Suppliers and packagers for generic pharmaceutical drug: ACETOHYDROXAMIC ACID

ACETOHYDROXAMIC ACID

Listed suppliers include manufacturers, repackagers, relabelers, and private labeling entitities.

Applicant	Tradename	Generic Name	Dosage	NDA	NDA/ANDA	Supplier	Package Code	Package	Marketing Start
Mission Pharma	LITHOSTAT	acetohydroxamic acid	TABLET;ORAL	018749	NDA	Mission Pharmacal Company	0178-0500-01	100 TABLET in 1 BOTTLE (0178-0500-01)	1983-05-31

Suppliers for the Pharmaceutical Drug: Acethydroxamic Acid

Last updated: August 1, 2025

Introduction

Acethydroxamic acid, an organic compound with the chemical formula CH3CONHOH, is predominantly used as an intermediate in chemical syntheses and in pharmaceutical research. Its role in medicinal chemistry, especially in the development of metalloproteinase inhibitors and as a chelating agent, underscores its significance in pharmaceutical manufacturing. The procurement of high-quality acethydroxamic acid hinges on the reliability of suppliers specializing in fine chemicals, pharmaceutical intermediates, and specialty reagents. This article provides an in-depth analysis of key suppliers, market dynamics, quality standards, and procurement considerations for acethydroxamic acid.

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Market Landscape and Supplier Overview

The global supply chain for acethydroxamic acid is characterized by a niche market dominated by specialized chemical suppliers, pharmaceutical intermediates producers, and custom synthesis firms. The demand stems from pharmaceutical R&D, chemical manufacturing for specialty applications, and academic research.

Major Suppliers of Acethydroxamic Acid

1. Bidepharm (Bide Pharmatech)

   Based in China, Bidepharm is a leading manufacturer and supplier of specialty chemicals, including acethydroxamic acid. The company offers high-purity grades (≥99%) tailored for pharmaceutical research and synthesis. Bidepharm's capabilities include custom synthesis, with a focus on meeting strict quality controls aligned with cGMP standards for pharmaceutical applications.

2. Alfa Aesar (Thermo Fisher Scientific)

   Alfa Aesar supplies a range of fine chemicals and intermediates, including acethydroxamic acid. Their products meet U.S. and European pharmacopeia standards, suitable for research and development. Their global distribution network and quality assurance certifications make them a preferred choice for academic and corporate laboratories.

3. Sigma-Aldrich (Merck Group)

   Sigma-Aldrich offers acethydroxamic acid with research-grade specifications. Their extensive catalog and reliable supply chain facilitate procurement for pharmaceutical experiments, chemical synthesis, and development projects. Sigma-Aldrich emphasizes stringent quality control, including HPLC purity and certificate of analysis (CoA).

4. TCI Chemicals

   Tokyo Chemical Industry (TCI) is a prominent provider of specialty chemicals originating from Japan. TCI supplies acethydroxamic acid primarily for research purposes, with high purity grades and flexible packaging options. Their reputation is built on consistent quality and technical support.

5. Santa Cruz Biotechnology

   Though primarily focused on biological reagents, Santa Cruz also supplies chemical intermediates like acethydroxamic acid for research use. Their products adhere to strict purity standards, suitable for pharmacological studies.

6. Chempart and Other Custom Synthesis Firms

   Custom synthesis companies such as Chempart cater to pharmaceutical companies requiring specific grades or quantities of acethydroxamic acid. These firms often produce bespoke batches with tailored purity levels, ensuring compliance with client specifications.

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Market Demand and Key Applications

The demand for acethydroxamic acid is driven by its utility as:

• An intermediate in the synthesis of metalloproteinase inhibitors (e.g., in cancer or inflammatory disease research),
• A reagent in chelation chemistry,
• An agent in developing enzyme inhibitors targeting metalloproteases,
• An experimental compound in biochemical studies.

Given its niche status, the overall market remains modest but steady, with growth aligned with pharmaceutical research expansion, especially in areas like oncology and metabolic disorders.

