Claims for Patent: 4,057,615

Summary for Patent: 4,057,615

Title:	Method of tagging excipients with 99M technetium
Abstract:	A method of using .sup.99m technetium for tagging excipients in medical diagnosis by scintigraphy comprises mixing, in an aqueous solution of alkali-metal pertechnetate, an excipient and a reducing agent in the form of a complex, which complex is such that the association constant of the anion with reduced technetium is less than the association constant of the excipient with reduced technetium, thereby forming a radio-pharmaceutical substance which is a complex between the excipient and .sup.99m technetium.
Inventor(s):	Bardy; Andre (Morangis, FR), Beydon; Jacqueline (Paris, FR), Gobin; Renee (Paris, FR), Hegesippe; Michel (Cernay-la-Ville, FR)
Assignee:	Commissariat a l\'Energie Atomique (Paris, FR)
Application Number:	05/599,977
Patent Claims:	1. A method of using .sup.99m Tc for tagging excipients in medical diagnosis by scintigraphy, which method comprises mixing, in an aqueous solution of alkalimetal pertechnetate, an excipient and a reducing agent complex present in a lower concentration, wherein the association constant of the anion of the reducing agent complex with reduced technetium is less than the association constant of the excipient with reduced technetium, thus forming a radio-pharmaceutical substance which is a complex between the excipient and 99.sup.m technetium. 2. A method of tagging according to claim 1, wherein sodium pertechnetate in 9% NaCl saline solution is used. 3. A method of tagging according to claim 1, wherein the excipient is selected from among DTPA, bleomycin, albumin from human serum, erythrocytes, tetracycline, disodium citrate, polyphosphates, gluconate and dimercaptosuccinate. 4. A method of tagging according to claim 1, wherein stannous pyrophosphate is the reducing agent complex. 5. The method of claim 3, wherein said stannous pyrophosphate and said excipient are mixed together in a neutral aqueous solution prior to mixing with said solution of alkali-metal pertechnetate. 6. A method of tagging according to claim 4, wherein a solution of tin pyrophosphate is used at a pH between 5.5 and 6.5, corresponding to an Sn.sup.II content of approx. 5.mu.g. 7. A method of tagging according to claim 4, wherein stannous pyrophosphate is used in solid form and in the form of a powder.

Details for Patent 4,057,615

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5	albumin (human)	For Injection	101138	10/21/1942		1994-11-08
Baxalta Us Inc.	BUMINATE, FLEXBUMIN	albumin (human)	Injection	101452	03/03/1954		1994-11-08
Csl Behring Ag	ALBURX	albumin (human)	Injection	102366	07/23/1976		1994-11-08
Grifols Biologicals Llc	ALBUTEIN	albumin (human)	Injection	102478	08/15/1978		1994-11-08
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	02/17/1995		1994-11-08
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	06/11/2003		1994-11-08