Suppliers and packagers for generic pharmaceutical drug: isocarboxazid

isocarboxazid

Listed suppliers include manufacturers, repackagers, relabelers, and private labeling entitities.

Applicant	Tradename	Generic Name	Dosage	NDA	NDA/ANDA	Supplier	Package Code	Package	Marketing Start
Lifsa Drugs	MARPLAN	isocarboxazid	TABLET;ORAL	011961	NDA	Lifsa Drugs LLC	72336-032-01	100 TABLET in 1 BOTTLE, PLASTIC (72336-032-01)	1959-07-01

Isocarboxazid: Supplier Landscape and Procurement Signals

Last updated: May 9, 2026

Isocarboxazid (API; CAS 111-46-6) is a niche, controlled MAOI product. Supplier access in practice is driven by (1) whether you buy API, formulated drug product, or bulk “reference” material, (2) controlled-substance and end-use compliance pathways, and (3) whether the supplier is certified for your target market and intended dosage form.

What supplier types exist for isocarboxazid procurement?

Pharma sourcing usually falls into four buckets:

Procurement route	What you buy	Typical buyer workflow	Key constraint
Branded drug product	Finished tablets/capsules	Source via wholesalers or tenders	Product availability varies by country and regulatory listing
Generic finished product	Marketed drug product	Get MA/DMF-aligned documentation	Supply continuity and lot release controls
API (active pharmaceutical ingredient)	Isocarboxazid raw material	API qualification, CoA, specs review	Controlled-substance handling and end-use declarations
Analytical/reference material	Lab standard/reference API	Method validation	Packaging, chain of custody, and assay spec tightness

If the goal is manufacturing, the API lane is the highest friction due to compliance and documentation.

Which suppliers commonly carry isocarboxazid as an API or reference material?

Public catalog coverage for isocarboxazid is uneven across vendors, but the market shows a consistent set of supplier archetypes: chemical catalog distributors, API manufacturers, and specialty reference-material providers. Based on vendor listings and typical catalog scope for isocarboxazid (API and/or reference standards), the following supplier groups are the most actionable starting points for a sourcing sprint.

Catalog distributors (API and/or reference)

These suppliers typically provide CoAs, assay/impurity info, and ship lab quantities, with scaling options depending on compliance.

• TCI Chemicals (Tokyo Chemical Industry)
  • Known for providing isocarboxazid for research and analytical use in many jurisdictions (catalog and reference supply model).
• Sigma-Aldrich / Merck (where listed)
  • Often sells isocarboxazid as a research/analytical chemical and may support bulk requests subject to compliance.
• Cayman Chemical
  • Frequently provides bioanalytical standards and research chemicals, often including MAOIs such as isocarboxazid as reference material.

API/chemical manufacturers (bulk API and custom supply pathways)

These suppliers may or may not publish isocarboxazid as a standard catalog item. When they do, they often route through regulatory documentation and controlled-substance handling.

• Broad chemical/API manufacturer networks (EU/Asia)
  • Isocarboxazid API is a specialized MAOI API, so supply is usually concentrated in a small number of manufacturers.
  • Buyers typically engage via quotations conditioned on GMP, DMF status, and documentation pack readiness.

Specialty reference-material providers (tight method-validation specs)

If your use case is analytical method validation (not manufacturing), reference-material suppliers are often the fastest route.

• Cayman Chemical
  • Reference standard model for quantitative assay work and LC/MS method development.
• Other analytical standard distributors
  • Often resell from a core reference-material source and align delivery to lab validation needs.

How to evaluate which suppliers are actually usable for pharma-grade supply?

For isocarboxazid, you should filter suppliers against documentation and compliance, not just catalog availability. The evaluation checklist below maps to what procurement and QA will demand for a controlled, niche API.

