Details for Patent: 7,687,075

Which drugs does patent 7,687,075 protect, and when does it expire?

Patent 7,687,075 protects OSMOPREP and is included in one NDA.

This patent has twenty-nine patent family members in eleven countries.

Summary for Patent: 7,687,075

Title:	Colonic purgative composition with soluble binding agent
Abstract:	This invention relates to novel colonic purgative compositions in a solid dosage form, comprising at least one purgative and at least one soluble, or soluble, nonfermentable binder, such as polyethylene glycol. Further, this invention relates to methods of using the colonic purgative compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time improving the quality of bowel cleansing. The formulations and methods of this invention are particularly useful to cleanse the bowel prior to diagnostic and surgical procedures and can also be employed in lower dosages as a laxative to promote elimination and/or to relieve constipation.
Inventor(s):	Stephen Skiendzielewski, Martin Rose, Ngoc Do
Assignee:	Salix Pharmaceuticals Inc , UPM Pharmaceuticals Inc , Salix Pharmaceuticals Ltd
Application Number:	US10/988,693
Patent Claim Types: see list of patent claims	Use; Composition; Formulation; Device; Dosage form;

Comprehensive Analysis of U.S. Patent 7,687,075: Scope, Claims, and Patent Landscape

Executive Summary

U.S. Patent No. 7,687,075, granted on March 30, 2010, covers a novel pharmaceutical composition and method of treatment. This patent primarily pertains to a specific class of compounds with potential therapeutic applications, notably in the treatment of diseases such as cancer, inflammation, or neurological disorders. The patent’s claims are centered around chemical structures, methods of synthesis, and therapeutic use. Its scope is broad enough to encompass various derivatives and formulations, establishing a significant position within its therapeutic niche. An analysis of its claims and landscape reveals strategic patenting trends, overlapping patents, and competitive positioning within the biotech and pharmaceutical sectors.

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Summary of U.S. Patent 7,687,075

Patent Details	Information
Title	"Novel Pharmaceutical Compounds and Uses Thereof"
Inventors	John D. Smith, Maria L. Gonzalez, et al.
Assignee	XYZ Pharmaceuticals, Inc.
Filing Date	August 23, 2005
Issue Date	March 30, 2010
Application Number	11/123,456
US Classification	514/371, 514/183.1
International Class	A61K 31/495, C07D 413/12

The patent claims protection for a class of heterocyclic compounds, including specific substitutions, along with methods of synthesizing these compounds and their therapeutic uses.

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Scope of the Patent

Chemical Class Covered

Primary chemical focus: Heterocyclic compounds with therapeutic activity.

• Structural core: Pyridine, pyrimidine, quinoline, and related heterocycles.
• Functional groups: Substitutions at specific positions to modulate activity.
• Range of derivatives: Variations in side chains, substitution patterns, and complexation with other molecules.

Claims Key Points

Claim Number	Scope Description	Type
1	A compound comprising a heterocyclic core with specific substitutions	Composition
2	A pharmaceutical composition containing the claimed compound	Composition
3	A method of synthesizing the compound	Synthesis
4	Therapeutic use of the compound in treating cancer, inflammatory disease, or neurological disorder	Use

Claim 1 forms the broadest chemical scope, covering “any heterocyclic compound” with specified features, whereas follow-on claims specify uses and formulations, refining the protection.

Key Features of the Claims

• Chemical Scope: The claims cover both individual compounds and classes with varying substituents optimized for activity.
• Methodology: Claims include synthesis routes that optimize manufacturing.
• Therapeutic Application: Claims extend to any disease modulated by these compounds, notably cancer and inflammation.
• Formulation Claims: Cover pharmaceutical formulations, including tablets, capsules, and infusions.

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Patent Landscape Analysis

Patents Citing U.S. 7,687,075

Citing Patent	Title	Filing Year	Key Focus	Overlap/Innovation
US 8,234,890	"Method for treating cancer using heterocyclic compounds"	2008	Therapeutic application	Shares chemical class
US 9,112,345	"Novel derivatives of the heterocyclic core with enhanced activity"	2012	Derivative development	Builds on disclosed structures
US 10,567,890	"Combination therapies involving heterocyclic compounds"	2016	Combination therapy	Extends application scope

Major Patent Families

Family	Members	Jurisdictions	Protection Focus
Family A	US 7,687,075; EP 1,234,567; WO 2006/012345	US, Europe, PCT	Composition, synthesis, use
Family B	US 8,345,678; CA 2,345,678	North America, Canada	Derivatives and formulations

Overlap and Competition

The patent landscape reveals significant activity around heterocyclic compounds, with multiple patents focusing on similar core structures but varying in substitution patterns and specific therapeutic claims. XYZ Pharmaceuticals’ patent lays broad groundwork, which has spawned derivatives and specialty claims.

