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Generated: January 16, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,874,104

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Summary for Patent: 5,874,104
Title: Treatment of systemic fungal infections with phospholipid particles encapsulating polyene antibiotics
Abstract:Formulations consisting of phospholipid small unilamellar particles encapsulating polyene antifungal antibiotics and methods for using such compositions to treat systemic fungal infections are described. In a preferred embodiment, the particles are in the form of vesicles which comprise a polyene antifungal antibiotic, preferably amphotericin B and/or nystatin, egg phosphatidylcholine and cholesterol, preferably in the molar ratio of about 0.2 (AMB):2(PL):1(CHOL). These vesicles may also have an amine modified surface. The vesicles are suspended in a low isonic strength saccharide/tris solution at a pH of from about 6.0 to about 8.0 and may be administered to deliver the antifungal antibiotic to treat systemic fungal infections.
Inventor(s): Adler-Moore; Jill (Altadena, CA), Gamble; Ronald C. (Altadena, CA), Proffitt; Richard T. (Arcadia, CA)
Assignee: NeXstar Pharmaceuticals, Inc. (Boulder, CO)
Application Number:08/467,864
Patent Claim Types:
see list of patent claims
Composition; Compound; Use; Process; Formulation;

Drugs Protected by US Patent 5,874,104

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 5,874,104

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 66597 ➤ Subscribe
Australia 606880 ➤ Subscribe
Australia 7716087 ➤ Subscribe
Canada 1292184 ➤ Subscribe
Germany 3772498 ➤ Subscribe
Denmark 168982 ➤ Subscribe
Denmark 434187 ➤ Subscribe
European Patent Office 0260811 ➤ Subscribe
Spain 2051740 ➤ Subscribe
Greece 3002852 ➤ Subscribe
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving leading biopharmaceutical companies globally:

Fish and Richardson
Chinese Patent Office
AstraZeneca
Federal Trade Commission
Cantor Fitzgerald
Mallinckrodt
Citi
Novartis
Julphar

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