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DEFINITY Drug Profile

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When do Definity patents expire, and when can generic versions of Definity launch?

Definity is a drug marketed by Lantheus Medcl and is included in one NDA. There are four patents protecting this drug.

This drug has forty-two patent family members in thirty countries.

The generic ingredient in DEFINITY is perflutren. One supplier is listed for this compound. Additional details are available on the perflutren profile page.

Summary for DEFINITY

International Patents:	42
US Patents:	4
Applicants:	1
NDAs:	1
Suppliers / Packagers:	1
Bulk Api Vendors:	32
Clinical Trials:	43
Patent Applications:	1,497
Formulation / Manufacturing:	see details
Drug Prices:	Drug price information for DEFINITY
DailyMed Link:	DEFINITY at DailyMed

Generic Entry Opportunity Date for DEFINITY

NDA:

021064

Dosage:

INJECTABLE;INTRAVENOUS

^*The generic entry opportunity date is the latter of the last compound-claiming patent and the last regulatory exclusivity protection. Many factors can influence early or later generic entry. This date is provided as a rough estimate of generic entry potential and should not be used as an independent source.

Pharmacology for DEFINITY

Drug Class	Contrast Agent for Ultrasound Imaging
Mechanism of Action	Ultrasound Contrast Activity

Synonyms for DEFINITY

1,1,1,2,2,3,3,3-Octafluoropropane

1,1,1,2,2,3,3,3-octakis(fluoranyl)propane

218599-63-4

300408-51-9

70024-90-7

76-19-7

A838638

AC1L1MIR

AC1Q4IBX

AKOS006228213

ALBUMINE HUMAN, ESSENTIALLY FATTY ACID FREE

Albumins human

AN-23892

AN-37829

C-50894

C3F8

C3F8-gas

CHEBI:31980

CHEMBL1663

CK0N3WH0SR

CTK5E2580

D01738

D0G5BK

DB-056033

DB00556

Definity (TN)

DM-115

DMP 115

DMP-115

DTXSID9052503

EINECS 200-941-9

FC 218

FC 218 (refrigerant)

FCH918400

Flutec PP30

Freon 218

FS-069

FS-69

FS069

FT-0621948

FT-0631321

Genetron 218

HFC 218

I14-14876

KB-59511

liposome-encapsulated perfluoropane microsphere

LS-120891

luminity

MFCD00039239

MRX 115

MRX-115

OCTAFLUOROPROPANE

OCTAFLUOROPROPANE (FC-218)

Octafluoropropane perflutren lipid microsphere

octafluoropropane-lipid microsphere

Octafluoropropaneor Refrigerant gas R 218

Octafluoropropaneor Refrigerant gas R 218 [UN2424] [Nonflammable gas]

Octafluoropropaneor Refrigerant gas R 218 [UN2424] [Nonflammable gas]

Octafluorpropan

Oktafluorpropan

Optison

Optison (Salt/Mix)

OR022104

OR242817

OR338603

PC6210

Perfluoropropane

Perfluoropropane (PFC-218) 99.9%

Perfluoropropane 99+%

Perfluoropropaneminimum

Perflutren

Perflutren (Aerosomes), Bristol-Myers Squibb Medical Imaging

Perflutren (Aerosomes), ImaRx/DuPont

Perflutren (Aerosomes), Lantheus

Perflutren (JAN/USAN/INN)

Perflutren [USAN]

Perflutren and Human Albumin

Perflutren Lipid Microsphere

Perflutren Protein-Type A Microspheres injection

Perflutren-lipid microsphere

PFC 218

Propane, 1,1,1,2,2,3,3,3-octafluoro-

Propane, octafluoro-

Propane,1,1,1,2,2,3,3,3-octafluoro-

QYSGYZVSCZSLHT-UHFFFAOYSA-N

R 218

RC 218, PFC 218

SBB090673

UN 2424

UN2424

UNII-CK0N3WH0SR

YM-454

YM454

ZINC8214651

ZX-AP010865

US Patents and Regulatory Information for DEFINITY

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Lantheus Medcl	DEFINITY	perflutren	INJECTABLE;INTRAVENOUS	021064-001	Jul 31, 2001		RX	Yes	Yes			Y
Lantheus Medcl	DEFINITY	perflutren	INJECTABLE;INTRAVENOUS	021064-001	Jul 31, 2001		RX	Yes	Yes
Lantheus Medcl	DEFINITY	perflutren	INJECTABLE;INTRAVENOUS	021064-001	Jul 31, 2001		RX	Yes	Yes
Lantheus Medcl	DEFINITY	perflutren	INJECTABLE;INTRAVENOUS	021064-001	Jul 31, 2001		RX	Yes	Yes

Expired US Patents for DEFINITY

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	Patent No.	Patent Expiration
Lantheus Medcl	DEFINITY	perflutren	INJECTABLE;INTRAVENOUS	021064-001	Jul 31, 2001
Lantheus Medcl	DEFINITY	perflutren	INJECTABLE;INTRAVENOUS	021064-001	Jul 31, 2001
Lantheus Medcl	DEFINITY	perflutren	INJECTABLE;INTRAVENOUS	021064-001	Jul 31, 2001
Lantheus Medcl	DEFINITY	perflutren	INJECTABLE;INTRAVENOUS	021064-001	Jul 31, 2001
Lantheus Medcl	DEFINITY	perflutren	INJECTABLE;INTRAVENOUS	021064-001	Jul 31, 2001
Lantheus Medcl	DEFINITY	perflutren	INJECTABLE;INTRAVENOUS	021064-001	Jul 31, 2001

International Patents for DEFINITY

Country	Document Number	Estimated Expiration
Estonia	04900
World Intellectual Property Organization (WIPO)	9936104
Brazil	9907066
Austria	447976
Germany	69941634
Eurasian Patent Organization	200000765

Supplementary Protection Certificates for DEFINITY

Supplementary Protection Certificate	SPC Country	SPC Expiration	SPC Description
90017-8	Sweden		PRODUCT NAME: LIPIDMIKROSFAERER INNEHALLANDE PERFLUTREN; REG. NO/DATE: EU/1/06/361/001 20060920
C/GB07/031	United Kingdom		PRODUCT NAME: PERFLUTREN-CONTAINING LIPID MICROSPHERES; REGISTERED: UK EU/1/06/361/001 20060920
00267	Netherlands		PRODUCT NAME: PERFLUTREN BEVATTENDE LIPIDE-MICROBOLLEN; REGISTRATION NO/DATE: EU/1/06/361/001 20060920