Details for Patent: 7,767,429
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Summary for Patent: 7,767,429
Title: | Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof |
Abstract: | The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity. |
Inventor(s): | Bookbinder; Louis H. (San Diego, CA), Kundu; Anirban (San Diego, CA), Frost; Gregory I. (Del Mar, CA) |
Assignee: | Halozyme, Inc. (San Diego, CA) |
Application Number: | 10/795,095 |
Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for patent 7,767,429 |
Patent Claim Types: see list of patent claims | Compound; Composition; Use; Formulation; Delivery; Dosage form; Device; |
Drugs Protected by US Patent 7,767,429
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International Family Members for US Patent 7,767,429
Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
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Austria | 448323 | ⤷ Try a Trial | |||
Australia | 2004218354 | ⤷ Try a Trial | |||
Australia | 2006216545 | ⤷ Try a Trial | |||
Australia | 2009245838 | ⤷ Try a Trial | |||
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