Claims for Patent: 6,403,758

Summary for Patent: 6,403,758

Title:	Bioresorbable compositions for implantable prostheses
Abstract:	Crosslinked compositions formed from a water-insoluble copolymer are disclosed. These compositions are copolymers having a bioresorbable region, a hydrophilic region and at least two crosslinkable functional groups per polymer chain. These compositions are able to form hydrogels in aqueous environments when crosslinked. These hydrogels are good sealants for implantable prostheses when in contact with an aqueous environment. In addition, such hydrogels can be used as delivery vehicles for therapeutic agents.
Inventor(s):	Loomis; Gary L. (Morristown, NJ)
Assignee:	Scimed Life Systems, Inc. (Maple Grove, MN)
Application Number:	09/436,774
Patent Claims:	1. A covalently crosslinkable composition comprising an aqueous emulsion comprising about 20% by weight of a water-insoluble copolymer having (i) a bioresorbable region; (ii) a hydrophilic region; and (iii) a plurality of crosslinkable functional groups per polymer chain. 2. The composition of claim 1, wherein said copolymer has the following chemical structure: ##STR2## wherein x is from about 10 to about 50 and y is from about 50 to about 300. 3. The composition of claim 1, wherein the ratio of said bioresorbable region to said hydrophilic region is from about 10:1 to about 1:1 on a percent by weight basis. 4. The composition of claim 1, wherein said bioresorbable region is selected from the group consisting of poly(esters), poly(hydroxy acids), poly (lactones), poly (amides), poly(ester-amides), poly (amino acids), poly(anhydrides), poly(orthoesters), poly(carbonates), poly(phosphazines), poly(phosphoesters), poly(thioesters), polysaccharides, polylactic acid, polyglycolic acid, polycaproic acid, polybutyric acid, polyvaleric acid and copolymers and mixtures thereof. 5. The composition of claim 1, wherein said hydrophilic region is selected from the group consisting of polyethers, polyalkylene oxides, polyols, poly(vinylpyrrolidine), poly(vinyl alcohol), poly(alkyl oxazolines), polysaccharides, carbohydrates, peptides, proteins and copolymers and mixtures thereof. 6. The compositions of claim 1, wherein said copolymer is selected from the group consisting of di-block copolymers, tri-block copolymers, and star copolymers. 7. The composition of claim 6, wherein said tri-block copolymer has the general formula: wherein A is the bioresorbable region, B is the hydrophilic region, and x is the crosslinkable functional group. 8. A process for forming a hydrogel, comprising: a. providing an aqueous emulsion comprising about 20% by weight of a water-insoluble covalently cross-linkable copolymer having (I) a bioresorbable region; (ii) a hydrophilic region; and (iii) a plurality of crosslinkable functional groups per polymer chain; and b. effecting crosslinking of said cross-linkable functional groups. 9. The process of claim 8, wherein said copolymer has the following chemical structure: ##STR3## wherein x is from about 10 to about 50 and y is from about 50 to about 300. 10. The process of claim 8, wherein the ratio of said bioresorbable region to said hydrophilic region is from about 1 0:1 to about 1:1 on a percent by weight basis. 11. The process of claim 8, wherein said bioresorbable region is selected from the group consisting of poly(esters), poly(hydroxy acids), poly (lactones), poly (amides), poly(ester-amides), poly (amino acids), poly(anhydrides), poly(orthoesters), poly(carbonates), poly(phosphazines), poly(phosphoesters), poly(thioesters), polysaccharides, polylactic acid, polyglycolic acid, polycaproic acid, polybutyric acid, polyvaleric acid and copolymers and mixtures thereof. 12. The process of claim 8, wherein said copolymer is selected from the group consisting of di-block copolymers, tri-block copolymers, and star copolymers. 13. The composition of claim 12, wherein said tri-block copolymer has the general formula: wherein A is the bioresorbable region, B is the hydrophilic region, and x is the crosslinkable functional group. 14. A medical device having on at least one surface thereof a bioresorbable coating composition, said composition comprising an aqueous emulsion comprising about 20% by weight of a water-insoluble copolymer having (I) a bioresorbable region; (ii) a hydrophilic region; and (iii) a plurality of crosslinkable functional groups per polymer chain. 15. The medical device of claim 14, wherein said hydrogel is useful as a drug or bio-active agent delivery vehicle. 16. The medical device of claim 15, wherein said drug or bio-active agent is selected from the group consisting of thrombo-resistant agents, antibiotic agents, anti-tumor agents, antiviral agents, anti-angiogenic agents, angiogenic agents, anti-inflammatory agents, cell cycle regulating agents, and chemically modified equivalents and combinations thereof. 17. The medical device of claim 16, wherein said thrombo-resistant agents are selected from the group consisting of heparin, heparin sulfate, hirudin, hyaluronic acid, chondroitin sulfate, dermatan sulfate, keratan sulfate, lytic agents, urokinase, streptokinase, and chemically modified equivalents and combinations thereof. 18. The medical device of claim 16, wherein said antibiotic agents are selected from the group consisting of penicillins, cephalosporins, vancomycins, aminoglycosides, quinolones, polymyxins, erythromycins, tetracyclines, chloramphenicols, clindamycins, lincomycins, sulfonamides, and chemically modified equivalents and combinations thereof. 19. The medical device of claim 16, wherein said anti-tumor agents are selected from the group consisting of paclitaxel, mechlorethamine, chlorambucil, cyclophosphamide, melphalan, ifosfamide, methotrexate, 6-mercaptopurine, 5-fluorouracil, cytarabine, vinblastine, vincristine, etoposide, doxorubicin, daunomycin, bleomycin, mitomycin, carmustine, lomustine, cisplatin, interferon, asparaginase, tamoxifen, flutamide, and chemically modified equivalents and combinations thereof. 20. The medical device of claim 16, wherein said anti-viral agents are selected from the group consisting of amantadines, rimantadines, ribavirins, idoxuridines, vidarabines, trifluridines, acyclovirs, ganciclovirs, zidovudines, foscarnets, interferons, and chemically modified equivalents and combinations thereof. 21. The medical device of claim 14 formed from an implantable material. 22. The medical device of claim 21, wherein said implantable material is selected from the group consisting of polymeric compositions, non-polymeric compositions and combinations thereof.

Details for Patent 6,403,758

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Microbix Biosystems Inc.	KINLYTIC	urokinase	For Injection	021846	01/16/1978		2017-08-18
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978		2017-08-18