Claims for Patent: 7,811,618

Summary for Patent: 7,811,618

Title:	Method for reducing asparagine in food products
Abstract:	A method for reducing the amount of asparagine, a pre-cursor of acrylamide, in food products that are thermally processed. This invention permits the production of foods having significantly reduced levels of acrylamide. The method relies on contacting a potato feed such as potato slices containing asparagine, an acrylamide pre-cursor, with a leaching solution to extract asparagine out of the potato feed. Thermally processing the leached potatoes will result in a potato product having a lower level of acrylamide than a non-leached, thermally processed potato product.
Inventor(s):	Boudreaux; Eric (Dallas, TX), Desai; Pravin Maganlal (Carrollton, TX), Elder; Vincent Allen (Carrollton, TX), Fulcher; John Gregory (Dallas, TX), Joseph; Ponnattu Kurian (Irving, TX), Li; Wu (Plano, TX), Rao; V.N. Mohan (Plano, TX), Topor; Michael Grant (Little Elm, TX), Vogel; Gerald (Plano, TX)
Assignee:	Frito-Lay North America, Inc. (Plano, TX)
Application Number:	11/627,810
Patent Claims:	1. A method of reducing asparagine in a food product comprising the steps of: (a) continuously providing an untreated food feed, said food feed comprising a first concentration of asparagine and starch; b) leaching asparagine out of said untreated food feed with an asparagine-deficient potato extract, thereby forming: a post-wash extract containing asparagine and having excess unbound starch, and a treated food stream having a second concentration of asparagine that is less than said first concentration; (c) removing excess unbound starch with a starch removal unit and removing asparagine from said post-wash extract with at least one asparagine removal unit, thereby regenerating said asparagine-deficient food extract; (d) reusing said asparagine-deficient food extract in step (b). 2. The method of reducing asparagine in a food product of claim 1 wherein said leaching of step (b) further comprises counter-current leaching. 3. The method of reducing asparagine in a food product of claim 1 wherein step (b) is performed using a screw-type extractor. 4. The method of reducing asparagine in a food product of claim 1 wherein step (b) is performed using a wash-tank type extractor. 5. The method of reducing asparagine in a food product of claim 1 wherein step (b) is performed using a Bollman-type percolation extractor. 6. The method of reducing asparagine in a food product of claim 1 wherein said asparagine-deficient food extract and said untreated food feed are in equilibrium with each other with respect to the concentrations of water-soluble matter other than asparagine. 7. The method of reducing asparagine in a food product of claim 1 wherein step (c) further comprises percolating said post-wash extract through an extraction column filled with an ion exchange resin. 8. The method of reducing asparagine in a food product of claim 1 wherein step (c) further comprises percolating said post-wash extract through an extraction column filled with an immobilized asparaginase resin. 9. The method of claim 8 further comprising the step of removing ammonia from said asparagine-deficient food extract. 10. The method of claim 1 wherein an effective amount of asparaginase is added to said post-wash extract at step c) such that said asparagine-deficient food extract comprises less than about 50% of the asparagine concentration in said post-wash extract. 11. The method of claim 10 further comprising the step of removing ammonia from said asparagine-deficient food extract. 12. The method of claim 1 wherein said treated food stream comprises food slices and wherein said food slices are par-fried in cooking oil having a temperature above about 120.degree. C. until said food slices have a moisture content of between about 3% by weight and about 10% by weight thereby forming a plurality of par-fried food slices, and cooking said par-fried food slices at less than about 120.degree. C. until said par-fried food slices have a final moisture content ranging from about 1% by weight to about 2% by weight thereby forming a plurality of food chips having a reduced acrylamide concentration. 13. A method of reducing asparagine in a food product comprising the steps of: (a) continuously providing a substantially untreated food feed wherein said untreated food feed contains asparagine; (b) leaching asparagine out of said untreated food feed with an asparagine-deficient food extract, thereby forming a post-wash extract containing asparagine and a treated food stream having reduced levels of asparagine. (c) removing asparagine from said post-wash extract with at least one asparagine removal unit thereby forming an asparagine-deficient food extract; (d) removing at least one reaction product selected from the group consisting of ammonia and aspartic acid from said asparagine-deficient food extract. 