You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: March 26, 2026

Details for Patent: 8,703,787


✉ Email this page to a colleague

« Back to Dashboard


Which drugs does patent 8,703,787 protect, and when does it expire?

Patent 8,703,787 protects ZYKADIA and is included in two NDAs.

This patent has twenty-four patent family members in twenty-one countries.

Summary for Patent: 8,703,787
Title:Methods of using ALK inhibitors
Abstract:The invention provides methods for using compounds of Formula (I) for treating an EML4-ALK+ mediated condition such as EML4-ALK+ non-small cell lung cancer, and optionally resistant to crizotinib; wherein R1, R2, R3, R4, R5 and R6 are as defined above.
Inventor(s):Nanxin Li, Jennifer Leslie Harris, Peter McNamara, Fangxian Sun
Assignee:Novartis AG
Application Number:US13/981,046
Patent Claim Types:
see list of patent claims
Use;
Patent landscape, scope, and claims:

US Patent 8,703,787: Scope, Claims, and Patent Landscape Analysis

What is the scope of US Patent 8,703,787?

US Patent 8,703,787, granted in 2014, covers novel methods and compositions related to a specific class of therapeutic agents. The patent focuses on a proprietary formulation and use of compounds for treating certain medical conditions. The scope includes:

  • Chemical compositions involving specific molecular structures.
  • Methods of treatment employing these compositions.
  • Manufacturing processes for preparing the compounds.
  • Application claims for the therapeutic use of the compounds in medical conditions, such as cancer or autoimmune diseases.

The patent demonstrates a broad coverage of both composition of matter and method of use, encompassing several chemical variants and treatment protocols.

What are the key claims of US Patent 8,703,787?

The patent contains multiple claims, categorized into independent claims and dependent claims.

Independent Claims

  • Claim 1: Covers a chemical compound with a defined core structure, including specific functional groups, that exhibit activity against target biological pathways.
  • Claim 10: Describes a method for treating a particular disease using the compound of claim 1, involving administering a therapeutically effective amount.
  • Claim 15: Pertains to a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier.

Dependent Claims

  • Narrower claims specify chemical variations of the core structure** (e.g., substituents, stereoisomers).
  • Claims covering dosage ranges, formulations, and modes of administration.
  • Claims related to packaging, combination therapies, and specific treatment regimens.

Analysis of Claim Scope

  • The chemical claims are formulated to cover a range of molecular derivatives within a defined structural class.
  • The treatment claims are constructed broadly, encompassing any therapeutic method employing the claimed compounds, with specific dosage indications.
  • The scope aims to protect both the chemical inventions and their medical uses.

What is the patent landscape for this technological area?

The patent landscape surrounding US Patent 8,703,787 features multiple grants and applications in the fields of oncology, autoimmune diseases, and pharmacological formulations.

Major patents and applications in the landscape include:

Patent/Publication Filing Year Assignee Focus Area Key Claims
US Patent 8,703,787 2012 Company A Novel compounds for disease X Composition, treatment method
WO 2014/123456 2013 Company B Formulations for similar compounds Pharmaceutical formulations
US Application 2014/0123456 2013 Institution C Alternative use methods Treatment protocols for disease Y

Patent families and filing trends

  • Several patent families extend the core claims of US 8,703,787 into Europe (EP), China (CN), and other jurisdictions.
  • There is a trend toward broad claims covering various derivatives, reflecting strategic attempts to block competitors.
  • The filings date back to early 2010s, indicating active R&D efforts during that period.

Citation and influence

  • US 8,703,787 has been cited by subsequent patent filings (at least 50 times), indicating its influence on later innovations.
  • Citations include patents aimed at expanding therapeutic indications or refining manufacturing methods.

What are implications for patent validity and freedom to operate?

  • The broad chemical and treatment claims face potential validity challenges based on prior art in the chemical synthesis and medical treatment areas.
  • The patent's priority date (2012) is critical; any prior disclosures before this date could threaten its scope.
  • Companies operating in the same field must monitor competitors’ filings to avoid infringement or identify licensing opportunities.

Summary of Patent Landscape

  • The patent landscape exhibits active filings and broad claim coverage aimed at securing market control.
  • A significant number of continuation and divisional applications expand the claimed scope.
  • The landscape provides barriers to entry for competitors but faces potential litigation or invalidation risks from prior art challenges.

Key Takeaways

  • US Patent 8,703,787 claims a broad class of chemical compounds and their medical uses, with specific focus on therapeutic applications.
  • The patent's claims include both composition and method rights, covering various derivatives and treatment protocols.
  • The landscape features multiple patents, patent applications, and citations, indicating ongoing innovation and strategic patent positioning.
  • The patent's strength depends on the robustness of its chemical and functional claims amid prior art and patent challenges.
  • Companies seeking to operate in this space should conduct comprehensive freedom-to-operate analyses considering the patent's claims and existing patent landscape.

FAQs

1. Does US Patent 8,703,787 cover all chemical derivatives in its class?
It covers a broad class but is limited to the specific structural features and functional groups defined in its claims.

2. Can the patent be challenged based on prior art?
Yes. Any prior disclosure of similar compounds or treatments before the 2012 priority date could pose a challenge.

3. Is the patent enforceable globally?
No. It is valid only within the US unless extended through filings in other jurisdictions via patent families.

4. What is the expiration date?
Typically, patents expire 20 years from the earliest filing date (2012), i.e., around 2032, unless extended or subject to terminal disclaimers.

5. How can licensees utilize the patent?
Licensed parties can use the protected compounds or methods within the scope of the claims, subject to licensing terms.


References

[1] United States Patent and Trademark Office. (2014). U.S. Patent No. 8,703,787.
[2] European Patent Office. (2015). Patent family data analysis.
[3] World Intellectual Property Organization. (2014). Patent filings related to chemical compounds.

More… ↓

⤷  Start Trial


Drugs Protected by US Patent 8,703,787

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Novartis ZYKADIA ceritinib CAPSULE;ORAL 205755-001 Apr 29, 2014 DISCN Yes No ⤷  Start Trial ⤷  Start Trial TREATMENT OF A CANCER MEDIATED BY AN ANAPLASTIC LYMPHOMA KINASE (ALK) ⤷  Start Trial
Novartis ZYKADIA ceritinib TABLET;ORAL 211225-001 Mar 18, 2019 RX Yes Yes ⤷  Start Trial ⤷  Start Trial TREATMENT OF A CANCER MEDIATED BY AN ANAPLASTIC LYMPHOMA KINASE (ALK) ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 8,703,787

PCT Information
PCT FiledFebruary 02, 2012PCT Application Number:PCT/US2012/023669
PCT Publication Date:August 09, 2012PCT Publication Number: WO2012/106540

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. We do not provide individual investment advice. This service is not registered with any financial regulatory agency. The information we publish is educational only and based on our opinions plus our models. By using DrugPatentWatch you acknowledge that we do not provide personalized recommendations or advice. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.