2S)-6-{4-[2-(dimethylamino)ethoxy]phenyl}-2-methyl-5-propoxy-1,2,3,4-- tetrahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-6-{4-[2-(dimethylamino)ethoxy]phenyl}-2-methyl-1,2,3,4-- tetrahydroquinolin-5-yl]oxy}-N,N-dimethylacetamide; 1-[(2S)-2-methyl-6-[3-(morpholine-4-carbonyl)phenyl]-5-propoxy-1,2,3,4-te- trahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-2-methyl-6-[3-(morpholine-4-carbonyl)phenyl]-1,2,3,4-te- trahydroquinolin-5-yl]oxy}-N,N-dimethylacetamide; N-{3-[(2S)-1-acetyl-2-methyl-5-propoxy-1,2,3,4-tetrahydroquinolin-6-yl]ph- enyl}methanesulfonamide; 2-{[(2S)-1-acetyl-6-(3-methanesulfonamidophenyl)-2-methyl-1,2,3,4-tetrahy- droquinolin-5-yl]oxy}-N,N-dimethylacetamide; 1-[(2S)-6-(3-methanesulfonylphenyl)-2-methyl-5-propoxy-1,2,3,4-tetrahydro- quinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-6-(3-methanesulfonylphenyl)-2-methyl-1,2,3,4-tetrahydro- quinolin-5-yl]oxy}-N,N-dimethylacetamide; N-{4-[(2S)-1-acetyl-2-methyl-5-propoxy-1,2,3,4-tetrahydroquinolin-6-yl]ph- enyl}methanesulfonamide; 2-{[(2S)-1-acetyl-6-(4-methanesulfonamidophenyl)-2-methyl-1,2,3,4-tetrahy- droquinolin-5-yl]oxy}-N,N-dimethylacetamide; 1-[(2S)-2-methyl-6-[4-(morpholine-4-carbonyl)phenyl]-5-propoxy-1,2,3,4-te- trahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-2-methyl-6-[4-(morpholine-4-carbonyl)phenyl]-1,2,3,4-te- trahydroquinolin-5-yl]oxy}-N,N-dimethylacetamide; 2-{4-[(2S)-1-acetyl-2-methyl-5-propoxy-1,2,3,4-tetrahydroquinolin-6-yl]ph- enyl}-1.lamda..sup.6,2-thiazolidine-1,1-dione; 2-{[(2S)-1-acetyl-6-[4-(1,1-dioxo-1.lamda..sup.6,2-thiazolidin-2-yl)pheny- l]-2-methyl-1,2,3,4-tetrahydroquinolin-5-yl]oxy}-N,N-dimethylacetamide; 1-[(2S)-6-(1-methanesulfonyl-2,3-dihydro-1H-indol-5-yl)-2-methyl-5-propox- y-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-6-(1-methanesulfonyl-2,3-dihydro-1H-indol-5-yl)-2-methy- l-1,2,3,4-tetrahydroquinolin-5-yl]oxy}-N,N-dimethylacetamide; N-{4-[(2S)-1-acetyl-2-methyl-5-propoxy-1,2,3,4-tetrahydroquinolin-6-yl]ph- enyl}-N-methylmethanesulfonamide; 2-{[(2S)-1-acetyl-2-methyl-6-[4-(N-methylmethanesulfonamido)phenyl]-1,2,3- ,4-tetrahydroquinolin-5-yl]oxy}-N,N-dimethylacetamide; 1-[(2S)-6-(1-benzofuran-2-yl)-2-methyl-5-propoxy-1,2,3,4-tetrahydroquinol- in-1-yl]ethan-1-one; 1-[(2S)-6-(1H-indol-2-yl)-2-methyl-5-propoxy-1,2,3,4-tetrahydroquinolin-1- -yl]ethan-1-one; methyl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-cyclobutoxy-2-methyl-1,2,3,4- -tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-2-methyl-5-propoxy-1,2,3,4-tet- rahydroquinoline-1-carboxylate; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-[1-(oxan-4-yl)-1H-py- razol-4-yl]-1,2,3,4-tetrahydroquinoline; 3-{4-[(2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahyd- roquinolin-6-yl]-1H-pyrazol-1-yl}-1.lamda..sup.6-thiane-1,1-dione; 3-{4-[(2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahyd- roquinolin-6-yl]-1H-pyrazol-1-yl}-1.lamda..sup.6-thietane-1,1-dione; 1-[(2S)-5-[(5-fluoropyrimidin-2-yl)oxy]-2-methyl-6-[1-(piperidin-4-yl)-1H- -pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[5-(trifluorom- ethyl)pyridin-2-yl]oxy}-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-(pyrimidin-2-yl- oxy)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[4-(trifluorom- ethyl)pyrimidin-2-yl]oxy}-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[2-(trifluorom- ethyl)pyrimidin-4-yl]oxy}-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-5-{[6-(morpholin-4-yl)pyrimidin-4-yl]oxy}-6-[1-(piperidi- n-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-[(6-cyclopropylpyrimidin-4-yl)oxy]-2-methyl-6-[1-(piperidin-4-y- l)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-[(5-cyclopropylpyrimidin-2-yl)oxy]-2-methyl-6-[1-(piperidin-4-y- l)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[5-(trifluorom- ethyl)pyrimidin-2-yl]oxy}-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 2-1{[(2S)-1-acetyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,- 4-tetrahydroquinolin-5-yl]oxy}pyridine-3-carboxamide; 1-[(2S)-5-{[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]oxy}-2-methyl-6-[1-(- piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-o- ne; methyl 6-{[(2S)-1-acetyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinolin-5-yl]oxy}pyridine-3-carboxylate; 6-{[(2S)-1-acetyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4- -tetrahydroquinolin-5-yl]oxy}pyridine-3-carboxamide; methyl (2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[5-(trifluorometh- yl)pyridin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-(pyrimidin-2-yloxy- )-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-(pyrazin-2-yloxy)-- 1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[3-(trifluorometh- yl)pyridin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[4-(trifluorometh- yl)pyrimidin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[2-(trifluorometh- yl)pyrimidin-4-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-5-{[6-(morpholin-4-yl)pyrimidin-4-yl]oxy}-6-[1-(piperidin-4- -yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(6-cyclopropylpyrimidin-4-yl)oxy]-2-methyl-6-[1-(piperidin-4-yl)-- 