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Last Updated: December 2, 2021

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Claims for Patent: 9,089,570

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Summary for Patent: 9,089,570
Title:Compositions for treating cancers having acquired resitance to prior chemotherapeutic and targeted drugs using carboxyamidotriazole orotate
Abstract: This invention provides methods and compositions useful for treating early and late stage metastatic cancer to prevent or treat acquired resistance due to gene amplification or mutation in response to chemotherapeutic and/or targeted drugs. In particular, the methods and compositions include carboxiamidotriazole orotate (CTO) alone or in combination with specific regimens of chemotherapeutic and/or targeted drugs designed to overcome the genomic resistance raised to prior therapy.
Inventor(s): Karmali; Rashida A (Brooklyn, NY)
Assignee: TACTICAL THERAPEUTICS INC (New York, NY)
Application Number:13/986,103
Patent Claims:1. A pharmaceutical composition of an effective amount of carboxyamidotriazole orotate that prevents or overcomes acquired resistance to chemotherapeutic drugs and targeted drugs due to by gene amplification or mutation, wherein the effective amount of the composition is in the range 50 mg/m.sup.2 to 1500 mg/m.sup.2 based on the patient's body surface.

2. The pharmaceutical composition according to claim 1, further comprising one or more chemotherapeutic drugs of choice used in a regimen designed for overcoming acquired drug resistance and treating a cancer selected from the group consisting of breast, colon, head and neck, malignant glioma, glioblastoma, lung, non-small cell lung, melanoma, testicular, gastrointestinal stromal tumor, ovarian, prostate and chronic myeloid leukemia.

3. The pharmaceutical composition according to claim 1, further comprising one or more targeted drugs of choice used in a regimen designed for overcoming acquired drag resistance and treating a cancer selected from the group consisting of breast, colon, head and neck, malignant glioma, glioblastoma, lung, non-small cell lung, melanoma, testicular, gastrointestinal stromal tumor, ovarian, prostate and chronic myeloid leukemia.

4. The pharmaceutical composition according to claim 1, further comprising a chemotherapeutic drug of choice used in a regimen designed for treating a cancer and a targeted drug of choice used in a regimen designed for overcoming acquired drug resistance and treating a cancer selected from the group consisting of breast, colon, head and neck, malignant glioma, glioblastoma, lung, non-small cell lung, melanoma, testicular, gastrointestinal stromal tumor, ovarian, prostate and chronic myeloid leukemia.

5. The pharmaceutical composition according to claim 2 wherein the chemotherapeutic is paclitaxel.

6. The pharmaceutical composition of 3 wherein the targeted is erlotinib.

7. The pharmaceutical composition according to claim 2 wherein the chemotherapeutic drug is carboplatin.

8. The pharmaceutical composition according to claim 2 wherein the chemotherapeutic drug is premetrexed.

9. The pharmaceutical composition according to claim 2 wherein the chemotherapeutic drug is docetaxel.

10. The pharmaceutical composition according to claim 2 wherein the chemotherapeutic drug is lomustine.

11. The pharmaceutical composition according to claim 2 wherein the chemotherapeutic drug is gemeitabine.

12. The pharmaceutical composition of claim 3 wherein the targeted drug is cetuximab.

13. The pharmaceutical composition of claim 3 wherein the targeted drug is panitumumab.

14. The pharmaceutical composition of claim 3 wherein the targeted drug is imatinib.

15. The pharmaceutical composition of claim 3 wherein the targeted drug is trastuzumab.

16. The pharmaceutical composition of claim 3 wherein the targeted drug is bevacizumab.

17. The pharmaceutical composition of claim 3 wherein the targeted drug is vemurafenib.

18. The pharmaceutical composition of claim 3 wherein the targeted drug is ipilimumab.

19. The pharmaceutical composition of claim 3 wherein the targeted drug is tarceva.

Details for Patent 9,089,570

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 1998-09-25 ⤷  Free Forever Trial 2039-02-26
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 2017-02-10 ⤷  Free Forever Trial 2039-02-26
Eli Lilly And Company ERBITUX cetuximab Injection 125084 2004-02-12 ⤷  Free Forever Trial 2039-02-26
Eli Lilly And Company ERBITUX cetuximab Injection 125084 2007-03-28 ⤷  Free Forever Trial 2039-02-26
Genentech, Inc. AVASTIN bevacizumab Injection 125085 2004-02-26 ⤷  Free Forever Trial 2039-02-26
Amgen, Inc. VECTIBIX panitumumab Injection 125147 2006-09-27 ⤷  Free Forever Trial 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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