You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: April 23, 2024

Claims for Patent: 8,337,811

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 8,337,811

Title:	Pharmaceutical composition of nanoparticles
Abstract:	The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
Inventor(s):	Sung; Hsing-Wen (Hsinchu, TW), Sonaje; Kiran (Hsinchu, TW), Nguyen; Ho-Ngoc (Hsinchu, TW), Chuang; Er-Yuan (Hsinchu, TW), Tu; Hosheng (Newport Beach, CA)
Assignee:	GP Medical, Inc. (Newport Beach, CA) National Tsing Hua University (Hsinchu, TW)
Application Number:	13/418,299
Patent Claims:	1. A pharmaceutical composition of nanoparticles for treatment of anemia of an animal subject, said nanoparticles consisting of a shell portion that is dominated by positively charged chitosan, a core portion that consists of said positively charged chitosan, one negatively charged substrate, at least one bioactive agent loaded within said nanoparticles, and optionally a zero-charge compound, wherein said at least one bioactive agent is an agent that stimulates red blood cell production of said subject. 2. The pharmaceutical composition according to claim 1, wherein said chitosan is N-trimethyl chitosan, EDTA-chitosan, low molecular weight chitosan, pegylated chitosan (PEG-chitosan), mono-N-carboxymethyl chitosan, N-palmitoyl chitosan (NPCS), chitosan derivatives, or combinations thereof. 3. The pharmaceutical composition according to claim 1, wherein said bioactive agent is erythropoietin or an erythropoiesis-stimulating agent. 4. The pharmaceutical composition according to claim 1, wherein said nanoparticles are freeze-dried, thereby said nanoparticles being in a powder form. 5. The pharmaceutical composition according to claim 1, wherein said nanoparticles are mixed with a cryoprotectant and then freeze-dried, thereby said nanoparticles being in a powder form. 6. The pharmaceutical composition according to claim 5, wherein said cryoprotectant is selected from the group consisting of trehalose, hexan-1,2,3,4,5,6-hexol, mannitol, dimethyl sulfoxide, ethylene glycol, glycol, 2-methyl-2,4-pentanediol, propylene, sucrose, and combinations thereof. 7. The pharmaceutical composition according to claim 1, wherein said nanoparticles are encapsulated in a capsule. 8. The pharmaceutical composition according to claim 7, wherein said capsule is made of methyl cellulose selected from the group consisting of hydroxypropyl methyl cellulose (HPMC), carboxymethyl cellulose, hydroxyethyl methyl cellulose (HEMC), and methyl cellulose derivatives. 9. The pharmaceutical composition according to claim 7, wherein said capsule is treated with an enteric coating. 10. The pharmaceutical composition according to claim 7, wherein said capsule further comprises a pharmaceutically acceptable carrier, diluent, excipient, desiccant, solubilizer, bubbling agent, or emulsifier. 11. The pharmaceutical composition according to claim 7, wherein said capsule further comprises at least one absorption enhancer. 12. The pharmaceutical composition according to claim 11, wherein said absorption enhancer is selected from the group consisting of bile salts, surfactants, medium-chain fatty acids, phosphate esters, chitosan, and chitosan derivatives. 13. The pharmaceutical composition according to claim 7, wherein said capsule is made of gelatin. 14. The pharmaceutical composition according to claim 1, wherein said nanoparticles are treated with an enteric coating. 15. The pharmaceutical composition according to claim 1, wherein said negatively charged substrate is PGA-complexone conjugate, .gamma.-PGA, .alpha.-PGA, derivatives of PGA, or salts of PGA. 16. The pharmaceutical composition according to claim 1, wherein said zero-charge compound is an absorption enhancer. 17. The pharmaceutical composition according to claim 1, wherein said bioactive agent is selected from the group consisting of Epoetin alfa (Procrit.RTM. or Epogen.RTM.), Epoetin beta (NeoRecormon.RTM.), Darbepoetin alfa (Aranesp.RTM.), and Methoxy polyethylene glycol-epoetin beta (Mircera.RTM.). 18. The pharmaceutical composition according to claim 1, wherein said bioactive agent is a peptide that lacks structural homolog of erythropoietin. 19. The pharmaceutical composition according to claim 1, wherein said bioactive agent is erythropoietin-mimetic peptide 1 (EMP-1) or peginesatide. 20. The pharmaceutical composition according to claim 1, wherein said bioactive agent is an agent for enhancing hypoxia inducible factor (HIF) stabilization.

Details for Patent 8,337,811

Subscribe to access the full database, or Try a Trial
Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Amgen, Inc.	EPOGEN/PROCRIT	epoetin alfa	Injection	103234	06/01/1989	⤷ Try a Trial	2025-01-04
Amgen, Inc.	EPOGEN/PROCRIT	epoetin alfa	Injection	103234		⤷ Try a Trial	2025-01-04
Amgen, Inc.	PROCRIT	epoetin alfa	Injection	103234		⤷ Try a Trial	2025-01-04
Amgen, Inc.	ARANESP	darbepoetin alpha	Injection	103951	09/17/2001	⤷ Try a Trial	2025-01-04
Amgen, Inc.	ARANESP	darbepoetin alpha	Injection	103951	07/19/2002	⤷ Try a Trial	2025-01-04
Amgen, Inc.	ARANESP	darbepoetin alpha	Injection	103951	12/17/2002	⤷ Try a Trial	2025-01-04
Amgen, Inc.	ARANESP	darbepoetin alpha	Injection	103951	12/12/2003	⤷ Try a Trial	2025-01-04
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.