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Last Updated: December 17, 2025

Claims for Patent: 6,331,415

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Summary for Patent: 6,331,415

Title:	Methods of producing immunoglobulins, vectors and transformed host cells for use therein
Abstract:	The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce both the heavy and light chains or fragments thereof in a single cell. The invention also relates to the vectors used to produce the immunoglobulin or fragment, and to cells transformed with the vectors.
Inventor(s):	Shmuel Cabilly, Herbert L. Heyneker, William E. Holmes, Arthur D. Riggs, Ronald B. Wetzel
Assignee:	Genentech Inc
Application Number:	US07/205,419

Details for Patent 6,331,415

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eli Lilly And Company	ERBITUX	cetuximab	Injection	125084	February 12, 2004	6,331,415	2018-12-18
Eli Lilly And Company	ERBITUX	cetuximab	Injection	125084	March 28, 2007	6,331,415	2018-12-18
Novartis Pharmaceuticals Corporation	ARZERRA	ofatumumab	Injection	125326	October 26, 2009	6,331,415	2018-12-18
Novartis Pharmaceuticals Corporation	ARZERRA	ofatumumab	Injection	125326	April 01, 2011	6,331,415	2018-12-18
Novartis Pharmaceuticals Corporation	KESIMPTA	ofatumumab	Injection	125326	August 20, 2020	6,331,415	2018-12-18
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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