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Serving hundreds of leading biopharmaceutical companies globally:

Cipla
Teva
Fish and Richardson
Express Scripts
Merck
Fuji
Cerilliant
Farmers Insurance
Argus Health

Generated: June 23, 2018

DrugPatentWatch Database Preview

Details for Patent: 6,583,115

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Summary for Patent: 6,583,115
Title: Methods for treating acromegaly and giantism with growth hormone antagonists
Abstract:The present invention relates to antagonists of vertebrate growth hormones obtained by mutation of the third alpha helix of such proteins (especially bovine or human GHs). These mutants-have growth-inhibitory or other GH-antagonizing effects. These novel hormones may be administered exogenously to animals, or transgenic animals may be made that express the antagonist. Animals have been made which exhibited a reduced growth phenotype. The invention also describes methods of treating acromegaly, gigantism, cancer, diabetes, vascular eye diseases (diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration, retinopathy of sickle-cell anemia, etc.) as well as nephropathy and other diseases, by administering an effective amount of a growth hormone antagonist. The invention also provides pharmaceutical formulations comprising one or more growth hormone antagonists.
Inventor(s): Kopchick; John J. (Athens, OH), Chen; Wen Y. (Athens, OH)
Assignee: Ohio University/Edison Biotechnology Institute (Athens, OH)
Application Number:08/486,793
Patent Claim Types:
see list of patent claims
Compound; Use;

Drugs Protected by US Patent 6,583,115

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Serving hundreds of leading biopharmaceutical companies globally:

Boehringer Ingelheim
Citi
AstraZeneca
Chinese Patent Office
Accenture
Farmers Insurance
Covington
Merck
US Army

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