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Generated: August 18, 2017

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Title: Substituted isoxazoles for the treatment of inflammation
Abstract:A class of substituted isoxazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II ##STR1## wherein R.sup.1 is selected from hydroxyl, lower alkyl, carboxyl, lower carboxyalkyl, lower aminocarbonylalkyl, lower alkoxycarbonylalkyl, lower aralkyl, lower alkoxyalkyl, lower aralkoxyalkyl, lower alkylthioalkyl, lower aralkylthioalkyl, lower alkylaminoalkyl, lower aryloxyalkyl, lower arylthioalkyl, lower haloalkyl, lower hydroxylalkyl, cycloalkyl, cycloalkylalkyl, and aralkyl; wherein R.sup.3 is selected from cycloalkyl, cycloalkenyl, aryl, and heteroaryl; wherein R.sup.3 is optionally substituted at a substitutable position with one or more radicals independently selected from lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, lower haloalkyl, hydroxyl, lower hydroxyalkyl, lower haloalkoxy, amino, lower alkylamino, lower arylamino, lower aminoalkyl, nitro, halo, lower alkoxy, aminosulfonyl, and lower alkylthio; and wherein R.sup.4 is selected from lower alkyl, hydroxyl and amino; or a pharmaceutically-acceptable salt thereof.
Inventor(s): Talley; John J. (Brentwood, MO), Brown; David L. (Chesterfield, MO), Nagarajan; Srinivasan (Chesterfield, MO), Carter; Jeffery S. (Chesterfield, MO), Weier; Richard M. (Lake Bluff, IL), Stealey; Michael A. (Libertyville, IL), Collins; Paul W. (Deerfield, IL), Rogers, deceased; Roland S. (late of Richmond Heights, MO), Seibert; Karen (St. Louis, MO)
Application Number:08/473,884
Patent Claim Types:
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Compound; Composition; Use;

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International Patent Family for Patent: ► Subscribe

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Finland120736► Subscribe
Finland973292► Subscribe
Spain2183935► Subscribe
European Patent Office1528059► Subscribe
Czech Republic9702546► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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