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Details for Patent: 5,549,892

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Summary for Patent: 5,549,892

Title: Enhanced in vivo uptake of glucocerebrosidase
Abstract:A pharmaceutical composition comprising remodelled recombinant glucocerebrosidase (GCR) is described that provides a therapeutic effect at doses that are lower then those required using remodelled naturally occurring GCR. A method of treating patients with Gaucher's disease using remodelled recombinant GCR is also provided. In vivo uptake of exogenous molecules can be determined by extracting a mixture of cells from a subject, enriching the target cells in vitro, lysing the cells and determining the amount of exogenous molecules.
Inventor(s): Friedman; BethAnn (Arlington, MA), Hayes; Michael (Acton, MA)
Assignee: Genzyme Corporation (Cambridge, MA)
Application Number:08/080,855
Patent Claim Types:
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Composition; Use;

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International Patent Family for Patent: 5,549,892

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria138686► Subscribe
Canada2006709► Subscribe
Canada2339888► Subscribe
Germany68926569► Subscribe
European Patent Office0401362► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.