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Generated: July 24, 2017

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Title: Use of purified surface modifiers to prevent particle aggregation during sterilization
Abstract:This invention discloses a composition comprised of nanoparticles having a purified polymeric surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier. Preferred purified polymeric surfactants are purified polyalkyleneoxide substituted ethylenediamine surfactants. A preferred cloud point modifier is polyethylene glycol. This invention further discloses a method of making nanoparticles having a purified polymeric surfactant as a surface modifier adsorbed on the surface and a cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.
Inventor(s): Hollister; Kenneth R. (Chester Springs, PA), Ladd; David (Wayne, PA), McIntire; Gregory L. (West Chester, PA), Na; George C. (Fort Washington, PA), Rajagopalan; Natarajan (Phoenixville, PA), Yuan; Barbara O. (Villanova, PA)
Assignee: Sterling Winthrop Inc. (New York, NY)
Application Number:07/991,639
Patent Claim Types:
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Composition; Use;

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Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
HungaryT65783► Subscribe
European Patent Office0605024► Subscribe
Finland935306► Subscribe
Hungary9303604► Subscribe
Czech Republic9302616► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving 500+ biopharmaceutical companies globally:

Mallinckrodt
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