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Serving leading biopharmaceutical companies globally:

Cipla
Deloitte
Dow
Merck
Healthtrust
US Department of Justice
Boehringer Ingelheim
Farmers Insurance
Baxter
Novartis

Generated: January 17, 2018

DrugPatentWatch Database Preview

Details for Patent: 7,767,429

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Summary for Patent: 7,767,429
Title:Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof
Abstract:The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
Inventor(s): Bookbinder; Louis H. (San Diego, CA), Kundu; Anirban (San Diego, CA), Frost; Gregory I. (Del Mar, CA)
Assignee: Halozyme, Inc. (San Diego, CA)
Application Number:10/795,095
Patent Claim Types:
see list of patent claims
Compound; Composition; Use; Formulation; Delivery; Dosage form; Device;

Drugs Protected by US Patent 7,767,429

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Halozyme Therap HYLENEX RECOMBINANT hyaluronidase recombinant human INJECTABLE;INJECTION 021859-001 Dec 2, 2005 RX Yes Yes ➤ Subscribe ➤ Subscribe Y Y ➤ Subscribe
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Non-Orange Book US Patents Family Members for Patent 7,767,429

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
8,105,586 Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases ➤ Subscribe
8,580,252 Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases ➤ Subscribe
2,015,196,623 ➤ Subscribe
8,431,124 Methods for treating a disease characterized by an excess of hyaluronan by administering a soluble hyaluronidase glycoprotein (sHASEGP) ➤ Subscribe
9,562,223 Methods for reducing intraocular pressure by administering a soluble hyaluronidase glycoprotein (sHASEGP) ➤ Subscribe
9,211,315 Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases ➤ Subscribe
8,765,685 Methods for treating edema by administering a Soluble Hyaluronidase Glycoprotein (sHASEGP) ➤ Subscribe
8,772,246 Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof ➤ Subscribe
9,677,061 Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof ➤ Subscribe
7,829,081 Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases ➤ Subscribe
Patent No. Title Estimated Patent Expiration

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International Patents Family Members for US Patent 7,767,429

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 448323 ➤ Subscribe
Australia 2004218354 ➤ Subscribe
Australia 2006216545 ➤ Subscribe
Australia 2009245838 ➤ Subscribe
Australia 2013202475 ➤ Subscribe
Brazil PI0408116 ➤ Subscribe
Brazil PI0608314 ➤ Subscribe
Canada 2517145 ➤ Subscribe
Canada 2598823 ➤ Subscribe
China 101163717 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Moodys
Dow
QuintilesIMS
Mallinckrodt
Express Scripts
Teva
Accenture
Deloitte
Citi

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