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Generated: August 21, 2017

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Title: Insulin analogues
Abstract:Novel rapid-acting human insulin analogues are provided having less tendency to self-association into dimers, tetramers, hexamers, or polymers. The novel human insulin analogues are formed by substituting one or more of the amino acid residues of human insulin with naturally occuring amino acid residues. The amino acid residue substitutions are preferably more hydrophilic than the natural amino acid residue at the respective position in the molecule. Furthermore, the insulin analogues have the same charge or a greater negative charge at neutral pH than that of human insulin. Preferred amino acid substitutions are Asp, Glu, Ser, Thr, His, and Ile, and more preferred substitutions are Asp and Glu. The novel insulin analogues can be used for the preparation of rapid-acting insulin solutions.
Inventor(s): Brange; Jens J. V. (Klampenborg, DK), Norris; Kjeld (Hellerup, DK), Hansen; Mogens T. (Lynge, DK)
Assignee: Novo Nordisk A/S (Bagsvaerd, DK)
Application Number:06/901,821
Patent Claim Types:
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Compound; Formulation;

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Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Denmark3956/85Aug 30, 1985
Denmark4677/85Oct 14, 1985

International Patent Family for Patent: ► Subscribe

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Greece862233► Subscribe
Denmark467785► Subscribe
European Patent Office0214826► SubscribeSPC/GB99/045United Kingdom► Subscribe
European Patent Office0214826► Subscribe99C0044Belgium► Subscribe
European Patent Office0214826► SubscribeC990042Netherlands► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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