Claims for Patent: 5,147,641

Summary for Patent: 5,147,641

Title:	Microcapsule for the removal of specific amino acids through the entero-portal recirculation
Abstract:	A microcapsule for oral administration comprising an outer layer membrane which is acid resistant and retains its structure in an alkaline environment, said membrane having dispersed therein at least one enzyme corresponding to an amino acid secreted into the intestinal or derived from a protein or peptide secreted into the intestinal tract. The present invention provides a microcapsule capable of removing specific unwanted amino acids secreted into the intestinal tract.
Inventor(s):	Chang; Thomas M. S. (St-Lambert, CA), Bourget; Louis (Pierrefonds, CA), Lister; Colin (Brossard, CA)
Assignee:	The Royal Institution for the Advancement of Learning (McGill University) (Quebec, CA)
Application Number:	07/719,110
Patent Claims:	1. A method for decreasing the reabsorption of at least one undesirable endogenous amino acid selected from only the amino acids secreted directly into the intestinal tract from the enteroportal recirculation system of the human body, which comprises orally administering microcapsules consisting of an outer-layer membrane which is acid resistant and retains its structure in an alkaline environment, said membrane encapsulating at least one enzyme capable of degrading said undesirable amino acid present in the intestinal tract or derived from a protein or peptide secreted into the intestinal tract wherein said undesirable amino acid in the intestinal tract will diffuse into said microcapsules where said amino acid is subjected to a partial or complete degradation by the encapsulated enzyme and the degradation products are then secreted from said microcapsules into the intestinal tract and said microcapsules are naturally excreted from the intestinal tract. 2. The method of claim 1, wherein the enzyme is asparaginase and the secreted amino acid is asparagine. 3. The method of claim 1, wherein the enzyme is tyrosinase and the secreted amino acid is tyrosine. 4. The method of claim 1, wherein the enzyme is glutaminase and the secreted amino acid is glutamine. 5. The method of claim 1, wherein the enzyme is histidinase and the secreted amino acid is histidine. 6. The method of claim 1, wherein the enzyme is tryptophanase and the secreted amino acid is tryptophan. 7. The method of claim 1, wherein the enzyme is phenylalanine ammonialyase and the secreted amino acid is valine. 8. The method of claim 1, wherein the enzyme is arginase and the secreted amino acid is arginine. 9. The method of claim 1, wherein the enzyme is lysine decarboxylase and the secreted amino acid is lysine. 10. The method of claim 1, wherein the enzyme is methionine racemase and the secreted amino acid is methionine. 11. The method of claim 1, wherein the enzyme is cystine desulphydrase and the secreted amino acid is cystine. 12. The method of claim 1, wherein the enzyme is a deaminase and the secreted amino acid is proline.

Details for Patent 5,147,641

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978		2009-09-15