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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
Moodys
Baxter
Farmers Insurance
Colorcon
Merck
Accenture
Fuji
Chinese Patent Office
Teva

Generated: December 12, 2017

DrugPatentWatch Database Preview

Details for Patent: 8,227,230

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Which drugs does patent 8,227,230 protect, and when does it expire?


Patent 8,227,230 protects ELELYSO and is included in one NDA.

This patent has seventy-four patent family members in twenty-five countries.

Summary for Patent: 8,227,230

Title:Human lysosomal proteins from plant cell culture
Abstract: A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production of enzymatically active high mannose lysosomal enzymes using transgenic plant root, particularly carrot cells. More particularly, the invention relates to host cells, particularly transgenic suspended carrot cells, vectors and methods for high yield expression and production of biologically active high mannose Glucocerebrosidase (GCD). The invention further provides for compositions and methods for the treatment of lysosomal storage diseases.
Inventor(s): Shaaltiel; Yoseph (Kibbutz HaSolelim-Doar-Na HaMovil, IL), Baum; Gideon (Kibbutz Ayelet HaShachar-D.N. Upper Galilee, IL), Bartfeld; Daniel (Moran--Doar-Na Bikat Beit HaKerem, IL), Hashmueli; Sharon (Ramot-Naftali, IL), Lewkowicz; Ayala (Kfar-Vradim, IL)
Assignee: Protalix Ltd. (Carmiel, IL)
Application Number:13/080,692
Patent Claim Types:
see list of patent claims
Compound; Use; Composition;

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Patent Submitted Product Substance Delist Req. Patented / Exclusive Use
PfizerELELYSOtaliglucerase alfaPOWDER;IV (INFUSION)022458-001May 1, 2012RXYesYes► Subscribe► Subscribe► SubscribeYY
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Foreign Priority and PCT Information for Patent: 8,227,230

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Israel155588Apr 27, 2003

Non-Orange Book Patents for Patent: 8,227,230

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
6,391,638 Cell/tissue culturing device and method► Subscribe
9,220,737Plant cell culture expressing human lysosomal proteins and uses thereof► Subscribe
8,741,620Human lysosomal proteins from plant cell culture► Subscribe
8,790,641Production of high mannose proteins in plant culture and therapeutic uses thereof► Subscribe
8,449,876Human lysosomal proteins from plant cell culture► Subscribe
7,951,557Human lysosomal proteins from plant cell culture► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Because of the complexity of determining patent expiration dates it is advisable to have patent counsel verify freedom to operate.

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International Patent Family for Patent: 8,227,230

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Ukraine89944► Subscribe
Slovenia2333083► Subscribe
Singapore2013021217► Subscribe
Singapore2007172737► Subscribe
Russian Federation2009143751► Subscribe
Russian Federation2535342► Subscribe
Russian Federation2009148012► Subscribe
Russian Federation2385928► Subscribe
Russian Federation2005136874► Subscribe
Portugal2333083► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Colorcon
Teva
Harvard Business School
Boehringer Ingelheim
Dow
Johnson and Johnson
Mallinckrodt
Daiichi Sankyo
Fish and Richardson
Deloitte

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