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Last Updated: October 18, 2019

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Claims for Patent: 8,198,299

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Summary for Patent: 8,198,299
Title:Cycloalkylidene and heterocycloalkylidene inhibitor compounds
Abstract: The present invention provides a compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound. ##STR00001##
Inventor(s): Melvin, Jr.; Lawrence S. (Longmont, CO), Graupe; Michael (Pacifica, CA), Venkataramani; Chandrasekar (Redwood City, CA), Guerrero; Juan A. (Concord, CA)
Assignee: Gilead Sciences, Inc. (Foster City, CA)
Application Number:13/284,559
Patent Claims:1. A compound of Formula (I) or a pharmaceutically acceptable salt thereof: ##STR00434## wherein Cy.sup.1 is cycloalkylidene or heterocycloalkylidene; Cy.sup.2 is imidazolyl, triazolyl, tetrazolyl, thiazolyl, pyridinyl or pyrimidinyl; provided that when Cy.sup.1 is heterocycloalkylidene, Cy.sup.2 is not thiazolyl; Ar is phenyl; m is an integer from 0 to the maximum number of substitutable positions on Ar; n is an integer from 0 to the maximum number of substitutable positions on Cy.sup.1; p is an integer from 0 to the maximum number of substitutable positions on Cy.sup.2; R.sup.1 is hydroxyl, aryl or heteroaryl, wherein aryl or heteroaryl is substituted with --NH.sub.2 or --OH, and aryl or heteroaryl is optionally further substituted with one or more groups selected from amino, halo, cyano, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, heterocyclyl, aryl, haloaryl and haloheterocyclyl, wherein alkyl, alkenyl or alkynyl is optionally further substituted with one or more groups selected from halo, hydroxyl, alkyl, haloalkyl, cycloalkyl, halophenyl, heterocyclyl, and trialkylsilyl; R.sup.2 is independently selected from the group consisting of halo, hydroxyl, oxo, nitro, cyano, trifluoromethyl, trifluoromethoxy, amino, carboxyl, carbamoyl, sulphamoyl, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.1-10 alkoxy, C.sub.1-10 alkanoyl, N--(C.sub.1-10 alkylamino, N,N--(C.sub.1-10 alkyl).sub.2 amino, C.sub.1-10 alkanoylamino, N--(C.sub.1-10 alkyl)carbamoyl, N,N--(C.sub.1-10 alkyl).sub.2 carbamoyl, C.sub.1-10 alkyl-S(O).sub.a wherein a is 0, 1 or 2, NH.sub.2--S(O).sub.2NH--, N--(C.sub.1-10 alkyl)sulphamoyl, N,N--(C.sub.1-10 alkyl).sub.2sulphamoyl, cycloalkyl, heterocyclyl and aryl; R.sup.3 is independently selected from the group consisting of halo, hydroxyl, oxo, nitro, cyano, trifluoromethyl, trifluoromethoxy, amino, carboxyl, carbamoyl, sulphamoyl, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.1-10 alkoxy, C.sub.1-10 alkanoyl, N--(C.sub.1-10 alkyl)amino, N,N--(C.sub.1-10 alkyl).sub.2 amino, C.sub.1-10 alkanoylamino, N--(C.sub.1-10 alkyl)carbamoyl, alkyl).sub.2 carbamoyl, C.sub.1-10 alkyl-S(O).sub.a wherein a is 0, 1 or 2, NH.sub.2--S(O).sub.2NH--, N--(C.sub.1-10 alkyl)sulphamoyl, N,N--(C.sub.1-10 alkyl).sub.2sulphamoyl, cycloalkyl, heterocyclyl and aryl, wherein each R.sup.3 is optionally substituted by one or more A; or two groups R.sup.3 are substituted on the same carbon ring atom of Cy.sup.1 and together with the carbon ring atom of Cy.sup.1 form a ring situated on Cy.sup.1 in a Spiro configuration, wherein the Spiro ring is cycloalkyl or heterocycloalkyl; R.sup.4 is independently selected from the group consisting of H, halo, nitro, cyano, hydroxyl, oxo, hydroxy(C.sub.1-10 alkyl), amino(C.sub.1-10 alkyl), haloalkyl, haloalkoxy, amino, azido, carboxyl, carbamoyl, mercapto, sulphamoyl, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.1-10 alkoxy, hydroxy(C.sub.1-10 alkoxy)(C.sub.1-10 alkoxy), (C.sub.1-10 alkoxy)(C.sub.1-10 alkoxy), (C.sub.1-10 alkoxy)(C.sub.1-10 alkyl), C.sub.1-10 alkanoyl, C.sub.1-10 alkanoyloxy, N--(C.sub.1-10 alkyl)amino, N,N--(C.sub.1-10 alkyl).sub.2-amino, C.sub.1-10 alkanoylamino, N--(C.sub.1-10 alkyl)carbamoyl, N,N--(C.sub.1-10 alkyl).sub.2-carbamoyl, C.sub.1-10 alkyl-S(O).sub.a wherein a is 0, 1 or 2, C.sub.1-10 alkoxycarbonyl, NH.sub.2--S(O).sub.2NH--, NH.sub.2--CO--NH--, N--(C.sub.1-10 alkyl)sulphamoyl, N,N--(C.sub.1-10 alkyl).sub.2sulphamoyl, aryl, arylalkyl, aryloxy, arylthio, cycloalkyl, cycloalkylalkyl, cycloalkyloxy, heterocyclyl, heterocyclylalkyl, heterocyclyl(C.dbd.O)--, heterocyclyloxy and heterocyclylthio, wherein if R.sup.4 is not aryl, cycloalkyl or heterocyclyl, each R.sup.4 is optionally substituted by one or more B, and if R.sup.4 is aryl, cycloalkyl or heterocyclyl, R.sup.4 is optionally further substituted by one or more R.sup.5, or when p is 2 or greater, two R.sup.4 groups form a 5- or 6-membered cyclic moiety to make a fused ring with Cy.sup.2 ring, wherein the cyclic moiety can contain one or more heteroatoms selected from N, O and S and the fused ring is optionally substituted by one or more R.sup.5; R.sup.5 is independently selected from halo, nitro, cyano, hydroxyl, oxo, hydroxy(C.sub.1-10 alkyl), amino(C.sub.1-10 alkyl), haloalkyl, haloalkoxy, amino, azido, carboxyl, carbamoyl, mercapto, sulphamoyl, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.1-10 alkoxy, hydroxy(C.sub.1-10 alkoxy)(C.sub.1-10 alkoxy), (C.sub.1-10 alkoxy)(C.sub.1-10 alkoxy), (C.sub.1-10 alkoxy)(C.sub.1-10 alkyl), C.sub.1-10 alkanoyl, C.sub.1-10 alkanoyloxy, N--(C.sub.1-10 alkyl)amino, N,N--(C.sub.1-10 alkyl).sub.2-amino, C.sub.1-10 alkanoylamino, N--(C.sub.1-10 alkyl)carbamoyl, N,N--(C.sub.1-10 alkyl).sub.2-carbamoyl, C.sub.1-10 alkyl-S(O).sub.a wherein a is 0, 1 or 2, C.sub.1-10 alkoxycarbonyl, NH.sub.2--S(O).sub.2NH--, NH.sub.2--CO--NH--, N--(C.sub.1-- alkyl)sulphamoyl, N,N--(C.sub.1-10 alkyl).sub.2sulphamoyl, aryl, arylalkyl, aryloxy, arylthio, cycloalkyl, cycloalkylalkyl, cycloalkyloxy, heterocyclyl, heterocyclylalkyl, heterocyclyl(C.dbd.O)--, heterocyclyloxy and heterocyclylthio, wherein each R.sup.5 is optionally substituted by one or more D; and A, B and D are independently selected from halo, nitro, cyano, hydroxyl, oxo, hydroxyalkyl, haloalkyl, haloalkoxy, amino, azido, carboxyl, carbamoyl, mercapto, sulphamoyl, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.1-10 alkoxy, C.sub.1-10 alkanoyl, C.sub.1-10 alkanoyloxy, N--(C.sub.1-10 alkyl)amino, N,N--(C.sub.1-10 alkyl).sub.2-amino, C.sub.1-10 alkanoylamino, N--(C.sub.1-10 alkyl)carbamoyl, N,N--(C.sub.1-10 alkyl).sub.2-carbamoyl, C.sub.1-10 alkyl-S(O).sub.a wherein a is 0, 1 or 2, C.sub.1-10 alkoxycarbonyl, N--(C.sub.1-10 alkyl)sulphamoyl, N,N--(C.sub.1-10 alkyl).sub.2sulphamoyl, H.sub.2NS(O).sub.2NH--, N--(C.sub.1-10 alkyl)NHS(O).sub.2NH--, N,N--(C.sub.1-10 alkyl).sub.2NS(O).sub.2NH--, aryl, aryloxy, arylthio, cycloalkyl, cycloalkyloxy, heterocyclyl, heterocyclyl(C.dbd.O)--, heterocyclyloxy and heterocyclylthio.

