Last updated: May 28, 2026
Nuprin suppliers: who makes Nuprin (ibuprofen) and how the supply chain is structured
Nuprin is a long-running ibuprofen brand. It is typically supplied as OTC tablets in the U.S. through a mix of brand-owner licensing and contract manufacturers, with multiple labelers appearing across NDCs. The exact “suppliers” depend on the specific dosage form (e.g., tablets, caplets, liquid gels), strength (e.g., 200 mg, 400 mg), and NDC on the bottle.
If you need the named manufacturers and label holders for “Nuprin” in the U.S., the authoritative place to pull them from is the FDA’s Drug Products database (NDC Directory) and the Orange Book for any listed drug applications, including supplement and manufacturer-level data where applicable. However, no specific Nuprin product (strength/dosage form/NDC) was provided, so an accurate supplier list cannot be produced from first principles.
Which companies supply Nuprin (ibuprofen) in the U.S.?
Featured snippet answer: Nuprin “suppliers” are shown per NDC in the FDA NDC Directory, with manufacturing and labeling entities varying by strength and dosage form. Without the specific Nuprin NDC(s), any company list would be incomplete and potentially wrong.
How supplier identity changes by dosage form and strength
- Different OTC presentations (tablets vs caplets vs gelcaps vs suspensions where offered) frequently have different manufacturing sites.
- Strength differences can map to separate manufacturing contracts and labeling entities.
- Private-label and retailer-specific “Nuprin” packages can use different NDCs even when the active ingredient and brand are the same.
Where to verify supplier names
- FDA NDC Directory: identifies labeler and the manufacturer of record for each NDC.
- Orange Book: for certain marketed products, can show application-level drug listing information (but OTC ibuprofen listings can be numerous and not always provide the same manufacturer detail as NDC records).
What is Nuprin’s FDA-listed status and who is the labeler?
Featured snippet answer: Nuprin’s regulatory status is tied to the ibuprofen OTC drug product in the FDA NDC Directory, and the labeler/manufacturer can differ by NDC.
Orange Book vs NDC Directory for supplier mapping
- NDC Directory is the practical data source for “who supplies what” at NDC level.
- Orange Book is best for patent and exclusivity questions; it is less reliable for full OTC supplier roster coverage.
How do contract manufacturers and site changes affect Nuprin supply?
Featured snippet answer: Most OTC ibuprofen brands run through multi-site manufacturing, so supplier identity can shift over time even if the brand stays constant.
Common operational patterns
- Brand owners retain the market-facing labeler role while manufacturing rotates among contract sites.
- Site changes typically show up as NDC manufacturer changes or as new NDCs with different manufacturing sites.
What generic competitors of Nuprin exist and who makes them?
Featured snippet answer: The market for OTC ibuprofen has many AB-rated generics; each generic is also mapped by NDC in the FDA NDC Directory, with supplier/manufacturer variation similar to Nuprin.
Competitive set (category level)
- Store-brand and national generics of ibuprofen 200 mg and 400 mg for pain/fever.
- Retailer private label ibuprofen mapped to different NDC labelers/manufacturers.
When could Nuprin supply be disrupted by manufacturing or IP constraints?
Featured snippet answer: For OTC ibuprofen, supply risk is typically driven by manufacturing capacity, raw material availability, and distribution, not patent/IP exclusivity.
IP is rarely the binding constraint for ibuprofen
- Ibuprofen is an established generic active ingredient.
- Competitive supply issues usually arise from manufacturing quality events, capacity constraints, and regulatory actions rather than patent lockups.
Key Takeaways
- “Nuprin suppliers” cannot be named accurately without the specific Nuprin product identifiers (at minimum: strength, dosage form, and NDC).
- For a defensible supplier list, the FDA NDC Directory is the governing source because it ties labeler and manufacturer to each NDC.
- Supplier identity often varies by presentation and can change over time through contract manufacturing and site rotation.
- IP constraints are not typically the main driver of OTC ibuprofen supply risk; manufacturing and regulatory events dominate.
FAQs
- How can I find the manufacturer for a specific Nuprin bottle? Check the NDC on the package and match it in the FDA NDC Directory.
- Do Nuprin 200 mg and 400 mg use the same manufacturer? Not necessarily; they can map to different NDCs and manufacturing sites.
- Is Nuprin covered by Orange Book exclusivity or patents? Ibuprofen is widely generic; Orange Book data is not the best route for full supplier mapping for OTC products.
- Why do supplier names change on OTC ibuprofen over time? Manufacturing sites and contracts can change, which updates NDC manufacturer records.
- Are Nuprin suppliers different from generic ibuprofen suppliers? At the NDC level, yes or no depending on whether the same manufacturing site/labeler is used for both brand and generic products.
References
- U.S. Food and Drug Administration. (n.d.). NDC Directory (Drug Products). FDA. https://www.accessdata.fda.gov/scripts/cder/daf/
- U.S. Food and Drug Administration. (n.d.). Drugs@FDA: Orange Book. FDA. https://www.accessdata.fda.gov/scripts/cder/ob/
