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Generated: November 18, 2017

DrugPatentWatch Database Preview

Claims for Patent: 6,191,148

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Claims for Patent: 6,191,148

Title: Omerazole process and compositions thereof
Abstract:The present invention describes an improved process for the preparation, isolation, and purification of the anti-ulcer agent omeprazole whereby the sulfide precursor pyrmetazole is reacted subsurfacely with exactly one molar equivalent of meta-chloroperoxybenzoic acid in a chlorinated aliphatic hydrocarbon or aromatic hydrocarbon solvent, such as methylene chloride or toluene; residual organic solvent is removed from the aqueous layer by vacuum distillation; crude product is obtained by reactive crystallization with an alkyl formate or formic acid solution and seeding; and pure product is isolated by recrystallization in methanol-water containing aqueous NaOH by subsurface addition of aqueous acetic acid to pH 9.0, seeding, filtration, washing, and drying. Omeprazole and compositions of omeprazole containing no chromatographically detectable levels of residual non-alcoholic organic reaction solvent and diminished levels of alcoholic solvent are also described.
Inventor(s): McManus; James W. (Albany, GA), Anousis; Nick (Albany, GA), Banks; Benjamin Newton (Albany, GA), Liu; Hui (Greenbrook, NJ), Zhou; Lingwen (North Brunswick, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Application Number:09/461,605
Patent Claims: 1. 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benz imidazole(omeprazole) of greater than 99.94% purity as determined by high-performance liquid chromatography and having less than 500 parts per million (p.p.m.) of residual ethanol relative to omeprazole.

2. Omeprazole according to claim 1 having less than 50 p.p.m. of residual ethanol relative to omeprazole.

3. Omeprazole according to claim 1 having less than 3 p.p.m. of residual ethanol relative to omeprazole.

4. Omeprazole according to claim 1 wherein none of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]-1H-benzimid azole (pyrmetazole); 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benz imidazole; and 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-1-oxo-2-pyridinyl)methyl]sulfonyl]-1 H-benzimidazole is present to an extent greater than 0.04%.

5. Omeprazole according to claim 1 further characterized by having less than 3 p.p.m. of residual chloroform or methylene chloride or a mixture thereof relative to omeprazole.

6. Omeprazole according to claim 5 further characterized by having less than 30 p.p.m. of residual methanol relative to omeprazole.

7. Omeprazole according to claim 1 further characterized by having less than 3 p.p.m. of residual toluene relative to omeprazole.

8. Omeprazole according to claim 7 further characterized by having less than 30 p.p.m. of residual methanol relative to omeprazole.

9. Omeprazole according to claim 6 containing less than 3 p.p.m. of residual chlorinated aliphatic hydrocarbon solvent relative to omeprazole.

10. Omeprazole according to claim 8 containing less than 3 p.p.m. of residual aromatic hydrocarbon solvent relative to omeprazole.

11. A composition comprising omeprazole according to claim 1.

12. The composition according to claim 11 wherein the omeprazole is further characterized by having less than 3 p.p.m. of residual toluene and less than 30 p.p.m. of residual methanol relative to omeprazole.

13. The composition according to claim 11 wherein the omeprazole is further characterized by having less than 3 p.p.m. of residual chloroform or methylene chloride or a mixture thereof and less than 30 p.p.m. of residual methanol relative to omeprazole.

14. A pharmaceutical composition comprising omeprazole according to claim 1 and a pharmaceutically acceptable excipient.

15. The pharmaceutical composition of claim 14 wherein the omeprazole is further characterized by having less than 3 p.p.m. of residual toluene and less than 30 p.p.m. of residual methanol relative to omeprazole.

16. The pharmaceutical composition of claim 14 wherein the omeprazole is further characterized by having less than 3 p.p.m. of residual chloroform or methylene chloride or a mixture thereof and less than 30 p.p.m. of residual methanol relative to omeprazole.
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Serving leading biopharmaceutical companies globally:

Daiichi Sankyo
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AstraZeneca
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Boehringer Ingelheim
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Cerilliant
Argus Health

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