2. The compound or pharmaceutically acceptable salt thereof of claim 1, wherein R.sup.1 is hydroxyl, phenyl, 5-membered or 6-membered heteroaryl, wherein phenyl or heteroaryl is substituted with --NH.sub.2 or --OH at a ring position adjacent to attachment of the --CONH-moiety, and phenyl or heteroaryl is optionally further substituted with one or more substituent selected from amino, halo, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, heterocyclyl, aryl, haloaryl, and haloheterocyclyl, wherein alkyl, alkenyl, or alkynyl is optionally further substituted with one or more groups selected from halo, hydroxyl, alkyl, haloalkyl and cycloalkyl.

3. The compound of claim 1 or pharmaceutically acceptable salt thereof, wherein Cy.sup.1 is C.sub.3-7 cycloalkylidene having from 3 to 7 ring members; and Cy.sup.2 is heterocyclyl.

4. The compound or pharmaceutically acceptable salt thereof of claim 1 selected from those of Formulae (I-c): ##STR00435## wherein m is 0, 1, 2, 3 or 4; Cy.sup.1 is C.sub.3-7 cycloalkylidene; R.sup.1 is hydroxyl, aryl or heteroaryl, wherein aryl or heteroaryl is substituted with --NH.sub.2 or --OH at a ring position adjacent to attachment of the --CONH-moiety, and aryl or heteroaryl is optionally further substituted with one or more substituent selected from amino, halo, cyano, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, heterocyclyl, aryl, haloaryl, and haloheterocyclyl, wherein alkyl, alkenyl, or alkynyl is optionally further substituted with one or more groups selected from halo, hydroxyl, alkyl, haloalkyl, cycloalkyl, halophenyl, heterocyclyl, and trialkylsilyl; and each R.sup.4 is independently selected from H, halo, nitro, cyano, hydroxyl, hydroxy(C.sub.1-10 alkyl), haloalkyl, haloalkoxy, amino, azido, carboxyl, carbamoyl, mercapto, sulphamoyl, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.1-10 alkoxy, C.sub.1-10 alkanoyl, alkanoyloxy, N--(C.sub.1-10 alkylamino, N,N--(C.sub.1-10 alkyl).sub.2-amino, C.sub.1-10 alkanoylamino, N--(C.sub.1-10 alkyl)carbamoyl, N,N--(C.sub.1-10 alkyl).sub.2-carbamoyl, C.sub.1-10 alkyl-S(O).sub.a wherein a is 0, 1 or 2, C.sub.1-10 alkoxycarbonyl, NH.sub.2--S(O).sub.2NH--, N--(C.sub.1-10 alkyl)sulphamoyl, N,N--(C.sub.1-10 alkyl).sub.2sulphamoyl, aryl, cycloalkyl and heterocyclyl wherein if R.sup.4 is not aryl, cycloalkyl or heterocyclyl, each R.sup.4 is optionally substituted by one or more B, and if R.sup.4 is aryl, cycloalkyl or heterocyclyl, R.sup.4 is optionally further substituted by one or more R.sup.5.

5. The compound of claim 4 or pharmaceutically acceptable salt thereof, which has a formula selected from the group consisting of: ##STR00436## ##STR00437## wherein R.sup.6', R.sup.7', R.sup.8, R.sup.9 and R.sup.10 are independently selected from H, halo, nitro, cyano, hydroxyl, hydroxyalkyl, haloalkyl, haloalkoxy, amino, azido, carboxyl, carbamoyl, mercapto, sulphamoyl, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, alkoxy, C.sub.1-10 alkanoyl, C.sub.1-10 alkanoyloxy, N--(C.sub.1-10 alkyl)amino, N,N--(C.sub.1-10 alkyl).sub.2-amino, C.sub.1-10 alkanoylamino, N--(C.sub.1-10 alkyl)carbamoyl, N,N--(C.sub.1-10 alkyl).sub.2-carbamoyl, C.sub.1-10 alkyl-S(O).sub.a wherein a is 0, 1 or 2, C.sub.1-10 alkoxycarbonyl, NH.sub.2--S(O).sub.2NH--, N--(C.sub.1-10 alkyl)sulphamoyl and N,N--(C.sub.1-10 alkyl).sub.2sulphamoyl, wherein each R.sup.6', R.sup.7', R.sup.8, R.sup.9 and R.sup.10 is optionally substituted by one or more D; and R.sup.11, R.sup.12, and R.sup.13 are independently selected from R.sup.4 optionally substituted by one or more B.

