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Serving leading biopharmaceutical companies globally:

Harvard Business School
Chinese Patent Office
Cipla
Merck
Dow
Cantor Fitzgerald
Deloitte
QuintilesIMS
Medtronic
US Army

Generated: February 19, 2018

DrugPatentWatch Database Preview

Details for Patent: 6,103,262

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Summary for Patent: 6,103,262
Title: Modified-release metronidazole compositions and methods for making and using same
Abstract:Pharmaceutical compositions having a modified release profile for once daily dosing of metronidazole, methods for making the pharmaceutical compositions, and methods for treating a microbial infection with once daily dosing of the pharmaceutical compositions of the invention are provided. The compositions given once daily exhibit substantial bioequivalence to immediate release metronidazole given three times per day. The compositions of the invention comprise: (a) a first portion of metronidazole which is about 59 wt % to about 79 wt % metronidazole; (b) about 1.5 wt % to about 3.0 wt % of an aqueous insoluble poly(meth)acrylic acid ester copolymer which is aqueous permeable, aqueous expandable and pH-independent; (c) about 0.1 wt % to about 2.0 wt % detackifier; (d) 0 to about 23 wt % of a first aqueous soluble pharmaceutical diluent; (e) 0 to about 23 wt % of a second aqueous soluble diluent which is suitable for forming a pharmaceutical tablet when compressed with the granules of (a), the second aqueous soluble diluent being the same as or different from the first aqueous soluble diluent; (f) 0 to about 20 wt % of a second portion of metronidazole; (g) 0 to about 0.2 wt % glidant; and (h) 0 to about 2 wt % lubricant; wherein the composition comprises metronidazole containing granules comprising (a), (b), (c) and (d), wherein the sum of the weight percentages of metronidazole provided by (a) and (f) is between about 72 wt % and about 79 wt %, and wherein the sum of the weight percentages of the aqueous soluble diluent provided by (d) and (e) is between about 16 wt % and about 23 wt %.
Inventor(s): Desai; Subhash (Grayslake, IL), Mancini; Alan Mark (Indian Head Park, IL), Schumann; Steven Charles (Elgin, IL)
Assignee: G. D. Searle & Company (Chicago, IL)
Application Number:08/187,568
Patent Claim Types:
see list of patent claims
Composition; Dosage form; Formulation; Use;

Drugs Protected by US Patent 6,103,262

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 6,103,262

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 216236 ➤ Sign Up
Australia 1596795 ➤ Sign Up
Australia 682248 ➤ Sign Up
Brazil 9506662 ➤ Sign Up
Canada 2181985 ➤ Sign Up
China 1095665 ➤ Sign Up
China 1139382 ➤ Sign Up
Germany 69526434 ➤ Sign Up
Denmark 0744947 ➤ Sign Up
European Patent Office 0744947 ➤ Sign Up
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Boehringer Ingelheim
Fuji
Daiichi Sankyo
UBS
AstraZeneca
Fish and Richardson
Cipla
Colorcon
US Army

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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