Last Updated: September 24, 2026

Details for Patent: 5,919,775

Name: Drug Patent Intelligence for US Patent 5919775
Creator: DrugPatentWatch
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Summary for Patent: 5,919,775

Title:	Method for inhibiting expression of inducible nitric oxide synthase with tetracycline
Abstract:	The invention is a method of inhibiting the production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo biological system. The method employs a tetracycline compound to inhibit the production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the biological system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.
Inventor(s):	Ashok R. Amin, Steven B. Abramson, Lorne M. Golub, Nungavaram S. Ramamurthy, Thomas F. McNamara, Robert A. Greenwald, Howard Trachtman
Assignee:	NYU HOSPITAL CENTER , New York University NYU , Research Foundation of the State University of New York
Application Number:	US09/061,286
Patent Claim Types: see list of patent claims	Use;

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Canada	2264552	⤷ Start Trial
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