6. The compound of claim 5 which is selected from the group consisting of: N-hydroxy-4-(1-(4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)cyclopro- pyl)benzamide; N-hydroxy-3-(1-(4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)cyclopropyl)- benzamide; N-(2-aminophenyl)-4-(1-(4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin- -2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-3-(1-(4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)cycl- opropyl)benzamide; N-hydroxy-4-(1-(4-(2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)cycl- opropyl)benzamide; N-hydroxy-3-(1-(4-(2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)cycl- opropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2- -yl)cyclopropyl)benzamide; N-(2-aminophenyl)-3-(1-(4-(2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2- -yl)cyclopropyl)benzamide; 4-(1-(4-(6-chloro-2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)cyclo- propyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(6-chloro-2-methylimidazo[1,2-a]pyridin-3-yl)py- rimidin-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(7-methoxy-2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin- -2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(7-methoxy-2-methylimidazo[1,2-a]pyridin-3-yl)p- yrimidin-2-yl)cyclopropyl)benzamide; 4-(1-(4-(7-((dimethylamino)methyl)imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-- yl)cyclopropyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(7-((dimethylamino)methyl)imidazo[1,2-a]pyridin- -3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(7-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridin-3-yl)py- rimidin-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(7-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridin- -3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(7-(morpholinomethyl)imidazo[1,2-a]pyridin-3-yl)pyrimid- in-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(7-(morpholinomethyl)imidazo[1,2-a]pyridin-3-yl- )pyrimidin-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(2-methyl-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl- )pyrimidin-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methyl-6-(trifluoromethyl)imidazo[1,2-a]pyri- din-3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(2-methyl-7-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl- )pyrimidin-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methyl-7-(trifluoromethyl)imidazo[1,2-a]pyri- din-3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)pyrimidin-4-yl)-N-(2-meth- oxyethyl)-2-methylimidazo[1,2-a]pyridine-7-carboxamide; 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)pyrimidin-4-yl)-N-(- 2-methoxyethyl)-2-methylimidazo[1,2-a]pyridine-7-carboxamide; 4-(1-(4-(7-cyano-2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)cyclop- ropyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(7-cyano-2-methylimidazo[1,2-a]pyridin-3-yl)pyr- imidin-2-yl)cyclopropyl)benzamide; 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)pyrimidin-4-yl)-2-methyl-- N-(2-morpholinoethyl)imidazo[1,2-a]pyridine-7-carboxamide; 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)pyrimidin-4-yl)-2-m- ethyl-N-(2-morpholinoethyl)imidazo[1,2-a]pyridine-7-carboxamide; methyl 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)pyrimidin-4-yl)-2-methyli- midazo[1,2-a]pyridine-7-carboxylate; methyl 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)pyrimidin-4-yl)-2-m- ethylimidazo[1,2-a]pyridine-7-carboxylate; N-hydroxy-4-(1-(4-(2-methyl-7-(4-methylpiperazine-1-carbonyl)imidazo[1,2-- a]pyridin-3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methyl-7-(4-methylpiperazine-1-carbonyl)imid- azo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)pyrimidin-4-yl)-2-methyli- midazo[1,2-a]pyridine-7-carboxylic acid; 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)pyrimidin-4-yl)-2-m- ethylimidazo[1,2-a]pyridine-7-carboxylic acid; N-hydroxy-4-(1-(4-(2-methyl-7-(2-morpholinoethoxy)imidazo[1,2-a]pyridin-3- -yl)pyrimidin-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methyl-7-(2-morpholinoethoxy)imidazo[1,2-a]p- yridin-3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; 4-(1-(4-(7-(2-(dimethylamino)ethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl)p- yrimidin-2-yl)cyclopropyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(7-(2-(dimethylamino)ethoxy)-2-methylimidazo[1,- 2-a]pyridin-3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(7-(2-methoxyethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl- )pyrimidin-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(7-(2-methoxyethoxy)-2-methylimidazo[1,2-a]pyri- din-3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; 4-(1-(4-(7-(2-(dimethylamino)ethylamino)-2-methylimidazo[1,2-a]pyridin-3-- yl)pyrimidin-2-yl)cyclopropyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(7-(2-(dimethylamino)ethylamino)-2-methylimidaz- o[1,2-a]pyridin-3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)pyrimidin-4-yl)-N-(2-meth- oxyethyl)-2-methylimidazo[1,2-a]pyridine-6-carboxamide; 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)pyrimidin-4-yl)-N-(- 2-methoxyethyl)-2-methylimidazo[1,2-a]pyridine-6-carboxamide; N-hydroxy-4-(1-(4-(2-methyl-6-(4-methylpiperazine-1-carbonyl)imidazo[1,2-- a]pyridin-3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methyl-6-(4-methylpiperazine-1-carbonyl)imid- azo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)pyrimidin-4-yl)-2-methyl-- N-(2-morpholinoethyl)imidazo[1,2-a]pyridine-6-carboxamide; 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)pyrimidin-4-yl)-2-m- ethyl-N-(2-morpholinoethyl)imidazo[1,2-a]pyridine-6-carboxamide; N-hydroxy-4-(1-(4-(6-(2-methoxyethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl- )pyrimidin-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(6-(2-methoxyethoxy)-2-methylimidazo[1,2-a]pyri- din-3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(6-methoxy-2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin- -2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(6-methoxy-2-methylimidazo[1,2-a]pyridin-3-yl)p- yrimidin-2-yl)cyclopropyl)benzamide; 4-(1-(4-(8-fluoro-2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)cyclo- propyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(8-fluoro-2-methylimidazo[1,2-a]pyridin-3-yl)py- rimidin-2-yl)cyclopropyl)benzamide; 4-(1-(4-(7-((dimethylamino)methyl)-2-methylimidazo[1,2-a]pyridin-3-yl)pyr- imidin-2-yl)cyclopropyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(7-((dimethylamino)methyl)-2-methylimidazo[1,2-- a]pyridin-3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; 4-(1-(4-(6-bromo-2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)cyclop- ropyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(6-bromo-2-methylimidazo[1,2-a]pyridin-3-yl)pyr- imidin-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(7-methoxy-2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-y- l)pyrimidin-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(7-methoxy-2-(trifluoromethyl)imidazo[1,2-a]pyr- idin-3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; and pharmaceutically acceptable salts thereof.

7. The compound of claim 5 or pharmaceutically acceptable salt thereof, which has a formula selected from the group consisting of: ##STR00438## wherein R.sup.6', R.sup.7', R.sup.8, R.sup.9 and R.sup.10 are independently selected from H, halo, nitro, cyano, hydroxyl, hydroxyalkyl, haloalkyl, haloalkoxy, amino, azido, carboxyl, carbamoyl, mercapto, sulphamoyl, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.1-10 alkoxy, C.sub.1-10 alkanoyl, C.sub.1-10 alkanoyloxy, N--(C.sub.1-10 alkylamino, N,N--(C.sub.1-10 alkyl).sub.2-amino, alkanoylamino, N--(C.sub.1-10 alkyl)carbamoyl, N,N--(C.sub.1-10 alkyl).sub.2-carbamoyl, C.sub.1-10 alkyl-S(O).sub.a wherein a is 0, 1 or 2, C.sub.1-10 alkoxycarbonyl, NH.sub.2--S(O).sub.2NH--, N--(C.sub.1-10 alkyl)sulphamoyl and N,N--(C.sub.1-10 alkyl).sub.2sulphamoyl, wherein each R.sup.6, R.sup.7, R.sup.8, R.sup.9 and R.sup.10 is optionally substituted by one or more D.

8. The compound of claim 7 which is selected from the group consisting of: N-hydroxy-4-(1-(4-(1-isopropyl-2-methylimidazol-5-yl)pyrimidin-2-yl)c- yclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(1-isopropyl-2-methylimidazol-5-yl)pyrimidin-2-- yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(4-isopropyl-5-methyl-1,2,4-triazol-3-yl)pyrimidin-2-yl- )cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(4-isopropyl-5-methyl-1,2,4-triazol-3-yl)pyrimi- din-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(pyridin-3-yl)pyrimidin-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(pyridin-3-yl)pyrimidin-2-yl)cyclopropyl)benzam- ide; N-hydroxy-4-(1-(4-(pyridin-4-yl)pyrimidin-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(pyridin-4-yl)pyrimidin-2-yl)cyclopropyl)benzam- ide; N-hydroxy-4-(1-(4-(pyridin-2-yl)pyrimidin-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(pyridin-2-yl)pyrimidin-2-yl)cyclopropyl)benzam- ide; and pharmaceutically acceptable salts thereof.