1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(5-cyclopropylpyrimidin-2-yl)oxy]-2-methyl-6-[1-(piperidin-4-yl)-- 1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(5-fluoropyrimidin-2-yl)oxy]-2-methyl-6-[1-(piperidin-4-yl)-1H-py- razol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-{[5-(trifluorometh- yl)pyrimidin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-5-[(5-methylpyrimidin-2-yl)oxy]-6-[1-(piperidin-4-yl)-1H-py- razol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-{[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]oxy}-2-methyl-6-[1-(pip- eridin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-{[5-(methoxycarbonyl)pyridin-2-yl]oxy}-2-methyl-6-[1-(piper- idin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(5-carbamoylpyridin-2-yl)oxy]-2-methyl-6-[1-(piperidin-4-y- l)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-5-{[3-(trifluoromethyl)pyridin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline; 2-{[(2S)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol- -4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oxy}pyridine-3-carbonitrile; (2S)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-5-{[5-(trifluoromethyl)pyridin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline; 1-[(2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-([5-(trifluorom- ethyl)pyrimidin-2-yl]oxy}-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-[(5-fluoropyrimidin-2-yl)oxy]-6-[1-(2-hydroxyethyl)-1H-pyrazol-- 4-yl]-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-[(4,6-dimethylpyrimidin-2-yl)oxy]-6-[1-(2-hydroxyethyl)-1H-pyra- zol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-{[5-(propan-2-y- l)pyrimidin-2-yl]oxy}-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-5-[(5-methoxypyrimidin-2-y- l)oxy]-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-[(5-cyclopropylpyrimidin-2-yl)oxy]-6-[1-(2-hydroxyethyl)-1H-pyr- azol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-[(5-fluoropyrimidin-2-yl)oxy]-6-(1-methanesulfonyl-2,3-dihydro-- 1H-indol-5-yl)-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-[(5-fluoropyrimidin-2-yl)oxy]-6-(4-methanesulfonylphenyl)-2-met- hyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-[(5-fluoropyrimidin-2-yl)oxy]-6-[1-(2-methanesulfonylethyl)-1H-- pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-[(5-fluoropyrimidin-2-yl)oxy]-6-[1-(2-hydroxy-2-methylpropyl)-1- H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-[(5-fluoropyrimidin-2-yl)oxy]-6-[1-(1-hydroxy-2-methylpropan-2-- yl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 2-{4-[(2S)-1-acetyl-5-[(5-fluoropyrimidin-2-yl)oxy]-2-methyl-1,2,3,4-tetr- ahydroquinolin-6-yl]phenyl}-1.lamda..sup.6,2-thiazolidine-1,1-dione; methyl (2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-5-([5- -(trifluoromethyl)pyridin-2-yl]oxy)-1,2,3,4-tetrahydroquinoline-1-carboxyl- ate; methyl (2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-{[5-(tri- fluoromethyl)pyridin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-{[5-(triflu- oromethyl)pyridin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-{[5-(trifluorome- thyl)pyridin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-5-(pyrazin-2- -yloxy)-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-(pyrazin- -2-yloxy)-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-(pyrazin-2-yloxy)-- 1,2,3,4-tetrahydroquino line-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(pyrazin-2-yloxy)-1,2,3- ,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-5-{[3-(trifl- uoromethyl)pyridin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-{- [3-(trifluoromethyl)pyridin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carbox- ylate; methyl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-{[3-(trifluorometh- yl)pyridin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-{[3-(trifluoromethyl)py- ridin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(3-cyanopyridin-2-yl)oxy]-6-[1-(2-methanesulfonylethyl)-1H-pyrazo- l-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(3-cyanopyridin-2-yl)oxy]-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyra- zol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(3-cyanopyridin-2-yl)oxy]-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-- 