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Generated: October 19, 2017

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Details for Patent: 5,760,069

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Summary for Patent: 5,760,069

Title: Method of treatment for decreasing mortality resulting from congestive heart failure
Abstract:A method of treatment using a compound of Formula I: ##STR1## wherein: R.sub.1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R.sub.2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl; R.sub.3 is hydrogen or lower alkyl of up to 6 carbon atoms; R.sub.4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R.sub.4 together with R.sub.5 can represent --CH.sub.2 --O--; X is a valency bond, --CH.sub.2, oxygen or sulfur; Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl; R.sub.5 and R.sub.6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a --CONH.sub.2 -- group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms, lower alkysulphinyl of up to 6 carbon atoms and lower alkylsulphonyl of up to 6 carbon atoms; or R.sub.5 and R.sub.6 together represent methylenedioxy; or a pharmaceutically acceptable salt thereof, alone or in conjunction with one or more other therapeutic agents, said agents being selected from the group consisting of ACE inhibitors, diuretics, and digoxin for decreasing mortality resulting from congestive heart failure (CHF) in mammals, particularly humans.
Inventor(s): Lukas-Laskey; Mary Ann (Philadelphia, PA), Ruffolo, Jr.; Robert (Spring City, PA), Shusterman; Neil Howard (Wynnewood, PA), Sponer; Gisbert (Laudenbach, DE), Strein; Klaus (Hemsbach, DE)
Assignee: Boehringer Mannheim Pharmaceuticals Corporation-SmithKline Beecham (Rockville, MD)
Application Number:08/483,635
Patent Claim Types:
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International Patent Family for Patent: 5,760,069

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Hungary9900773► Subscribe
Czech Republic292002► Subscribe
Germany19503995► Subscribe
Germany69602424► Subscribe
Denmark0808162► Subscribe
European Patent Office0808162► Subscribe
Spain2134588► Subscribe
Finland973255► Subscribe
Greece3030966► Subscribe
Hong Kong1014861► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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