9. The compound of claim 1 or a pharmaceutically acceptable salt thereof, selected from those of Formulae (I-f), (I-g), (I-q), and (I-r), and pharmaceutically acceptable salts thereof: ##STR00439## wherein m is 0, 1, 2, 3 or 4; Cy.sup.1 is C.sub.3-7 cycloalkylidene or heterocycloalkylidene; R.sup.1 is hydroxyl, aryl or heteroaryl, wherein aryl or heteroaryl is substituted with --NH.sub.2 or --OH at a ring position adjacent to attachment of the --CONH-moiety, and aryl or heteroaryl is optionally further substituted with one or more substituent selected from amino, halo, cyano, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, heterocyclyl, aryl, haloaryl, and haloheterocyclyl, wherein alkyl, alkenyl, or alkynyl is optionally further substituted with one or more groups selected from halo, hydroxyl, alkyl, haloalkyl, cycloalkyl, halophenyl, heterocyclyl, and trialkylsilyl; and each R.sup.4 is independently selected from H, halo, nitro, cyano, hydroxyl, hydroxy(C.sub.1-10 alkyl), haloalkyl, haloalkoxy, amino, azido, carboxyl, carbamoyl, mercapto, sulphamoyl, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.1-10 alkoxy, C.sub.1-10 alkanoyl, C.sub.1-10 alkanoyloxy, N--(C.sub.1-10 alkyl)amino, N,N--(C.sub.1-10 alkyl).sub.2-amino, C.sub.1-10 alkanoylamino, N--(C.sub.1-10 alkyl)carbamoyl, N,N--(C.sub.1-10 alkyl).sub.2-carbamoyl, C.sub.1-10 alkyl-S(O).sub.a wherein a is 0, 1 or 2, C.sub.1-10 alkoxycarbonyl, NH.sub.2--S(O).sub.2NH--, N--(C.sub.1-10 alkyl)sulphamoyl, N,N--(C.sub.1-10 alkyl).sub.2sulphamoyl, aryl, cycloalkyl and heterocyclyl, wherein if R.sup.4 is not aryl, cycloalkyl or heterocyclyl, each R.sup.4 is optionally substituted by one or more B, and if R.sup.4 is aryl, cycloalkyl or heterocyclyl, R.sup.4 is optionally further substituted by one or more R.sup.5.

10. The compound of claim 9 selected from the group consisting of: N-(2-aminophenyl)-4-(1-(pyridin-2-yl)cyclopropyl)benzamide; N-(4-amino-4'-fluorobiphenyl-3-yl)-4-(1-(pyridin-2-yl)cyclopropyl)benzami- de; N-(2-amino-5-(5-chlorothiophen-2-yl)phenyl)-4-(1-(pyridin-2-yl)cyclopr- opyl)benzamide; N-(2-aminophenyl)-4-(4-(pyridin-2-yl)tetrahydro-2H-pyran-4-yl)benzamide; N-(4-amino-4'-fluorobiphenyl-3-yl)-4-(4-(pyridin-2-yl)tetrahydro-2H-pyran- -4-yl)benzamide; N-(2-amino-5-(5-chlorothiophen-2-yl)phenyl)-4-(4-(pyridin-2-yl)tetrahydro- -2H-pyran-4-yl)benzamide; N-(2-aminophenyl)-4-(4-(4,6-bis(2-hydroxypropan-2-yl)pyridin-2-yl)tetrahy- dro-2H-pyran-4-yl)benzamide; N-(4-amino-4'-fluorobiphenyl-3-yl)-4-(4-(4,6-bis(2-hydroxypropan-2-yl)pyr- idin-2-yl)tetrahydro-2H-pyran-4-yl)benzamide; N-(2-amino-5-(5-chlorothiophen-2-yl)phenyl)-4-(4-(4,6-bis(2-hydroxypropan- -2-yl)pyridin-2-yl)tetrahydro-2H-pyran-4-yl)benzamide; N-(2-aminophenyl)-4-(4-(2,3-dihydropyridin-2-yl)tetrahydro-2H-pyran-4-yl)- benzamide; N-(4-amino-4'-fluorobiphenyl-3-yl)-4-(4-(2,3-dihydropyridin-2-y- l)tetrahydro-2H-pyran-4-yl)benzamide; N-(2-amino-5-(thiophen-2-yl)phenyl)-4-(4-(2,3-dihydropyridin-2-yl)tetrahy- dro-2H-pyran-4-yl)benzamide; 4-(4-(1H-tetrazol-5-yl)tetrahydro-2H-pyran-4-yl)-N-(2-aminophenyl)benzami- de; 4-(4-(1H-tetrazol-5-yl)tetrahydro-2H-pyran-4-yl)-N-(4-amino-4'-fluorob- iphenyl-3-yl)benzamide; 4-(4-(1H-tetrazol-5-yl)tetrahydro-2H-pyran-4-yl)-N-(2-amino-5-(thiophen-2- -yl)phenyl)benzamide; N-(2-aminophenyl)-4-(4-(4-(pyrazin-2-yl)-1H-imidazol-2-yl)tetrahydro-2H-p- yran-4-yl)benzamide; N-(2-aminophenyl)-4-(4-(1-methyl-4-(pyrazin-2-yl)-1H-imidazol-2-yl)tetrah- ydro-2H-pyran-4-yl)benzamide; N-(4-amino-4'-fluorobiphenyl-3-yl)-4-(4-(1-methyl-4-(pyrazin-2-yl)-1H-imi- dazol-2-yl)tetrahydro-2H-pyran-4-yl)benzamide; N-(2-aminophenyl)-4-(4-(4-phenyl-1H-imidazol-2-yl)tetrahydro-2H-pyran-4-y- l)benzamide; N-(2-aminophenyl)-4-(4-(1-methyl-4-phenyl-1H-imidazol-2-yl)tetrahydro-2H-- pyran-4-yl)benzamide; N-(4-amino-4'-fluorobiphenyl-3-yl)-4-(4-(1-methyl-4-phenyl-1H-imidazol-2-- yl)tetrahydro-2H-pyran-4-yl)benzamide; 2-aminophenyl 4-(4-(3-methyl-1H-1,2,4-triazol-5-yl)tetrahydro-2H-pyran-4-yl)benzoate; 4-amino-4'-fluorobiphenyl-3-yl-4-(4-(3-methyl-1H-1,2,4-triazol-5-yl)tetra- hydro-2H-pyran-4-yl)benzoate; 2-amino-5-(5-chlorothiophen-2-yl)phenyl-4-(4-(3-methyl-1H-1,2,4-triazol-5- -yl)tetrahydro-2H-pyran-4-yl)benzoate, and pharmaceutically acceptable salts thereof.

11. A pharmaceutical composition comprising an effective amount of one or more compounds according to claim 1 and a pharmaceutically-acceptable carrier.

