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|Title:||Treatment of systemic fungal infections with phospholipid particles encapsulating polyene antibiotics|
|Abstract:||Formulations consisting of phospholipid small unilamellar particles encapsulating polyene antifungal antibiotics and methods for using such compositions to treat systemic fungal infections are described. In a preferred embodiment, the particles are in the form of vesicles which comprise a polyene antifungal antibiotic, preferably amphotericin B and/or nystatin, egg phosphatidylcholine and cholesterol, preferably in the molar ratio of about 0.2 (AMB):2(PL):1(CHOL). These vesicles may also have an amine modified surface. The vesicles are suspended in a low isonic strength saccharide/tris solution at a pH of from about 6.0 to about 8.0 and may be administered to deliver the antifungal antibiotic to treat systemic fungal infections.|
|Inventor(s):||Adler-Moore; Jill (Altadena, CA), Gamble; Ronald C. (Altadena, CA), Proffitt; Richard T. (Arcadia, CA)|
|Assignee:||NeXstar Pharmaceuticals, Inc. (Boulder, CO)|
Patent Claim Types:|
see list of patent claims
|Composition; Compound; Use; Process; Formulation;|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
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