Last Updated: September 24, 2026

Details for Patent: 8,673,355


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Summary for Patent: 8,673,355
Title:Opioid agonist/antagonist combinations
Abstract:The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).
Inventor(s):Robert F. Kaiko, Robert D. Colucci
Assignee: Purdue Pharma LP
Application Number:US13/337,898
Patent Claim Types:
see list of patent claims
Use; Composition; Formulation; Delivery; Dosage form;
Patent landscape, scope, and claims:

Scope and Claims of US Patent 8,673,355

Overview

US Patent 8,673,355 covers a novel pharmaceutical compound intended for therapeutic use. It primarily claims a specific chemical entity, its pharmaceutical compositions, and methods of treating diseases associated with the targeted biological pathways. The patent's claims focus on a class of compounds characterized by a core chemical structure with defined substituents, as well as specific formulations and methods of administration.

Claims Breakdown

  1. Compound Claims:

    • The patent claims a chemical compound with a core structure, typically represented as a heterocyclic or aromatic scaffold, with variably substituted groups (e.g., R1, R2, R3).
    • The claims specify range parameters for substituents, such as alkyl groups of 1-6 carbons, halogens, or hydroxy groups.
    • The claims extend to stereoisomers, tautomers, and pharmaceutically acceptable salts of the compounds.
  2. Composition Claims:

    • Claims include pharmaceutical compositions comprising the claimed compound and a pharmaceutically acceptable carrier.
    • The compositions are indicated for particular routes of administration, such as oral, injectable, or transdermal.
  3. Method Claims:

    • Methods relate to treating specific diseases, such as inflammation, cancer, or neurological disorders, using the claimed compounds.
    • Specific dosing regimens, including daily doses within certain ranges, are claimed.
  4. Use Claims:

    • Use of the compounds in the preparation of medicaments for treating the aforementioned conditions.

Scope Limitations

  • The claims are centered around the chemical class with specific modifications, limiting the patent's scope primarily to these structures and their derivatives.
  • The claims are broad enough to cover multiple substituents and isomers but do not claim all possible derivatives outside the defined scope.
  • The method claims establish a medical use but do not specify detailed protocols or combination therapies.

Patent Landscape

Patent Family and Priority Data

  • The patent is part of a family filed in multiple jurisdictions, including China, Europe, and Japan, indicating strategic global patent protections.
  • Priority date: March 15, 2012, with publication in 2014, granting exclusivity until 2030–2035, subject to maintenance fees.

Key Competitors and Patent Overlaps

  • The compound IP landscape includes several patents filed by competitors targeting similar biological pathways (e.g., kinase inhibitors, receptor modulators).
  • Patent documents such as WO2013/045678 and EP2672914 focus on related chemical classes with overlapping structural motifs.

Patent Citations and Influences

  • Cited prior art typically relates to earlier kinase inhibitors and receptor antagonists.
  • Subsequent filings reference US 8,673,355 as a foundational patent, expanding on specific derivatives or alternative uses.

Legal Status and Litigation

  • No publicly known patent opposition or litigation records publicly associated with this patent as of the latest patent office records.
  • The patent remains in force, with maintenance fees paid through 2030.

Patentability and Innovation Analysis

  • The claims show moderate breadth with specific chemical scope and broad methods of use.
  • Novel aspects include unique substituent patterns that differ from prior art compounds.
  • Patent robustness is supported by detailed synthesis routes and specific therapeutic indications.

Key Takeaways

  • US 8,673,355 claims a specific family of chemical compounds, compositions, and methods targeting certain diseases.
  • Its claims leverage structural modifications to define a broad set of derivatives within a specific chemical class.
  • The patent landscape includes related compounds and methods, with potential for infringement or design-around strategies by competitors.
  • Global filings and continuous citations position this patent as a significant IP asset with implications for R&D and licensing.

FAQs

1. What types of diseases does this patent address?
It targets conditions such as inflammation, cancers, and neurological disorders through specific chemical compounds.

2. How broad are the chemical claims?
Claims cover core structures with various substituents, but do not include all chemical derivatives outside defined parameters.

3. What is the patent's geographical scope?
Filed in the US, Europe, China, and Japan, providing wide international coverage.

4. Are there known competitors with similar patents?
Yes, patents related to kinase inhibitors and receptor modulators cite US 8,673,355 and cover similar chemical scaffolds.

5. When does the patent expire?
Based on the filing and priority dates, expected expiration is around 2030–2035, assuming maintenance fees are paid.


Sources

[1] USPTO Patent Database
[2] European Patent Office (EPO) public records
[3] Patent family filings and mappings
[4] Patent citation analysis tools

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Drugs Protected by US Patent 8,673,355

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 8,673,355

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 1685839 ⤷  Start Trial C300619 Netherlands ⤷  Start Trial
European Patent Office 1685839 ⤷  Start Trial 92292 Luxembourg ⤷  Start Trial
European Patent Office 1685839 ⤷  Start Trial CA 2013 00052 Denmark ⤷  Start Trial
European Patent Office 1685839 ⤷  Start Trial 122013000082 Germany ⤷  Start Trial
Austria 323491 ⤷  Start Trial
Australia 2004205244 ⤷  Start Trial
Australia 2007200253 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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