12. The pharmaceutical composition according to claim 11, further comprising one or more anti-cancer agents selected from the group consisting of cyclophosphamide, dacarbazine, cisplatin, methotrexate, mercaptopurine, thioguanine, fluorouracil, cytarabine, vinblastine, paclitaxel, doxorubicin, bleomycin, mitomycin, prednisone, tamoxifen, flutamide, asparaginase, rituximab, trastuzumab, imatinib, retinoic acid, colony-stimulating factor, amifostine, lenalidomide, HDAC inhibitor, CDK inhibitor, camptothecin and topotecan.

13. The compound of claim 9 selected from the group consisting of: N-(4-amino-4'-fluorobiphenyl-3-yl)-4-(4-(pyridin-2-yl)tetrahydropyran-4-y- l)benzamide; 4-[4-(5-methyl-2H-[1,2,4]triazol-3-yl)-tetrahydro-pyran-4-yl]-benzoic acid 4-amino-4'-fluoro-biphenyl-3-yl ester; 4-[1-(5-acetyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-yl)-cyclopropy- l]-N-2-amino-phenyl)-benzamide, or pharmaceutically acceptable salt thereof.

14. The compound or pharmaceutically acceptable salt thereof of claim 1 selected from those of Formulae (I-a), (I-b), (I-c), and (I-d): ##STR00440## wherein m is 0, 1, 2, 3 or 4; Cy.sup.1 is C.sub.3-7 cycloalkylidene; R.sup.1 is hydroxyl, aryl or heteroaryl, wherein aryl or heteroaryl is substituted with --NH.sub.2 or --OH at a ring position adjacent to attachment of the --CONH-moiety, and aryl or heteroaryl is optionally further substituted with one or more substituent selected from amino, halo, cyano, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, heterocyclyl, aryl, haloaryl, and haloheterocyclyl, wherein alkyl, alkenyl, or alkynyl is optionally further substituted with one or more groups selected from halo, hydroxyl, alkyl, haloalkyl, cycloalkyl, halophenyl, heterocyclyl, and trialkylsilyl; and each R.sup.4 is independently selected from H, halo, nitro, cyano, hydroxyl, hydroxy(C.sub.1-10 alkyl), haloalkyl, haloalkoxy, amino, azido, carboxyl, carbamoyl, mercapto, sulphamoyl, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.1-10 alkoxy, C.sub.1-10 alkanoyl, C.sub.1-10 alkanoyloxy, N--(C.sub.1-10 alkyl)amino, N,N--(C.sub.1-10 alkyl).sub.2-amino, C.sub.1-10 alkanoylamino, N--(C.sub.1-10 alkyl)carbamoyl, N,N--(C.sub.1-10 alkyl).sub.2-carbamoyl, C.sub.1-10 alkyl-S(O).sub.a wherein a is 0, 1 or 2, C.sub.1-10 alkoxycarbonyl, NH.sub.2--S(O).sub.2NH--, N--(C.sub.1-10 alkyl)sulphamoyl, N,N--(C.sub.1-10 alkyl).sub.2sulphamoyl, aryl, cycloalkyl and heterocyclyl wherein if R.sup.4 is not aryl, cycloalkyl or heterocyclyl, each R.sup.4 is optionally substituted by one or more B, and if R.sup.4 is aryl, cycloalkyl or heterocyclyl, R.sup.4 is optionally further substituted by one or more R.sup.5, or when the compound is selected from Formula (I-a) and (I-b), p is 2 and two R.sup.4 groups are substituted at positions 4 and 5 of the thiazole ring and form a 5- or 6-membered cyclic moiety to make a fused ring with the thiazole ring, wherein the cyclic moiety can contain one or more heteroatoms selected from N, O and S and the fused ring is optionally substituted by one or more R.sup.5.

15. The compound or pharmaceutically acceptable salt thereof of claim 14 which has Formula (I-a0): ##STR00441## wherein R.sup.6 and R.sup.7 are independently selected from H, halo, nitro, cyano, hydroxyl, hydroxy(C.sub.1-10 alkyl), haloalkyl, haloalkoxy, amino, azido, carboxyl, carbamoyl, mercapto, sulphamoyl, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.1-10 alkoxy, C.sub.1-10 alkanoyl, C.sub.1-10 alkanoyloxy, N--(C.sub.1-10 alkyl)amino, N,N--(C.sub.1-10 alkyl).sub.2-amino, C.sub.1-10 alkanoylamino, N--(C.sub.1-10 alkyl)carbamoyl, N,N--(C.sub.1-10 alkyl).sub.2-carbamoyl, C.sub.1-10 alkyl-S(O).sub.a wherein a is 0, 1 or 2, C.sub.1-10 alkoxycarbonyl, NH.sub.2--S(O).sub.2NH--, N--(C.sub.1-10 alkyl)sulphamoyl, and N,N--(C.sub.1-10 alkyl).sub.2sulphamoyl, or form a 5- or 6-membered cyclic moiety to make a fused ring with the thiazole ring, wherein the cyclic moiety can contain one or more heteroatoms selected from N, O and S, wherein each R.sup.6 and R.sup.7 is optionally substituted by one or more B.

16. The compound of claim 14 which is selected from the group consisting of: 4-(1-(5-acetyl-4-methylthiazol-2-yl)cyclopropyl)-N-hydroxybenzamide; 4-(1-(5-acetyl-4-methylthiazol-2-yl)cyclopropyl)-N-(2-aminophenyl)benzami- de; N-hydroxy-4-(1-(4-((2-methoxyethylamino)methyl)thiazol-2-yl)cyclopropy- l)benzamide; N-(2-aminophenyl)-4-(1-(4-((2-methoxyethylamino)methyl)thiazol-2-yl)cyclo- propyl)benzamide; N-hydroxy-4-(1-(4-((pyridin-2-ylamino)methyl)thiazol-2-yl)cyclopropyl)ben- zamide; N-(2-aminophenyl)-4-(1-(4-((pyridin-2-ylamino)methyl)thiazol-2-yl)- cyclopropyl)benzamide; N-hydroxy-4-(1-(4-((2,2,2-trifluoroethylamino)methyl)thiazol-2-yl)cyclopr- opyl)benzamide; N-(2-aminophenyl)-4-(1-(4-((2,2,2-trifluoroethylamino)methyl)thiazol-2-yl- )cyclopropyl)benzamide; 4-(1-(4-((cyclopropylmethylamino)methyl)thiazol-2-yl)cyclopropyl)-N-hydro- xybenzamide; N-(2-aminophenyl)-4-(1-(4-((cyclopropylmethylamino)methyl)thiazol-2-yl)cy- clopropyl)benzamide; 2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)-N,N,4-trimethylthiazole-5-c- arboxamide; 2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)-N,N-4-trimethylthiazo- le-5-carboxamide; 2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)-N-isopropylthiazole-4-carbo- xamide; 2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)-N-isopropylthi- azole-4-carboxamide; N-hydroxy-4-(1-(4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)cyclopropyl)benzam- ide; N-(2-aminophenyl)-4-(1-(4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)cyclop- ropyl)benzamide; ethyl 2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)-6,7-dihydrothiazolo[5,4-c]p- yridine-5(4H)-carboxylate; ethyl 2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)-6,7-dihydrothiazolo[5- ,4-c]pyridine-5(4H)-carboxylate; N-hydroxy-4-(1-(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)cyclopropyl- )benzamide; N-(2-aminophenyl)-4-(1-(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)cyc- lopropyl)benzamide; tert-butyl 2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)-6,7-dihydrothiazolo[5,4-c]p- yridine-5(4H)-carboxylate; and tert-butyl 2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)-6,7-dihydrothiazolo[5- ,4-c]pyridine-5(4H)-carboxylate; N-(2-aminophenyl)-4-(1-(4-methylthiazol-2-yl)cyclopropyl)benzamide; (S)-4-(1-(5-(2-amino-3-methylbutanoyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]p- yridin-2-yl)cyclopropyl)-N-(2-aminophenyl)benzamide; N-(2-amino-5-fluorophenyl)-4-(1-(thiazol-2-yl)cyclopropyl)benzamide; N-(4-amino-4'-fluorobiphenyl-3-yl)-4-(1-(thiazol-2-yl)cyclopropyl)benzami- de; N-(2-amino-5-(thiophen-2-yl)phenyl)-4-(1-(thiazol-2-yl)cyclopropyl)ben- zamide; N-(2-amino-5-(5-methylthiophen-2-yl)phenyl)-4-(1-(thiazol-2-yl)cyc- lopropyl)benzamide; N-(4-amino-4'-fluorobiphenyl-3-yl)-4-(1-(5-methyl-4,5,6,7-tetrahydrothiaz- olo[5,4-c]pyridine-2-yl)cyclopropyl)benzamide; N-(4-amino-4'-fluorobiphenyl-3-yl)-4-(1-(6,7-dihydropyrano[4,3-d]thiazol-- 2-yl)cyclopropyl)benzamide; and pharmaceutically acceptable salts thereof.

