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Serving hundreds of leading biopharmaceutical companies globally:

Teva
Julphar
Boehringer Ingelheim
Colorcon
Deloitte
Daiichi Sankyo
Mallinckrodt
Federal Trade Commission
Medtronic

Generated: June 18, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,352,459

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Summary for Patent: 5,352,459
Title: Use of purified surface modifiers to prevent particle aggregation during sterilization
Abstract:This invention discloses a composition comprised of nanoparticles having a purified polymeric surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier. Preferred purified polymeric surfactants are purified polyalkyleneoxide substituted ethylenediamine surfactants. A preferred cloud point modifier is polyethylene glycol. This invention further discloses a method of making nanoparticles having a purified polymeric surfactant as a surface modifier adsorbed on the surface and a cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.
Inventor(s): Hollister; Kenneth R. (Chester Springs, PA), Ladd; David (Wayne, PA), McIntire; Gregory L. (West Chester, PA), Na; George C. (Fort Washington, PA), Rajagopalan; Natarajan (Phoenixville, PA), Yuan; Barbara O. (Villanova, PA)
Assignee: Sterling Winthrop Inc. (New York, NY)
Application Number:07/991,639
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 5,352,459
Patent Claim Types:
see list of patent claims
Composition; Use;

Drugs Protected by US Patent 5,352,459

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Family Members for US Patent 5,352,459

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia 5046693 ➤ Try a Free Trial
Australia 663010 ➤ Try a Free Trial
Canada 2102356 ➤ Try a Free Trial
Czech Republic 9302616 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

QuintilesIMS
US Army
Chubb
Federal Trade Commission
Daiichi Sankyo
Merck
Boehringer Ingelheim
Moodys
Express Scripts

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