2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(3-cyanopyridin-2-yl)oxy]-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-met- hyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(5-cyclopropylpyrimidin-2-yl)oxy]-6-[1-(2-methanesulfonylethyl)-1- H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(5-cyclopropylpyrimidin-2-yl)oxy]-6-[1-(2-hydroxy-2-methylpropyl)- -1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(5-cyclopropylpyrimidin-2-yl)oxy]-6-[1-(2-hydroxyethyl)-1H- -pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-[(5-cyclopropylpyrimidin-2-yl)ox- y]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(5-fluoropyrimidin-2-yl)oxy]-6-[1-(2-methanesulfonylethyl)-1H-pyr- azol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(5-fluoropyrimidin-2-yl)oxy]-6-[1-(2-hydroxy-2-methylpropyl)-1H-p- yrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(5-fluoropyrimidin-2-yl)oxy]-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-y- l]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-[(5-fluoropyrimidin-2-yl)oxy]-2-- methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-5-{[5-(trifl- uoromethyl)pyrimidin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-{- [5-(trifluoromethyl)pyrimidin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carb- oxylate; methyl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-{[5-(trifluorometh- yl)pyrimidin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-{[5-(trifluoromethyl)py- rimidin-2-yl]oxy}-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-methanesulfonylethyl)-1H-pyrazol-4-yl]-2-methyl-5-[(5-methyl- pyrimidin-2-yl)oxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-[(5-meth- ylpyrimidin-2-yl)oxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-2-methyl-5-[(5-methylpyrimidi- n-2-yl)oxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[(5-methylpyrimidin-2-y- l)oxy]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(3-carbamoylpyridin-2-yl)oxy]-6-[1-(2-methanesulfonylethyl)-1H-py- razol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-[(3-carbamoylpyridin-2-yl)oxy]-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2- -methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-{[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]oxy}-6-[1-(2-methanesul- fonylethyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carbox- ylate; methyl (2S)-5-{[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]oxy}-6-[1-(2-hydroxy-2-- methylpropyl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carb- oxylate; methyl (2S)-5-{[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]oxy}-6-[1-(2-hydroxyeth- yl)-1H-pyrazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-{[3-fluoro-5-(trifluorome- thyl)pyridin-2-yl]oxy}-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-fluorophenoxy)-2-methyl-6-[1-(oxan-4-yl)-1H-pyrazol-4-yl- ]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-5-(4-fluorophenoxy)-2-methyl-1- ,2,3,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-phenoxy-1,2,3,4-tetr- ahydroquinolin-1-yl]ethan-1-one; 4-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}-N,N-dimethylbenzamide; methyl (2S)-5-(3-cyanophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1- ,2,3,4-tetrahydroquinoline-1-carboxylate; 1-[6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-phenoxy-1,2,3,4-tetrahydr- oquinolin-1-yl]ethan-1-one; 1-cyclopropanecarbonyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-pheno- xy-1,2,3,4-tetrahydroquinoline; methyl 6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-phenoxy-1,2,3,4-tetrahydroqu- inoline-1-carboxylate; 1-[(2S)-2-methyl-6-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-5-[(3R)-pyrrolidin-3- -ylmethoxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-6-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]-5-[(3S)-pyrrolidin-3- -ylmethoxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[(3R)-pyrrolidin-3-y- lmethoxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[(3S)-pyrrolidin-3-y- lmethoxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-methyl-5-[(3S)- -pyrrolidin-3-ylmethoxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-5-propoxy-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-2-methyl-1,2,3,4-tetrahydroquinolin-5-yl]oxy}-N,N-dimet- hylacetamide; 1-[(2S)-5-(cyclopentylmethoxy)-2-methyl-1,2,3,4-tetrahydroquinolin-1-yl]e- than-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-({1-[(1E)-prop-1-en-- 1-yl]-1H-1,3-benzodiazol-2-yl}oxy)-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1- -one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-({1-[(1Z)-prop-- 1-en-1-yl]-1H-1,3-benzodiazol-2-yl}oxy)-1,2,3,4-tetrahydroquinolin-1-yl]et- han-1-one; methyl (2S)-5-cyclobutoxy-2-methyl-6-[1-methyl-2-(piperazin-1-yl)-1H-imidazol-4-- yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-2-methyl-6-[2-(piperazin-1-yl)-1,3-thiazol-4-yl]-1,2,3- ,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-[2-(3-hydroxyazetidin-1-yl)-1,3-thiazol-4-yl]-2-meth- yl-1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-(1,2-oxazol-4-yl)-1,- 2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-6-(1,2-oxazol-4-yl)-5-phenoxy-1,2,3,- 4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-8-fluoro-2-methyl-6-[1-(piperid- in-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-6-(1-cyclopropyl-1H-pyrazol-4-y- l)-8-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-8-fluoro-2-methyl-6-(1H-pyrazol- -4-yl)-1,2,3,4-tetrahydroquinoline; methyl (2S)-5-cyclobutoxy-8-fluoro-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-(1-cyclopropyl-1H-pyrazol-4-yl)-8-fluoro-2-methyl-1,- 