Claims for Patent: 8,944,072

Summary for Patent: 8,944,072

Title:	Thermal treatment process for tobacco materials
Abstract:	A method of preparing a tobacco material for use in a smoking article is provided, including (i) mixing a tobacco material, water, and an additive selected from the group consisting of lysine, glycine, histidine, alanine, methionine, glutamic acid, aspartic acid, proline, phenylalanine, valine, arginine, di- and trivalent cations, asparaginase, saccharides, phenolic compounds, reducing agents, compounds having a free thiol group, oxidizing agents, oxidation catalysts, plant extracts, and combinations thereof; (ii) heating the mixture; and (iii) incorporating the heat-treated mixture into a smoking article as a smokable material. A smoking article in the form of a cigarette is also provided that includes a tobacco material pre-treated to inhibit reaction of asparagine to form acrylamide in mainstream smoke. Upon smoking, the smoking article is characterized by an acrylamide content of mainstream smoke that is reduced relative to an untreated control smoking article.
Inventor(s):	Chen; Gong (Winston-Salem, NC), Gerardi; Anthony Richard (Winston-Salem, NC), Mua; John-Paul (Advance, NC), Holton, Jr.; Darrell Eugene (Clemmons, NC), Cantrell; Daniel Verdin (Lewisville, NC), St. Charles; Frank Kelley (Bowling Green, KY), Moldoveanu; Serban C. (Winston-Salem, NC), Brinkley; Paul Andrew (Winston-Salem, NC)
Assignee:	R.J. Reynolds Tobacco Company (Winston-Salem, NC)
Application Number:	12/855,343
Patent Claims:	1. A method of preparing a tobacco material for use in a smoking article, comprising: (i) mixing a tobacco material, water, a buffering agent that buffers within a pH range of about 6 to about 10 and an additive capable of inhibiting reaction of asparagine to form acrylamide upon heating or burning of the tobacco material, thereby forming a moist tobacco mixture, wherein the additive is asparaginase; (ii) heating the moist tobacco mixture to form a heat-treated tobacco mixture, wherein the pH of the moist tobacco mixture during the heating step is less than about 10; and (iii) incorporating the heat-treated tobacco mixture into a smoking article as a smokable material, wherein the smoking article is in the form of a cigarette comprising a rod of smokable material circumscribed by a wrapping material and a filter attached to the rod at one end thereof, wherein the smokable material comprises the heat-treated tobacco mixture. 2. The method of claim 1, wherein the tobacco material is in the form of cut filler. 3. The method of claim 1, wherein the tobacco material is in the form of a tobacco blend. 4. The method of claim 1, wherein the additive is present in an amount of between about 100 ppm to about 10 weight percent, based on the dry weight of the tobacco mixture. 5. The method of claim 1, wherein the smoking article is a cigarette. 6. The method of claim 1, wherein the smoking article, upon smoking, is characterized by an acrylamide content of mainstream smoke that is reduced relative to an untreated control smoking article. 7. The method of claim 6, wherein the amount of acrylamide reduction by weight in mainstream smoke is at least about 10 percent as compared to an untreated control smoking article. 8. The method of claim 7, wherein the amount of acrylamide reduction in mainstream smoke is at least about 30 percent as compared to an untreated control smoking article. 9. The method of claim 8, wherein the amount of acrylamide reduction in mainstream smoke is at least about 50 percent as compared to an untreated control smoking article. 10. The method of claim 9, wherein the amount of acrylamide reduction in mainstream smoke is at least about 60 percent as compared to an untreated control smoking article. 11. The method of claim 1, wherein the heat-treated tobacco mixture comprises less than about 2000 ppb of acrylamide. 12. The method of claim 11, wherein the heat-treated tobacco mixture comprises less than about 1500 ppb of acrylamide. 13. The method of claim 12, wherein the heat-treated tobacco mixture comprises less than about 1000 ppb of acrylamide. 14. A smoking article in the form of a cigarette prepared according to the method of claim 1. 15. A smoking article in the form of a cigarette comprising a rod of smokable material circumscribed by a wrapping material and a filter attached to the rod at one end thereof, wherein the smokable material comprises a tobacco material pre-treated to inhibit reaction of asparagine to form acrylamide in mainstream smoke, wherein the pre-treatment comprises heating the tobacco material at a pH of less than about 10 in the presence of an additive, wherein the additive is asparaginase, and wherein the tobacco material comprises a buffering agent that buffers within a pH range of about 6 to about 10. 16. The smoking article of claim 15, wherein the smoking article, upon smoking, is characterized by an acrylamide content of mainstream smoke that is reduced relative to an untreated control smoking article. 17. The smoking article of claim 16, wherein the amount of acrylamide reduction by weight in mainstream smoke is at least about 10 percent as compared to an untreated control smoking article. 18. The smoking article of claim 17, wherein the amount of acrylamide reduction in mainstream smoke is at least about 30 percent as compared to an untreated control smoking article. 19. The smoking article of claim 18, wherein the amount of acrylamide reduction in mainstream smoke is at least about 50 percent as compared to an untreated control smoking article. 20. The smoking article of claim 19, wherein the amount of acrylamide reduction in mainstream smoke is at least about 60 percent as compared to an untreated control smoking article. 21. The smoking article of claim 15, wherein the buffering agent is selected from the group consisting of metal carbonates, metal bicarbonates, and mixtures thereof. 22. The smoking article of claim 15, wherein the buffering agent comprises sodium carbonate and sodium bicarbonate.

Details for Patent 8,944,072

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978		2029-06-02