17. The compound of claim 1 or pharmaceutically acceptable salt thereof, which has a formula selected from the group consisting of: ##STR00442## ##STR00443## wherein R.sup.6', R.sup.7', R.sup.8, R.sup.9 and R.sup.10 are independently selected from H and the functional groups of R.sup.5, wherein each R.sup.6', R.sup.7', R.sup.8, R.sup.9 and R.sup.10 is optionally substituted by one or more D.

18. The compound of claim 17 which is selected from the group consisting of: N-hydroxy-4-(1-(4-(imidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopropy- l)benzamide; N-hydroxy-3-(1-(4-(imidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopropyl)be- nzamide; N-hydroxy-4-(1-(4-(imidazo[1,2-a]pyridin-3-yl)-5-methylthiazol-2-- yl)cyclopropyl)benzamide; N-hydroxy-3-(1-(4-(imidazo[1,2-a]pyridin-3-yl)-5-methylthiazol-2-yl)cyclo- propyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(imidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclop- ropyl)benzamide; N-(2-aminophenyl)-3-(1-(4-(imidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclop- ropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(imidazo[1,2-a]pyridin-3-yl)-5-methylthiazol-2-- yl)cyclopropyl)benzamide; N-(2-aminophenyl)-3-(1-(4-(imidazo[1,2-a]pyridin-3-yl)-5-methylthiazol-2-- yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclop- ropyl)benzamide; N-hydroxy-3-(1-(4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclop- ropyl)benzamide; N-hydroxy-4-(1-(5-methyl-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-- yl)cyclopropyl)benzamide; N-hydroxy-3-(1-(5-methyl-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-- yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-y- l)cyclopropyl)benzamide; N-(2-aminophenyl)-3-(1-(4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-y- l)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(5-methyl-4-(2-methylimidazo[1,2-a]pyridin-3-yl)th- iazol-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-3-(1-(5-methyl-4-(2-methylimidazo[1,2-a]pyridin-3-yl)th- iazol-2-yl)cyclopropyl)benzamide; 4-(1-(4-(6-chloro-2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopr- opyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(6-chloro-2-methylimidazo[1,2-a]pyridin-3-yl)th- iazol-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(7-methoxy-2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2- -yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(7-methoxy-2-methylimidazo[1,2-a]pyridin-3-yl)t- hiazol-2-yl)cyclopropyl)benzamide; 4-(1-(4-(7-((dimethylamino)methyl)imidazo[1,2-a]pyridin-3-yl)thiazol-2-yl- )cyclopropyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(7-((dimethylamino)methypimidazo[1,2-a]pyridin-- 3-yl)thiazol-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(7-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridin-3-yl)th- iazol-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(7-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridin- -3-yl)thiazol-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(7-(morpholinomethyl)imidazo[1,2-a]pyridin-3-yl)thiazol- -2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(7-(morpholinomethyl)imidazo[1,2-a]pyridin-3-yl- )thiazol-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(2-methyl-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl- )thiazol-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methyl-6-(trifluoromethyl)imidazo[1,2-a]pyri- din-3-yl)thiazol-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(2-methyl-7-(trifluoromethypimidazo[1,2-a]pyridin-3-yl)- thiazol-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methyl-7-(trifluoromethyl)imidazo[1,2-a]pyri- din-3-yl)thiazol-2-yl)cyclopropyl)benzamide; 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)thiazol-4-yl)-N-(2-methox- yethyl)-2-methylimidazo[1,2-a]pyridine-7-carboxamide; 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)thiazol-4-yl)-N-(2-- methoxyethyl)-2-methylimidazo[1,2-a]pyridine-7-carboxamide; 4-(1-(4-(7-cyano-2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopro- pyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(7-cyano-2-methylimidazo[1,2-a]pyridin-3-yl)thi- azol-2-yl)cyclopropyl)benzamide; 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)thiazol-4-yl)-2-methyl-N-- (2-morpholinoethyl)imidazo[1,2-a]pyridine-7-carboxamide; 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)thiazol-4-yl)-2-met- hyl-N-(2-morpholinoethyl)imidazo[1,2-a]pyridine-7-carboxamide; methyl 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)thiazol-4-yl)-2-methylimi- dazo[1,2-a]pyridine-7-carboxylate; methyl 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)thiazol-4-yl)-2-met- hylimidazo[1,2-a]pyridine-7-carboxylate; N-hydroxy-4-(1-(4-(2-methyl-7-(4-methylpiperazine-1-carbonyl)imidazo[1,2-- a]pyridin-3-yl)thiazol-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methyl-7-(4-methylpiperazine-1-carbonyl)imid- azo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopropyl)benzamide; 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)thiazol-4-yl)-2-methylimi- dazo[1,2-a]pyridine-7-carboxylic acid; 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)thiazol-4-yl)-2-met- hylimidazo[1,2-a]pyridine-7-carboxylic acid; N-hydroxy-4-(1-(4-(2-methyl-7-(2-morpholinoethoxy)imidazo[1,2-a]pyridin-3- -yl)thiazol-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methyl-7-(2-morpholinoethoxy)imidazo[1,2-a]p- yridin-3-yl)thiazol-2-yl)cyclopropyl)benzamide; 4-(1-(4-(7-(2-(dimethylamino)ethoxy)-2-methyl imidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopropyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(7-(2-(dimethylamino)ethoxy)-2-methylimidazo[1,- 2-a]pyridin-3-yl)thiazol-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(7-(2-methoxyethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl- )thiazol-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(7-(2-methoxyethoxy)-2-methyl imidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopropyl)benzamide; 4-(1-(4-(7-(2-(dimethylamino)ethylamino)-2-methylimidazo[1,2-a]pyridin-3-- yl)thiazol-2-yl)cyclopropyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(7-(2-(dimethylamino)ethylamino)-2-methylimidaz- o[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopropyl)benzamide; 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)thiazol-4-yl)-N-(2-methox- yethyl)-2-methylimidazo[1,2-a]pyridine-6-carboxamide; 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)thiazol-4-yl)-N-(2-- methoxyethyl)-2-methylimidazo[1,2-a]pyridine-6-carboxamide; N-hydroxy-4-(1-(4-(2-methyl-6-(4-methylpiperazine-1-carbonyl)imidazo[1,2-- a]pyridin-3-yl)thiazol-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methyl-6-(4-methylpiperazine-1-carbonyl)imid- azo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopropyl)benzamide; 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopropyl)thiazol-4-yl)-2-methyl-N-- (2-morpholinoethyl)imidazo[1,2-a]pyridine-6-carboxamide; 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopropyl)thiazol-4-yl)-2-met- hyl-N-(2-morpholinoethyl)imidazo[1,2-a]pyridine-6-carboxamide; N-hydroxy-4-(1-(4-(6-(2-methoxyethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl- )thiazol-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(6-(2-methoxyethoxy)-2-methylimidazo[1,2-a]pyri- din-3-yl)thiazol-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(6-methoxy-2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2- -yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(6-methoxy-2-methylimidazo[1,2-a]pyridin-3-yl)t- hiazol-2-yl)cyclopropyl)benzamide; 4-(1-(4-(8-fluoro-2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopr- opyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(8-fluoro-2-methylimidazo[1,2-a]pyridin-3-yl)th- iazol-2-yl)cyclopropyl)benzamide; 4-(1-(4-(7-((dimethylamino)methyl)-2-methylimidazo[1,2-a]pyridin-3-yl)thi- azol-2-yl)cyclopropyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(7-((dimethylamino)methyl)-2-methylimidazo[1,2-- a]pyridin-3-yl)thiazol-2-yl)cyclopropyl)benzamide; 4-(1-(4-(6-bromo-2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopro- pyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(6-bromo-2-methylimidazo[1,2-a]pyridin-3-yl)thi- azol-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(7-methoxy-2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-y- l)thiazol-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(7-methoxy-2-(trifluoromethyl)imidazo[1,2-a]pyr- idin-3-yl)thiazol-2-yl)cyclopropyl)benzamide; and pharmaceutically acceptable salts thereof.

