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Generated: December 17, 2017

DrugPatentWatch Database Preview

Details for Patent: 6,165,497

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Summary for Patent: 6,165,497

Title: Subsaturated nicotine transdermal therapeutic system
Abstract:Rate controlled transdermal nicotine delivery systems are disclosed which utilize an in-line adhesive to maintain the systems on the skin. The initial equilibrated concentration of nicotine in the nicotine reservoir and the adhesive is below saturation, preferably at a thermodynamic activity no greater than 0.50, and the reservoir comprises the nicotine dissolved in a polymer with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of nicotine in the reservoir is sufficient to prevent the activity of the nicotine in the reservoir from decreasing by more than about 75% and preferably no more than about 25% during the predetermined period of administration; and the thicknesses of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and, preferably at least 75% initial equilibrated nicotine loading is in the reservoir layer.
Inventor(s): Osborne; James L. (Mountain View, CA), Nelson; Melinda (Sunnyvale, CA), Enscore; David J. (Saratoga, CA), Yum; Su Il (Los Altos, CA), Gale; Robert M. (Los Altos, CA)
Assignee: ALZA Corporation (Mountain View, CA)
Application Number:07/662,857
Patent Claim Types:
see list of patent claims
Device; Use;

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International Patent Family for Patent: 6,165,497

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria161734► Subscribe
Australia3852189► Subscribe
Australia3913695► Subscribe
Australia4491193► Subscribe
Australia630614► Subscribe
Australia666208► Subscribe
Australia682813► Subscribe
Australia684394► Subscribe
Australia8585291► Subscribe
Canada1338700► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Federal Trade Commission
US Department of Justice
Argus Health
Fish and Richardson
US Army

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