2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-8-fluoro-2-methyl-6-(1H-pyrazol-4-yl)-1,2,3,4-tetrahyd- roquinoline-1-carboxylate; 1-[(2S)-5-cyclobutoxy-8-fluoro-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-- 4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-cyclobutoxy-6-(1-cyclopropyl-1H-pyrazol-4-yl)-8-fluoro-2-methyl- -1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-cyclobutoxy-8-fluoro-2-methyl-6-(1H-pyrazol-4-yl)-1,2,3,4-tetra- hydroquinolin-1-yl]ethan-1-one; (2S)-1-cyclopropanecarbonyl-8-fluoro-2-methyl-5-phenoxy-6-[1-(piperidin-4- -yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-8-fluoro-2-- methyl-5-phenoxy-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-8-fluoro-2-methyl-5-phenoxy-6-(1H-pyrazol-4-y- l)-1,2,3,4-tetrahydroquinoline; methyl (2S)-8-fluoro-2-methyl-5-phenoxy-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1- ,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-8-fluoro-2-methyl-5-phenoxy-1,2,3,- 4-tetrahydroquinoline-1-carboxylate; methyl (2S)-8-fluoro-2-methyl-5-phenoxy-6-(1H-pyrazol-4-yl)-1,2,3,4-tetrahydroqu- inoline-1-carboxylate; 1-[(2S)-8-fluoro-2-methyl-5-phenoxy-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl- ]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-8-fluoro-2-methyl-5-phenoxy-1,2- ,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-8-fluoro-2-methyl-5-phenoxy-6-(1H-pyrazol-4-yl)-1,2,3,4-tetrahydr- oquinolin-1-yl]ethan-1-one; 1-[(2S)-5-cyclobutoxy-7,8-difluoro-2-methyl-6-[1-(piperidin-4-yl)-1H-pyra- zol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-cyclobutoxy-6-(1-cyclopropyl-1H-pyrazol-4-yl)-7,8-difluoro-2-me- thyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-(1H-pyrazol-1-yl)-1,- 2,3,4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-(2H-1,2,3-triazol-2-- yl)-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-(1H-pyrazol-1-yl)-1,2,3,- 4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-(2H-1,2,3-triazol-2-yl)-- 1,2,3,4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-- 1H-pyrazol-3-yl]-1,2,3,4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-- 1H-pyrazol-5-yl]-1,2,3,4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-[2-(piperidin-4-yl)-- 2H-1,2,3-triazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-- 1H-1,2,3-triazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-[5-(piperidin-4-yl)-- 1H-imidazol-2-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-[1-(piperidin-4-yl)-1H-p- yrazol-3-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-[1-(piperidin-4-yl)-1H-p- yrazol-5-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-[2-(piperidin-4-yl)-2H-1- ,2,3-triazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-[1-(piperidin-4-yl)-1H-1- ,2,3-triazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-[5-(piperidin-4-yl)-1H-i- midazol-2-yl]-1,2,3,4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-8-fluoro-2-methyl-6-(1-methyl-1- H-1,2,3-triazol-4-yl)-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-8-fluoro-2-methyl-6-(1-methyl-1H-1,2,3-triazo- l-4-yl)-5-phenoxy-1,2,3,4-tetrahydroquinoline; methyl (2S)-5-cyclobutoxy-8-fluoro-2-methyl-6-(1-methyl-1H-1,2,3-triazol-4-yl)-1- ,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-8-fluoro-2-methyl-6-(1-methyl-1H-1,2,3-triazol-4-yl)-5-phenoxy-1,2,3- ,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-5-cyclobutoxy-8-fluoro-2-methyl-6-(1-methyl-1H-1,2,3-triazol-4-yl- )-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-8-fluoro-2-methyl-6-(1-methyl-1H-1,2,3-triazol-4-yl)-5-phenoxy-1,- 2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; (2S)-1-cyclopropanecarbonyl-2-methyl-5-[(6-methylpyridin-2-yl)oxy]-6-[1-(- piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-[(2,6-dimethylpyridin-3-yl)oxy]-2-methyl-6-- [1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-[(2,6-dimethylpyridin-4-yl)oxy]-2-methyl-6-- [1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-5-[(6-chloropyridin-2-yl)oxy]-1-cyclopropanecarbonyl-2-methyl-6-[1-(- piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-5-(pyridin-2-yloxy)-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-[(6-fluoropyridin-2-yl)oxy]-2-methyl-6-[1-(- piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; methyl (2S)-2-methyl-5-[(6-methylpyridin-2-yl)oxy]-6-[1-(piperidin-4-yl)-1H-pyra- zol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2 S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-(pyridin-2-yloxy)-1,- 2,3,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-2-methyl-5-[(6-methylpyridin-2-yl)oxy]-6-[1-(piperidin-4-yl)-1H-p- yrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; (2S)-1-cyclopropanecarbonyl-2-methyl-6-[4-(morpholin-4-yl)-1H-pyrazol-1-y- l]-5-phenoxy-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-[4-(piperazin-1-yl)-1H-p- yrazol-1-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-[4-(piperidin-4-yl)-1H-p- yrazol-1-yl]-1,2,3,4-tetrahydroquinoline; methyl (2S)-2-methyl-6-[4-(morpholin-4-yl)-1H-pyrazol-1-yl]-5-phenoxy-1,2,3,4-te- trahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-5-phenoxy-6-[4-(piperazin-1-yl)-1H-pyrazol-1-yl]-1,2,3,4-te- trahydroquinoline-1-carboxylate; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-1,2,3,4-tetrahydroquinolin- e-6-carbonitrile; (2S)-1-cyclopropanecarbonyl-6-ethynyl-2-methyl-5-phenoxy-1,2,3,4-tetrahyd- roquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-(prop-1-yn-1-yl)-1,2,3,4- -tetrahydroquinoline; methyl (2S)-6-cyano-2-methyl-5-phenoxy-1,2,3,4-tetrahydroquinoline-1-carboxylate- ; methyl (2S)-6-ethynyl-2-methyl-5-phenoxy-1,2,3,4-tetrahydroquinoline-1-c- arboxylate; methyl (2S)-6-[2-(azetidin-3-yl)-1,3-thiazol-4-yl]-5-cyclobutoxy-2-methyl-1,2,3,- 4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-[2-(3-fluoroazetidin-3-yl)-1 3-thiazol-4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-[2-(3-hydroxyazetidin-3-yl)-1,3-thiazol-4-yl]- -2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-[2-(3-methoxyazetidin-3-yl)-1,3-thiazol-4-yl]-2-meth- yl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-6-(2-carbamoyl-1,3-thiazol-4-yl)-5-cyclobutoxy-2-methyl-1,2,3,4-tetr- ahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-2-methyl-6-[2-(methylcarbamoyl)-1,3-thiazol-4-yl]-1,2,- 3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-(2-acetamido-1,3-thiazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinoline-1-carboxylate; (2S)-1-cyclopropanecarbonyl-6-cyclopropyl-2-methyl-5-phenoxy-1,2,3,4-tetr- ahydroquinoline; methyl (2S)-6-cyclopropyl-2-methyl-5-phenoxy-1,2,3,4-tetrahydroquinoline-1-carbo- xylate; (2S)-1-cyclopropanecarbonyl-8-fluoro-5-(3-methoxyphenoxy)-2-methyl- -6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; methyl (2S)-2-methyl-6-(1-methyl-1H-1,2,3-triazol-4-yl)-5-phenoxy-1,2,3,4- -tetrahydroquinoline-1-carboxylate; 1-[(2S)-2-methyl-6-(1-methyl-1H-1,2,3-triazol-4-yl)-5-phenoxy-1,2,3,4-tet- rahydroquinolin-1-yl]ethan-1-one; (2S)-1-cyclopropanecarbonyl-5-(3-methoxyphenoxy)-2-methyl-6-(1-methyl-1H-- 1,2,3-triazol-4-yl)-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-(2,5-difluorophenoxy)-2-methyl-6-(1-methyl-- 1H-1,2,3-triazol-4-yl)-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-(3,4-difluorophenoxy)-2-methyl-6-(1-methyl-- 1H-1,2,3-triazol-4-yl)-1,2,3,4-tetrahydroquinoline; 2-{[(2S)-1-cyclopropanecarbonyl-2-methyl-6-(1-methyl-1H-1,2,3-triazol-4-y- l)-1,2,3,4-tetrahydroquinolin-5-yl]oxy}benzonitrile; (2S)-1-cyclopropanecarbonyl-5-(3-fluorophenoxy)-2-methyl-6-(1-methyl-1H-1- ,2,3-triazol-4-yl)-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-(2-fluorophenoxy)-2-methyl-6-(1-methyl-1H-1- ,2,3-triazol-4-yl)-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-(4-fluorophenoxy)-2-methyl-6-(1-methyl-1H-1- ,2,3-triazol-4-yl)-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-[(6-methoxypyridin-2-yl)oxy]-2-methyl-6-[1-- (piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; methyl (2S)-5-[(6-methoxypyridin-2-yl)oxy]-2-methyl-6-[1-(piperidin-4-yl)-1H-pyr- azol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-5-[(6-methoxypyridin-2-yl)oxy]-2-methyl-6-[1-(piperidin-4-yl)-1H-- pyrazol-4-yl]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-5-cyclobutoxy-6-[1-(1,1-dioxo-1.lamda..sup.6-thian-4-yl)-1H-pyrazol-- 4-yl]-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; 4-{4-[(2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-1,2,3,4-tetrahyd- roquinolin-6-yl]-1H-pyrazol-1-yl}-1.lamda..sup.6-thiane-1,1-dione; 1-[(2S)-6-(1-acetylpiperidin-4-yl)-2-methyl-5-propoxy-1)-2-methyl-5-propo- xy-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-6-(1-methanesulfonylpiperidin-4-yl)-2-methyl-5-propoxy-1,2,3,4-te- trahydroquinolin-1-yl]ethan-1-one; tert-butyl 4-[(2S)-1-acetyl-2-methyl-5-propoxy-1,2,3,4-tetrahydroquinolin-6-yl]-1,2,- 3,6-tetrahydropyridine-1-carboxylate; 1-[(2S)-2-methyl-6-(piperidin-4-yl)-5-propoxy-1,2,3,4-tetrahydroquinolin-- 1-yl]ethan-1-one; 4-[(2S)-1-acetyl-2-methyl-5-propoxy-1,2,3,4-tetrahydroquinolin-6-yl]-N-et- hylpiperidine-1-carboxamide; methyl 4-[(2S)-1-acetyl-2-methyl-5-propoxy-1,2,3,4-tetrahydroquinolin-6-yl]piper- idine-1-carboxylate; 1-[(2S)-6-(1-ethylpiperidin-4-yl)-2-methyl-5-propoxy-1,2,3,4-tetrahydroqu- inolin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-5-(phenylamino)-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1- ,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-5-cyclobutoxy-6-{-[(3S,4R)-3-fluoropiperidin-4-yl]-1H-pyrazol-4-yl}-- 