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Chinese Patent Office
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Generated: February 23, 2018

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Claims for Patent: 5,914,396

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Summary for Patent: 5,914,396
Title: 2'-O-modified nucleosides and phosphoramidites
Abstract:2'-O-Modified nucleosides, nucleotides, and oligonucleotides. These 2'-O-modified oligonucleotides are resistant to nuclease digestion and can effectively hybridize to a complementary polynucleotide.
Inventor(s): Cook; Phillip Dan (San Marcos, CA), Guinosso; Charles John (Vista, CA)
Assignee: ISIS Pharmaceuticals, Inc. (Carlsbad, CA)
Application Number:08/373,298
Patent Claims: 1. A compound having the structure: ##STR6## wherein: B.sub.x is adenine, guanine, hypoxanthine, uracil, thymine, cytosine, 2-aminoadenine or 5-methylcytosine;

T.sub.3 and T.sub.5, independently, are OH, a nucleotide, a nucleoside, or an oligonucleotide;

X is R.sub.1 -R.sub.2 ;

R.sub.1 is C.sub.1 -C.sub.20 alkyl; and

R.sub.2 is O-alkyl, S-alkyl, NH-alkyl, N-dialkyl, O-aryl, S-aryl, NH-aryl, O-aralkyl, S-aralkyl, or NH-aralkyl.

2. The compound of claim 1 wherein R.sub.2 is O-alkyl.

3. The compound of claim 1 wherein R.sub.2 is NH-alkyl.

4. The compound of claim 1 wherein R.sub.2 is N-dialkyl.

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