Claims for Patent: 7,850,992

Summary for Patent: 7,850,992

Title:	Cucurbituril-containing gel and method of preparing the same
Abstract:	Provided are a gel including a compound represented by Formula 1 below and a method of preparing the same: ##STR00001## wherein n, X, A.sub.1, and A.sub.2 are as defined in the specification.
Inventor(s):	Kim; Kimoon (Pohang, KR), Hwang; II Ha (Pohang, KR), Jeon; Woo Sung (Pohang, KR), Kim; Hee Joon (Pohang, KR), Kim; Dongwoo (Pohang, KR), Selvapalam; Narayanan (Pohang, KR), Nagarajan; Erumaipatty R. (Pohang, KR)
Assignee:	Postech Academy-Industry Foundation (Pohang, KR) Postech Foundation (Pohang, KR)
Application Number:	11/552,624
Patent Claims:	1. A gel comprising a compound represented by Formula 1 below; and at least one compound selected from the group consisting of a pharmacologically active substance and a stimulus-responsive compound comprising an azobenzene group or a stilbene group: ##STR00006## wherein n is an integer of 4 to 20; X is O, S, or NH; and A.sub.1 and A.sub.2 are each independently H, OR, SR, or NHR where R is selected from the group consisting of H, substituted or unsubstituted C.sub.1-C.sub.30 alkyl, substituted or unsubstituted C.sub.2-C.sub.30 alkenyl, substituted or unsubstituted C.sub.2-C.sub.30 alkynyl, substituted or unsubstituted C.sub.2-C.sub.30 carbonylalkyl, substituted or unsubstituted C.sub.1-C.sub.30 thioalkyl, substituted or unsubstituted C.sub.1-C.sub.30 alkylthiol, substituted or unsubstituted C.sub.1-C.sub.30 hydroxyalkyl, substituted or unsubstituted C.sub.1-C.sub.30 alkylsilyl, substituted or unsubstituted C.sub.1-C.sub.30 aminoalkyl, substituted or unsubstituted C.sub.1-C.sub.30 aminoalkylthioalkyl, substituted or unsubstituted C.sub.5-C.sub.30 cycloalkyl, substituted or unsubstituted C.sub.2-C.sub.30 heterocycloalkyl, substituted or unsubstituted C.sub.6-C.sub.30 aryl, substituted or unsubstituted C.sub.6-C.sub.20 arylalkyl, substituted or unsubstituted C.sub.4-C.sub.30 heteroaryl, and substituted or unsubstituted C.sub.4-C.sub.30 heteroarylalkyl. 2. The gel of claim 1, wherein A.sub.1 or A.sub.2 is an allyloxy group. 3. The gel of claim 1, wherein n is 7, X is O, and A.sub.1 and A.sub.2 are each H. 4. The gel of claim 1, wherein the content of the compound of Formula 1 is 1 to 10 wt %. 5. The gel of claim 1, further comprising an acid. 6. The gel of claim 5, wherein the acid is selected from the group consisting of sulfuric acid, hydrochloric acid, nitric acid, phosphoric acid, chloric acid, HBF.sub.4, HPF.sub.6, acetic acid, trifluoroacetic acid, oxalic acid, benzoic acid, ascorbic acid, and HAuCl.sub.4. 7. The gel of claim 1, further comprising a base. 8. The gel of claim 7, wherein the base is selected from the group consisting of sodium hydroxide, potassium hydroxide, calcium hydroxide, methylamine, ethylamine, pyridine, and aniline. 9. The gel of claim 1, wherein the pharmacologically active substance is an organic compound selected from the group consisting of hydrocortisone, prednisolone, spironolatone, testosterone, megestrol acetate, danasol, progesterone, indometasine, amphotericin B, and a combination thereof. 10. The gel of claim 1, wherein the pharmacologically active substance is a protein selected from the group consisting of human growth hormone, G-CSF (granulocyte colony-stimulating factor), GM-CSF (granulocyte-macrophage colony-stimulating factor), erythropoietin, vaccine, antibody, insulin, glucagon, calcitonin, ACTH (adrenocorticotropic hormone), somatostatin, somatotropin, somatomedin, parathormone, thyroxine, a substance secreted from hypothalamus, prolactin, endorphin, VEGF (vascular endothelial growth factor), enkephalin, vasopressin, nerve growth factor, non-naturally occurring opioid, interferon, asparaginase, alginase, superoxide dismutase, trypsin, chymotrypsin, pepsin, and a combination thereof. 11. The gel of claim 1, wherein the stimulus-responsive compound is quinone, benzoquinone, naphthoquinone, anthraquinone, hydroquinone, catechol, viologen, or a compound comprising one of these.

Details for Patent 7,850,992

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978		2026-01-04