2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-{1-[(3R,4S)-3-fluoropiperidin-4-yl]-1H-pyrazol-4-yl}- -2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-{1-[(3S,4S)-3-fluoropiperidin-4-yl]-1H-pyrazol-4-yl}- -2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-fluorophenoxy)-6-{1-[(3S,4S)-3-fluoropiperidin-4-yl]-1H-pyrazol- -4-yl}-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-fluorophenoxy)-6-{1-[(3S,4R)-3-fluoropiperidin-4-yl}-1H-pyrazol- -4-yl)-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-fluorophenoxy)-6-{1-[(3R,4S)-3-fluoropiperidin-4-yl]-1H-pyrazol- -4-yl}-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-{1-[(3R,4R)-3-fluoropiperidin-4-yl]-1H-pyrazol-4-yl}- -2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(4-fluorophenoxy)-6-{1-[(3R,4R)-3-fluoropiperidin-4-yl]-1H-pyrazol- -4-yl)}-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-2-methyl-6-[1-(2-methylpiperidin-4-yl)-1H-pyrazol-4-yl- ]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-2-methyl-6-[1-(2-methylpiperidin-4-yl)-1H-pyrazol-4-yl- ]-1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-6-{1-[(3S,4R)-3-fluoropiperidin- -4-yl]-1H-pyrazol-4-yl}-2-methyl-1,2,3,4-tetrahydroquinoline; methyl (2S)-5-cyclobutoxy-6-[5-fluoro-1-(piperidin-4-yl)-1H-pyrazol-4-yl]-2-meth- yl-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-{1-[(3R*,4S*)-4-fluoropyrrolidin-3-yl]-1H-pyrazol-4-- yl}-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; and (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-6-{1-[(3R*,4S*)-4-fluoropiperid- in-3-yl]-1H-pyrazol-4-yl}-2-methyl-1,2,3,4-tetrahydroquinoline. 16. The compound of claim 15 selected from the group consisting: methyl (2S)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-5-propoxy-1,2,3,4-te- trahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,- 4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(2-fluoro-2-methylpropoxy)-2-- methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 2-{[(2S)-1-acetyl-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-1,2,3,4-tetr- ahydroquinolin-5-yl]oxy}benzonitrile; 2-{[(2S)-1-acetyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4- -tetrahydroquinolin-5-yl]oxy}benzonitrile; 1-[(2S)-5-(4-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(4-chlorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-(2-chlorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-2-methyl-5-phenoxy-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4- -tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-5-(4-methoxyphenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]- -1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-2-methyl-5-phenoxy-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-te- trahydroquinoline-1-carboxylate; methyl (2S)-5-(2-methoxyphenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]- -1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(3-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-- 1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(3-chlorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-- 1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(3-cyanophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1- ,2,3,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-5-(2-fluorophenoxy)-2-methyl-1,- 2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-5-(4-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-- 1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-- 1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-(4-fluorophenoxy)-2-methyl-6-[1-(piperidin-- 4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; 1-[(2S)-5-(2-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; 1-[(2S)-5-[(5-chloropyridin-2-yl)oxy]-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2- -methyl-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; methyl (2S)-5-(2-cyano-3-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazo- l-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-(3-chloro-4-fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyraz- ol-4-yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-2-methyl-6-[1-(oxan-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tet- rahydroquinoline-1-carboxylate; methyl (2S)-5-cyclobutoxy-6-{1-[(3S,4R)-3-fluoropiperidin-4-yl]-1H-pyrazol-4-yl)- -2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[(6-methylpyridin-2-- yl)oxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one; (2S)-5-(4-chlorophenoxy)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-- 4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; 4-{[(2S)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol- -4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oxy}benzonitrile; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-[1-(piperidin-4-yl)-1H-p- yrazol-4-yl]-1,2,3,4-tetrahydroquinoline; 2-{[(2S)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol- -4-yl]-1,2,3,4-tetrahydroquinolin-5-yl]oxy}benzonitrile; methyl (2S)-6-[1-(1,1-dioxo-11.sup.6-thietan-3-yl)-1H-pyrazol-4-yl]-5-(4-fluorop- henoxy)-2-methyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-5-(3-chloro-4-fluorophenoxy)-1-cyclopropanecarbonyl-2-methyl-6-[1-(p- iperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-6-[1-(azetidin-3-yl)-1H-pyrazol-4-yl]-1-cyclopropanecarbonyl-5-(4-fl- uorophenoxy)-2-methyl-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-(2-fluorophenoxy)-2-methyl-6-[1-(piperidin-- 4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-5-(2-chlorophenoxy)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-- 