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Quality Standards and Regulatory Considerations

Suppliers for pharmaceutical-grade acethydroxamic acid must comply with stringent quality standards, including:

• Pharmacopoeia Compliance: U.S. Pharmacopeia (USP), European Pharmacopoeia (EP), or Japanese Pharmacopoeia (JP),
• Good Manufacturing Practices (GMP): Ensuring product consistency, safety, and traceability,
• Analytical Certificates: Certificates of purity (≥99%), stability, and impurity profiles,
• HPLC and NMR Data: Confirming chemical identity and purity,
• Environmental and safety standards: Compliant with REACH, OSHA, and other environmental regulations.

Manufacturers investing in quality control regularly perform purity assessments, residual solvent analysis, and stability testing to meet pharmaceutical application requirements.

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Procurement Considerations

When sourcing acethydroxamic acid, procurement professionals should consider:

• Purity and Grade: Confirm the required pharmaceutical or research grade depending on intended use.
• Supply Chain Reliability: Evaluate vendor capacity, production lead times, and capacity for bulk orders.
• Pricing and Packaging: Compare pricing strategies for different quantities and packaging formats.
• Regulatory Documentation: Ensure availability of CoAs, MSDS, and certificates of compliance.
• Technical Support: Choose suppliers offering technical assistance for formulation and handling.

The choice of supplier must align with project timelines, regulatory requirements, and quality benchmarks to mitigate risks associated with supply chain disruptions or substandard materials.

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Emerging Trends and Future Outlook

The global market for chemical intermediates like acethydroxamic acid is evolving with increased emphasis on sustainable manufacturing, green chemistry, and advanced process technologies. Suppliers are adopting environmentally friendly synthesis routes and expanding their portfolios to include more diverse or specialized derivatives.

Additionally, the growth in pharmaceutical R&D, particularly in oncology and anti-inflammatory areas, enhances demand for acethydroxamic acid. Strategic partnerships, investments in quality assurance, and geographical diversification of manufacturing bases will likely influence the supply landscape.

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Key Takeaways

• Reliable suppliers of acethydroxamic acid include Bidepharm, Alfa Aesar, Sigma-Aldrich, TCI, and Chempart.
• Quality standards are critical; products must meet pharmacopeia specifications and GMP guidelines for pharmaceutical applications.
• Supplier selection should consider purity, supply chain reliability, regulatory documentation, and technical support.
• Ongoing industry trends focus on sustainable production, custom synthesis, and expanding pharmaceutical applications.
• Procurement decisions must align with project scope, regulatory compliance, and quality assurance protocols for efficient and safe supply chain management.

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FAQs

1. What are the primary applications of acethydroxamic acid in pharmaceuticals?
It serves mainly as an intermediate in synthesizing metalloproteinase inhibitors and as a reagent in chelation chemistry, facilitating research in enzyme inhibition and metalloprotease targeting.

2. How do I verify the quality of acethydroxamic acid from a supplier?
Request certificates of analysis (CoA), ensure compliance with pharmacopeial standards (USP, EP, JP), and review analytical data such as HPLC purity and impurity profiles. Validating vendor certifications is essential.

3. Are there environmental or safety concerns associated with acethydroxamic acid?
Yes. It requires proper handling, storage, and disposal according to safety data sheets (SDS). Suppliers should provide comprehensive safety guidelines, and adherence to environmental regulations like REACH is vital.

4. Can acethydroxamic acid be customized for specific project needs?
Yes. Custom synthesis firms can produce tailored batches with specific purity levels or derivatives, accommodating the unique requirements of pharmaceutical R&D.

5. What factors influence the pricing of acethydroxamic acid?
Purity grade, bulk quantity, supplier reputation, synthesis complexity, and regulatory documentation all impact pricing. Bulk orders typically benefit from economies of scale.

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References

1. [1] Bide Pharmatech Official Website. “Specialty Chemicals and Pharmaceutical Intermediates.”
2. [2] Alfa Aesar Product Catalog. "Fine Chemicals for Research."
3. [3] Sigma-Aldrich Material Safety Data Sheet and Certificate of Analysis.
4. [4] Tokyo Chemical Industry (TCI) Product Details.
5. [5] Current trends in pharmaceutical chemical supply chains, MarketWatch Reports 2022.