Generated: December 16, 2017
DrugPatentWatch Database Preview
Details for Patent: 5,849,700
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Summary for Patent: 5,849,700
|Title:|| Pharmaceutical formulation|
|Abstract:||A pharmaceutical preparation comprising a growth hormone and histidine or a derivative of histidine as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved preparation at ambient temperature. Crystallization of growth hormone in the presence of histidine or a derivative thereof gives rise to a higher yield of crystals having a higher purity than known methods.|
|Inventor(s):|| S.o slashed.rensen; Hans Holmegaard (Virum, DK), Skriver; Lars (Ved.ae butted.k, DK), Hoelgaard; Annie Rassing (Holte, DK) |
|Assignee:|| Novo Nordisk A/S (Bagsvaerd, DK) |
Patent Claim Types:|
see list of patent claims
|Use; Composition; Formulation; |
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Foreign Priority and PCT Information for Patent: 5,849,700
|Foriegn Application Priority Data|
||Foreign Patent Number
||Foreign Patent Date
|Denmark||2046/91||Dec 20, 1991|
|Denmark||1364/92||Nov 10, 1992|
International Patent Family for Patent: 5,849,700
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