4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-(3-fluorophenoxy)-2-methyl-6-[1-(piperidin-- 4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-(3,4-difluorophenoxy)-2-methyl-6-[1-(piperi- din-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; methyl (2S)-5-(3,4-difluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-- yl]-1,2,3,4-tetrahydroquino line-1-carboxylate; (2S)-1-cyclopropanecarbonyl-5-(2,4-difluorophenoxy)-2-methyl-6-[1-(piperi- din-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-6-(1-methyl-1H-1,2,3-triazol-4-yl)-5- -phenoxy-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-5-phenoxy-6-(1H-pyrazol-4-yl)-1,2,3,- 4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-2-methyl-6-(1-methyl-1H-imidazol-4-yl)-5-phen- oxy-1,2,3,4-tetrahydroquinoline; (2S)-5-(3-chlorophenoxy)-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-- 4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-(2,5-difluorophenoxy)-2-methyl-6-[1-(piperi- din-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; methyl (2S)-5-(3,5-difluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-- yl]-1,2,3,4-tetrahydroquinoline-1-carboxylate; (2S)-1-cyclopropanecarbonyl-5-(3,5-di fluorophenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1,2,3,4-te- trahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-(3-methoxyphenoxy)-2-methyl-6-[1-(piperidin- -4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-6-{1-[(3S,4R)-3-fluoropiperidin- -4-yl]-1H-pyrazol-4-yl}-2-methyl-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-5-(2-methoxyphenoxy)-2-methyl-6-[1-(piperidin- -4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; methyl (2S)-5-(3-methoxyphenoxy)-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]- -1,2,3,4-tetrahydroquinoline-1-carboxylate; 3-{4-[(2S)-1-cyclopropanecarbonyl-5-(4-fluorophenoxy)-2-methyl-1,2,3,4-te- trahydroquinolin-6-yl]-1H-pyrazol-1-yl}-11.sup.6-thietane-1,1-dione; 3-{4-[(2S)-1-cyclopropanecarbonyl-5-(4-fluorophenoxy)-2-methyl-1,2,3,4-te- trahydroquinolin-6-yl]-1H-pyrazol-1-yl}-11.sup.6-thiane-1,1-dione; (2S)-1-cyclopropanecarbonyl-5-(4-methoxyphenoxy)-2-methyl-6-[1-(piperidin- -4-yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; (2S)-1-cyclopropanecarbonyl-8-fluoro-2-methyl-5-phenoxy-6-[1-(piperidin-4- -yl)-1H-pyrazol-4-yl]-1,2,3,4-tetrahydroquinoline; methyl (2S)-5-cyclobutoxy-8-fluoro-2-methyl-6-[1-(piperidin-4-yl)-1H-pyrazol-4-y- l]-1,2,3,4-tetrahydroquinoline-1-carboxylate; methyl (2S)-8-fluoro-2-methyl-5-phenoxy-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1- ,2,3,4-tetrahydroquinoline-1-carboxylate; and 1-[(2S)-8-fluoro-2-methyl-5-phenoxy-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl- ]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one. 17. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier. 18. The pharmaceutical composition of claim 17, further comprising therapeutically effective amounts of one or more additional therapeutic agents. 19. The pharmaceutical composition of claim 18, wherein said additional therapeutic agents are selected from the group consisting of cytotoxic agent, cisplatin, doxorubicin, etoposide, irinotecan, topotecan, paclitaxel, docetaxel, the epothilones, tamoxifen, 5-fluorouracil, methotrexate, temozolomide, cyclophosphamide, Lonafarib, tipifarnib, 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)m- ethyl)benzonitrile hydrochloride, (R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiophen-2-ylsulfonyl)-2,3,4- ,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile, cetuximab, imatinib , interferon alfa-2b, Peg-Intron.RTM., Pegylated interferon alfa-2b, aromatase combinations, gemcitabine, uracil mustard, chlormethine, ifosfamide, melphalan, chlorambucil, pipobroman, triethylenemelamine, triethylenethiophosphoramine, busulfan, carmustine, lomustine, streptozocin, dacarbazine, floxuridine, cytarabine, 6-mercaptopurine, 6-thioguanine, fludarabine phosphate, leucovorin, oxaliplatin, pentostatine, vinblastine, vincristine, vindesine, bleomycin, dactinomycin, daunorubicin, epirubicin, idarubicin, mithramycin, deoxycoformycin, mitomycin-C, L-asparaginase, teniposide 17a-ethinyl estradiol, diethylstilbestrol, testosterone, prednisone, fluoxymesterone, dromostanolone propionate, testolactone, megestrol acetate, methylprednisolone, methyltestosterone, prednisolone, triamcinolone, chlorotrianisene, 17.alpha.hydroxyprogesterone, aminoglutethimide, estramustine, medroxyprogesteroneacetate, leuprolide, flutamide, toremifene citrate, goserelin acetate, carboplatin, hydroxyurea, amsacrine, procarbazine, mitotane, mitoxantrone, levamisole, vinorelbine, anastrazole, letrazole, capecitabine, raloxafene, droloxafine, hexamethylmelamine, bevacizumab, trastuzumab, tositumomab, bortezomib, britumomab tiuxetan, arsenic trioxide, porfimer sodium, cetuximab, thioTEPA, altretamine, melphalan, fulvestrant, exemestane, rituximab, alemtuzumab, dexamethasone, bicalutamide, chlorambucil, and valrubicin. 