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Last Updated: April 26, 2024

Claims for Patent: 7,473,559

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Summary for Patent: 7,473,559

Title:	Method for measuring the content of a botulinum toxin in a formulation
Abstract:	A method of measuring the concentration of a bioactive agent is disclosed.
Inventor(s):	Lee; Charles (Los Angeles, CA)
Assignee:
Application Number:	11/400,161
Patent Claims:	1. A method of determining the concentration of a bioactive agent in a pharmaceutical formulation comprising a bioactive agent, comprising: determining a correlation between the bioactive agent and a marker compound in the formulation by deriving a ratio of the bioactive agent to the marker compound in the formulation, measuring the concentration of the marker compound in the formulation, and determining the concentration of the bioactive agent using the concentration of the marker compound and the ratio of the bioactive agent to the marker compound, wherein the bioactive agent is a botulinum toxin, and wherein the marker compound is selected from the group consisting of albumin, and human serum albumin. 2. The method of claim 1, wherein the marker compound is albumin. 3. The method of claim 1, wherein the marker compound is human serum albumin (HSA). 4. The method of claim 1, wherein the marker compound is detected by high-performance liquid chromatography, fluorescence spectroscopy, liquid-chromatography/mass-spectrometry, ultraviolet/visible spectroscopy. 5. The method of claim 1, wherein the bioactive agent is Clostridium Botulinum toxin A. 6. The method of claim 2, wherein the bioactive agent is Clostridium Botulinum toxin A. 7. The method of claim 3, wherein the bioactive agent is Clostridium Botulinum toxin A. 8. The method of claim 4, wherein the bioactive agent is Clostridium Botulinum toxin A. 9. The method of claim 1, wherein the formulation is a liquid formulation. 10. The method of claim 3, wherein the formulation is a liquid formulation. 11. The method of claim 4, wherein the formulation is a liquid formulation. 12. A method of providing cosmetic treatment using a botulinum toxin, comprising: determining the content of the botulinum toxin in a formulation according to the method of claim 1, providing an amount of botulinum toxin according to the content determined according to the determining step, and administering to a user the amount of the botulinum toxin in the formulation. 13. A method of providing cosmetic treatment using a botulinum toxin, comprising: determining the content of the botulinum toxin in a formulation according to the method of claim 3, providing an amount of botulinum toxin according to the content determined according to the determining step, and administering to a user the amount of the botulinum toxin in the formulation. 14. The method of claim 12, wherein the botulinum toxin is Clostridium Botulinum A. 15. The method of claim 13, wherein the botulinum toxin is Clostridium Botulinum A.

Details for Patent 7,473,559

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5	albumin (human)	For Injection	101138	10/21/1942	⤷ Try a Trial	2040-01-28
Baxalta Us Inc.	BUMINATE, FLEXBUMIN	albumin (human)	Injection	101452	03/03/1954	⤷ Try a Trial	2040-01-28
Csl Behring Ag	ALBURX	albumin (human)	Injection	102366	07/23/1976	⤷ Try a Trial	2040-01-28
Grifols Biologicals Llc	ALBUTEIN	albumin (human)	Injection	102478	08/15/1978	⤷ Try a Trial	2040-01-28
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	02/17/1995	⤷ Try a Trial	2040-01-28
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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