ZOSYN IN PLASTIC CONTAINER Drug Patent Profile

When do Zosyn In Plastic Container patents expire, and what generic alternatives are available?

Zosyn In Plastic Container is a drug marketed by Baxter Hlthcare Corp and is included in one NDA.

The generic ingredient in ZOSYN IN PLASTIC CONTAINER is piperacillin sodium; tazobactam sodium. There are sixteen drug master file entries for this compound. Seventeen suppliers are listed for this compound. Additional details are available on the piperacillin sodium; tazobactam sodium profile page.

Summary for ZOSYN IN PLASTIC CONTAINER

US Patents:	0
Applicants:	1
NDAs:	1
Finished Product Suppliers / Packagers:	2
Raw Ingredient (Bulk) Api Vendors:	6
DailyMed Link:	ZOSYN IN PLASTIC CONTAINER at DailyMed

Pharmacology for ZOSYN IN PLASTIC CONTAINER

Drug Class	Penicillin-class Antibacterial beta Lactamase Inhibitor
Mechanism of Action	beta Lactamase Inhibitors

US Patents and Regulatory Information for ZOSYN IN PLASTIC CONTAINER

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Baxter Hlthcare Corp	ZOSYN IN PLASTIC CONTAINER	piperacillin sodium; tazobactam sodium	INJECTABLE;INJECTION	050750-003	Feb 24, 1998		RX	Yes	Yes
Baxter Hlthcare Corp	ZOSYN IN PLASTIC CONTAINER	piperacillin sodium; tazobactam sodium	INJECTABLE;INJECTION	050750-001	Feb 24, 1998		RX	Yes	Yes
Baxter Hlthcare Corp	ZOSYN IN PLASTIC CONTAINER	piperacillin sodium; tazobactam sodium	INJECTABLE;INJECTION	050750-002	Feb 24, 1998		RX	Yes	Yes

Expired US Patents for ZOSYN IN PLASTIC CONTAINER

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	Patent No.	Patent Expiration
Baxter Hlthcare Corp	ZOSYN IN PLASTIC CONTAINER	piperacillin sodium; tazobactam sodium	INJECTABLE;INJECTION	050750-002	Feb 24, 1998
Baxter Hlthcare Corp	ZOSYN IN PLASTIC CONTAINER	piperacillin sodium; tazobactam sodium	INJECTABLE;INJECTION	050750-003	Feb 24, 1998
Baxter Hlthcare Corp	ZOSYN IN PLASTIC CONTAINER	piperacillin sodium; tazobactam sodium	INJECTABLE;INJECTION	050750-002	Feb 24, 1998
Baxter Hlthcare Corp	ZOSYN IN PLASTIC CONTAINER	piperacillin sodium; tazobactam sodium	INJECTABLE;INJECTION	050750-001	Feb 24, 1998

International Patents for ZOSYN IN PLASTIC CONTAINER

See the table below for patents covering ZOSYN IN PLASTIC CONTAINER around the world.

Country	Patent Number	Title	Estimated Expiration
United Kingdom	2400557	Inhibition of Particulate Formation in Piperacillin/Tazobactam Parenteral Combinations, using Aminocarboxylic Acid Chelating Agents
Brazil	PI0409450	composições que contêm peperacilina e tazobactamo, úteis para injeção
Poland	1468697
Israel	171337	PHARMACEUTICAL COMPOSITIONS CONTAINING PIPERACILLIN AND TAZOBACTAM, USES THEREOF AND PROCESSES FOR THE PREPARATION THEREOF

ZOSYN IN PLASTIC CONTAINER Market Analysis and Financial Projection

Last updated: February 10, 2026

What Are the Market Dynamics for ZOSYN in Plastic Container?

ZOSYN, a brand of piperacillin-tazobactam, is a broad-spectrum antibiotic used primarily for serious bacterial infections. The shift toward plastic containers for its formulation impacts supply chain dynamics, patient safety, and environmental considerations.

Market Drivers

• Growing Antibiotic Resistance: Rising resistance to standard antibiotics increases demand for broad-spectrum agents like ZOSYN.
• Hospital Usage: ZOSYN is extensively used in hospitals for intra-abdominal infections, pneumonia, and sepsis, underpinning consistent demand.
• Formulation Preference: Plastic containers improve stability, reduce contamination risk, and facilitate more efficient hospital inventory management.
• Regulatory Trends: Favoring plastic over glass containers mitigates breakage risks, aligning with hospital safety policies.

