Last Updated: November 12, 2026

Details for Patent: 9,623,014

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Summary for Patent: 9,623,014
Title:β-lactamase inhibitor compounds
Abstract:The present invention is directed to compounds which are beta-lacatamase inhibitors. The compounds and their pharmaceutically acceptable salts, are useful in combination with beta-lactam antibiotics, or alone, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to formula (Ia): or a pharmaceutically acceptable salt thereof, wherein the values of R1, R2, R3 and R4 are described herein.
Inventor(s):Helen McGuire, Shanta Bist, Neil Bifulco, Liang Zhao, Ye Wu, Hoan Huynh, Hui Xiong, Janelle Comita-Prevoir, Daemian Dussault, Bolin Geng, Brendan Chen, Thomas Francois Durand-Reville, Satenig Guler
Assignee: AstraZeneca UK Ltd , Entasis Therapeutics Ltd , AstraZeneca Pharmaceuticals LP
Application Number:US15/056,090
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 9,623,014
Patent Claim Types:
see list of patent claims
Use;

Drugs Protected by US Patent 9,623,014

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Entasis Therap XACDURO (COPACKAGED) durlobactam sodium; durlobactam sodium; sulbactam sodium POWDER;INTRAVENOUS 216974-001 May 23, 2023 RX Yes Yes ⤷  Start Trial ⤷  Start Trial TREATMENT OF HOSPITAL-ACQUIRED BACTERIAL PNEUMONIA AND VENTILATOR-ASSOCIATED BACTERIAL PNEUMONIA (HABP/VABP) ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 9,623,014

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 090539 ⤷  Start Trial
Australia 2013245399 ⤷  Start Trial
Brazil 112014024279 ⤷  Start Trial
Canada 2866467 ⤷  Start Trial
Chile 2014002589 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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