Last Updated: November 13, 2026

Biologic Drugs With Established Pharmaceutical Class: RANK Ligand Inhibitor

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Patent Expiration
Amgen, Inc.	PROLIA	denosumab	Injection	125320	2010-06-01	⤷ Start Trial	⤷ Start Trial
Amgen Inc.	PROLIA	denosumab	Injection	125320	2010-06-01	10,167,492	⤷ Start Trial
Amgen Inc.	PROLIA	denosumab	Injection	125320	2010-06-01	10,421,987	⤷ Start Trial
Amgen Inc.	PROLIA	denosumab	Injection	125320	2010-06-01	10,513,723	⤷ Start Trial
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Patent Expiration

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