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Serving hundreds of leading biopharmaceutical companies globally:

Chubb
Farmers Insurance
Healthtrust
Cerilliant
Colorcon
McKesson
Federal Trade Commission
Deloitte
Dow

Generated: April 26, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,773,001

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Summary for Patent: 5,773,001
Title: Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
Abstract:This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.
Inventor(s): Hamann; Philip Ross (Garnerville, NY), Hinman; Lois (N. Tarrytown, NY), Hollander; Irwin (Monsey, NY), Holcomb; Ryan (Glen Rock, NJ), Hallett; William (New City, NY), Tsou; Hwei-Ru (New City, NY), Weiss; Martin J. (Ft. Lee, NJ)
Assignee: American Cyanamid Company (Madison, NJ)
Application Number:08/253,877
Patent Claim Types:
see list of patent claims
Compound; Use; Composition; Formulation;

Drugs Protected by US Patent 5,773,001

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Serving hundreds of leading biopharmaceutical companies globally:

Baxter
Fish and Richardson
Cantor Fitzgerald
US Department of Justice
US Army
Cipla
McKinsey
Citi
Deloitte

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