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Last Updated: March 16, 2026

Claims for Patent: 11,124,578

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Summary for Patent: 11,124,578

Title:	Method of treating transplant rejection with silent Fc variants of anti-CD40 antibodies
Abstract:	The present invention relates to silent Fc variants of anti-CD40 antibodies and compositions and methods of use of said antibodies for treating pathological disorders such as autoimmune and inflammatory disorders and/or for preventing or reducing the risk of graft rejection in transplantation.
Inventor(s):	Heusser Christoph, Rush James, Vincent Karen
Assignee:	NOVARTIS AG
Application Number:	US16399250
Patent Claims:

Details for Patent 11,124,578

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Janssen Biotech, Inc.	REMICADE	infliximab	For Injection	103772	August 24, 1998	11,124,578	2039-04-30
Immunex Corporation	ENBREL	etanercept	For Injection	103795	November 02, 1998	11,124,578	2039-04-30
Immunex Corporation	ENBREL	etanercept	For Injection	103795	May 27, 1999	11,124,578	2039-04-30
Immunex Corporation	ENBREL	etanercept	Injection	103795	September 27, 2004	11,124,578	2039-04-30
Immunex Corporation	ENBREL	etanercept	Injection	103795	February 01, 2007	11,124,578	2039-04-30
Immunex Corporation	ENBREL MINI	etanercept	Injection	103795	September 14, 2017	11,124,578	2039-04-30
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 11,124,578

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Country	Patent Number	Estimated Expiration
South Africa	201302532	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	2012065950	⤷ Get Started Free
Uruguay	39292	⤷ Get Started Free
Uruguay	33728	⤷ Get Started Free
United States of America	9828433	⤷ Get Started Free
United States of America	9688768	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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