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Details for Patent: 6,583,115

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Summary for Patent: 6,583,115

Title: Methods for treating acromegaly and giantism with growth hormone antagonists
Abstract:The present invention relates to antagonists of vertebrate growth hormones obtained by mutation of the third alpha helix of such proteins (especially bovine or human GHs). These mutants-have growth-inhibitory or other GH-antagonizing effects. These novel hormones may be administered exogenously to animals, or transgenic animals may be made that express the antagonist. Animals have been made which exhibited a reduced growth phenotype. The invention also describes methods of treating acromegaly, gigantism, cancer, diabetes, vascular eye diseases (diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration, retinopathy of sickle-cell anemia, etc.) as well as nephropathy and other diseases, by administering an effective amount of a growth hormone antagonist. The invention also provides pharmaceutical formulations comprising one or more growth hormone antagonists.
Inventor(s): Kopchick; John J. (Athens, OH), Chen; Wen Y. (Athens, OH)
Assignee: Ohio University/Edison Biotechnology Institute (Athens, OH)
Application Number:08/486,793
Patent Claim Types:
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Compound; Use;

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Premature patent expiration for: 6,583,115

Expiration due to failure to pay maintenance fee

Patent Number Expiration Date
6,583,115 June 24, 2015

International Patent Family for Patent: 6,583,115

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria195339► subscribe
Australia1893092► subscribe
Australia5881996► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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