20. A method of inhibiting one or more of BET-family bromodomains in a patient comprising administering to the patient in need thereof an effective amount of the compound of claim 1. 21. A method of inhibiting one or more of BET-family bromodomains in a patient comprising administering to the patient in need thereof an effective amount of the pharmaceutical composition of claim 17. 22. A method of treating or inhibiting a cancer associated with the activity of one or more BET-family bromodomains in a patient comprising administering to said patient in need thereof a therapeutically effective amount of the compound of claim 1, wherein the cancer is selected from the group consisting of lung cancer, cervix cancer, colon cancer, breast cancer, stomach cancers, hematologic cancers, leukemia, lymphoma, multiple myeloma, midline carcinomas, mesenchymal tumors, hepatic tumors, renal tumors, and neurological tumors, melanomas, actinic keratosis, squamous cell carcinoma, and cutaneous T-cell lymphoma. 23. A method of treating, inhibiting, or eliminating an inflammatory disorder associated with the activity of one or more BET-family bromodomains in a patient comprising administering to said patient in need thereof a therapeutically effective amount of the compound of claim 1, wherein the inflammatory disorder is a chronic autoimmune inflammatory condition or an acute inflammatory condition selected from the group consisting of systemic lupus erythematosus, rheumatoid arthritis, atherosclerosis, psoriasis and alopecia. 24. The compound of claim 1, wherein the compound is (S)-1-(6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-(quinazolin-2-yloxy)-- 3,4-dihydroquinolin-1(2H)-yl)ethanone. 25. The compound of claim 1, wherein the compound is (2S)-5-cyclobutoxy-1-cyclopropanecarbonyl-2-methyl-6-[1-(piperidin-4-yl)-- 1Hpyrazol-4-yl]-1,2,3,4-tetrahydroquinoline. 26. The compound of claim 1, wherein the compound is (S)-methyl 5-(4-chloro-2-cyanophenoxy)-2-methyl-6-(1-(piperidin-4-yl)-1 Hpyrazol-4-yl)-3,4-dihydroquinoline-1(2H)-carboxylate. 27. The compound of claim 1, wherein the compound is (S)-1-(5-(2-fluorophenoxy)-2-methyl-6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl- )-3,4-dihydroquinolin-1(2H)-yl)ethanone. 28. The compound of claim 1, wherein the compound is 1-[(2S)-6-(1-cyclopropyl-1H-pyrazol-4-yl)-2-methyl-5-[(4-methylpyridin-2-- yl)oxy]-1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-one. 29. A pharmaceutical composition comprising the compound of claim 24 and a pharmaceutically acceptable carrier. 30. A pharmaceutical composition comprising the compound of claim 25 and a pharmaceutically acceptable carrier. 31. A pharmaceutical composition comprising the compound of claim 26 and a pharmaceutically acceptable carrier. 32. A pharmaceutical composition comprising the compound of claim 27 and a pharmaceutically acceptable carrier. 33. A pharmaceutical composition comprising the compound of claim 28 and a pharmaceutically acceptable carrier. 34. A method of treating leukemia comprising administering to a patient in need thereof a therapeutically effective amount of the compound of claim 24. 35. A method of treating leukemia comprising administering to a patient in need thereof a therapeutically effective amount of the compound of claim 25. 36. A method of treating leukemia comprising administering to a patient in need thereof a therapeutically effective amount of the compound of claim 26. 37. A method of treating leukemia comprising administering to a patient in need thereof a therapeutically effective amount of the compound of claim 27. 38. A method of treating leukemia comprising administering to a patient in need thereof a therapeutically effective amount of the compound of claim 28. 39. A method of treating lymphoma comprising administering to a patient in need thereof a therapeutically effective amount of the compound of claim 24. 40. A method of treating lymphoma comprising administering to a patient in need thereof a therapeutically effective amount of the compound of claim 25. 41. A method of treating lymphoma comprising administering to a patient in need thereof a therapeutically effective amount of the compound of claim 26. 42. A method of treating lymphoma comprising administering to a patient in need thereof a therapeutically effective amount of the compound of claim 27. 43. A method of treating lymphoma comprising administering to a patient in need thereof a therapeutically effective amount of the compound of claim 28. 44. The method of claim 23, wherein the inflammatory disorder is rheumatoid arthritis.

Details for Patent 9,388,161

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978		2033-11-18
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986		2033-11-18
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132			2033-11-18
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132			2033-11-18
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	11/26/1997		2033-11-18
Idec Pharmaceuticals Corp.	RITUXAN	rituximab	Injection	103737	02/19/2002		2033-11-18