14. The method of reducing asparagine in a food product of claim 13 wherein said untreated food feed further contains starch, step (b) further comprises leaching starch out of said untreated food feed with said stream of pure water. 15. The method of reducing asparagine in a food product of claim 13 wherein step (d) is performed using an aspartic acid removal unit. 16. The method of reducing asparagine in a food product of claim 13 wherein step (d) is performed using an ammonia removal unit. 17. The method of reducing asparagine in a food product of claim 16 wherein said ammonia unit further comprises a sorbent. 18. The method of reducing asparagine in a food product of claim 15 wherein said reaction product is removed with an ion exchange resin. 19. The method of reducing asparagine in a food product of claim 13 wherein said ammonia is removed by one or more removal methods selected from heating said asparagine-deficient food extract, reducing pressure of the asparagine-deficient food extract, and bubbling a gas through said asparagine-deficient food extract. 20. The method of reducing asparagine in a food product of claim 13 wherein said reaction product is removed by adjusting a pH of said asparagine-deficient food extract. 21. The method of reducing asparagine in a food product of claim 13 wherein said aspartic acid is removed with an ultra-filtration membrane. 22. The method of reducing asparagine in a food product of claim 13 wherein step (c) further comprises percolating said post-wash extract through an extraction column filled with an ion exchange resin. 23. The method of claim 22 further comprising the step of removing ammonia from said asparagine-deficient food extract. 24. The method of reducing asparagine of claim 13 wherein the removal unit at step c) comprises post wash extract and an asparagine-deficient food extract wherein step c) further comprises adding an effective amount of asparaginase such that said asparagine-deficient food extract comprises less than about 50% of the asparagine concentration in said post-wash extract. 25. The method of claim 24 further comprising the step of removing ammonia from said asparagine-deficient food extract. 26. The method of claim 13 wherein said treated food stream comprises food slices and wherein said food slices are par-fried in cooking oil having a temperature above about 120.degree. C. until said food slices have a moisture content of between about 3% by weight and about 10% by weight thereby forming a plurality of par-fried food slices, and cooking said par-fried food slices at less than about 120.degree. C. until said par-fried food slices have a final moisture content ranging from about 1% by weight to about 2% by weight thereby forming a plurality of food chips having a reduced acrylamide concentration. 27. The method of claim 13 wherein said leaching at step b) occurs for at least 15 minutes. 28. The method of claim 13 wherein said asparagine-deficient food extract is heated to a temperature of between about 100.degree. F. and about 150.degree. F. 29. The method of claim 13 wherein said asparagine-deficient food extract at step b) comprises between about 0.5 grams and about 2 grams of a raw potato per 1 mL of added solution. 30. The method of claim 13 wherein said asparagine-deficient food extract comprises between about 3000 units to about 100,000 units of asparaginase per 1.4 liters of said asparagine-deficient food extract. 31. The method of claim 1 wherein said leaching at step b) occurs for at least 15 minutes. 32. The method of claim 1 wherein said asparagine-deficient food extract is heated to a temperature of between about 100.degree. F. and about 150.degree. F. 33. The method of claim 1 wherein said asparagine-deficient food extract at step b) comprises between about 0.5 grams and about 2 grams of a raw food per 1 mL of added solution. 34. The method of claim 1 wherein said asparagine-deficient food extract comprises between about 3,000 units to about 100,000 units of asparaginase per kilogram of a raw food used to make said asparagine deficient food extract. 35. The method of claim 1 wherein said food ingredient comprises a sliced food ingredient. 36. The method of claim 35 wherein said sliced food ingredient comprises potato. 37. The method of claim 1 wherein said food ingredient comprises French fries. 38. The method of claim 1 comprising one or more food ingredients selected from rice, wheat, corn, barley, soy, oats, and roasted cacao beans.

Details for Patent 7,811,618

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978		2022-09-19