Last Updated: July 1, 2026

Patent: 10,421,987

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Summary for Patent: 10,421,987

Title:	Methods for increasing mannose content of recombinant proteins
Abstract:	The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.
Inventor(s):	Chung-Jr HUANG, Xiaoming Yang
Assignee:	Amgen Inc
Application Number:	US16/039,123
Patent Claims:	see list of patent claims

Details for Patent 10,421,987

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Amgen Inc.	PROLIA	denosumab	Injection	125320	June 01, 2010	⤷ Start Trial	2038-07-18
Amgen Inc.	XGEVA	denosumab	Injection	125320	November 18, 2010	⤷ Start Trial	2038-07-18
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,421,987

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Country	Patent Number	Estimated Expiration
United States of America	9481901	⤷ Start Trial
United States of America	2024200115	⤷ Start Trial
United States of America	2023250460	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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