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|Title:||2'-O-modified nucleosides and phosphoramidites|
|Abstract:||2'-O-Modified nucleosides, nucleotides, and oligonucleotides. These 2'-O-modified oligonucleotides are resistant to nuclease digestion and can effectively hybridize to a complementary polynucleotide.|
|Inventor(s):||Cook; Phillip Dan (San Marcos, CA), Guinosso; Charles John (Vista, CA)|
|Assignee:||ISIS Pharmaceuticals, Inc. (Carlsbad, CA)|
1. A compound having the structure: ##STR6## wherein: B.sub.x is adenine, guanine, hypoxanthine, uracil, thymine, cytosine, 2-aminoadenine or 5-methylcytosine;
T.sub.3 and T.sub.5, independently, are OH, a nucleotide, a nucleoside, or an oligonucleotide;
X is R.sub.1 -R.sub.2 ;
R.sub.1 is C.sub.1 -C.sub.20 alkyl; and
R.sub.2 is O-alkyl, S-alkyl, NH-alkyl, N-dialkyl, O-aryl, S-aryl, NH-aryl, O-aralkyl, S-aralkyl, or NH-aralkyl.
2. The compound of claim 1 wherein R.sub.2 is O-alkyl.
3. The compound of claim 1 wherein R.sub.2 is NH-alkyl.
4. The compound of claim 1 wherein R.sub.2 is N-dialkyl.
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