Documentation pack (minimum target set)

Ask each supplier for the following as part of your qualification packet:

• Certificate of Analysis (CoA) for the specific lot
• Analytical specification sheet (assay, impurities, water content, residual solvents where applicable)
• GMP status: whether the material is manufactured under GMP and for which scope
• Regulatory documentation if targeting commercialization (DMF/CEP support, where available)
• Shipping and chain-of-custody documentation aligned to controlled handling

Quality signals that matter for isocarboxazid

Isocarboxazid is used in psychiatry and is sensitive to impurity control. Quality scrutiny usually focuses on:

• Assay within spec
• Impurity profile (including oxidative and related impurities for hydrazine-related chemistry)
• Moisture and stability-related parameters
• Consistency lot-to-lot

What sourcing friction is typical for isocarboxazid?

Isocarboxazid is not widely stocked at scale. The friction typically shows up as:

• Long lead times for API-grade material when it is not a routine catalog item
• Packaging constraints for controlled-substance or regulated chemical transport
• End-use restrictions for lab-only versus manufacturing use
• Documentation delays when GMP batches are not the default offering

Supplier selection: decision matrix for business use

Use the matrix below to route procurement to the right supplier category.

Your need	Best supplier category	Why it fits
Analytical standards for method validation	Reference-material providers (e.g., Cayman)	Fast lab workflow, tight characterization
Pilot-scale or commercial API sourcing	GMP-capable API manufacturers or qualified distributors	Compliance pack and reproducibility
Small quantities for R&D screening	Catalog distributors (TCI, Sigma-Aldrich)	Quick availability for non-GMP needs
Regulatory commercialization	Suppliers who can support DMF/CEP or equivalent	Enables dossier alignment

Where market participants typically start for isocarboxazid sourcing

For a sourcing sprint, the most time-efficient path is usually:

1. Check catalog availability first with major chemical distributors and reference-material providers to confirm immediate access and baseline assay/grade.
2. Convert to a pharma-grade path only after you confirm:
   • GMP/manufacturing scope
   • impurity specs and control strategy
   • controlled-substance handling capacity
3. Engage GMP/API manufacturers once your QA requirements are clear, because niche MAOI API supply tends to be limited.

Is there supplier concentration risk for isocarboxazid?

Yes. The product is niche and the API is not broadly manufactured compared with mass-market APIs. Concentration risk typically manifests as:

• fewer qualified GMP sources
• limited backup inventory
• higher turnaround for documentation and lot release

Key Takeaways

• Isocarboxazid procurement commonly breaks into three practical routes: reference/lab standards, API (GMP-capable) supply, and finished drug product sourcing.
• The most actionable vendor starting points are chemical catalog distributors (e.g., TCI; Sigma-Aldrich/Merck where listed) and reference-material suppliers (e.g., Cayman Chemical).
• For manufacturing-grade supply, the real discriminator is GMP scope, impurity specs, and controlled-substance compliant shipping/chain of custody, not just whether a vendor lists the chemical.

FAQs

1) Can I source isocarboxazid API from general chemical catalog vendors?

Often yes for small-scale research use, but pharma-grade manufacture requires confirmation of GMP scope, CoA specs, and controlled handling aligned to your intended use.

2) Which suppliers are best for analytical reference standards of isocarboxazid?

Specialty reference-material suppliers such as Cayman Chemical are typically the most direct fit for quantitative LC/MS or assay method validation.

3) Why is isocarboxazid harder to source than common MAOI or antidepressant APIs?

It is a niche API with a smaller manufacturing base, which creates inventory and documentation lead-time constraints and higher supplier concentration risk.

4) What documents matter most when qualifying an isocarboxazid API supplier?

Your qualification packet should prioritize CoAs, detailed impurity and assay specifications, GMP evidence, and end-use and controlled-shipping documentation.

5) Is it faster to buy finished isocarboxazid drug product than API?

In many jurisdictions, yes, because finished product supply can route through established pharmaceutical distribution channels. API remains the higher-friction path due to GMP qualification and controlled-handling requirements.

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References

[1] TCI Chemicals. Isocarboxazid product listing and technical information. https://www.tcichemicals.com/
[2] Merck/Sigma-Aldrich. Isocarboxazid product listing (research/analytical chemical). https://www.sigmaaldrich.com/
[3] Cayman Chemical. Isocarboxazid reference standard listing and datasheets. https://www.caymanchem.com/