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|Title:||Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors|
|Abstract:||Bridged bicyclic aromatic compounds are provided having the structure ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and n are as defined herein. The novel compounds are useful for modulating gene expression of retinoic acid receptors, vitamin D receptors and thyroid receptors. Pharmaceutical compositions and methods for modulating gene expression are provided as well.|
|Inventor(s):||Dawson; Marcia L. (Menlo Park, CA), Cameron; James F. (Palo Alto, CA), Hobbs; Peter D. (Moss Beach, CA), Jong; Ling (Sunnyvale, CA), Pfahl; Magnus (Solana Beach, CA), Zhang; Xiao-kun (La Jolla, CA), Lehmann; Jurgen M. (Solana Beach, CA)|
|Assignee:||SRI International (Menlo Park, CA) La Jolla Cancer Research Foundation (La Jolla, CA)|
Patent Claim Types:|
see list of patent claims
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
|Japan||2007001982||<disabled in preview>|
|Brazil||9307528||<disabled in preview>|
|Canada||2149882||<disabled in preview>|
| This preview shows a limited data set|
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