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Cantor Fitzgerald
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Boehringer Ingelheim
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Generated: November 24, 2017

DrugPatentWatch Database Preview

Details for Patent: 6,100,376

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Summary for Patent: 6,100,376

Title: A.sup.21, B.sup.30, modified insulin derivatives having an altered action profile
Abstract:New insulin derivatives of the formula II with an iso-electric point between 5 and 8.5, with improved stability in weakly acid aqueous medium and with a special action profile, and the physiologically tolerated salts of these insulin derivatives, for the treatment of diabetes mellitus; formula II is: ##STR1## in which R.sup.1 denotes H or H-Phe, R.sup.2 denotes a genetically encodable L-amino acid which contains no amide group, R.sup.30 represents the residue of a neutral genetically encodable L-amino acid, R.sup.31 represents a physiologically acceptable organic group which is basic in nature and has up to 50 carbon atoms, in whose structure 0 to 3 .alpha.-amino acids are involved and whose terminal carboxyl group which is present where appropriate can be free, in the form of an ester functionality, an amide functionality, a lactone or reduced to CH.sub.2 0H, and X represents a genetically encodable L-amino acid.
Inventor(s): Dorschug; Michael (Bochum, DE)
Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DE)
Application Number:08/842,794
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

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Foreign Priority and PCT Information for Patent: 6,100,376

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Germany3837825Nov 08, 1988

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Serving leading biopharmaceutical companies globally:

Farmers Insurance
Chinese Patent Office
Johnson and Johnson

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