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Last Updated: May 8, 2024

Claims for Patent: 7,700,554

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Summary for Patent: 7,700,554

Title:	Compositions for modulating blood-brain barrier transport
Abstract:	This invention provides conjugates of therapeutic or active agents with melanotransferrin or with other ligands of a melanotransferrin receptor, melanotransferrin receptor modulators, and related compositions and methods for modulating blood-brain barrier transport by providing methods of screening and selecting such conjugates, ligands, and modulators in vitro and in vivo, and methods of use of such conjugates, modulators and ligands in diagnosis and the treatment of diseases, including particularly diseases of the central nervous system or lysosomal storage diseases.
Inventor(s):	Beliveau; Richard (Ile Des Soeurs, CA), Demeule; Michel (Longueuil, CA), Yang; Joseph (North Delta, CA), Kennard; Malcolm L. (North Vancouver, CA), Gabathuler; Reinhard (San Rafael, CA)
Assignee:	Raptor Pharmaceuticals Inc. (Novato, CA)
Application Number:	11/580,497
Patent Claims:	1. A sterile composition comprising (a) a conjugate comprising receptor associated protein (RAP) and a chemotherapeutic agent, and (b) a sterile pharmaceutically acceptable carrier wherein the chemotherapeutic agent is selected from the group consisting of an alkylating agent, an alkaloid, an anti-metabolite, and an antibiotic. 2. The composition of claim 1 wherein the chemotherapeutic agent is selected from the group consisting of mechlorethamine hydrochloride, cyclopho sphamide, ifosfamide, chlorambucil, melphalan, busulfan, thiotepa (triethylenethiophosphoramide), carmustine, lomustine, streptozocin, vincristine, vinblastine, paclitaxel, methotrexate, mercaptopurine, thioguanine, fluorouracil, cytarabine, azacitidine, dactinomycin, doxorubicin, daunorubicin, idarubicin, bleomycin, picamycin, mitomycin, hydroxyurea, procarbazine, dacarbazine, cisplatin, carboplatin, asparaginase, etoposide, amsarcrine, mitotane, and mitoxantrone.

Details for Patent 7,700,554

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978	⤷ Try a Trial	2021-07-25
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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