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Last Updated: May 10, 2024

Details for Patent: 5,466,810

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Summary for Patent: 5,466,810

Title:	2-amino-3-aroyl-benzo[.beta.]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[.beta.] thiophenes
Abstract:	A group of 2-amino-3-aroyl-benzo[.beta.]thiophenes are prepared by treating an aldehyde with an anion of dimethylamino thioformamide, cyclizing the .alpha.-hydroxy thioamide, and subsequently acylating the benzo[.beta.]thiophene to yield the 2-amino-3-aryl derivative. These compounds may be treated with suitable phenyl Grignard reagents, and after deprotection, yield 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[.beta .]thiophene.
Inventor(s):	Godfrey; Alexander G. (Greenwood, IN)
Assignee:	Eli Lilly and Company (Indianapolis, IN)
Application Number:	08/257,859
Patent Claim Types: see list of patent claims	Compound;

Drugs Protected by US Patent 5,466,810

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>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Patented / Exclusive Use	>Submissiondate

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Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
Austria	200671	⤷ Try a Trial
Australia	2702995	⤷ Try a Trial
Brazil	9507956	⤷ Try a Trial
Canada	2192097	⤷ Try a Trial
Germany	69520738	⤷ Try a Trial
Denmark	0765321	⤷ Try a Trial
European Patent Office	0765321	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration	>Supplementary Protection Certificate	>SPC Country	>SPC Expiration

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