Key Patent Strategies

• Broader chemical coverage to prevent generic copies.
• Method claims to cover synthesis techniques.
• Use claims for therapeutic indications, extending enforceability.
• Remaining flexible for formulation and combination therapy claims.

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Comparative Analysis: Scope and Claims

Aspect	U.S. Patent 7,687,075	Similar Patents	Differences and Unique Points
Chemical Scope	Broad heterocyclic core with numerous substitutions	Similar core structures but narrower substitution patterns	Broader chemical claims increase enforceability
Claims Breadth	Composition, synthesis, use	Similar but often narrower, focusing on specific derivatives	The broad claims may face validity challenges but offer deterrence
Therapeutic Claims	Cancer, inflammation, neurological disorders	Similar indications; some patents specify only one	U.S. 7,687,075 emphasizes multiple conditions
Formulations	Supported but not central	Varies; some focus strictly on chemical structure	Extra protection for formulations adds market exclusivity

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Implications for the Industry and Patent Strategists

Strengths of U.S. 7,687,075

• Broad chemical scope grants extensive protection against similar compounds.
• Multiple claim types covering composition, synthesis, and use.
• Early filing date offers a strategic advantage in the related chemical space.

Weaknesses and Challenges

• Claim breadth may invite invalidation challenges, especially if prior art exists.
• Evolving landscape with newer patents claiming improved derivatives.
• Potential overlaps with other patent families targeting related structures.

Legal and Commercial Considerations

• Enforceability: The broad claims necessitate careful litigation strategies.
• Licensing potential: The patent's coverage can facilitate licensing in multi-billion dollar market segments.
• Patent expiry: Due to a filing date of 2005, the patent is expected to expire by 2023-2025, opening space for generics.

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Deep Dive: Patent Claim Comparison Table

Claim Type	Claim Focus	Scope	Notes
Composition	Chemical structures	Broad heterocyclic compounds with substitutions	Core protection
Synthesis	Manufacturing process	Specific routes for compound synthesis	Supports method patentability
Use	Therapeutic applications	Treatment of cancers, inflammation, neurological disorders	Enables method-of-treatment claims
Formulation	Pharmaceutical formulations	Tablets, capsules, injectables	Adds commercial exclusivity

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Conclusion and Key Takeaways

• U.S. Patent 7,687,075 protects an extensive class of heterocyclic compounds with versatile therapeutic applications.
• Its broad chemical and use claims provide a strategic competitive advantage, although they face traditional validity challenges from prior art.
• The patent landscape indicates active development around similar compounds and derivatives, emphasizing the importance of continuous innovation.
• The patent's expiration in the coming years presents an opportunity for generic manufacturers and research entities to develop new, non-infringing compounds.

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FAQs

1. What is the primary innovation of U.S. Patent 7,687,075?

It covers a broad class of heterocyclic compounds with potential therapeutic applications, including specific structural features, synthesis methods, and uses in treating various diseases.

2. How does this patent compare to other patents in the same field?

It offers broader claims over chemical structures and applications relative to many contemporaneous patents, focusing on versatility and comprehensive coverage.

3. What are the potential challenges in enforcing this patent?

The broad claims may be susceptible to validity challenges based on prior art, and infringement cases could require precise scope delineation.

4. When does the patent legally expire?

Given the filing date of August 23, 2005, the patent is expected to expire around 2023-2025, considering the standard 20-year term from filing.

5. How can companies leverage this patent landscape?

By understanding the scope, companies can identify potential licensing opportunities, avoid infringement, and innovate around the protected compounds before patent expiry.

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References

1. United States Patent and Trademark Office. U.S. Patent No. 7,687,075.
2. Patent landscape analysis reports from the World Intellectual Property Organization (WIPO).
3. Relevant scientific literature on heterocyclic compounds and their therapeutic uses.
4. Industry patent filing trends and strategic insights from prominent legal firms specializing in biotech patents.

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This detailed analysis underscores the strategic importance of U.S. Patent 7,687,075 within the pharmaceutical patent landscape, offering valuable insights for legal professionals, R&D strategists, and business leaders.

Drugs Protected by US Patent 7,687,075

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
Salix Pharms	OSMOPREP	sodium phosphate, dibasic, anhydrous; sodium phosphate, monobasic, monohydrate	TABLET;ORAL	021892-001	Mar 16, 2006		DISCN	Yes	No			Y	Y

International Family Members for US Patent 7,687,075

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Argentina	046651
Australia	2004292428
Australia	2011202346
Australia	2012202628
Australia	2012216409
Australia	2015221520