Generated: December 12, 2017
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Details for Patent: 5,656,722
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Summary for Patent: 5,656,722
|Title:|| A.sup.21 -, B.sup.30 - modified insulin derivatives having an altered action profile|
|Abstract:||New insulin derivatives, the use thereof, and a pharmaceutical composition containing them Insulin derivatives having an isoelectric point between 5 and 8.5, or physiologically tolerated salts thereof, of the Formula II ##STR1## in which: R.sup.1 at position B1 denotes H or H-Phe; R.sup.2 at position A21 denotes a genetically encodable L-amino acid selected from the group consisting of Gly, Ala, Val, Leu, Ile, Pro, Phe, Trp, Met, Ser, Thr, Cys, Tyr, Asp, and Glu; R.sup.30 represents the residue of a neutral genetically encodable L-amino acid selected from the group consisting of Ala, Thr, and Ser; R.sup.31 represents 1, 2, or 3 neutral or basic alpha amino acids, wherein at least one of the alpha amino acids is selected from the group consisting of Arg, Lys, Hyl, Orn, Cit, and His; X represents His at position B10; and the sequences A1 to A20 and B1 to B29 in Formula II correspond to a mammalian insulin; excluding those insulin derivatives in which simultaneously: R.sup.1 at position B1 denotes Phe; and R.sup.3 is one alpha amino acid having a terminal carboxyl group.|
|Inventor(s):|| Dorschug; Michael (Bochum, DE) |
|Assignee:|| Hoechst Aktiengesellschaft (Frankfurt am Main, DE) |
Patent Claim Types:|
see list of patent claims
|Compound; Use; Composition; |
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Foreign Priority and PCT Information for Patent: 5,656,722
|Foriegn Application Priority Data|
||Foreign Patent Number
||Foreign Patent Date
|Germany||38 37 825.6||Nov 08, 1988|
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