Market Challenges

• Environmental Concerns: Plastic waste disposal liabilities complicate logistics, especially in the context of increasing environmental regulation.
• Cost Dynamics: Transitioning to plastic containers involves higher raw material costs but potentially lowers packaging labor costs.
• Competitive Landscape: Alternative antibiotics with narrow-spectrum activity threaten ZOSYN's market share.
• Generic Competition: At least three major pharmaceutical companies produce ZOSYN generics, intensifying price competition.

Market Size and Growth

The global intravenous (IV) antibiotics market, encompassing ZOSYN, was valued at approximately USD 6.4 billion in 2022. The segment of ZOSYN specifically in plastic containers is difficult to quantify precisely but is projected to grow at a compound annual growth rate (CAGR) of 4-6% through 2028, driven largely by hospital procurement policies and formulation innovations.

Geographical Trends

• North America: Dominates the market, driven by high hospital adoption and regulations favoring plastic packaging.
• Europe: Witnesses steady growth; environmental policies may influence container choice.
• Asia-Pacific: Fastest growth rate, owing to expanding healthcare infrastructure and increasing infection rates.

How Does the Financial Trajectory Look?

Revenue Profile

Major producers of ZOSYN, including Pfizer, account for an estimated USD 800-1,200 million annually in sales globally. Plastic container formulations represent around 85% of sales based on current packaging trends, translating to roughly USD 680-1,020 million.

Cost Structure

• Raw Materials: Plastic resins contribute 40-50% of packaging costs; active pharmaceutical ingredients (API) cost margins vary between 20-30%.
• Manufacturing: Conversion from glass to plastic reduces labor and handling costs, partially offsetting raw material increases.
• Distribution: Plastic containers enhance logistics efficiency, reducing spoilage and breakage costs.

Profitability and Margin Impact

• Increased competition in generics has compressed profit margins. Estimated gross margins for ZOSYN formulations hover around 55-60%. Transitioning to plastic containers can improve margins by reducing waste and labor costs, but involves upfront capital investments.
• Price erosion in key markets due to patent expiries diminishes revenue growth potential.

Market Outlook

The industry's shift to plastic container formulations is expected to support stable revenue streams, with moderate growth driven by hospital procurements and formulary preferences. Expect revenue increments of 3-5% annually over the next five years, contingent on infection rate trends and antimicrobial stewardship policies.

Key Financial Risks

• Stringent environmental policies may impose higher costs or restrict plastic use.
• Price competition from generics may limit revenue increases.
• Disruption in supply chains for raw materials or manufacturing capacity could hinder sales growth.

Key Takeaways

• The increasing global prevalence of bacterial infections and antibiotic resistance fuels demand for broad-spectrum antibiotics like ZOSYN.
• Plastic containers dominate its packaging, equating to a significant portion of sales revenue.
• Cost efficiencies from plastic packaging support profitability despite competitive pressures.
• Growth is steady, with regional variations influenced by healthcare infrastructure and environmental policies.
• Environmental and regulatory factors introduce risks to the growth trajectory.

FAQs

Q1: What is the main reason for moving ZOSYN to plastic containers?
A1: Plastic containers offer improved stability, safety, and logistics efficiency over glass, reducing contamination and breakage risks.

Q2: How does environmental policy affect ZOSYN's plastic packaging?
A2: Stricter waste management regulations and sustainability initiatives may increase costs or limit plastic container use.

Q3: Are generic versions impacting the market for ZOSYN?
A3: Yes; generic competition has eroded profit margins and pressured pricing strategies.

Q4: What is the forecasted growth rate for ZOSYN in plastic containers?
A4: Approximately 4-6% CAGR through 2028, driven by hospital procurement trends.

Q5: Which regions offer the most significant growth opportunities?
A5: Asia-Pacific presents the fastest growth due to expanding healthcare infrastructure, followed by North America.

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References

1. MarketWatch. "Global IV Antibiotics Market Size & Share Report 2022-2028."
2. Pfizer Annual Reports. "ZOSYN Product Overview," 2022.
3. Allied Market Research. "Plastic Packaging Market Insights," 2023.
4. WHO. "Antimicrobial Resistance," 2021.
5. European Medicines Agency. "Guidelines on Packaging and Environmental Considerations," 2022.