19. The compound or pharmaceutically acceptable salt thereof of claim 1 which has a formula selected from the group consisting of: ##STR00444## ##STR00445## wherein R.sup.6', R.sup.7', R.sup.8, R.sup.9 and R.sup.10 are independently selected from H and the functional groups of R.sup.5, wherein each R.sup.6', R.sup.7', R.sup.8, R.sup.9 and R.sup.10 is optionally substituted by one or more D.

20. The compound of claim 19 which is selected from the group consisting of: N-hydroxy-4-(1-(4-(1-isopropyl-2-methylimidazol-5-yl)thiazol-2-yl)cyc- lopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(1-isopropyl-2-methylimidazol-5-yl)thiazol-2-yl- )cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(4-isopropyl-5-methyl-1,2,4-triazol-3-yl)thiazol-2-yl)c- yclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(4-isopropyl-5-methyl-1,2,4-triazol-3-yl)thiazo- l-2-yl)cyclopropyl)benzamide; N-hydroxy-4-(1-(4-(pyridin-3-yl)thiazol-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(pyridin-3-yl)thiazol-2-yl)cyclopropyl)benzamid- e; N-hydroxy-4-(1-(4-(pyridin-4-yl)thiazol-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(pyridin-4-yl)thiazol-2-yl)cyclopropyl)benzamid- e; N-hydroxy-4-(1-(4-(pyridin-2-yl)thiazol-2-yl)cyclopropyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(pyridin-2-yl)thiazol-2-yl)cyclopropyl)benzamid- e; N-(2-aminophenyl)-4-(1-(4-(pyrazin-2-yl)thiazol-2-yl)cyclopropyl)benzam- ide; and pharmaceutically acceptable salts thereof.

21. The compound of claim 1 or pharmaceutically acceptable salt thereof which has a formula selected from the group consisting of: ##STR00446## wherein q is 2, 3, 4, or 5; R.sup.6 and R.sup.7 are independently H or the functional groups of R.sup.4, or form a 5- or 6-membered cyclic moiety to make a fused ring with the thiazole ring, wherein the cyclic moiety can contain one or more heteroatoms selected from N, O and S; wherein each R.sup.6 and R.sup.7 is optionally substituted by one or more B; and R.sup.6', R.sup.7', R.sup.8, R.sup.9 and R.sup.10 are independently selected from H, halo, nitro, cyano, hydroxyl, hydroxy(C.sub.1-10 alkyl), haloalkyl, haloalkoxy, amino, azido, carboxyl, carbamoyl, mercapto, sulphamoyl, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.1-10 alkoxy, C.sub.1-10 alkanoyl, C.sub.1-10 alkanoyloxy, N--(C.sub.1-10 alkyl)amino, N,N--(C.sub.1-10 alkyl).sub.2-amino, alkanoylamino, N--(C.sub.1-10 alkyl)carbamoyl, N,N--(C.sub.1-10 alkyl).sub.2-carbamoyl, C.sub.1-10 alkyl-S(O).sub.a wherein a is 0, 1 or 2, C.sub.1-10 alkoxycarbonyl, NH.sub.2--S(O).sub.2NH--, N--(C.sub.1-10 alkyl)sulphamoyl, and N,N--(C.sub.1-10 alkyl).sub.2sulphamoyl, wherein each R.sup.6', R.sup.7', R.sup.8, R.sup.9 and R.sup.10 is optionally substituted by one or more D.

