Claims for Patent: 8,637,565

Summary for Patent: 8,637,565

Title:	Salinosporamides and methods for use thereof
Abstract:	The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonosporaceae, and the generic epithet Salinospora has been proposed for this obligate marine group. The reaction products produced by this strain are classified as salinosporamides, and are particularly advantageous in treating neoplastic disorders due to their low molecular weight, low IC.sub.50 values, high pharmaceutical potency, and selectivity for cancer cells over fungi.
Inventor(s):	Fenical; William (Del Mar, CA), Jensen; Paul (San Diego, CA), Mincer; Tracy (San Diego, CA), Feling; Robert H.R. (Wiesbaden, DE)
Assignee:	The Regents of the University of California (Oakland, CA)
Application Number:	13/477,364
Patent Claims:	1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of a compound having the structure: ##STR00014## wherein the pharmaceutical composition further comprises sucrose. 2. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition further comprises an additional anti-neoplastic agent. 3. The pharmaceutical composition of claim 2, wherein the additional anti-neoplastic agent is selected from an antimetabolite, an alkylating agent, a plant alkaloid, an antibiotic, a hormone and an enzyme. 4. The pharmaceutical composition of claim 3, wherein the antimetabolite is selected from methotrexate, 5-fluorouracil, 6-mercaptopurine, cytosine arabinoside, hydroxyurea and 2-chlorodeoxyadenosine. 5. The pharmaceutical composition of claim 3, wherein the alkylating agent is selected from cyclophosphamide, melphalan, busulfan, paraplatin, chlorambucil and nitrogen mustard. 6. The pharmaceutical composition of claim 3, wherein the plant alkaloid is selected from vincristine, vinblastine, taxol and etoposide. 7. The pharmaceutical composition of claim 3, wherein the antibiotic is selected from doxorubicin, daunorubicin, mitomycin c and bleomycin. 8. The pharmaceutical composition of claim 3, wherein the hormone is selected from calusterone, diomostavolone, propionate, epitiostanol, mepitiostane, testolactone, tamoxifen, polyestradiol phosphate, megesterol acetate, flutamide, nilutamide and trilotane. 9. The pharmaceutical composition of claim 3, wherein the enzyme is selected from L-asparaginase derivatives and aminoacridine derivatives. 10. The pharmaceutical composition of claim 9, wherein the aminoacridine derivative is amsacrine.

Details for Patent 8,637,565

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978		2022-06-24