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|Title:||2'-O-modified nucleosides and phosphoramidites|
|Abstract:||2'-O-Modified nucleosides, nucleotides, and oligonucleotides. These 2'-O-modified oligonucleotides are resistant to nuclease digestion and can effectively hybridize to a complementary polynucleotide.|
|Inventor(s):||Cook; Phillip Dan (San Marcos, CA), Guinosso; Charles John (Vista, CA)|
|Assignee:||ISIS Pharmaceuticals, Inc. (Carlsbad, CA)|
Patent Claim Types:|
see list of patent claims
|PCT Filed||July 20, 1993||PCT Application Number:||PCT/US93/06807|
|PCT Publication Date:||February 03, 1994||PCT Publication Number:||WO94/02501|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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