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Details for Patent: 5,686,060

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Patent 5,686,060 protects LUMASON and is included in one NDA.

This patent has one hundred and thirty-six patent family members in twenty-eight countries.

Summary for Patent: 5,686,060

Title: Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography
Abstract:Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.
Inventor(s): Schneider; Michel (Troinex, CH), Brochot; Jean (Feigeres, FR), Puginier; Jerome (Le Chable-Beaumont, FR), Yan; Feng (Meyrin, CH)
Assignee: Bracco International BV (NL)
Application Number:08/420,677
Patent Claim Types:
see list of patent claims
Composition;

Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Bracco
LUMASON
sulfur hexafluoride lipid-type a microspheres
FOR SUSPENSION;INTRAVENOUS203684-001Oct 15, 2014RXYes5,686,060► subscribeYY
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Non-Orange Book Patents for Patent: 5,686,060

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
5,567,414 Stable microbubbles suspensions injectable into living organisms► subscribe
5,846,518 Gas mixtures useful as ultrasound contrast media contrast agents containing the media and method► subscribe
5,597,549 Stable microbubble suspensions as enhancement agents for ultrasound echography► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Because of the complexity of determining patent expiration dates it is advisable to have patent counsel verify freedom to operate.

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International Patent Family for Patent: 5,686,060

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria112173► subscribe
Austria125711► subscribe
Austria146972► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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