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Generated: May 22, 2019

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Details for Patent: 6,191,148

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Which drugs does patent 6,191,148 protect, and when does it expire?

Patent 6,191,148 protects NEXIUM and PRILOSEC and is included in two NDAs.

Protection for NEXIUM has been extended six months for pediatric studies, as indicated by the *PED designation in the table below.

This patent has twenty-five patent family members in seventeen countries.

Summary for Patent: 6,191,148
Title: Omerazole process and compositions thereof
Abstract:The present invention describes an improved process for the preparation, isolation, and purification of the anti-ulcer agent omeprazole whereby the sulfide precursor pyrmetazole is reacted subsurfacely with exactly one molar equivalent of meta-chloroperoxybenzoic acid in a chlorinated aliphatic hydrocarbon or aromatic hydrocarbon solvent, such as methylene chloride or toluene; residual organic solvent is removed from the aqueous layer by vacuum distillation; crude product is obtained by reactive crystallization with an alkyl formate or formic acid solution and seeding; and pure product is isolated by recrystallization in methanol-water containing aqueous NaOH by subsurface addition of aqueous acetic acid to pH 9.0, seeding, filtration, washing, and drying. Omeprazole and compositions of omeprazole containing no chromatographically detectable levels of residual non-alcoholic organic reaction solvent and diminished levels of alcoholic solvent are also described.
Inventor(s): McManus; James W. (Albany, GA), Anousis; Nick (Albany, GA), Banks; Benjamin Newton (Albany, GA), Liu; Hui (Greenbrook, NJ), Zhou; Lingwen (North Brunswick, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Application Number:09/461,605
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 6,191,148
Prior Art and Litigation SupportOrder Prior Art and Litigation support for Patent 6,191,148
Patent Claim Types:
see list of patent claims
Compound; Composition;

Drugs Protected by US Patent 6,191,148

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Astrazeneca Pharms NEXIUM esomeprazole magnesium CAPSULE, DELAYED REL PELLETS;ORAL 021153-001 Feb 20, 2001 AB RX Yes No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Astrazeneca Pharms NEXIUM esomeprazole magnesium CAPSULE, DELAYED REL PELLETS;ORAL 021153-002 Feb 20, 2001 AB RX Yes Yes ➤ Sign Up ➤ Sign Up ➤ Sign Up
Astrazeneca Pharms PRILOSEC omeprazole CAPSULE, DELAYED REL PELLETS;ORAL 019810-003 Oct 5, 1995 DISCN Yes No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate

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Serving hundreds of leading biopharmaceutical companies globally:

Teva
Chubb
Mallinckrodt
Chinese Patent Office
Covington
Accenture

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