22. The compound of claim 21 which is selected from the group consisting of: N-hydroxy-4-(1-(4-(imidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopenty- l)benzamide; N-hydroxy-4-(1-(4-(imidazo[1,2-a]pyridin-3-yl)-5-methylthiazol-2-yl)cyclo- pentyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(imidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclop- entyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(imidazo[1,2-a]pyridin-3-yl)-5-methylthiazol-2-- yl)cyclopentyl)benzamide; N-hydroxy-4-(1-(4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclop- entyl)benzamide; N-hydroxy-4-(1-(5-methyl-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-- yl)cyclopentyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-y- l)cyclopentyl)benzamide; N-(2-aminophenyl)-4-(1-(5-methyl-4-(2-methylimidazo[1,2-a]pyridin-3-yl)th- iazol-2-yl)cyclopentyl)benzamide; 4-(1-(4-(6-chloro-2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclope- ntyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(6-chloro-2-methylimidazo[1,2-a]pyridin-3-yl)th- iazol-2-yl)cyclopentyl)benzamide; N-hydroxy-4-(1-(4-(7-methoxy-2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2- -yl)cyclopentyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(7-methoxy-2-methylimidazo[1,2-a]pyridin-3-yl)t- hiazol-2-yl)cyclopentyl)benzamide; 4-(1-(4-(7-((dimethylamino)methyl)imidazo[1,2-a]pyridin-3-yl)thiazol-2-yl- )cyclopentyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(7-((dimethylamino)methyl)imidazo[1,2-a]pyridin- -3-yl)thiazol-2-yl)cyclopentyl)benzamide; N-hydroxy-4-(1-(4-(7-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridin-3-yl)th- iazol-2-yl)cyclopentyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(7-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridin- -3-yl)thiazol-2-yl)cyclopentyl)benzamide; N-hydroxy-4-(1-(4-(7-(morpholinomethyl)imidazo[1,2-a]pyridin-3-yl)thiazol- -2-yl)cyclopentyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(7-(morpholinomethyl)imidazo[1,2-a]pyridin-3-yl- )thiazol-2-yl)cyclopentyl)benzamide; N-hydroxy-4-(1-(4-(2-methyl-6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl- )thiazol-2-yl)cyclopentyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methyl-6-(trifluoromethyl)imidazo[1,2-a]pyri- din-3-yl)thiazol-2-yl)cyclopentyl)benzamide; N-hydroxy-4-(1-(4-(2-methyl-7-(trifluoromethypimidazo[1,2-a]pyridin-3-yl)- thiazol-2-yl)cyclopentyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methyl-7-(trifluoromethyl)imidazo[1,2-a]pyri- din-3-yl)thiazol-2-yl)cyclopentyl)benzamide; 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopentyl)thiazol-4-yl)-N-(2-methox- yethyl)-2-methylimidazo[1,2-a]pyridine-7-carboxamide; 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopentyl)thiazol-4-yl)-N-(2-- methoxyethyl)-2-methylimidazo[1,2-a]pyridine-7-carboxamide; 4-(1-(4-(7-cyano-2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopen- tyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(7-cyano-2-methylimidazo[1,2-a]pyridin-3-yl)thi- azol-2-yl)cyclopentyl)benzamide; 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopentyl)thiazol-4-yl)-2-methyl-N-- (2-morpholinoethyl)imidazo[1,2-a]pyridine-7-carboxamide; 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopentyl)thiazol-4-yl)-2-met- hyl-N-(2-morpholinoethyl)imidazo[1,2-a]pyridine-7-carboxamide; methyl 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopentyl)thiazol-4-yl)-2-methylimi- dazo[1,2-a]pyridine-7-carboxylate; methyl 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopentyl)thiazol-4-yl)-2-met- hylimidazo[1,2-a]pyridine-7-carboxylate; N-hydroxy-4-(1-(4-(2-methyl-7-(4-methylpiperazine-1-carbonyl)imidazo[1,2-- a]pyridin-3-yl)thiazol-2-yl)cyclopentyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methyl-7-(4-methylpiperazine-1-carbonyl)imid- azo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopentyl)benzamide; 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopentyl)thiazol-4-yl)-2-methylimi- dazo[1,2-a]pyridine-7-carboxylic acid; 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopentyl)thiazol-4-yl)-2-met- hylimidazo[1,2-a]pyridine-7-carboxylic acid; N-hydroxy-4-(1-(4-(2-methyl-7-(2-morpholinoethoxy)imidazo[1,2-a]pyridin-3- -yl)thiazol-2-yl)cyclopentyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methyl-7-(2-morpholinoethoxy)imidazo[1,2-a]p- yridin-3-yl)thiazol-2-yl)cyclopentyl)benzamide; 4-(1-(4-(7-(2-(dimethylamino)ethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl)t- hiazol-2-yl)cyclopentyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(7-(2-(dimethylamino)ethoxy)-2-methylimidazo[1,- 2-a]pyridin-3-yl)thiazol-2-yl)cyclopentyl)benzamide; N-hydroxy-4-(1-(4-(7-(2-methoxyethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl- )thiazol-2-yl)cyclopentyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(7-(2-methoxyethoxy)-2-methyl imidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopentyl)benzamide; 4-(1-(4-(7-(2-(dimethylamino)ethylamino)-2-methylimidazo[1,2-a]pyridin-3-- yl)thiazol-2-yl)cyclopentyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(7-(2-(dimethylamino)ethylamino)-2-methylimidaz- o[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopentyl)benzamide; 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopentyl)thiazol-4-yl)-N-(2-methox- yethyl)-2-methylimidazo[1,2-a]pyridine-6-carboxamide; 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopentyl)thiazol-4-yl)-N-(2-- methoxyethyl)-2-methylimidazo[1,2-a]pyridine-6-carboxamide; N-hydroxy-4-(1-(4-(2-methyl-6-(4-methylpiperazine-1-carbonyl)imidazo[1,2-- a]pyridin-3-yl)thiazol-2-yl)cyclopentyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(2-methyl-6-(4-methylpiperazine-1-carbonyl)imid- azo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopentyl)benzamide; 3-(2-(1-(4-(hydroxycarbamoyl)phenyl)cyclopentyl)thiazol-4-yl)-2-methyl-N-- (2-morpholinoethyl)imidazo[1,2-a]pyridine-6-carboxamide; 3-(2-(1-(4-(2-aminophenylcarbamoyl)phenyl)cyclopentyl)thiazol-4-yl)-2-met- hyl-N-(2-morpholinoethyl)imidazo[1,2-a]pyridine-6-carboxamide; N-hydroxy-4-(1-(4-(6-(2-methoxyethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl- )thiazol-2-yl)cyclopentyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(6-(2-methoxyethoxy)-2-methylimidazo[1,2-a]pyri- din-3-yl)thiazol-2-yl)cyclopentyl)benzamide; N-hydroxy-4-(1-(4-(6-methoxy-2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2- -yl)cyclopentyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(6-methoxy-2-methylimidazo[1,2-a]pyridin-3-yl)t- hiazol-2-yl)cyclopentyl)benzamide; 4-(1-(4-(8-fluoro-2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclope- ntyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(8-fluoro-2-methylimidazo[1,2-a]pyridin-3-yl)th- iazol-2-yl)cyclopentyl)benzamide; 4-(1-(4-(7-((dimethylamino)methyl)-2-methylimidazo[1,2-a]pyridin-3-yl)thi- azol-2-yl)cyclopentyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(7-((dimethylamino)methyl)-2-methylimidazo[1,2-- a]pyridin-3-yl)thiazol-2-yl)cyclopentyl)benzamide; 4-(1-(4-(6-bromo-2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopen- tyl)-N-hydroxybenzamide; N-(2-aminophenyl)-4-(1-(4-(6-bromo-2-methylimidazo[1,2-a]pyridin-3-yl)thi- azol-2-yl)cyclopentyl)benzamide; N-hydroxy-4-(1-(4-(7-methoxy-2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-y- l)thiazol-2-yl)cyclopentyl)benzamide; N-(2-aminophenyl)-4-(1-(4-(7-methoxy-2-(trifluoromethyl)imidazo[1,2-a]pyr- idin-3-yl)thiazol-2-yl)cyclopentyl)benzamide; N-(2-Amino-phenyl)-4-[1-(4-pyridin-3-yl-thiazol-2-yl)-cyclopentyl]-benzam- ide; and pharmaceutically acceptable salts thereof.

Details for Patent 8,198,299

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Gilead Sciences, Inc. (Foster City, CA) 2028-07-28 RX search
Genentech RITUXAN rituximab VIAL 103705 001 1997-11-26   Start Trial Gilead Sciences, Inc. (Foster City, CA) 2028-07-28 RX search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial Gilead Sciences, Inc. (Foster City, CA) 2028-07-28 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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